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Articles 1 - 30 of 38
Full-Text Articles in Engineering
The Geometric Growth Of M&S Education: Pushing Forward, Pushing Outward, John A. Sokolowski, Catherine M. Banks
The Geometric Growth Of M&S Education: Pushing Forward, Pushing Outward, John A. Sokolowski, Catherine M. Banks
VMASC Publications
M&S education is experiencing a geometric growth that is placing it front and center as a discipline and as an interdisciplinary tool. This article discusses the evolution of the discipline of M&S. It answers: Why has M&S education experienced a forward and outward growth? What is it that makes this discipline unique? What is the current state of M&S education?
Negative Dielectrophoretic Capture Of Bacterial Spores In Food Matrices, Mehti Koklu, Seungkyung Park, Suresh D. Pillai, Ali Beskok
Negative Dielectrophoretic Capture Of Bacterial Spores In Food Matrices, Mehti Koklu, Seungkyung Park, Suresh D. Pillai, Ali Beskok
Mechanical & Aerospace Engineering Faculty Publications
A microfluidic device with planar square electrodes is developed for capturing particles from high conductivity media using negative dielectrophoresis (n-DEP). Specifically, Bacillus subtilis and Clostridium sporogenes spores, and polystyrene particles are tested in NaCl solution (0.05 and 0.225 S/m), apple juice (0.225 S/m), and milk (0.525 S/m). Depending on the conductivity of the medium, the Joule heating produces electrothermal flow (ETF), which continuously circulates and transports the particles to the DEP capture sites. Combination of the ETF and n-DEP results in different particle capture efficiencies as a function of the conductivity. Utilizing 20 μm height DEP chambers, “almost complete” and …
Dielectrophoretic Separation Of Mouse Melanoma Clones, Ahmet C. Sabuncu, Jie A. Liu, Stephen J. Beebe, Ali Beskok
Dielectrophoretic Separation Of Mouse Melanoma Clones, Ahmet C. Sabuncu, Jie A. Liu, Stephen J. Beebe, Ali Beskok
Bioelectrics Publications
Dielectrophoresis (DEP) is employed to differentiate clones of mouse melanoma B16F10 cells. Five clones were tested on microelectrodes. At a specific excitation frequency, clone 1 showed a different DEP response than the other four. Growth rate, melanin content, recovery from cryopreservation, and in vitro invasive studies were performed. Clone 1 is shown to have significantly different melanin content and recovery rate from cryopreservation. This paper reports the ability of DEP to differentiate between two malignant cells of the same origin. Different DEP responses of the two clones could be linked to their melanin content.
Modified Sequential Kriging Optimization For Multidisciplinary Complex Product Simulation, Wang Hao, Wang Shaoping, Mileta M. Tomovic
Modified Sequential Kriging Optimization For Multidisciplinary Complex Product Simulation, Wang Hao, Wang Shaoping, Mileta M. Tomovic
Engineering Technology Faculty Publications
Directing to the high cost of computer simulation optimization problem, Kriging surrogate model is widely used to decrease the computation time. Since the sequential Kriging optimization is time consuming, this article extends the expected improvement and put forwards a modified sequential Kriging optimization (MSKO). This method changes the twice optimization problem into once by adding more than one point at the same time. Before re-fitting the Kriging model, the new sample points are verified to ensure that they do not overlap the previous one and the distance between two sample points is not too small. This article presents the double …
Nato Human View Architecture And Human Networks, Holly A. H. Handley, Nancy P. Houston
Nato Human View Architecture And Human Networks, Holly A. H. Handley, Nancy P. Houston
Engineering Management & Systems Engineering Faculty Publications
The NATO Human View is a system architectural viewpoint that focuses on the human as part of a system. Its purpose is to capture the human requirements and to inform on how the human impacts the system design. The viewpoint contains seven static models that include different aspects of the human element, such as roles, tasks, constraints, training and metrics. It also includes a Human Dynamics component to perform simulations of the human system under design. One of the static models, termed Human Networks, focuses on the human-to-human communication patterns that occur as a result of ad hoc or deliberate …
Crystallization Of Community-Acquired Respiratory Distress Syndrome Toxin From Mycoplasma Pneumonia, Olga N. Pakhomova, Alexander B. Taylor, Argentina Becker, Stephen P. Holloway, T. R. Kannan, Joel B. Baseman, P. John Hart
Crystallization Of Community-Acquired Respiratory Distress Syndrome Toxin From Mycoplasma Pneumonia, Olga N. Pakhomova, Alexander B. Taylor, Argentina Becker, Stephen P. Holloway, T. R. Kannan, Joel B. Baseman, P. John Hart
Bioelectrics Publications
Community-acquired respiratory distress syndrome toxin (CARDS TX) is a 591-amino-acid protein with ADP-ribosyltransferase and vacuolating activities that damages the cells lining the respiratory tracts of patients infected with the bacterial pathogen Mycoplasma pneumoniae. Crystals of CARDS TX were grown in space group C2, with unit-cell parameters a = 191.4, b = 107.4, c = 222.1 A, beta = 90.6 degrees. A complete 2.2 A data set was obtained from a single CARDS TX crystal.
Electrically Mediated Delivery Of Plasmid Dna To The Skin, Using A Multielectrode Array, Richard Heller, Yolmari Criz, Loree C. Heller, Richard A. Gilbert, Mark J. Jaroszeski
Electrically Mediated Delivery Of Plasmid Dna To The Skin, Using A Multielectrode Array, Richard Heller, Yolmari Criz, Loree C. Heller, Richard A. Gilbert, Mark J. Jaroszeski
Bioelectrics Publications
The easy accessibility of skin makes it an excellent target for gene transfer protocols. To take full advantage of skin as a target for gene transfer, it is important to establish an efficient and reproducible delivery system. Electroporation is a strong candidate to meet this delivery criterion. Electroporation of the skin is a simple, direct, in vivo method to deliver genes for therapy. Previously, delivery to the skin was performed by means of applicators with relatively large distances between electrodes, resulting in significant muscle stimulation and pain. These applicators also had limitations in controlling the directionality of the applied field. …
An Evaluation Of Risk Management Courses Offered In Engineering Management Programs, S. Jimmy Gandhi, C. Ariel Pinto
An Evaluation Of Risk Management Courses Offered In Engineering Management Programs, S. Jimmy Gandhi, C. Ariel Pinto
Engineering Management & Systems Engineering Faculty Publications
For this paper, the authors have surveyed a total of 22 engineering management (EM) programs in the United States (both accredited and non-accredited). The purpose of this study was to analyze the offering of risk management courses as part of the engineering management curriculum. The findings showed that the majority of the programs did not offer a single dedicated course on risk management and merely covered the topic as part of other courses such as project management. The authors have made recommendations that risk management should be included as a required part of the EM curriculum due to the higher …
Goal Approach To Risk Scenario Identification In Systems Development, Cesar Ariel Pinto, Andreas Tolk, Rafael Landaeta
Goal Approach To Risk Scenario Identification In Systems Development, Cesar Ariel Pinto, Andreas Tolk, Rafael Landaeta
Engineering Management & Systems Engineering Faculty Publications
The scope of this paper is the exploration of fundamental issues in identifying risk scenarios during systems development. Systems development refers to a series of processes which span conceptualization, designing the architecture, obtaining the elements, and eventually integrating all these elements into the fully developed final system. For truly sustainable and green systems, identifying risk scenarios early and continuously over the system development processes is vital. This paper contains various descriptions of risk from the project (i.e. programmatic) and technical perspectives, an exploration of the generally accepted risk management process, and how these relate to systems development through system goals. …
Challenges For Human, Social, Cultural, And Behavioral Modeling, S. K. Numrich, Andreas Tolk
Challenges For Human, Social, Cultural, And Behavioral Modeling, S. K. Numrich, Andreas Tolk
Computational Modeling & Simulation Engineering Faculty Publications
Today's military focus has moved away from the force-on-force battlefield of the past century and into the domain of irregular warfare and its companion security, stability, transition and reconstruction missions. With that change in focus has come a need to examine the operational environment from a wider perspective, one that includes the whole range of human experiences and circumstances. As the set of factors and list of players expands, the need for reliable modeling and simulation increases, if for no other reason than to help the human decision maker make sense of this expanded decision space. However, to do this, …
Project And Risk Management: A Systematic Approach, Baqer Alali, C. Ariel Pinto, Andreas Tolk, Rafael Landaeta
Project And Risk Management: A Systematic Approach, Baqer Alali, C. Ariel Pinto, Andreas Tolk, Rafael Landaeta
Engineering Management & Systems Engineering Faculty Publications
The main purpose of this paper is to discuss three related topics of project management, systems management, and risk management. The issue that would be addressed in this paper is how risks are addressed in project and systems management, and how risks are propagated between projects and systems. A framework is proposed to overcome the problem of risk propagation from project to the systems. It was shown that the proposed framework can be deployed to existing risk management process with reasonable interventions (e.g. process prescribed by PMI). Finally a proof-of-concept application shows potential of the framework for various types of …
Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller
Bioelectric Applications For Treatment Of Melanoma, Stephen J. Beebe, Karl H. Schoenbach, Richard Heller
Bioelectrics Publications
Two new cancer therapies apply bioelectric principles. These methods target tumor structures locally and function by applying millisecond electric fields to deliver plasmid DNA encoding cytokines using electrogene transfer (EGT) or by applying rapid rise-time nanosecond pulsed electric fields (nsPEFs). EGT has been used to locally deliver cytokines such as IL-12 to activate an immune response, resulting in bystander effects. NsPEFs locally induce apoptosis-like effects and affect vascular networks, both promoting tumor demise and restoration of normal vascular homeostasis. EGT with IL-12 is in melanoma clinical trials and nsPEFs are used in models with B16F10 melanoma in vitro and in …
Destruction Of Α -Synuclein Based Amyloid Fibrils By A Low Temperature Plasma Jet, Erdinc Karakas, Agatha Munyanyi, Lesley Greene, Mounir Laroussi
Destruction Of Α -Synuclein Based Amyloid Fibrils By A Low Temperature Plasma Jet, Erdinc Karakas, Agatha Munyanyi, Lesley Greene, Mounir Laroussi
Electrical & Computer Engineering Faculty Publications
Amyloid fibrils are ordered beta-sheet aggregates that are associated with a number of neurodegenerative diseases such as Alzheimer and Parkinson. At present, there is no cure for these progressive and debilitating diseases. Here we report initial studies that indicate that low temperature atmospheric pressure plasma can break amyloid fibrils into smaller units in vitro. The plasma was generated by the plasma pencil, a device capable of emitting a long, low temperature plasma plume/jet. This avenue of research may facilitate the development of a plasma-based medical treatment.
Finite Element Analysis Of Ring-Shaped Emission Profile In Plasma Bullet, Yukinori Sakiyama, David B. Graves, Julien Jarrige, Mounir Laroussi
Finite Element Analysis Of Ring-Shaped Emission Profile In Plasma Bullet, Yukinori Sakiyama, David B. Graves, Julien Jarrige, Mounir Laroussi
Electrical & Computer Engineering Faculty Publications
Using a one-way coupled model of neutral gas flow and plasma dynamics we report a mechanism to explain the ring-shaped emission pattern that has been observed experimentally in plasma bullets at atmospheric pressure. We solve a fluid model with the local field approximation in one-dimensional cylindrical coordinates, corresponding to a cross-section of a plasma bullet. Pulselike uniform electric field is assumed to be applied perpendicular to the simulation domain. Time and spatially resolved spectroscopic measurements support the simulation results.
Experimental Studies On The Plasma Bullet Propagation And Its Inhibition, Erdinc Karakas, Mounir Laroussi
Experimental Studies On The Plasma Bullet Propagation And Its Inhibition, Erdinc Karakas, Mounir Laroussi
Electrical & Computer Engineering Faculty Publications
Plasma bullets generated by atmospheric pressure low temperature plasma jets have recently been an active research topic due to their unique properties and their enhanced plasma chemistry. In this paper, experimental insights into the plasma bullet lifetime and its velocity are reported. Data obtained from intensified charge-coupled device camera and time-resolved optical emission spectroscopy (OES) elucidated the existence of a weakly ionized channel between the plasma bullet and its source (such as the plasma pencil). Factors responsible for the inhibition of the propagation of the bullet, such as low helium mole fraction, the magnitude of the applied voltage, and the …
Uncertainty Analysis And Instrument Selection Using A Web-Based Virtual Experiment, Praveen Malali, Pooja Bais, Robert Choate, Sushil Chaturvedi
Uncertainty Analysis And Instrument Selection Using A Web-Based Virtual Experiment, Praveen Malali, Pooja Bais, Robert Choate, Sushil Chaturvedi
Mechanical & Aerospace Engineering Faculty Publications
A methodology has been developed and successfully implemented for transforming physical experiments in an undergraduate thermo-fluids laboratory at Old Dominion University (ODU), a doctoral university, into web-based virtual experiments while the Mechanical Engineering (ME) faculty at Western Kentucky University (WKU), an undergraduate university, have developed and implemented a Design of Experiments (DOE) Plan to assure that graduates of their program have acquired the skills necessary to design and conduct experiments and analyze experimental results. This paper presents details about a web-based virtual experiment designed to teach students about selection of instruments based on the uncertainty estimated from the virtual experiment. …
Design Of Organic Tandem Solar Cells Using Pcpdtbt: Pc61 Bm And P3ht: Pc71bm, Gon Namkoong, Patrick Boland, Keejoo Lee, James Dean
Design Of Organic Tandem Solar Cells Using Pcpdtbt: Pc61 Bm And P3ht: Pc71bm, Gon Namkoong, Patrick Boland, Keejoo Lee, James Dean
Electrical & Computer Engineering Faculty Publications
We conducted optical and electrical simulations with the goal of determining the optimal design for conjugated polymer-fullerene tandem solar cells using poly[2,6-(4,4-bis-(2-ethylhexyl)- 4H-cyclopenta[2,1- b;3,4- b′] dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] (PCPDTBT): [6,6]-phenyl C61 butyric acid methyl ester (PC61 BM) as a bottom cell and poly(3-hexylthiophene) (P3HT): [6,6]-phenyl C71 butyric acid methyl ester (PC71BM) as a top cell. The effects of photon density, absorption, balanced and unbalanced charge carrier transport, and bimolecular recombination in the two subcells were incorporated into the simulations. We found that the maximum energy conversion efficiency (η) is 9% when charge carrier mobilities in …
Security In Ad Hoc Networks And Pervasive Computing, Isaac Z. Wu, X.-Y. Li, M. Song, C.-M. Liu
Security In Ad Hoc Networks And Pervasive Computing, Isaac Z. Wu, X.-Y. Li, M. Song, C.-M. Liu
Electrical & Computer Engineering Faculty Publications
Pervasive computing is an exciting and blooming research field, in which innovative techniques and applications are continuously emerging and aim to provide ambient and personalized services to users with high quality. Ad hoc networks are wireless, self-organizing systems formed by cooperating nodes within communication range of each other that form temporary networks. Their topology is dynamic, decentralized, ever changing and the nodes may move around arbitrarily. The last few years have witnessed a wealth of research ideas on ad hoc networking that are moving rapidly into implemented standards. Technology under development for ad hoc networks and pervasive computing is making …
Frustrated Drift Of An Anchored Scroll-Wave Filament And The Geodesic Principle, Marcel Wellner, Christian W. Zemlin, Arkady M. Pertsov
Frustrated Drift Of An Anchored Scroll-Wave Filament And The Geodesic Principle, Marcel Wellner, Christian W. Zemlin, Arkady M. Pertsov
Bioelectrics Publications
We investigate anchored scroll-wave filaments in an excitable medium whose diffusivity matrix, including its determinant, is spatially nonuniform. The study is motivated by cardiological applications where scroll-wave behavior in the presence of diffusivity gradients is believed to play an important role in the development of severe arrhythmias. A diffusivity gradient is expected to make the filament drift, unless drift is prevented ("frustrated") by anchoring to localized defects in the propagation medium. The resulting stationary filament is a geodesic curve, as demonstrated here in the case of a nonzero but constant gradient. That is, the diffusivity matrix has a determinant that …
Towards A Center For Modeling And Simulation: The Case For Jordan, Ghaith Rabadi, Hazem Kaylani, Joseph Barjis (Ed.), Murali Mohan Narasipuram (Ed.), Ghaith Rabadi (Ed.), Jolita Ralyt (Ed.), Pierluigi Plebani (Ed.)
Towards A Center For Modeling And Simulation: The Case For Jordan, Ghaith Rabadi, Hazem Kaylani, Joseph Barjis (Ed.), Murali Mohan Narasipuram (Ed.), Ghaith Rabadi (Ed.), Jolita Ralyt (Ed.), Pierluigi Plebani (Ed.)
Engineering Management & Systems Engineering Faculty Publications
Modeling and Simulation (M&S) has recently become an important area that is pursued by many researchers and practitioners due to the role it plays in understanding complex systems and problems. We have therefore witnessed the establishment of many M&S organizations in the last two decades especially in the more developed world. Less developed countries are starting to recognize the need for such capability especially that the problems they face are not less complex. In this paper, we present a preliminary study towards a business plan for establishing a scientific center for Modeling, Analysis, Simulation and Animation in Jordan (JoSAMA) and …
Development Of A Framework To Evaluate Human Risk Towards Sustainable Risk Management, Ra'ed M. Jaradat, Rani A. Kady, C. Ariel Pinto
Development Of A Framework To Evaluate Human Risk Towards Sustainable Risk Management, Ra'ed M. Jaradat, Rani A. Kady, C. Ariel Pinto
Engineering Management & Systems Engineering Faculty Publications
Risk managers are constantly faced with the challenge of making decisions at various levels of their organizations. One of the challenges, which often times is unavoidable, lies in assigning a monetary value to human risks. Such challenge necessitates engineering managers to make educated decisions on the level of risk that the organizations and businesses should accept when it comes to human. The purpose of this study is to suggest a suitable framework that captures this aspect of engineering Risk Management in order to make rational and sustainable decisions about such assessed risk. This will be accomplished by exploring the tools, …
Implementing Tablet Pcs In A Distance Learning Environment, Glenda Scales, Sharon Caraballo, James Groves, Rosalyn Hobson, Linda Vahala, Catherine Amelink
Implementing Tablet Pcs In A Distance Learning Environment, Glenda Scales, Sharon Caraballo, James Groves, Rosalyn Hobson, Linda Vahala, Catherine Amelink
Electrical & Computer Engineering Faculty Publications
(First paragraph) The Commonwealth Graduate Engineering Program (CGEP) is a collaborative distance education program developed by leading Universities in the Commonwealth of Virginia. It is over 25 years old and its main goal is to deliver graduate engineering courses to qualified professionals located across the Commonwealth of Virginia. Traditionally, the courses delivered to students in this program are done through interactive video conferencing (IVC) technology and most students are required to drive to a physical location. However, an increasing number of working professionals are beginning to want more flexibility with the timing and locations of these classes. With these changes …
Rf And Structural Characterization Of Srf Thin Films, A.M. Valente-Feliciano, H.L. Phillips, C.E. Reece, J. Spradlin, X. Zhao, D. Gu, H. Baumgart, D. Beringer, R.A. Lukaszew, B. Xiao, K. Seo
Rf And Structural Characterization Of Srf Thin Films, A.M. Valente-Feliciano, H.L. Phillips, C.E. Reece, J. Spradlin, X. Zhao, D. Gu, H. Baumgart, D. Beringer, R.A. Lukaszew, B. Xiao, K. Seo
Electrical & Computer Engineering Faculty Publications
In the past years, energetic vacuum deposition methods have been developed in different laboratories to improve Nb/Cu technology for superconducting cavities. JLab is pursuing energetic condensation deposition via Electron Cyclotron Resonance. As part of this study, the influence of the deposition energy on the material and RF properties of the Nb thin film is investigated. The film surface and structure analyses are conducted with various techniques like X-ray diffraction, Transmission Electron Microscopy, Auger Electron Spectroscopy and RHEED. The microwave properties of the films are characterized on 50 mm disk samples with a 7.5 GHz surface impedance characterization system. This paper …
Individualized Cognitive Modeling For Close-Loop Task Mitigation, Guangfan Zhang, Roger Xu, Wei Wang, Jiang Li, Tom Schnell, Mike Keller, Thomas E. Pinelli (Ed.)
Individualized Cognitive Modeling For Close-Loop Task Mitigation, Guangfan Zhang, Roger Xu, Wei Wang, Jiang Li, Tom Schnell, Mike Keller, Thomas E. Pinelli (Ed.)
Electrical & Computer Engineering Faculty Publications
An accurate real-time operator functional state assessment makes it possible to perform task management, minimize risks, and improve mission performance. In this paper, we discuss the development of an individualized operator functional state assessment model that identifies states likely leading to operational errors. To address large individual variations, we use two different approaches to build a model for each individual using its data as well as data from subjects with similar responses. If a subject's response is similar to that of the individual of interest in a specific functional state, all the training data from this subject will be used …
Prostate Cancer Region Prediction Using Maldi Mass Spectra, Ayyappa Vadlamudi, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie
Prostate Cancer Region Prediction Using Maldi Mass Spectra, Ayyappa Vadlamudi, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie
Electrical & Computer Engineering Faculty Publications
For the early detection of prostate cancer, the analysis of the Prostate-specific antigen (PSA) in serum is currently the most popular approach. However, previous studies show that 15% of men have prostate cancer even their PSA concentrations are low. MALDI Mass Spectrometry (MS) proves to be a better technology to discover molecular tools for early cancer detection. The molecular tools or peptides are termed as biomarkers. Using MALDI MS data from prostate tissue samples, prostate cancer biomarkers can be identified by searching for molecular or molecular combination that can differentiate cancer tissue regions from normal ones. Cancer tissue regions are …
Prediction Of Brain Tumor Progression Using A Machine Learning Technique, Yuzhong Shen, Debrup Banerjee, Jiang Li, Adam Chandler, Yufei Shen, Frederic D. Mckenzie, Jihong Wang, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)
Prediction Of Brain Tumor Progression Using A Machine Learning Technique, Yuzhong Shen, Debrup Banerjee, Jiang Li, Adam Chandler, Yufei Shen, Frederic D. Mckenzie, Jihong Wang, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)
Electrical & Computer Engineering Faculty Publications
A machine learning technique is presented for assessing brain tumor progression by exploring six patients' complete MRI records scanned during their visits in the past two years. There are ten MRI series, including diffusion tensor image (DTI), for each visit. After registering all series to the corresponding DTI scan at the first visit, annotated normal and tumor regions were overlaid. Intensity value of each pixel inside the annotated regions were then extracted across all of the ten MRI series to compose a 10 dimensional vector. Each feature vector falls into one of three categories:normal, tumor, and normal but progressed to …
Risk And System-Of-Systems: Toward A Unified Concept, C. Ariel Pinto, Michael K. Mcshane, Rani Kady
Risk And System-Of-Systems: Toward A Unified Concept, C. Ariel Pinto, Michael K. Mcshane, Rani Kady
Engineering Management & Systems Engineering Faculty Publications
The scope of this paper is the survey of both fundamental and most recent publications in system-of-systems, business and insurance, as well as risk analysis, modeling, and management for the purpose of better describing the concept of risk in recognition of emergence and complexity which characterizes many systems within the concern of engineering and business managers. The ultimate goal is to provide engineering and business managers the necessary perspective on the concept of risk and in its management for the next generation of sustainable systems - including various descriptions of risk and discussion of the relevance of properties of system-of-systems …
Electroporation-Mediated Delivery Of A Naked Dna Plasmid Expressing Vegf To The Porcine Heart Enhances Protein Expression, W. G. Marshall Jr., B. A. Boone, J. D. Burgos, S. I. Gografe, M. K. Baldwin, M. L. Danielson, M. J. Larson, D. R. Caretto, Y. Cruz, B. Ferraro, L. C. Heller, K. E. Ugen, M. J. Jaroszeski, R. Heller
Electroporation-Mediated Delivery Of A Naked Dna Plasmid Expressing Vegf To The Porcine Heart Enhances Protein Expression, W. G. Marshall Jr., B. A. Boone, J. D. Burgos, S. I. Gografe, M. K. Baldwin, M. L. Danielson, M. J. Larson, D. R. Caretto, Y. Cruz, B. Ferraro, L. C. Heller, K. E. Ugen, M. J. Jaroszeski, R. Heller
Bioelectrics Publications
Gene therapy is an attractive method for the treatment of cardiovascular disease. However, using current strategies, induction of gene expression at therapeutic levels is often inefficient. In this study, we show a novel electroporation (EP) method to enhance the delivery of a plasmid expressing an angiogenic growth factor (vascular endothelial growth factor, VEGF), which is a molecule previously documented to stimulate revascularization in coronary artery disease. DNA expression plasmids were delivered in vivo to the porcine heart with or without coadministered EP to determine the potential effect of electrically mediated delivery. The results showed that plasmid delivery through EP significantly …
Using Simulation Systems For Decision Support, Andreas Tolk
Using Simulation Systems For Decision Support, Andreas Tolk
Computational Modeling & Simulation Engineering Faculty Publications
This chapter describes the use of simulation systems for decision support in support of real operations, which is the most challenging application domain in the discipline of modeling and simulation. To this end, the systems must be integrated as services into the operational infrastructure. To support discovery, selection, and composition of services, they need to be annotated regarding technical, syntactic, semantic, pragmatic, dynamic, and conceptual categories. The systems themselves must be complete and validated. The data must be obtainable, preferably via common protocols shared with the operational infrastructure. Agents and automated forces must produce situation adequate behavior. If these requirements …
M&S Body Of Knowledge: Progress Report And Look Ahead, Andreas Tolk
M&S Body Of Knowledge: Progress Report And Look Ahead, Andreas Tolk
Computational Modeling & Simulation Engineering Faculty Publications
No abstract provided.