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Computational Modeling and Simulation Engineering Faculty Publications

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Full-Text Articles in Engineering

Neuroimaging And Neuromodulation Approaches To Study Eating Behavior And Prevent And Treat Eating Disorders And Obesity, D. Val-Laillet, E. Aarts, B. Weber, M. Ferrari, V. Quaresima, L. E. Stoeckel, M. Alonso-Alonso, M. Audette, C. H. Malbert, E. Stice Jan 2015

Neuroimaging And Neuromodulation Approaches To Study Eating Behavior And Prevent And Treat Eating Disorders And Obesity, D. Val-Laillet, E. Aarts, B. Weber, M. Ferrari, V. Quaresima, L. E. Stoeckel, M. Alonso-Alonso, M. Audette, C. H. Malbert, E. Stice

Computational Modeling and Simulation Engineering Faculty Publications

Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at ...