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Full-Text Articles in Engineering
Oct-Based Elastography For Large And Small Deformations, Donald D. Duncan, Sean J. Kirkpatrick, Ruikang K. Wang
Oct-Based Elastography For Large And Small Deformations, Donald D. Duncan, Sean J. Kirkpatrick, Ruikang K. Wang
Electrical and Computer Engineering Faculty Publications and Presentations
We present two approaches to speckle tracking for optical coherence tomography (OCT)-based elastography, one appropriate for small speckle motions and the other for large, rapid speckle motions. Both approaches have certain advantages over traditional cross-correlation based motion algorithms. We apply our algorithms to quantifying the strain response of a mechanically inhomogeneous, bi-layered polyvinyl alcohol tissue phantom that is subjected to either small or large dynamic compressive forces while being imaged with a spectral domain OCT system. In both the small and large deformation scenarios, the algorithms performed well, clearly identifying the two mechanically disparate regions of the phantom. The stiffness …
Imaging The Mechanical Stiffness Of Skin Lesions By In Vivo Acousto-Optical Elastography, Sean J. Kirkpatrick, Donald D. Duncan, Ruikang K. Wang, Molly Kulesz-Martin, Ken Lee
Imaging The Mechanical Stiffness Of Skin Lesions By In Vivo Acousto-Optical Elastography, Sean J. Kirkpatrick, Donald D. Duncan, Ruikang K. Wang, Molly Kulesz-Martin, Ken Lee
Electrical and Computer Engineering Faculty Publications and Presentations
Optical elastography is an imaging modality that relies on variations in the local mechanical properties of biological tissues as the contrast mechanism for image formation. Skin lesions, such as melanomas and other invasive conditions, are known to alter the arrangement of collagen fibers in the skin and thus should lead to alterations in local skin mechanical properties. We report on an acousto-optical elastography (AOE) imaging modality for quantifying the mechanical behavior of skin lesions. The method relies upon stimulating the tissue with a low frequency acoustic force and imaging the resulting strains in the tissue by means of quantifying the …