Engineering Commons^™

Impact Of Population Based Indoor Residual Spraying With And Without Mass Drug Administration With Dihydroartemisinin-Piperaquine On Malaria Prevalence In A High Transmission Setting: A Quasi-Experimental Controlled Before-And-After Trial In Northeastern Uganda, Richard C. Elliott

Materials Science and Engineering Faculty Publications and Presentations

Background: Declines in malaria burden in Uganda have slowed. Modelling predicts that indoor residual spraying (IRS) and mass drug administration (MDA), when co-timed, have synergistic impact. This study investigated additional protective impact of population-based MDA on malaria prevalence, if any, when added to IRS, as compared with IRS alone and with standard of care (SOC).

Methods: The 32-month quasi-experimental controlled before-and-after trial enrolled an open cohort of residents (46,765 individuals, 1st enumeration and 52,133, 4th enumeration) of Katakwi District in northeastern Uganda. Consented participants were assigned to three arms based on residential subcounty at study start: MDA+IRS, IRS, SOC. IRS …

Molecular Dynamic Studies Of Dye–Dye And Dye–Dna Interactions Governing Excitonic Coupling In Squaraine Aggregates Templated By Dna Holliday Junctions, German Barcenas, Austin Biaggne, Olga A. Mass, William B. Knowlton, Bernard Yurke, Lan Li

Materials Science and Engineering Faculty Publications and Presentations

Dye molecules, arranged in an aggregate, can display excitonic delocalization. The use of DNA scaffolding to control aggregate configurations and delocalization is of research interest. Here, we applied Molecular Dynamics (MD) to gain an insight on how dye–DNA interactions affect excitonic coupling between two squaraine (SQ) dyes covalently attached to a DNA Holliday junction (HJ). We studied two types of dimer configurations, i.e., adjacent and transverse, which differed in points of dye covalent attachments to DNA. Three structurally different SQ dyes with similar hydrophobicity were chosen to investigate the sensitivity of excitonic coupling to dye placement. Each dimer configuration was …

Probing Dna Structural Heterogeneity By Identifying Conformational Subensembles Of A Bicovalently Bound Cyanine Dye, Matthew S. Barclay, Azhad U. Chowdhury, Austin Biaggne, Jonathan S. Huff, Nicholas D. Wright, Paul H. Davis, Lan Li, William B. Knowlton, Bernard Yurke, Ryan D. Pensack, Daniel B. Turner

Materials Science and Engineering Faculty Publications and Presentations

DNA is a re-configurable, biological information-storage unit, and much remains to be learned about its heterogeneous structural dynamics. For example, while it is known that molecular dyes templated onto DNA exhibit increased photostability, the mechanism by which the structural dynamics of DNA affect the dye photophysics remains unknown. Here, we use femtosecond, two-dimensional electronic spectroscopy measurements of a cyanine dye, Cy5, to probe local conformations in samples of single-stranded DNA (ssDNA–Cy5), double-stranded DNA (dsDNA–Cy5), and Holliday junction DNA (HJ–DNA–Cy5). A line shape analysis of the 2D spectra reveals a strong excitation–emission correlation present in only the dsDNA–Cy5 complex, which is …

Three-Port Bi-Directional Dc–Dc Converter With Solar Pv System Fed Bldc Motor Drive Using Fpga, Arun Kumar Udayakumar, Raghavendra Rajan Vijaya Raghavan, Mohamad Abou Houran, Rajvikram Madurai Elavarasan, Anushkannan Nedumaran Kalavathy, Eklas Hossain

Electrical and Computer Engineering Faculty Publications and Presentations

The increased need for renewable energy systems to generate power, store energy, and connect energy storage devices with applications has become a major challenge. Energy storage using batteries is most appropriate for energy sources like solar, wind, etc. A non-isolated three-port DC–DC-converter energy conversion unit is implemented feeding the brushless DCmotor drive. In this paper, a non-isolated three-port converter is designed and simulated for battery energy storage, interfaced with an output drive. Based on the requirements, the power extracted from the solar panel during the daytime is used to charge the batteries through the three-port converter. The proposed three-port converter …

Investigating R(T) Functions For Spike-Timing-Dependent Plasticity In Memristive Neural Networks, Farhana Afrin, Kurtis D. Cantley

Electrical and Computer Engineering Faculty Publications and Presentations

Brain-inspired neuromorphic computation can be extremely efficient at very large scales due to inherent parallelism, scalability, and fault and failure tolerance. One widely used, biologically plausible synaptic learning mechanism is spike-timing-dependent plasticity (STDP). The proposed generic model of time-varying resistance, or R(t) elements in this work, can produce classical and beyond classical STDP in electronic spiking neural networks with memristive synapses. Hebbian and Anti-Hebbian STDP is verified with the proposed generic R(t) model by tuning the R(t) function. By appropriately placing R(t) functions with selective resistance values, symmetric or non-classical STDP learning behavior is achieved.

Board 341: Mobile Learning In Stem: A Case Study In An Undergraduate Engineering Course, Krishna Pakala, Maeve Bakic, Diana Bairaktarova, Devshikha Bose

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Student-centered educational system is needed for better educational outcomes. Technology enabled pedagogy has helped immensely during the pandemic times when rapid transition to remote learning was essential. This poster reports findings on year one of a two-year research study to utilize mobile technologies and a technology-enhanced curriculum to improve student engagement and learning in STEM undergraduate courses. This poster describes a quasi-experimental mixed methods study on implementing mobile devices (iPad and Pencil) and a technology-enhanced curriculum in an undergraduate thermal-fluids engineering course, a foundational engineering class.

The technology-enabled curriculum was fully integrated in the thermal-fluids course to deliver content and …