Engineering Commons^™

A Review Of Acetabular Prostheses For Total Hip Arthroplasty, Jennifer Anne Citarella

Theses

This study explores the evolution, design, and clinical progress of contemporary prostheses used in orthopaedic reconstruction of the socket of the hip joint. A literature search was performed to study acetabular implants, as used in total hip arthroplasty. The history of the design of these implants is chronicled. Next, the anatomy of the acetabular region and the surgical technique performed to replace the hip socket are presented. A comprehensive discussion of the design features, rationale, and clinical results for commercially available cemented and cementless prostheses follows.

Hydroxyapatite, a bioceramic which has just recently been approved for applications in total hip …

An Experimental Investigation Of Wear Behavior Of Ultra-High Molecular Weight Polyethylene Under Sliding Motion, Elham Zand-Moghaddam

Theses

This project investigates the effect of sliding motion on the materials that are used as bearing surfaces of human total-joint replacement prostheses.

The tests are performed with a specially designed equipment based on pin-on-disk machine. The testing machine is designed and constructed to reproduce sliding motion, applied to spherical ended metal "Canine-Head" components such as dog hip acting on a flat polyethylene surface. The sliding motion is performed by applying different constant loads for 5,000,000 cycles. The tests are carried out with the wear specimen lubricated by deionized water.

The purpose is to produce delamination, which is the severe wear …

Computer Simulation Of Intracranial Hemodynamics During The Induction Phase Of Anesthesia, Gopinath P. Sundaram

Theses

The induction of general anesthesia is associated with severe hemodynamic compromises which, in turn, may cause acute elevation of intracranial pressure (ICP). Quantitative assessment of cerebrovascular responses arising from multiple mechanical and pharmacological interventions occurring in a short time interval require a large number of human studies which are difficult to perform. The purpose of this project is to evaluate the effect of various stimuli on the intracranial hemodynamics during induction using a mathematical model of cerebrovascular circulation.

A five compartmental model of the cerebrovascular system is used for our simulation. Autoregulation is modeled by adjusting arterial-arteriolar resistance in order …

Dynamics Of Blood Coagulation, Jie Gao

Theses

In this paper we present a new method to analyze whole blood coagulation dynamics. Using a PC-286 computer equipped with a DASH-16 AID board.

The row data from a SONOCLOT analyzer is amplified and digitized on the DASH-16 A/D board and stored in the PC-286 hard disk. The data is filtered through a digital Butterworth filter. The filtered data is then fit to mathematical relationship by the least square method. The coefficients which define the mathematical relationships are used to identify blood specimens with normal coagulation dynamics as distinguished from specimens with abnormal dynamics.

The digital filter and curve-fitting routine …

Fingerprint Pattern Recognition For Medical Uses, Feng You

Theses

The purpose of my research is to provide a method to automatically classify fingerprints into three subgroups: whorl, loop and arch, which can help medical scientists to study the relationship between fingerprint patterns and medical disorders. In the research, two different kinds of approaches were developed. The first one is performing pattern recognition in the frequency domain, which uses the feature of Fourier spectrum. That is, prominent peaks in the spectrum give the principal direction of fingerprint patterns. Using the above feature, we can obtain the principal direction of every subregion, after which the pattern of the whole image can …

A Study Of Pulsation Of Chest Wall Using Microwave Interferometer, Paul Zeno

Theses

The microwave interferometer is utilized to pick up vibrations of the anterior chest wall produced by the cardiac activity. The objective of this project is to find the causes of different peaks in the output of the microwave interferometer. The output of the microwave interferometer is recorded simultaneously with EKG and jugular pressure pulses. Eighteen subjects had their mechanical vibrations of the chest wall, EKG and jugular pressure pulses recorded. The processed interferometer data, when compared with EKG and jugular pressure pulses appear to have a close relation to the mechanical events in the cardiac cycle. Four peaks in the …

The Thermal Model Of The Rat Under Hemorrhagic Shock Hypothermia With Microwave Intervention, Liu Zhe

Theses

A whole body thermal model simulating heat distribution and temperature regulation in rats during hemorrhagic shock and during post-shock microwave core rewarming period was developed. An electrical circuit was used to simulate the thermal system and a software named PSpice? was used to analyze the circuit. The temperature regulation as the result of the simulation is demonstrated to match the measured temperature histories of rats in hemorrhagic shock and the microwave rewarming experiment.

The blood pressure drop and cardiac output decrease were considered in the simulation and the so called "set point temperature" was investigated in the model. Linear decrease …

Computer Aided Finite Element Stress Analysis Of A Three Dimension Mandibular Bone Model Using I-Deas Software, Yixiong Xu

Theses

A three dimensional model of half of the mandibular bone, with 487 tetrahedra elements and 1,047 nodes, is established and analyzed by means of I-DEAS software. The masseter muscle is assumed to be 15° deviation from y-axis, and the Umetani boundary conditions are allowed to be varied. A 337 lb force was applied along the midline of the mandible to simulate a trauma force caused by the auto accident. The maximum principal stress is 18,400 psi and the minimum principal stress is -1,340 psi. Depending on the experimental results of dispalcement and maximum principal stress, the conclusions are drawn: 1) …

A Review Of Energy Storing Prosthetic Feet And Computer Aided Structural Optimization Of A Below-Knee Prosthesis, Poonam Gope Lalwani

Theses

Because people with physical disabilities have shown an interest in participation in sports, a new class of prosthetic feet known as "energy storing prosthetic feet" has been developed. These new developments in prosthetic foot design utilize energy storage and return to improve ambulation. This thesis reviews the design, materials, advantages and disadvantages of various energy storing prosthetic feet. Research studies, comparing gait in below-knee amputees using different prosthetic designs, can be applied to the design of prosthetic feet that are lighter, stronger and more reliable. Comparisions among these feet are reviewed in the context of functional capability and patient satisfaction. …

Quantitative Assessment Of Myocardial Oxygen Supply And Demand Using A Dynamic Model Of The Cardiovascular System, Badrinath R. Puranic

Theses

A quantitative understanding of the changes in coronary, pulmonary and systemic hemodynamic variables and their effect on myocardial supply and demand is important to the better management of anesthetic care of patients with impaired cardiac function. Animal studies have identified those hemodynamic factors that play an important role in determining the balance between oxygen supply and demand for the myocardium. These include myocardial contractility, left ventricular end-diastolic volume, systemic arterial pressure, systemic vascular resistance, and heart rate. The interactions of these factors are complex and their combined effects on myocardial oxygen supply and demand are difficult to predict a priori. …

The Acoustic Properties Of Human Femoral Bone, Mark Lacianca

Theses

Over the last decade, interest has grown in the use of the scanning acoustic microscope (SAM), with a single lens being used for both transmitting and receiving the acoustic signal. A major objective of this thesis was to determine if the transmission and ultrasonic techniques yield similar "quantitative" results, when measuring the elastic constants of human femoral bone. The transmission technique has been used since 1970 to yield values for the elastic properties of calcified tissue. Previously the SAM has been used as a qualitative tool, where an acoustic impedance map is produced. This map can show areas of bone …

Posterior Stabilized Knee Design Biomechanical Considerations, Donald E. Mcnulty

Theses

Numerous posterior stabilized knee systems are available for primary and revision total knee arthroplasty. Design of these systems requires an understanding of the articulating geometries and kinematic/kinetic biomechanical considerations of the normal knee. The findings for the normal knee are integrated into the design of a prosthetic system.

The natural femoral, tibial and patella articulating geometries are defined to enable subsequent kinematic and kinetic analyses. The articulating geometries are characterized from review of anthropometric studies of the tibiofemoral and patellofemoral joint.

The kinematic analysis of the natural knee defines knee motion in terms of rotation, adduction/abduction, range of motion and …

Mathematical Model And Simulation Of The Progression Of Cutaneous T-Cell Lymphoma, Maria L. Agostinho

Theses

A simple mathematical model and simulation of the progression of cancer with particular emphasis on Cutaneous T Cell Lymphoma was investigated. The mathematical model consists of a set of differential equations that first satisfies the homeostasis levels of the different components present and second predicts the dynamics during a diseased or unhealthy condition. The simulation was done using a FORTRAN program for integrating the differential equations.

Simulation of the immune system is important in evaluating the usefulness of particular sorts of biologically targeted therapies and in selecting the most promising treatment strategies for clinical trials. In particular, the effects of …

Slow, Red-Green Counterphase (Parvo) And Fast, Black-White Magno) Snow In The Detection Of Scotomata In Primary Open-Angle Glaucoma, Rey Favis

Theses

No one knows why Primary Open Angle Glaucoma sufferers can detect their glaucoma induced blindspots by monocularly fixating on a mark in the center of a screen of television snow. An attempt was made to determine which of two pathways from retina to lateral geniculate nucleus is more involved in the detection of the blindspots. Previous studies demonstrated that the large diameter axon, magno cellular pathway is maximally stimulated by 30 Hertz high contrast black-white patterns. The small diameter axon, parvo cellular pathway is known from past research to be maximally stimulated by 12 Hertz red-green counterphase patterns. It was …

A Computer Implementation Of A Multi-Neuron Expandable Network, Mary Ellen Ellen Aleksza

Theses

The primary goal of this thesis is to develop a small, expandable neural network that oscillates when presented with an appropriate stimulus. This model will be used in the future as a base to create larger networks. Future studies of these larger networks may be used in the simulation of neuronal activity such biological oscillators.

This thesis encompasses a study of neuron activity, neural networks, neuron models and biological oscillators. The focus of the thesis is the modification and expansion of a single neuron simulation into a simulation of an interconnected multi-neuron oscillatory network.

A single neuron model based on …

The Effects Of Twist On Pressure Through A Teflon Vascular Prosthesis, Steven Alfred Olivieri

Theses

A closed loop fluid system was developed which mimics the flow curve in the human circulatory system in order to test the effects of pressure drop and flow velocity on artificial arterial implants. This device consists of a piston pump connected to a microcomputer controlled servo-motor. Fluid (in this case distilled water) flows through transparent Tygon tubing to a test chamber. The prosthetic tube is placed in the fluid but is attached through a specially constructed chamber. The pressure across the implant can be measured for different conditions. System compliance was generated by using flexible tubing in the return loop …

Ultrasonic Ranging System For Gait Analysis, Mu Wu

Theses

A new method of measuring range for gait analysis is described. The method is based on a coherent measurement of the phase shift of an ultrasonic signal as a function of range.

A prototype of the ranging system was breadboarded, tested, and found to have a relative accuracy of better than 0.5 mm over a range of 3 meters. The maximum range the system is at least 20 meters. The method used here is new and has not been found in the literature. Tt is demonstrated by experiments with a prototype system that can measure distance with a higher accuracy …

Effect Of 2,3-Butanedione Monoxide On Whole-Cell Potassium Channel Currents In Rat Single Myocytes, Youliang Zhou

Theses

The patch clamp technique is a simple procedure which can isolate ion channels on cell membranes. Our previous data have shown that 2,3-Butanedione Monoxime (BDM) could inhibit the calcium current by dephosphorylation of the channel. In this study, the effect of BDM on the potassium channels were investigated with the whole-cell recording method in single myocytes enzymatically isolated from the left ventricle of 3-4 months old rats. Superfusion of myocytes with BDM elicited a dose dependent decrease of the outward transient potassium current. BDM with concentrations of 5, 20 and 50 mM reduced the maximal peak potassium current by 7.3 …

Wear And Friction Of Titanium Nitride On Ultra High Molecular Weight Polyethylene Under Oscillating Motion For Evaluation Of Use In Articulating Orthopedic Applications, David Scott Jacobson

Theses

Materials are a factor in the performance of articulating orthopedic implants. An oscillating tribometer is utilized to investigate mechanisms of wear and friction of TiN (titanium nitride) coated on Ti-6Al-4V (titanium) alloy against UHMWPe (ultra high molecular weight polyethylene). Three thicknesses of TiN coating (1.76 pm, 4.15 µm, and 10.5 µm) are used to evaluate the performance of each in UHMWPe wear reduction and coating integrity. An uncoated Co-Cr (cobalt chromium) coupon is used against UHMWPe pins for control purposes. Oscillations are carried out to 10 million cycles to discover and evaluate short- and long-term wear mechanisms. Mass differentials and …

Image Deblurring For Visualization Of Coronary Microcirculation, Kaijun Wang

Theses

Blurred images of the rat coronary microcirculation have been obtained and processed. Heart motion, blood flow and noise cause the blur of the images. The objective of this thesis work was to study the effects of these factors on image quality and assess several models for image deblurring. The Wiener Filter and the Powei Spectrum Equalization Filter were implemented and were added to the existing image processing software. The images obtained after the application of these filters showed significant improvement over the original blurred images.

Automated Eeg Analysis And Spike Detection, Walter Vanderschraaf

Theses

EEG analysis of epileptic patients is extremely time consuming. Patients are monitored up to 36 hours at a time. The neurologist must visually review stacks of EEG records to determine whether they contain epileptic or artifactual activity. This process is very subjective and can vary from one neurologist to another based on his or her training and experience. The neurologist is only human and may tire or lose his or her concentration. Automated EEG analysis can efficiently reduce the amount of data and time involved in analysis. It is also more consistent and objective than human analysis.

The main objective …

Three Dimensional Visualisation Of Tmj Anatomy Using Mri Techniques, Mythreyi T. Krishnaswamy

Theses

The best assessment of temporomandibular joint (TMJ) can only be done by the scanning the jaw and getting an image without invivo analysis which causes patient discomfort. There have been innumerable efforts to get the best view using CT techniques for three dimensional visualisation. But very few have done work using MRI techniques.

The TMJ is an integral part of the jaw and helps in mastication and biting. Since the joint is a hinge sliding articulation any dislocation causes immense pain and discomfort.

To get a better assessment of the TMJ, MRI techniques have been used for data acquisition. The …

Calcium Channel Dynamics In Hippocampal Neurons : Simulation And Physiological Studies, Prasad D. Jasthi

Theses

Mathematical modelling and computer simulations of neurons was presented by various researchers in the past. Computer simulations provide a time efficient and cost effective method to obtain required information about the physiological system. The objective of this project is to study the kinetics of calcium channels in hippocampal neurons. In an attempt to study the calcium channel activity we have developed a mathematical model for the CA3 region of the hippocampus and have analysed the calcium current noise obtained from the physiological recordings. The Simulation results had reproduced the action potential and activities of sodium and potassium channels, but did …

Deconvolution Applications In Arterial Dynamics, Shanthi Ganesan

Theses

This thesis deals with the computation of the Arterial Impulse Response Function by deconvolving aortic pressure and flow signals in time domain. Several methods have been developed in the past to obtain a solution for the convolution integral. These are (1) Transform method, and (2) Numerical Approximation methods : a. Conventional method b. Relaxation methods.

These methods have been applied in the past to the RC network model and it was found to work well. In this thesis, the methods are applied to data from more realistic models and also on data obtained from dogs. The model considered is a …

Bio-Mechanics Of The Hip Joint And The Engineering Considerations In The Treatment Of Unstable Intertrochanteric Fractures, Manoj D. Nene

Theses

Numerous previous attempts have been made to determine the magnitude and the direction of forces acting on the hip joint. The mechanism of femoral neck fractures and the frequently occurring failure of its internal fixation has led engineers to analyze the forces involved. An unstable intertrochanteric fracture is one which lacks continuity of the bone cortex on the opposing surfaces of the proximal and digital fragments. A mathematical model is created in this study to examine the 135° and 150° nail plate. The results give an approximate estimation of stresses on the two plates. A 3D finite element model of …

A Biomechanical Analysis Of Three Humeral Fracture Fixation Systems, Alina Michelle Waite

Theses

Often, humeral fractures requiring internal fixation can be a challenging orthopaedic procedure. Each method of treatment possesses clinical and biomechanical advantages and disadvantages. Rigid plate fixation is highly successful in treating a large variety of long bone fractures. Nevertheless, excessive soft tissue dissection is necessary, and vascular and neural anatomy of the humerus can make plate application and removal difficult. An intramedullary nail offers a relatively simple procedure, thereby reducing these anatomical concerns. However, rotational instability at the fracture site is a common complication with a conventional intramedullary nail. Thus, a study was conducted to evaluate a new interlocking intramedullary …

An Approach To Improving The Antithrombogenesis Of Pneumatic Diaphragm Artificial Ventricle : Fabrication And Design Considerations, Hui-Sun Wang

Theses

Thrombus formation is one of the major problems in artificial heart development and its clinical applications. In order to improve the antithrombogenesis in the artificial ventricles, three aspects of investigation have been done in the laboratory.

1] the surface features and the surface defects on specially prepared samples made of polyurethane and silicon rubber were studied and analyzed by scanning electron microscopy ( SEM ), light microscopy and KEVEX Feature Analysis for understanding and controlling the blood contacting surface.

2] the polyurethane blood contacting surface with smooth surface fabricated by solution cast process, the material treatment, and the fabrication procedure …

Oscillatory Potentials Model And Parameter Identification, Huizhong Pan

Theses

Two mathematicals model are presented for the oscillatory potentials of the electroretinogram. These models represent the oscillatory potential in terms of sets of parameters whose values may provide information of diagnostic value.

The test setup and protocol for obtaining the oscillatory potentials are described, as well as the data processing including acquisition up to identification of the model parameters.

Data from eight subjects, five normals and three diabetics, were used to evaluate the two models. These preliminary test results show a marked difference in the values of some of the model parameters between normals and diabetics.

Image Enhancement And Analysis Of Leukocyte Adhesion, Yee-Ruh Lin

Theses

The image of leukocyte adhesion to microvascular walls in the isolated rat perfused heart model has been observed and processed. Some of the fluorescent labeled leukocytes are barely visible due to microscope focal plane and the motion of objects. The purpose of this thesis is to extract leukocyte from the image of the experimental data using image enhancement and analysis (segmentation) techniques and develop a program to handle automatically counting of leukocytes in a predefined scene.

Eeg Data Compression, Yun-Chu Wu

Theses

This paper presents two different ways to compress EEC data-direct data com pression and a data transformation technique. The Adaptive Delta modulation and Huffman coding are used in the former method to predict or interpolate the data. Linear orthognal transformation algorithms are used in the latter method to detect and reduce the redundancies of the data by analyzing the spectral and energy distribution. Each method is implemented by programming the computer. The experimental results of their efficiencies and errors with different requirements and under different situations are compared and discussed. By comparing the EEC data compression degree and normalized square …