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Full-Text Articles in Education
The Potent M1 Receptor Allosteric Agonist Gsk1034702 Improves Episodic Memory In Humans In The Nicotine Abstinence Model Of Cognitive Dysfunction, Pradeep J. Nathan, Jeannette Watson, Jesper Lund, Ceri H. Davies, Gary Peters, Chris M. Dodds, Bridget Swirski, Philip Lawrence, Graham D. Bentley, Barry V. O'Neill, Jon Robertson, Stephen Watson, Gareth A. Jones, Paul Maruff, Rodney J. Croft, Marc Laruelle, Edward T. Bullmore
The Potent M1 Receptor Allosteric Agonist Gsk1034702 Improves Episodic Memory In Humans In The Nicotine Abstinence Model Of Cognitive Dysfunction, Pradeep J. Nathan, Jeannette Watson, Jesper Lund, Ceri H. Davies, Gary Peters, Chris M. Dodds, Bridget Swirski, Philip Lawrence, Graham D. Bentley, Barry V. O'Neill, Jon Robertson, Stephen Watson, Gareth A. Jones, Paul Maruff, Rodney J. Croft, Marc Laruelle, Edward T. Bullmore
Faculty of Social Sciences - Papers (Archive)
Episodic memory deficits are a core feature of neurodegenerative disorders. Muscarinic M1 receptors play a critical role in modulating learning and memory and are highly expressed in the hippocampus. We examined the effect of GSK1034702, a potent M1 receptor allosteric agonist, on cognitive function, and in particular episodic memory, in healthy smokers using the nicotine abstinence model of cognitive dysfunction. The study utilized a randomized, double-blind, placebo-controlled, cross-over design in which 20 male nicotine abstained smokers were tested following single doses of placebo, 4 and 8 mg GSK1034702. Compared to the baseline (nicotine on-state), nicotine abstinence showed statistical significance in …
Relative Importance Of Abstinence In Clients' And Clinicians' Perspectives Of Recovery From Drug And Alcohol Abuse, Lauren Maffina, Frank P. Deane, Geoffrey C.B Lyons, Trevor P. Crowe, Peter J. Kelly
Relative Importance Of Abstinence In Clients' And Clinicians' Perspectives Of Recovery From Drug And Alcohol Abuse, Lauren Maffina, Frank P. Deane, Geoffrey C.B Lyons, Trevor P. Crowe, Peter J. Kelly
Faculty of Social Sciences - Papers (Archive)
This study collected data on drug and alcohol workers' (n = 55) and clients' (n = 139) perspectives on what constitutes a "recovery" from substance use disorder. Data were collected during 2010 from four residential faith-based treatment programs across the east coast of Australia. Self-report surveys specifically designed for this study were administered. Responses were compared using nonparametric test. Abstinence was seen as an important component of recovery but nonabstinent factors were also seen as having an important role. Staff placed more emphasis on clients taking responsibility for their problems and on the role of spiritual development. The importance of …