Education Commons^™

The Effectiveness Of A Religiously Framed Hpv Vaccination Message Among Christian Parents Of Unvaccinated Adolescents In The United States, Ayokunle Olagoke, Jennifer Herbert-Beirne, Brenikki Floyd, Rachel Caskey, Andrew D. Boyd, Yamilé Molina

Health and Kinesiology Faculty Publications

Background: The uptake of the human papillomavirus (HPV) vaccines has been controversial among religious parents due to beliefs that their children are expected to practice sexual purity and so do not need protection from a sex-related infection. Also, if at all they get infected in the future, God can protect them from sickness without a vaccine. Yet, most HPV vaccination messages are secular, lacking spiritual themes. This study compared the effectiveness of the Centers for Disease Control and Prevention (CDC) Vaccine Information Statement (VIS) on HPV with our intervention message- a scripture-embedded HPV vaccination message (using a randomized controlled …

The Content Of Covid-19 Information Searches And Vaccination Intention: An Implication For Risk Communication, Ayokunle A. Olagoke, Brenikki Floyd, Comfort T. Adebayo, Ayomide Owoyemi, Ashley M. Hughes

Health and Kinesiology Faculty Publications

Objective:

The main objective of this study was to examine the association between COVID-19 information search activities and vaccination intention.

Methods:

Cross-sectional data were collected using online surveys. Independent variables included COVID-19 information search on the (1) science of viral effects of COVID-19 on the body, (2) origin of COVID-19, (3) symptoms and outcomes, (4) transmission and prevention, (5) future outbreak, and (6) policies/procedures to follow. The outcome variable was vaccination intention. A multivariable regression analysis was conducted.

Results:

Participants (N = 501) had a mean age of 32.44 ± 11.94 years, were 55.3% female, and 67.9% were white. Most …

Intentional Storytelling To Sustain Low-Cost/Free Breast Cancer Services: A Latina Example Of Community-Driven Advocacy, Ayokunle Olagoke, Katherine Reyes, Liliana G. San Miguel, Paola Torres, Casandra Robledo, William Kling, Maria Medina, Juanita Arroyo, Carmen Garcia, Nora Coronado, Olivia Hernandez, Araceli Lucio, Hunter T. Norris, Vida Henderson, Yamilé Molina

Health and Kinesiology Faculty Publications

Background: Community-based public health advocacy efforts are crucial to sustaining the low-cost/free breast cancer services that support underserved populations.

Objectives: We introduce two ways in which narrative theory may be a useful tool for developing advocacy materials and provide an example, using a community–academic partnership to promote Latina breast health in Chicago, Illinois.

Methods: Community and academic partners 1) engaged 25 Spanish-speaking Latinas in an advocacy workshop, 2) leveraged narrative theory to develop multi-media advocacy materials, and 3) disseminated materials to policymakers.

Lessons Learned: Our project highlights 1) that narrative theory may be useful to describe how Latinas engage policy-makers …

Intentional Storytelling To Sustain Low-Cost/Free Breast Cancer Services: A Latina Example Of Community-Driven Advocacy, Ayokunle Olagoke, Katherine Reyes, Liliana G. San Miguel, Paola Torres, Casandra Robledo, William Kling, Maria Medina, Juanita Arroyo, Carmen Garcia, Nora Coronado, Olivia Hernandez, Hunter T. Norris, Vida Henderson, Yamilé Molina

Health and Kinesiology Faculty Publications

Background: Community-based public health advocacy efforts are crucial to sustaining the low-cost/free breast cancer services that support underserved populations.

Objectives: We introduce two ways in which narrative theory may be a useful tool for developing advocacy materials and provide an example, using a community–academic partnership to promote Latina breast health in Chicago, Illinois.

Methods: Community and academic partners 1) engaged 25 Spanish-speaking Latinas in an advocacy workshop, 2) leveraged narrative theory to develop multi-media advocacy materials, and 3) disseminated materials to policymakers.

Lessons Learned: Our project highlights 1) that narrative theory may be useful to describe how Latinas engage policy-makers …

The Moderating Role Of Partners’ Education On Early Antenatal Care In Northern Ghana, Paschal Awingura Apanga, Maxwell Tii Kumbeni, James Kotuah Sakeah, Ayokunle Olagoke, Olufemi Ajumobi

Health and Kinesiology Faculty Publications

Background

Early antenatal care (ANC) is essential for improving maternal and child health outcomes. The primary aims of this study were to 1) estimate the association between partners’ education attainment and early ANC, and 2) determine whether partners’ level of education modified the relationship between mothers’ education, mothers’ age, planned pregnancy, employment status and early ANC.

Methods

Data were obtained from a cross-sectional study conducted from April to May 2021 among 519 mothers with a live birth in the past year in the Nabdam district in the Upper East Region in northern Ghana. Generalized estimating equations were used to assess …

Impaired Microcirculatory Function, Mitochondrial Respiration, And Oxygen Utilization In Skeletal Muscle Of Claudicating Patients With Peripheral Artery Disease, Song-Young Park, Elizabeth J. Pekas, Cody Anderson, Tyler N. Kambis, Paras K. Mishra, Molly Schieber, Tesean Wooden, Jonathan R. Thompson, Kyung-Soo Kim, Iraklis Pipinos

Health and Kinesiology Faculty Publications

Peripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and muscle function in the lower limbs. A skeletal muscle myopathy characterized by mitochondrial dysfunction and oxidative damage is present in PAD; however, the underlying mechanisms are not well established. We investigated the impact of chronic ischemia on skeletal muscle microcirculatory function and its association with leg skeletal muscle mitochondrial function and oxygen delivery and utilization capacity in PAD. Gastrocnemius samples and arterioles were harvested from patients with PAD (n = 10) and age-matched controls (Con, n = 11). Endothelium-dependent and independent vasodilation was assessed in response …

Combined Effects Of Aerobic Exercise And 40-Hz Light Flicker Exposure On Early Cognitive Impairments In Alzheimer’S Disease Of 3×Tg Mice, Sang-Seo Park, Hye-Sang Park, Change-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Kim

Health and Kinesiology Faculty Publications

Alzheimer’s disease (AD) is a progressive degenerative brain disease and the primary cause of dementia. At an early stage, AD is generally characterized by short-term memory impairment, owing to dysfunctions of the cortex and hippocampus. We previously reported that a combination of exercise and 40-Hz light flickering can protect against AD-related neuroinflammation, gamma oscillations, reduction in Aβ, and cognitive decline. Therefore, we sought to extend our previous findings to the 5-mo-old 3×Tg-AD mouse model to examine whether the same favorable effects occur in earlier stages of cognitive dysfunction. We investigated the effects of 12 wk of exercise combined with 40-Hz …

Effects Of Passive And Active Leg Movements To Interrupt Sitting In Mild Hypercapnia On Cardiovascular Function In Healthy Adults, Song-Young Park, Tesean Wooden, Elizabeth J. Pekas, Santosh K. Yadav, Dustin Slivka, Gwenael Layec

Health and Kinesiology Faculty Publications

Prolonged sitting in a mild hypercapnic environment impairs peripheral vascular function. The effects of sitting interruptions using passive or active skeletal muscle contractions are still unclear. Therefore, we sought to examine the vascular effects of brief periods (2 min every half hour) of passive and active lower limb movement to interrupt prolonged sitting with mild hypercapnia in adults. Fourteen healthy adults (24 ± 2 yr) participated in three experimental visits sitting for 2.5 h in a mild hypercapnic environment (CO2 = 1,500 ppm): control (CON, no limb movement), passive lower limb movement (PASS), and active lower limb movement (ACT) during …

Disentangling The Role Of Religiosity In Human Papillomavirus Vaccination Amidst Covid-19 Pandemic, Ayokunle Olagoke, Brenikki Floyd, Rachel Caskey, Jennifer Hebert-Beirne, Andrew D. Boyd, Yamilé Molina

Health and Kinesiology Faculty Publications

Religion is a complex and sociocultural driver of human papillomavirus (HPV) vaccination decisions, but its exact role has been mixed/unclear. We used a cross-sectional study of 342 Christian parents to examine the associations between the three domains of religiosity (organizational, non-organizational, and intrinsic) and the intention to (i) seek HPV information and (ii) receive the HPV vaccine. Organizational religiosity was the only domain that was positively associated with information-seeking intention regardless of the type of covariates included. Mixed findings in the association between religiosity and HPV vaccination decisions may depend on the religiosity domain being assessed.

The Interdependent Roles Of The Psychosocial Predictors Of Human Papillomavirus Vaccination Among Christian Parents Of Unvaccinated Adolescents, Ayokunle Olagoke, Rachel Caskey, Brenikki Floyd, Jennifer Herbert-Beirne, Andrew D. Boyd, Yamilé Molina

Health and Kinesiology Faculty Publications

Despite the availability of the human papillomavirus (HPV) vaccine, uptake has been sub-optimal among certain religious groups. Psychosocial factors (threat appraisal, coping appraisal, and attitudes) have been identified as independent determinants of HPV vaccination. However, their interdependent effects have not been tested. We examined the interdependency of these psychosocial factors in predicting HPV vaccination intention among Christian parents of unvaccinated adolescents (using a theory-driven conceptual model). A cross-sectional study of 342 participants showed that perceived self-efficacy (β = 0.2, 0.11–0.29, p = <0.0001) and perceived response efficacy of HPV vaccine (β = 0.65, 0.53–0.77. p < .0001) were positively associated with vaccination intention. Our mediation analysis (using the Preachers and Hayes’ approach) shows that attitudes toward HPV vaccination mediated 59% of the relationship between perceived self-efficacy to vaccinate child and HPV …

Cigarette Smoking After Aerobic Exercise: The Unfavorable Impacts On Vascular Function, Elizabeth J. Pekas, Song-Young Park

Health and Kinesiology Faculty Publications

It is well-accepted that vascular dysfunction plays a key role in the pathophysiology of cardiovascular diseases. Although vascular dysfunction is multi-faceted, exercise is a commonly recommended prophylactic strategy to preserve vascular function. We and others have shown that exercise training can elicit beneficial effects on vascular function (e.g., blood pressure and conduit artery function) in healthy and clinical populations^1-4. In fact, indices of vascular function are enhanced shortly after acute exercise^5,6, suggesting that the postexercise recovery period may be a crucial component for facilitating long-term vascular adaptations⁷. Poor habits may be …

Shared Determinants For Human Papillomavirus And Covid-19 Vaccination Intention: An Opportunity For Resource Consolidation, Ayokunle A. Olagoke, Leslie R. Carnahan, Olakanmi Olagoke, Yamile Molina

Health and Kinesiology Faculty Publications

Purpose

Design

Setting

Subject

Measures

Analysis

Acute High-Intensity Exercise And Skeletal Muscle Mitochondrial Respiratory Function: Role Of Metabolic Perturbation, Matthew T. Lewis, Gregory M. Blain, Corey R. Hart, Gwenael Layec, Matthew J. Rossman, Song-Young Park, Joel D. Trinity, Jayson R. Gifford, Simranjit K. Sidhu, Joshua C. Weavil, Russell S. Richardson

Health and Kinesiology Faculty Publications

Recently it was documented that fatiguing, high-intensity exercise resulted in a significant attenuation in maximal skeletal muscle mitochondrial respiratory capacity, potentially due to the intramuscular metabolic perturbation elicited by such intense exercise. With the utilization of intrathecal fentanyl to attenuate afferent feedback from group III/IV muscle afferents, permitting increased muscle activation and greater intramuscular metabolic disturbance, this study aimed to better elucidate the role of metabolic perturbation on mitochondrial respiratory function. Eight young, healthy males performed high-intensity cycle exercise in control (CTRL) and fentanyl-treated (FENT) conditions. Liquid chromatography-mass spectrometry and high-resolution respirometry were used to assess metabolites and mitochondrial respiratory …

Phi-010 - Beating The Bugs: The Role Of Microbiology Tests In Antimicrobial Stewardship In Spinal Cord Injury Units, Harveen Kaur, Ayokunle Olagoke, Ashley M. Hughes

Health and Kinesiology Faculty Publications

Background: Antimicrobial Stewardship Programs (ASPs) aim to optimize the prescription of antibiotics to combat antimicrobial resistance (AMR), reduce Clostridioides difficile infections, and lower antibiotic expenditures. Although ASPs are implemented in Veterans Health Administrations (VHAs) in the US, they are not targeted at the Spinal Cord Injury (SCI) population, which, relative to other patient populations, is more vulnerable to AMR. The goals of the study were to (1) assess the effectiveness of microbiology testing as a strategy to combat AMR and (2) assess the potential for collaboration among ASP leaders and SCI prescribers for implementation of ASPs in SCI units in …

Sympathoinhibition And Vasodilation Contribute To The Acute Hypotensive Response Of The Superoxide Dismutase Mimic, Mntnbuoe-2-Pyp5+, In Hypertensive Animals, Sarah L. Schlichte, Elizabeth J. Pekas, Taylor J. Bruett, Elizabeth A. Kosmacek, Bryan T. Hackfort, Jordan M. Rasmussen, Kaushik P. Patel, Song-Young Park, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman

Health and Kinesiology Faculty Publications

The pathogenesis of hypertension has been linked to excessive levels of reactive oxygen species (ROS), particularly superoxide (O2•−), in multiple tissues and organ systems. Overexpression of superoxide dismutase (SOD) to scavenge O2•− has been shown to decrease blood pressure in hypertensive animals. We have previously shown that MnTnBuOE-2-PyP5+ (BuOE), a manganese porphyrin SOD mimic currently in clinical trials as a normal tissue protector for cancer patients undergoing radiation therapy, can scavenge O2•− and acutely decrease normotensive blood pressures. Herein, we hypothesized that BuOE decreases hypertensive blood pressures. Using angiotensin II (AngII)-hypertensive mice, we demonstrate that BuOE administered both intraperitoneally and …

Body Mass-Normalized Moderate Dose Of Dietary Nitrate Intake Improves Endothelial Function And Walking Capacity In Patients With Peripheral Artery Disease, Elizabeth J. Pekas, Tesean Wooden, Santosh K. Yadav, Song-Young Park

Health and Kinesiology Faculty Publications

Peripheral artery disease (PAD) is characterized by the accumulation of atherosclerotic plaques in the lower extremity conduit arteries, which impairs blood flow and walking capacity. Dietary nitrate has been used to reduce blood pressure (BP) and improve walking capacity in PAD. However, a standardized dose for PAD has not been determined. Therefore, we sought to determine the effects of a body mass-normalized moderate dose of nitrate (0.11 mmol nitrate/kg) as beetroot juice on serum nitrate/nitrite, vascular function, walking capacity, and tissue oxygen utilization capacity in patients with PAD. A total of 11 patients with PAD received either nitrate supplement or …

Microvascular Dysfunction In Peripheral Artery Disease: Is Heat Therapy A Viable Treatment?, Cody P. Anderson, Elizabeth J. Pekas, Song-Young Park

Health and Kinesiology Faculty Publications

Peripheral artery disease (PAD) is characterized by the development of atherosclerotic plaques in the lower-body conduit arteries. PAD is commonly accompanied by microvascular disease, which may result in poor wound healing, plantar ulcer development, and subsequent limb amputation. Understanding the mechanisms underlying the development of plantar ulcers is a critical step in the development of adequate treatment options for patients with PAD. Skin is classified into two major components: glabrous and non-glabrous. These skin types have unique microcirculation characteristics, making it important to differentiate between the two when investigating mechanisms for plantar ulcer development in PAD. There is evidence for …

Psychological Pathways Linking Public Trust During The Coronavirus Pandemic To Mental And Physical Well-Being, Ayokunle Olagoke, Olakanmi Olagoke, Ashley M. Hughes

Health and Kinesiology Faculty Publications

The well-being of the public during the 2019 coronavirus (COVID-19) pandemic is deeply rooted in institutional trust in the government’s risk communication effort. The objective of this study was to examine the psychological pathway through which public trust in the government is associated with mental and physical well-being. We collected cross-sectional data from 501 participants aged ≥18 years using an online panel. Public trust in the government was assessed as our exposure variable. We screened for psychological distress by combining the Patient Health Questionnaire and the General Anxiety Disorder scale. Physical well-being was examined using self-rated health. We further assessed …

Intention To Vaccinate Against The Novel 2019 Coronavirus Disease: The Role Of Health Locus Of Control And Religiosity, Ayokunle Olagoke, Olakanmi Olagoke, Ashley M. Hughes

Health and Kinesiology Faculty Publications

The urgency to develop a vaccine against the 2019 coronavirus (COVID-19) has waxed stronger in speed, scale, and scope. However, wisdom dictates that we take a vantage position and start to examine the demographic predictors of COVID-19 vaccine hesitancy. The objective of this study was to examine the role of health locus of control (HLOC) in the relationship between religiosity and COVID-19 vaccination intention. In a cross-sectional survey (N = 501), we found a significantly negative association between religiosity and COVID-19 vaccination intention. This relationship was partially mediated by external HLOC. Collaborative efforts with religious institutions may influence COVID-19 vaccine …

Correlation Of Pre-Hypertension With Carotid Artery Damage In Middle-Aged And Older Adults, Jinkee Park, Yongseong Na, Yunjung Jang, Song-Young Park, Hyuntae Park

Health and Kinesiology Faculty Publications

The intima–media thickness (IMT), luminal diameters (LDs), flow velocities (FVs), compliance, and β-stiffness of the carotid artery (CA) are considered as independent risk factors for cardiovascular diseases (CVDs). Pre-hypertension (PHT) is also an independent CVD risk factor. This study investigated the association between CA damage (CAD) and PHT. A total of 544 adults participated; their blood pressures (BPs) and CA characteristics were measured using a mercury-free sphygmomanometer and ultrasound. Analysis of covariance (ANCOVA) was performed to assess the differences in the CA characteristics according to the BPs, multinomial logistic regression to evaluate the risk of CAD associated with PHT. In …

Functional, Proteomic And Bioinformatic Analyses Of Nrf2- And Keap1- Null Skeletal Muscle, Lie Gao, Vikas Kumar, Neetha Nanoth Vellichirammal, Song-Young Park, Tara L. Rudebush, Li Yu, Won-Mok Son, Elizabeth J. Pekas, Ahmed M. Wafi, Juan Hong, Peng Xiao, Chittibabu Guda, Han-Jun Wang, Harold D. Scultz, Irving H. Zucker

Health and Kinesiology Faculty Publications

Key points

• Nrf2 is a master regulator of endogenous cellular defences, governing the expression of more than 200 cytoprotective proteins, including a panel of antioxidant enzymes.
• Nrf2 plays an important role in redox haemostasis of skeletal muscle in response to the increased generation of reactive oxygen species during contraction.
• Employing skeletal muscle-specific transgenic mouse models with unbiased-omic approaches, we uncovered new target proteins, downstream pathways and molecular networks of Nrf2 in skeletal muscle following Nrf2 or Keap1 deletion.
• Based on the findings, we proposed a two-way model to understand Nrf2 function: a tonic effect through a Keap1-independent mechanism under basal …

Acute Mitochondrial Antioxidant Intake Improves Endothelial Function, Antioxidant Enzyme Activity, And Exercise Tolerance In Patients With Peripheral Artery Disease, Song-Young Park, Elizabeth J. Pekas, Ronald Headid Iii, Won-Mok Son, Tesean Wooden, Jiwon Song, Gwenael Layec, Santosh K. Yadav, Paras K. Mishra, Iraklis Pipinos

Health and Kinesiology Faculty Publications

Peripheral artery disease (PAD) is a manifestation of atherosclerosis in the leg arteries, which causes claudication. This may be in part due to vascular mitochondrial dysfunction and excessive reactive oxygen species (ROS) production. A mitochondrial-targeted antioxidant (MitoQ) has been shown to improve vascular mitochondrial function that, in turn, led to improved vascular function in older adults and animal models. However, the roles of vascular mitochondria in vascular function including endothelial function and arterial stiffness in patients with PAD are unknown; therefore, with the use of acute MitoQ intake, this study examined the roles of vascular mitochondria in endothelial function, arterial …

Combined Anthocyanins And Bromelain Supplement Improves Endothelial Function And Skeletal Muscle Oxygenation Status In Adults: A Double-Blind Placebo-Controlled Randomised Crossover Clinical Trial, Elizabeth J. Pekas, Jaehyun Shin, Ronald Headid Iii, Won-Mok Son, Gwenael Layec, Santosh K. Yadav, Steven D. Scott, Song-Young Park

Health and Kinesiology Faculty Publications

Anthocyanins and bromelain have gained significant attention due to their antioxidative and anti-inflammatory properties. Both have been shown to improve endothelial function, blood pressure (BP) and oxygen utility capacity in humans; however, the combination of these two and the impacts on endothelial function, BP, total antioxidant capacity (TAC) and oxygen utility capacity have not been previously investigated. The purpose of this study was to investigate the impacts of a combined anthocyanins and bromelain supplement (BE) on endothelial function, BP, TAC, oxygen utility capacity and fatigability in healthy adults. Healthy adults (n 18, age 24 (SD 4) years) received BE or …

Habitual Combined Exercise Protects Against Age-Associated Decline In Vascular Function And Lipid Profiles In Elderly Postmenopausal Women, Elizabeth J. Pekas, Won-Mok Son, Ronald Headid Iii, Song-Young Park, John Shin

Health and Kinesiology Faculty Publications

Postmenopausal status is associated with increased risks for cardiovascular diseases (CVD). This study investigated differences in vascular function, lipids, body composition, and physical fitness in elderly postmenopausal women active in combined resistance and aerobic exercise (CRAE) training for 1 year versus a sedentary cohort of similar-in-age counterparts. Elderly postmenopausal women performing habitual CRAE training for 1 year (age ~75 year; CRAE, n = 57) and elderly sedentary postmenopausal women (age ~78 year; SED, n = 44) were recruited. Arterial stiffness (brachial-to-ankle pulse-wave velocity, baPWV), blood pressure, blood lipids, anthropometrics, 2-min walking distance, and muscular strength were assessed for both groups. …

Exposure To Coronavirus News On Mainstream Media: The Role Of Risk Perceptions And Depression, Ayokunle Olagoke, Olakanmi Olagoke, Ashley M. Hughes

Health and Kinesiology Faculty Publications

Objective

The mainstream media tend to rely on news content that will increase risk perceptions of pandemic outbreaks to stimulate public response and persuade people to comply with preventive behaviours. The objective of this study was to examine associations between exposure to coronavirus disease (COVID-19) news, risk perceptions, and depressive symptoms.

Methods

Cross-sectional data were collected from 501 participants who were ≥18 years. Exposure to COVID-19 news was assessed as our exposure variable. We screened for depression (outcome variable) with the Patient Health Questionnaire and examined the roles of risk perceptions. Multiple linear regressions and mediation analysis with 1000 bootstrap …

The Effects Of Mat Pilates Training On Vascular Function And Body Fatness In Obese Young Women With Elevated Blood Pressure, Alexei Wong, Arturo Figueroa, Stephen M. Fischer, Reza Bagheri, Song-Young Park

Health and Kinesiology Faculty Publications

BACKGROUND

Effective nonpharmacological interventions targeting the enhancement of vascular function and decline of body fatness (BF) in obese individuals are indispensable for the prevention of hypertension and cardiovascular events in young adults. Mat Pilates training (MPT) has gained significant popularity worldwide, yet its effects on vascular function and body composition are understudied. We examined the effects of MPT on vascular function and BF in young obese women with elevated blood pressure (BP). METHODS

Twenty-eight young obese women with elevated BP were randomized to an MPT (n = 14) or a nonexercising control (CON, n = 14) group for 12 …

The Impact Of Aspirin Intake On Lactate Dehydrogenase, Arterial Stiffness, And Oxidative Stress During High-Intensity Exercise: A Pilot Study, Sang-Ho Lee, Elizabeth J. Pekas, Seungyong Lee, Ronald Headid Iii, Song-Young Park

Health and Kinesiology Faculty Publications

Aspirin is a common nonsteroidal anti-inflammatory drug used to reduce fever, pain, and inflammation. However, aspirin's anti-inflammatory properties may also prevent increased levels of blood lactate dehydrogenase, vascular arterial stiffness and oxidative stress induced by high-intensity exercise. The purpose of this study was to investigate the effects of 4 weeks of aspirin supplementation on lactate dehydrogenase activity, lactate, arterial stiffness, and antioxidant capacity during high-intensity exercise in Taekwondo athletes. Participants were randomly divided into two groups: aspirin supplementation (n = 10) and placebo-control (n = 10). Blood levels of lactate dehydrogenase (LDH) enzyme activity and lactate were assessed to examine …

Vasodilatory And Vascular Mitochondrial Respiratory Function With Advancing Age: Evidence Of A Free Radically Mediated Link In The Human Vasculature, Soung Hun Park, Oh-Sung Kwon, Song-Young Park, Joshua C. Weavil, Jay R. Hydren, Van Reese, Robert H. I. Andtbacka, John R. Hyngstrom, Russell S. Richardson

Health and Kinesiology Faculty Publications

Recognizing the age-related decline in skeletal muscle feed artery (SMFA) vasodilatory function, this study examined the link between vasodilatory and mitochondrial respiratory function in the human vasculature. Twenty-four SMFAs were harvested from young (35 ± 6 yr, n = 9) and old (71 ± 9 yr, n = 15) subjects. Vasodilation in SMFAs was assessed, by pressure myography, in response to flow-induced shear stress, acetylcholine (ACh), and sodium nitroprusside (SNP) while mitochondrial respiration was measured, by respirometry, in permeabilized SMFAs. Endothelium-dependent vasodilation was significantly attenuated in the old, induced by both flow (young: 92 ± 3, old: 45 ± 4%) …

Mmp9 Mediates Acute Hyperglycemia-Induced Human Cardiac Stem Cell Death By Upregulating Apoptosis And Pyroptosis In Vitro, Santosh K. Yadav, Tyler N. Kambis, Sumit Kar, Song-Young Park, Paras K. Mishra

Health and Kinesiology Faculty Publications

Providing a conducive microenvironment is critical to increase survival of transplanted stem cells in regenerative therapy. Hyperglycemia promotes stem cell death impairing cardiac regeneration in the diabetic heart. Understanding the molecular mechanisms of high glucose-induced stem cell death is important for improving cardiac regeneration in diabetic patients. Matrix metalloproteinase-9 (MMP9), a collagenase, is upregulated in the diabetic heart, and ablation of MMP9 decreases infarct size in the non-diabetic myocardial infarction heart. In the present study, we aim to investigate whether MMP9 is a mediator of hyperglycemia-induced cell death in human cardiac stem cells (hCSCs) in vitro. We created MMP9−/− hCSCs …

Effects Of Heated Water-Based Versus Land-Based Exercise Training On Vascular Function In Individuals With Peripheral Artery Disease, Song-Young Park, Alexei Wong, Won-Mok Son, Elizabeth J. Pekas

Health and Kinesiology Faculty Publications

Peripheral artery disease (PAD) is an atherosclerotic disease that is associated with poor vascular function, walking impairment, and reduced quality of life. Land-based exercise therapy (LBET) is frequently recommended to improve walking and reduce symptoms. Recently, evidence has suggested that heated-water exercise therapy (HWET) is an effective intervention for PAD. However, the efficacy of LBET versus HWET in PAD patients had not been elucidated. Therefore, we sought to compare effects of LBET with HWET on cardiovascular function, exercise tolerance, physical function, and body composition in PAD patients. PAD patients (n = 53) were recruited and randomly assigned to a …