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Comparison Of 15 Minutes And 30 Minutes Of Moderate Intensity Exercise On Natural Killer Cell Levels In Blood, Nathan Fuentes, Rebekah Hunt, Rachel Banh, Lynssie Mcbride, Macarthur Bolden Iii, Karla Laurea, Emily Lavoy
Comparison Of 15 Minutes And 30 Minutes Of Moderate Intensity Exercise On Natural Killer Cell Levels In Blood, Nathan Fuentes, Rebekah Hunt, Rachel Banh, Lynssie Mcbride, Macarthur Bolden Iii, Karla Laurea, Emily Lavoy
International Journal of Exercise Science: Conference Proceedings
Exercise has been shown to significantly mobilize white blood cells, such as Natural Killer (NK) cells, transiently into circulation. NK cells are a key part of the innate immune system that can quickly destroy infected cells and can serve as a first line of defense against pathogens. However, the duration of exercise that is needed to significantly increase these cells has yet to be established. PURPOSE: Comparing the effects of 15 minutes vs 30 minutes of moderate-intensity exercise on the levels of total NK cells, CD16+, and CD57+ NK cells circulating within the blood. METHODS: 9 healthy male …
The Inflammatory Response To Different Hiit Modalities, John G. Wallace Iii, Jared Moore, E. Todd Schroeder
The Inflammatory Response To Different Hiit Modalities, John G. Wallace Iii, Jared Moore, E. Todd Schroeder
International Journal of Exercise Science: Conference Proceedings
Pro-inflammatory and anti-inflammatory cytokines have been documented to change in response to long-duration, aerobic exercise. Little work has been performed in high-intensity interval training (HIIT). Furthermore, it has yet to be elucidated whether the modality of HIIT affects this inflammatory response. PURPOSE: The purpose of this study was to investigate the changes in IL-8 and IL-10 cytokine concentrations pre-post and post-1hr following HIIT protocols using two different exercise modalities, treadmill running (TM) and stationary cycling (CE). METHODS: Eight young, healthy, recreationally active volunteers (1 female, 7 males; 25.50 ± 3.25 years) completed a 4x4 HIIT protocol (4-minute 85-95% …
Effects Of Social Jetlag On Exercise-Induced Adaptations In Skeletal Muscle Mitochondrial Content In Mice, Austin R. Cooper, Michael Dial, Nikoleta Vasileva, Greco Neblina, Elias M. Malek, Graham Mcginnis 8954626
Effects Of Social Jetlag On Exercise-Induced Adaptations In Skeletal Muscle Mitochondrial Content In Mice, Austin R. Cooper, Michael Dial, Nikoleta Vasileva, Greco Neblina, Elias M. Malek, Graham Mcginnis 8954626
International Journal of Exercise Science: Conference Proceedings
Social jetlag (SJL) occurs when the sleep/wake schedule differs on work days (weekdays) and free days (weekends). Previous studies have shown that individuals with SJL have lower physical fitness and are prone to obesity. While exercise reverses this phenotype (i.e. - via increasing skeletal muscle mitochondrial content), the effects of social jetlag on exercise training adaptations have yet to be shown. PURPOSE: To determine how social jetlag impacts skeletal muscle adaptations to exercise training in mice. METHODS: Male C57BL/6J mice aged 10-weeks (n=40) were assigned to four groups, with experimental conditions persisting for 6-weeks; control sedentary (C-SED), control with voluntary …
C-Reactive Protein Changes Following Treadmill And Cycling High-Intensity Interval Training, Juliet Moore, George Salem
C-Reactive Protein Changes Following Treadmill And Cycling High-Intensity Interval Training, Juliet Moore, George Salem
International Journal of Exercise Science: Conference Proceedings
ABSTRACT: The acute inflammatory response to exercise has been well-studied in long duration activities such as marathons and triathlons; however, little work has been done investigating this response in high-intensity interval training (HIIT), which is characterized by intermittent bouts of higher and lower intensity cycles. PURPOSE: The purpose of this study was to investigate the changes in C-reactive protein (CRP) immediately following and 1-hour post HIIT protocols using two different exercise modalities, treadmill running and stationary cycling. METHODS: Eight young, healthy, recreationally active volunteers (1 female, 7 males; 25.50 ± 3.25 years) completed a 4x4 HIIT protocol …
Minimal Differences Between Males And Females In Exercise-Induced Increase Of Circulating T Cells Subsets In Older Adults, Seth Rinehart, Kristofer Jennings, Melissa Markofski
Minimal Differences Between Males And Females In Exercise-Induced Increase Of Circulating T Cells Subsets In Older Adults, Seth Rinehart, Kristofer Jennings, Melissa Markofski
International Journal of Exercise Science: Conference Proceedings
PURPOSE: To examine potential differences between older adult males and females’ acute post-exercise circulating T cell response. METHODS: Participants were healthy older adults with an average age of 63.0 ± 1.0 years (n= 24, females = 70.8%) and BMI of 24.7 ± 0.7 kg∙m-2. All females were post-menopausal. A single bout of cardiorespiratory exercise at ~70% heart rate reserve and a separate bout of eight resistance exercises at ~70% 1 repetition maximum were conducted at least one week apart. T cell count changes were determined via blood sample at rest and immediately post-exercise for each bout. Multi-color …
Inflammatory Response Following High-Intensity Interval Training (Hiit) Across Different Exercise Modalities: A Pilot Study, Bailey Mclagan, Jared Moore, George Salem
Inflammatory Response Following High-Intensity Interval Training (Hiit) Across Different Exercise Modalities: A Pilot Study, Bailey Mclagan, Jared Moore, George Salem
International Journal of Exercise Science: Conference Proceedings
Exercise-related muscular contractions produce and release numerous myokines, namely interleukins (IL) 6, 8, and 10. Most studies have focused on longer duration (>60 minutes) exercise and suggest that the IL-6 response to running is greater than that of cycling. However, to date, the effect of 4x4 High-Intensity Interval Training (HIIT) and modality on the inflammatory response to exercise have not been reported. PURPOSE: This pilot investigation characterized the inflammatory biomarker response to HIIT 4x4 running and cycling protocols. METHODS: Five young, recreationally active volunteers (1 female, 4 males; 27.20 ± 3.42 years) completed a heart rate max …
Stimulated Muscle Contractions Regulate Membrane-Bound And Soluble Tlr4 To Prevent Lps-Induced Signaling And Myotube Atrophy In Skeletal Muscle Cells, Jeremy B. Ducharme, Zachary J. Fennel, Zachary J. Mckenna, Quint N. Berkemeier, Michael R. Deyhle
Stimulated Muscle Contractions Regulate Membrane-Bound And Soluble Tlr4 To Prevent Lps-Induced Signaling And Myotube Atrophy In Skeletal Muscle Cells, Jeremy B. Ducharme, Zachary J. Fennel, Zachary J. Mckenna, Quint N. Berkemeier, Michael R. Deyhle
International Journal of Exercise Science: Conference Proceedings
Toll-like receptor 4 (TLR4) activation by lipopolysaccharides (LPS) contributes to chronic inflammation and causes upregulation of muscle atrophy signaling pathways. Exercise can suppress LPS/TLR4 axis activation by reducing the expression of TLR4 on immune cells. It is unknown how this regulation occurs, and it is not clear how exercise affects TLR4 on skeletal muscle. PURPOSE: To uncover the nature and mechanisms by which exercise affects TLR4 expression and intracellular signaling using cell culture models and human experiments. METHODS: C2C12 myotubes were subjected to electrical pulse stimulation (EPS) with and without subsequent treatment with 500 ng/mL lipopolysaccharide (LPS) along with …
Exercise Mobilizes Early And Late Differentiated Cd8 T Cells Expressing A Marker Of Exhaustion, Rebekah Hunt, Mahmoud Elzayat, Emily C. Lavoy
Exercise Mobilizes Early And Late Differentiated Cd8 T Cells Expressing A Marker Of Exhaustion, Rebekah Hunt, Mahmoud Elzayat, Emily C. Lavoy
International Journal of Exercise Science: Conference Proceedings
T cell differentiation occurs following activation of key functions, such as proliferation and cytokine production. Naïve (NA) and central memory (CM) T cells are early differentiated, whereas effector memory (EM) and RA+ effector memory cells (EMRA) are later differentiated. CD57 expression, a putative marker of exhaustion, has also been used to identify later differentiated cells, although recent data indicate CD57 can also be expressed by NA and CM. Exercise mobilizes EM and EMRA to a greater extent than NA and CM. Separately, exercise has been shown to preferentially mobilize CD57+ cells. Whether these exercise responsive CD57+ cells arise from highly …
Sex Dimorphism In Muscle Damage-Induced Inflammation, Casey Appell, Mohamed Fokar, Jakob Vingren, Hui-Ying Luk
Sex Dimorphism In Muscle Damage-Induced Inflammation, Casey Appell, Mohamed Fokar, Jakob Vingren, Hui-Ying Luk
International Journal of Exercise Science: Conference Proceedings
Evidence suggests that estrogen can provide a protective effect against muscle damage-induced inflammation. However, to date, no study has directly compared the muscle damage-induced intramuscular cytokines gene expression between men and women. Purpose: The purpose was to determine the intramuscular cytokine response to a bout of unaccustomed eccentric exercise in men and women. Methods: Untrained men (n=8, 22 ± 3y) and women (n=8, 20 ± 1y) completed a session of 80 unilateral maximal eccentric knee extensions. Vastus lateralis samples were collected and analyzed for gene expression of Interleukin (IL)-6, IL-10, IL-15, tumor necrosis factor (TNF)-α, and transforming growth factor (TGF)-ß …
The Effects Of A Dynamic Warm-Up On Exercise-Induced Redistribution Of Monocytes And Natural Killer Cells, Mahmoud T. Elzayat, Emily C. Lavoy
The Effects Of A Dynamic Warm-Up On Exercise-Induced Redistribution Of Monocytes And Natural Killer Cells, Mahmoud T. Elzayat, Emily C. Lavoy
International Journal of Exercise Science: Conference Proceedings
Proportions of leukocyte subsets in peripheral blood are altered post-exercise and return to baseline during recovery. This is caused in part by exercise-induced increases in stress hormones. Inclusion of a pre-exercise dynamic warm-up has been shown to decrease markers of cardiovascular stress during exercise. However, whether a warm-up can attenuate changes to the immune system with exercise has not yet been examined PURPOSE: To compare monocyte and natural killer (NK) cell mobilization following a bout of high intensity aerobic exercise with and without a dynamic pre-exercise warm-up. METHODS: 16 physically active adults (7 women, 27.8±4.4 years) cycled 30 …
Can A Dynamic Warm-Up Reduce The Magnitude Of Immune Perturbation Following Vigorous Aerobic Exercise, Mahmoud T. Elzayat, Emily C. Lavoy
Can A Dynamic Warm-Up Reduce The Magnitude Of Immune Perturbation Following Vigorous Aerobic Exercise, Mahmoud T. Elzayat, Emily C. Lavoy
International Journal of Exercise Science: Conference Proceedings
Exercise transiently increases several leukocyte populations in peripheral blood in an intensity-dependent manner, with numbers returning to baseline or lower during recovery. This mobilization of immune cells is explained in part by sympathetic activity and the release of stress hormones (catecholamines and cortisol). The literature examining immune responses to exercise has by and large failed to control for the presence of a warm-up prior to the experimental bout. Gradually increasing exercise intensity over a period of minutes may reduce the stress of the exercise bout and thus may influence the immune response to a given exercise protocol. PURPOSE: To …
The Effect Of Repeated 40 Meter Sprint Trials On Salivary Cortisol In Elite Youth Female Soccer Players, Michael D. Oldham, Matthew Brisebois, Todd Castleberry, Ryan A. Gordon, Ola Kayed, Manisha Rao, Ada Simpson, Matt Sokoloski, Emily L. Zumbro, Vic Ben-Ezra, Kyle Biggerstaff
The Effect Of Repeated 40 Meter Sprint Trials On Salivary Cortisol In Elite Youth Female Soccer Players, Michael D. Oldham, Matthew Brisebois, Todd Castleberry, Ryan A. Gordon, Ola Kayed, Manisha Rao, Ada Simpson, Matt Sokoloski, Emily L. Zumbro, Vic Ben-Ezra, Kyle Biggerstaff
International Journal of Exercise Science: Conference Proceedings
The outcome of an intense exercise session is a stress response, potentially resulting in an increase in circulating cortisol. The acute cortisol response due to intense exercise may vary when comparing elite youth athletes and may not be noticeable in athletic performance. PURPOSE: The purpose of this study was to compare salivary cortisol responses between older (17-19 yo) and younger (11-13 yo) elite female soccer players after repeated 40m sprint trials. METHODS: All participants (n=8) were current United States Soccer Federation Development Academy players. Participants were placed into young (n=4, mean ± SD; age 12 ± 0 yrs; …
Irisin Treatment During Chronic Inflammatory Bowel Disease In An Rodent Model Improves Bone Formation Rate, Anne M. Anderson, Corinne Metzger, Susan Bloomfield
Irisin Treatment During Chronic Inflammatory Bowel Disease In An Rodent Model Improves Bone Formation Rate, Anne M. Anderson, Corinne Metzger, Susan Bloomfield
International Journal of Exercise Science: Conference Proceedings
Bone is a dynamic tissue that responds to many stressors including physical stress and certain disease states. Chronic systemic inflammatory conditions, like inflammatory bowel disease (IBD), result in increased bone resorption and decreased bone formation leading to low bone mass and high fracture incidence. There currently are no effective, safe treatments for IBD. Irisin is a hormone that is released during exercise and has previously been shown to increase bone mass. PURPOSE: Determine if exogenous treatment with irisin can mitigate the inflammatory insult of chronic IBD on bone. We hypothesized that young male rats with induced IBD and treatment …
Acute Exercise-Induced Response Of Platelet-Monocyte Complexes In Obese, Postmenopausal Women, Michael M. Levitt, Maria A. Cardenas, Bryan Richie, Carmen A. Cook, Shaohan Lu, Kara L. Steck, Jay Haynes, Andreas Kreutzer, Joel B. Mitchell, Melody D. Phillips
Acute Exercise-Induced Response Of Platelet-Monocyte Complexes In Obese, Postmenopausal Women, Michael M. Levitt, Maria A. Cardenas, Bryan Richie, Carmen A. Cook, Shaohan Lu, Kara L. Steck, Jay Haynes, Andreas Kreutzer, Joel B. Mitchell, Melody D. Phillips
International Journal of Exercise Science: Conference Proceedings
Inactivity-related diseases such as cardiovascular disease (CVD) are linked to chronic low-grade, systemic inflammation. Platelet-monocyte complexes (PMCs) are markers of in vivo platelet activation and atherosclerosis, and may be early indicators of subclinical inflammation. PURPOSE: To examine the effects of an exercise bout on PMCs in those at risk for CVD. METHODS: Twenty-five overweight-obese (BMI 32.7 ± 5.2 kg×m-2, 55-75 yr) women were randomly assigned to either the exercise (EX, n=13) or non-exercise control (CON, n=12) group. EX performed 2 sets of 8 resistance exercises and a 25-min treadmill walk at 70-80% HRR. Blood was obtained pre-exercise (PR), …
Exercise Training Improved Plasma Glucose And Lipid Profiles In Obese Hispanic Women, Yonghyeon Jo, Katie Martin, Kaylee Clyma, Kyung-Shin Park, Yunsuk Koh
Exercise Training Improved Plasma Glucose And Lipid Profiles In Obese Hispanic Women, Yonghyeon Jo, Katie Martin, Kaylee Clyma, Kyung-Shin Park, Yunsuk Koh
International Journal of Exercise Science: Conference Proceedings
Obesity is strongly associated with increased morbidity and mortality, notably among Hispanic women. Exercise may improve cardiovascular health by positively altering plasma lipids and lipoproteins; however, the effects of different intensities of exercise on plasma glucose and lipid profiles have not been extensively studied within Hispanic women. PURPOSE: The current study examined the effects of a 12-week aerobic exercise training at either high or low intensity on plasma glucose and lipid profiles in obese Hispanic females. METHODS: Thirty physically inactive, obese females (age= 26.07±4.4 years, height= 161.4±4.1 cm, weight= 89.8±8.1 kg and %body fat= 40.9 ±4.9%) were randomly …
Exercise-Induced Th17 Lymphocyte Response And Their Relationship To Cardiovascular Disease Risk Factors In Obese, Post-Menopausal Women, Maria A. Cardenas, Michael M. Levitt, Bryan Richie, Shaohan Lu, Elise Erickson, Carmen Cook, Jay Haynes, Andreas Kreutzer, Joel B. Mitchell, Melody D. Phillips
Exercise-Induced Th17 Lymphocyte Response And Their Relationship To Cardiovascular Disease Risk Factors In Obese, Post-Menopausal Women, Maria A. Cardenas, Michael M. Levitt, Bryan Richie, Shaohan Lu, Elise Erickson, Carmen Cook, Jay Haynes, Andreas Kreutzer, Joel B. Mitchell, Melody D. Phillips
International Journal of Exercise Science: Conference Proceedings
Obesity-induced inflammation promotes type 2 diabetes and cardiovascular disease (CVD). A causative link between adaptive immunity and pathogenesis of obesity-associated diseases has been established. PURPOSE: To examine the effects of exercise on circulating T-helper (Th) 17 lymphocytes in overweight/obese post-menopausal women. METHODS: Twenty-seven overweight/obese women (BMI 32.7 ± 5.1 kg×m-2, 55-75 yr) were randomly assigned to the exercise (EX, n=14) or education (ED, n=13) groups. EX performed a 25-min walk (75-80% HRR) and 2 sets of 8 resistance exercises (70-80% 1RM) with blood samples obtained at: pre-exercise, post-exercise, one-hour and two-hour post-exercise. Blood samples were obtained …
Effects Of Submaximal Downhill Running On Cytokine Expression In Young, Endurance Trained Men And Women, J. Macko, R. Sapp, R. Landers-Ramos, J. Skelton, J. Hagberg
Effects Of Submaximal Downhill Running On Cytokine Expression In Young, Endurance Trained Men And Women, J. Macko, R. Sapp, R. Landers-Ramos, J. Skelton, J. Hagberg
International Journal of Exercise Science: Conference Proceedings
Please see the pdf version of the abstract.