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1. Types Of Alignment: Presentations & Demos Assignment, Sarah O'Leary-Driscoll
1. Types Of Alignment: Presentations & Demos Assignment, Sarah O'Leary-Driscoll
Sequence Alignments
Pairwise Alignment: DNA
Pairwise Alignment: Protein
Multiple Sequence Alignment: DNA
Multiple Sequence Alignment: Protein
Sequencing Techniques: A Comparison Assignment, Sarah O'Leary-Driscoll
Sequencing Techniques: A Comparison Assignment, Sarah O'Leary-Driscoll
Sequencing & Genome Mining
With your partner, create some sort of visual (table, map, chart, other, ask me!) that compares the main types of sequencing that we discussed, as well as two of the techniques considered 'next generation'.
Discussion Questions: Genome Mining, Sarah O'Leary-Driscoll
Discussion Questions: Genome Mining, Sarah O'Leary-Driscoll
Sequencing & Genome Mining
No abstract provided.
Alignment Information, Sarah O'Leary-Driscoll
Alignment Information, Sarah O'Leary-Driscoll
Sequence Alignments
Pairwise DNA alignment is frequently used to identify similar regions that will show how two sequences have functional or structural similarities. It can also be used to show how exons and introns change between different sequences and whether they have an effect on the final structure of the RNA after the DNA is processed within a cell.
Alignment Outline, Sarah O'Leary-Driscoll
2: Sequence Alignment Practice Activity, Sarah O'Leary-Driscoll
2: Sequence Alignment Practice Activity, Sarah O'Leary-Driscoll
Sequence Alignments
Now that you have learned how to do the four basic sequence alignments (Pairwise and Multiple for both nucleotide and protein sequences) select a gene/protein, it may be one that you've used before, and run each of these alignments.
Pt. 2: Presentation / Paper Guidelines, Sarah O'Leary-Driscoll
Pt. 2: Presentation / Paper Guidelines, Sarah O'Leary-Driscoll
Research Project
The presentations for your project should follow the same format that the paper would, but in a much more abbreviated form, aim for 5-7 minutes.
Project Guidelines, Sarah O'Leary-Driscoll
Pt. 1: Research Question & Background, Sarah O'Leary-Driscoll
Pt. 1: Research Question & Background, Sarah O'Leary-Driscoll
Research Project
No abstract provided.
Primer Design Activity, Sarah O'Leary-Driscoll
Obtaining Genomic Sequence Practice, Sarah O'Leary-Driscoll
Obtaining Genomic Sequence Practice, Sarah O'Leary-Driscoll
Introduction to NCBI
No abstract provided.
Dna Timeline And Poster Project, Sarah O'Leary-Driscoll
Dna Timeline And Poster Project, Sarah O'Leary-Driscoll
Genomics: Past & Future
The DNA timeline goes through many of the major discoveries that have driven our understanding of genetics since Mendel. Pick two scientists and create a PowerPoint slide poster (to be printed out on regular printer sized paper) that covers the following:
3: Genomics: Past & Future Bibliography, Sarah O'Leary-Driscoll
3: Genomics: Past & Future Bibliography, Sarah O'Leary-Driscoll
Genomics: Past & Future
No abstract provided.
Future Of Genomics: Presentations, Sarah O'Leary-Driscoll
Future Of Genomics: Presentations, Sarah O'Leary-Driscoll
Genomics: Past & Future
In his testimony to a House of Representatives sub-committee on health, director of the National Human Genome Research Institute, Francis S. Collins, said that the future of genomics had three main focal points:
"Genomics to Biology: The human genome sequence provides foundational information that now will allow development of a comprehensive catalog of all of the genome's components, determination of the function of all human genes, and deciphering of how genes and proteins work together in pathways and networks.
Genomics to Health: Completion of the human genome sequence offers a unique opportunity to understand the role of genetic factors in …
Database/Resource Acronyms, Sarah O'Leary-Driscoll
Database/Resource Acronyms, Sarah O'Leary-Driscoll
Course Information
No abstract provided.
What Is Bioinformatics?, Sarah O'Leary-Driscoll
What Is Bioinformatics?, Sarah O'Leary-Driscoll
Course Information
Bioinformatics has evolved into a full-fledged multidisciplinary subject that integrates developments in information and computer technology as applied to Biotechnology and Biological Sciences. Bioinformatics uses computer software tools for database creation, data management, data warehousing, data mining and global communication networking. Bioinformatics is the recording, annotation, storage, analysis, and searching/retrieval of nucleic acid sequence (genes and RNAs), protein sequence and structural information. This includes databases of the sequences and structural information as well methods to access, search, visualize and retrieve the information. Bioinformatics concern the creation and maintenance of databases of biological information whereby researchers can both access existing information …
Comprehensive Course Syllabus, Sarah O'Leary-Driscoll
Comprehensive Course Syllabus, Sarah O'Leary-Driscoll
Course Information
The bioinformatics seminar is focused on developing an understanding of the principles behind genomic analyses, developing skills using the different available bioinformatics programs, and becoming aware of the past developments and current research avenues that are benefited by these types of analyses.
Glossary Of Bioinformatics Terms, National Human Genome Research Institute
Glossary Of Bioinformatics Terms, National Human Genome Research Institute
Course Information
No abstract provided.
1: "To Know Ourselves", The U.S. Department Of Energy, The Human Genome Project
1: "To Know Ourselves", The U.S. Department Of Energy, The Human Genome Project
Genomics: Past & Future
AT THE END OF THE ROAD in Little Cottonwood Canyon, near Salt Lake City, Alta is a place of near-mythic renown among skiers. In time it may well assume similar status among molecular geneticists. In December 1984, a conference there, co-sponsored by the U.S. Department of Energy, pondered a single question: Does modern DNA research offer a way of detecting tiny genetic mutations—and, in particular, of observing any increase in the mutation rate among the survivors of the Hiroshima and Nagasaki bombings and their descendants? In short the answer was, Not yet. But in an atmosphere of rare intellectual fertility, …
2: "The Mapping Of Chromosome 16", Norman A. Doggett, Raymond L. Stallings, Carl E. Hildebrand, Robert K. Moyzis
2: "The Mapping Of Chromosome 16", Norman A. Doggett, Raymond L. Stallings, Carl E. Hildebrand, Robert K. Moyzis
Genomics: Past & Future
Human chromosome 16 is the main focus of the mapping efforts at Los Alamos. The large photomicrograph on these opening pages illustrates the starting point for those mapping efforts, the evaluation of our chromosome-16-specific library of cloned fragments. Among the 23 pairs of human chromosomes, one pair, chromosome 16, is identified by fluorescence in-situ hybridization. Thousands of yellow fluorescent probes derived from the clone library have hybridized to both copies of chromosome 16. The high density and uniform coverage of the fluorescent signals were a strong indication that we could use the library to construct a map of overlapping cloned …