Management Information Systems Commons^™

Knowledge Discovery And Modeling In Genomic Databases, Michael M. Yin

Dissertations

This dissertation research is targeted toward developing effective and accurate methods for identifying gene structures in the genomes of high eukaryotes, such as vertebrate organisms. Several effective hidden Markov models (HMMs) are developed to represent the consensus and degeneracy features of the functional sites including protein-translation start sites, mRNA splicing junction donor and acceptor sites in vertebrate genes. The HMM system based on the developed models is fully trained using an expectation maximization (EM) algorithm and the system performance is evaluated using a 10-way cross-validation method. Experimental results show that the proposed HMM system achieves high sensitivity and specificity in …

Intramural, Collaborative Learning Systems, Robert S. Friedman

Theses

This thesis focuses on three related concepts: problem-based collaborative learning; the use of multimedia tools in learning systems; and participatory design as a software engineering methodology to create multimedia tools to be used in learning systems. A literature review of the three areas is followed by an overview of the pedagogical, technological, and business trends that affect the direction of innovation in education, including problem-based learning. A discussion of a software engineering project to develop a multimedia application that enhances the learning of geography skills and puts the programming, interface design and multimedia systems capabilities of college students into action …

Leadership Antecedents Of Informal Knowledge Acquisition And Dissemination, Siu Loon Hoe, Steve Mcshane

Research Collection School Of Computing and Information Systems

Knowledge management is emerging as one of the leading influences on an organisation’s survival and competitive advantage (Blumentritt & Johnston 1999). Knowledge management is concerned with the effective acquisition, sharing, storage and utilisation of knowledge (Huber 1991; Saffady 1998). Corporate leaders are increasingly aware of the notion that an organisation’s long-term survival depends on its ability to generate new knowledge and continuously learn from the environment. The importance of a superior organisational learning capability as a source of competitive advantage is a common refrain among both managers and scholars (e.g. Kohli & Jaworski 1990; Nonaka 1991; Quinn 1992; Slater & …

Development And Characterization Of Methodology And Technology For The Alignment Of Fmri Time Series, Carlo Ciulla

Dissertations

This dissertation has developed, implemented and tested a novel computer based system (AUTOALIGN) that incorporates an algorithm for the alignment of functional Magnetic Resonance Image (fMRI) time series. The algorithm assumes the human brain to be a rigid body and computes a head coordinate system on the basis of three reference points that lie on the directions correspondent to two of the eigenvectors of inertia of the volume, at the intersections with the head boundary. The eigenvectors are found weighting the inertia components with the voxel's intensity values assumed as mass. The three reference points are found in the same …

Collaborative Problem Solving And Program Development Model, Joanna Defranco-Tommarello

Dissertations

A model to enhance collaborative problem solving and program development is presented. The collaborative model is a detailed cognitive model that takes into consideration the cognitive and social activities that occur during collaborative problem solving and program development. The cognitive activities required for collaborative problem solving and program development are identified and integrated into a six-stage model. An extensive literature review in the associated fields is presented to show the need for the model described in this dissertation. In addition, a comprehensive study of tools to support collaboration during problem solving and program development was also performed as well as …

Pricing And Product Mix Optimization In Freight Transportation, Michael F. Gorman

MIS/OM/DS Faculty Publications

We propose improved pricing and market mix can improve the profitability of the freight transportation provider through the reduction of equipment repositioning costs. We hypothesize that because of complexities surrounding pricing and equipment repositioning costing, existing pricing strategies in freight transportation fail to fully consider these costs. We test this hypothesis in an applied setting in which Monte Carlo simulation captures the stochasticity of market conditions inherent in the problem. We use a heuristic to improve the nondifferentiable, discontinuous objective function.

Our results from test cases show with high confidence that current prices are not optimal, as indicated by a …

Using Real Options Analysis For Evaluating Uncertain Investments In Information Technology: Insights From The Icis 2001 Debate, Paul P. Tallon, Robert J. Kauffman, Henry C. Lucas, Andrew B. Whinston, Kevin Zhu

Research Collection School Of Computing and Information Systems

Business and information systems (IS) executives continue to grapple with issues of risk and uncertainty in evaluating investments in information technology (IT). Despite the use of net present value (NPV) and other investment appraisal techniques, executives are often forced to rely on instinct when finalizing IT investment decisions. Recognizing the shortcomings of NPV, real options analysis has been suggested as an alternative approach, one that considers the risks associated with an investment while recognizing the ability of corporations to defer an investment until a later period or to make a partial investment instead. Responding to a growing interest in real …

Medtextus: An Ontology-Enhanced Medical Portal, Gondy Leroy, Hsinchun Chen

CGU Faculty Publications and Research

In this paper we describe MedTextus, an online medical search portal with dynamic search and browse tools. To search for information, MedTextus lets users request synonyms and related terms specifically tailored to their query. A mapping algorithm dynamically builds the query context based on the UMLS ontology and then selects thesaurus terms that fit this context. Users can add these terms to their query and meta-search five medical databases. To facilitate browsing, the search results can be reviewed as a list of documents per database, as a set of folders into which all the documents are automatically categorized based on …

Filling Preposition-Based Templates To Capture Information From Medical Abstracts, Gondy Leroy, Hsinchun Chen

CGU Faculty Publications and Research

Due to the recent explosion of information in the biomedical field, it is hard for a single researcher to review the complex network involving genes, proteins, and interactions. We are currently building GeneScene, a toolkit that will assist researchers in reviewing existing literature, and report on the first phase in our development effort: extracting the relevant information from medical abstracts. We are developing a medical parser that extracts information, fills basic prepositional-based templates, and combines the templates to capture the underlying sentence logic. We tested our parser on 50 unseen abstracts and found that it extracted 246 templates with a …