Accounting Commons^™

Optimization Of Adult Multipotent Stromal Cell-Bioscaffold Interactions For Tissue Regeneration With Bioreactors, Lin Xie

LSU Doctoral Dissertations

Adult multipotent stromal cells (MSCs) in combination with biocompatible scaffolds may augment well-established medical and surgical techniques. Pre-implantation cell loading and viability on scaffold carriers followed by in vitro differentiation and extracellular matrix (ECM) formation contribute to the efficacy of in vivo tissue formation. Given the specificity of the parameters for each cell-scaffold construct, it is vital to assess the relative potential of various combinations to select the best option for various clinical needs. High demand for equine and human bone regeneration especially non-union fracture repair is still largely unaddressed. Therefore osteogenesis potential of both equine and human MSCs engrafted …