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2010

American Studies

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Articles 1 - 30 of 1115

Full-Text Articles in Arts and Humanities

Corrole Synthesis And Catalytic Applications Toward Cobalt(Iii)-Catalyzed Epoxidation, N-H Insertion, And Cyclopropanation, Chung Sik Kim Dec 2010

Corrole Synthesis And Catalytic Applications Toward Cobalt(Iii)-Catalyzed Epoxidation, N-H Insertion, And Cyclopropanation, Chung Sik Kim

Graduate Theses and Dissertations

A variety of bromocorroles, useful precusors for Pd-based cross coupling, were sucessfully synthesized in moderate to good yields. Chiral corroles were also synthesized through use of chiral amides in the aforementioned cross coupling reactions. Cobalt complexes bearing π-acceptor (CNtBu) and σ-donor (PPh3) ligands were also prepared in excellent yields. In this dissertation, cobalt (III) corrole complexes were applied to three different reaction areas: epoxidation, N-H insertion, and cyclopropanation. Cobalt(III) corroles were found to be efficient catalysts for epoxidation reactions. The epoxidation reactions can be carried out using ethyl phenyldiazoacetate, an acceptor/donor diazo compound, as a carbenoid precusor.The ...


Design And Synthesis Of Beta-Hairpin Peptidomimetics For Modulating Integrin Mediated Cell Adhesion, Abeta Fibrillogenesis And P53-Mdm2 Protein-Protein Interactions, Priyesh Jain Dec 2010

Design And Synthesis Of Beta-Hairpin Peptidomimetics For Modulating Integrin Mediated Cell Adhesion, Abeta Fibrillogenesis And P53-Mdm2 Protein-Protein Interactions, Priyesh Jain

Graduate Theses and Dissertations

Inhibiting therapeutically important protein-protein interactions has been a tremendous challenge for medicinal chemists. The folded 3D structures of peptides and proteins, mainly comprise secondary structural elements i.e α-helices and β-sheet have created an opportunity to design small molecules and peptidomimetic inhibitors of protein-protein interaction (PPI). Hence, information about the formation and stabilization of these secondary structures is vital for designing future drugs. In this dissertation, several cyclic beta-hairpin peptidomimetics that mimic the recognition surface have been designed and synthesized as inhibitors for different targets such as integrin mediated extracellular matrix -cell adhesion in multiple myeloma, p53-MDM2 PPI, amyloid beta ...


Comparison Of Safety Performance By Design Types At Freeway Diverge Areas And Exit Ramp Sections, Hongyun Chen Dec 2010

Comparison Of Safety Performance By Design Types At Freeway Diverge Areas And Exit Ramp Sections, Hongyun Chen

Graduate Theses and Dissertations

The primary objective of the study is to evaluate the safety performance of different freeway exit types used in current practical designs. More specific, the research objectives include the following two parts: 1) to compare the safety performance of different design types at freeway diverge areas and exit ramp sections; and 2) to identify the impact factors contributing to the crashes happening at these two specific segments.

The study area includes four subjects, the freeway widely-spaced diverge areas; the freeway closely-spaced diverge areas; the left-side off-ramps and the exit ramp sections. For the freeway diverge areas, design types were defined ...


Down, But Not Out: An Ethnographic Study Of Women Who Struggled With And Overcame Methamphetamine Addiction, Jodi Nettleton Dec 2010

Down, But Not Out: An Ethnographic Study Of Women Who Struggled With And Overcame Methamphetamine Addiction, Jodi Nettleton

Graduate Theses and Dissertations

Women suffer methamphetamine (meth) addiction at a rate much higher than rates for addiction to other drugs. Female meth users are susceptible and predisposed to gender-related risks: high rates of unprotected vaginal and anal sex, sex-work, and sexual coercion. Precursors for addiction (e.g., abuse, body dysphasia) put females in a difficult position for recovery and highlight the need for gender-specific research and treatment.

Methamphetamine (a synthetically derived stimulant) creates psychological and physical dependency that affects every neuron of the brain and damages the body immediately. Women ingest meth for initial effects that allay social pressures: feeling euphoric, connecting with ...


Exploring Evaluation In School Districts: School District Evaluators And Their Practice, Susan Hibbard Dec 2010

Exploring Evaluation In School Districts: School District Evaluators And Their Practice, Susan Hibbard

Graduate Theses and Dissertations

This study explored the evaluation practices of internal evaluators in public school districts in a large southern state. The individuals who conduct evaluations in school districts as internal evaluators were identified and background information was collected. The education and training in evaluation was investigated and the types of evaluations typically conducted by those individuals. Respondents (n = 134) revealed conducting evaluations was a secondary role and part of their main job responsibilities. The types of evaluations carried out and the way in which evaluation was practices were revealed. A descriptive framework of the individuals who conduct evaluations in school districts and ...


Design And Fabrication Of A Membrane Integrated Microfluidic Cell Culture Device Suitable For High-Resolution Imaging, Alla Epshteyn Dec 2010

Design And Fabrication Of A Membrane Integrated Microfluidic Cell Culture Device Suitable For High-Resolution Imaging, Alla Epshteyn

Graduate Theses and Dissertations

Malaria remains a serious concern for people living and traveling to warm climates in Africa, Asia, and some parts of America. Understanding the mechanism of the malaria parasite in the liver phase could lead to important discoveries for preventative and treatment therapeutics before the disease develops into the blood stage. While in vitro liver cell culture models have been explored, a device that mimics the liver cell architecture with the capability of high-resolution imaging has never been created. In this research, a cell culture microfluidic device was designed and fabricated with a membrane integrated design to mimic the architecture of ...


Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey Dec 2010

Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey

Graduate Theses and Dissertations

Epithelial ovarian cancer (EOC) is a leading cause of morbidity and mortality among women in the United States, and the etiology is incompletely understood. Common, low penetrant genetic variants such as single nucleotide polymorphisms (SNPs) likely contribute to a significant proportion of EOC. We examined whether SNPs in two understudied yet biologically important types of genes, mitochondrial-related and miRNA-related genes, may contribute to EOC susceptibility using data from a large, homogeneous study population of 1,815 EOC cases and 1,900 controls (frequency-matched on age-group and race/ethnicity) genotyped through stage 1 of an ongoing genome-wide association study. Inter-individual variation ...


Epidemiological Study Of Contributing Factors In The Development Of Peptic Ulcer And Gastric Cancer Initiated By Helicobacter Pylori Infection In India, Rahul Suresh Mhaskar Dec 2010

Epidemiological Study Of Contributing Factors In The Development Of Peptic Ulcer And Gastric Cancer Initiated By Helicobacter Pylori Infection In India, Rahul Suresh Mhaskar

Graduate Theses and Dissertations

Background: Helicobacter pylori (H. pylori) infection is a significant risk factor for peptic ulcer (PU) and gastric cancer (GC). Apart from the virulent CagA genotype of H. pylori environmental and dietary factors influence disease outcomes. There have been no studies addressing these factors in Western India. Hence, we conducted a case control study enrolling PU, GC patients and controls at Pune, India.

Methods: Risk factors for PU and H. pylori infection were assessed in participant interview. H. pylori status was assessed from stool by monoclonal antigen detection. To understand treatment effect, we followed 100 H. pylori positive patients.

Results: We ...


A Framework For Determining The Reliability Of Nanoscale Metallic Oxide Semiconductor (Mos) Devices, Wilkistar Otieno Dec 2010

A Framework For Determining The Reliability Of Nanoscale Metallic Oxide Semiconductor (Mos) Devices, Wilkistar Otieno

Graduate Theses and Dissertations

An increase in worldwide investments during the past several decades has pro-pelled scienti c breakthroughs in nanoscience and technology research to new and exciting levels. To ensure that these discoveries lead to commercially viable prod-ucts, it is important to address some of the fundamental engineering and scientific challenges related to nanodevices. Due to the centrality of reliability to product integrity, nanoreliability requires critical analysis and understanding to ensure long-term sustainability of nanodevices and systems. In this study, we construct a relia-bility framework for nanoscale dielectric lms used in Metallic Oxide Semiconductor (MOS) devices. The successful fabrication and incorporation of metallic ...


Evaluation Of Oncology Nurses' Knowledge, Practice Behaviors, And Confidence Specific To Chemotherapy Induced Peripheral Neuropathy, Rebecca Denise Mcallister Dec 2010

Evaluation Of Oncology Nurses' Knowledge, Practice Behaviors, And Confidence Specific To Chemotherapy Induced Peripheral Neuropathy, Rebecca Denise Mcallister

Graduate Theses and Dissertations

Chemotherapy induced peripheral neuropathy (CIPN) remains one of the most serious and challenging symptoms oncology nurses encounter in caring for patients receiving neurotoxic chemotherapy. CIPN is under-addressed, under-reported, and symptoms are minimized by healthcare providers, which adversely affect patient quality of life, physical function, and emotional well-being. There is an absence of research examining nurses’ knowledge and practice behaviors related to CIPN. The purpose of this study was to explore oncology nurses knowledge, practice behaviors, confidence, and the relationship between education, experience, and knowledge specific to CIPN.

Data was collected at Oncology Nursing Society (ONS) Chapter meetings throughout central and ...


Dewey's Pragmatism And The Great Community, Philip Schuyler Bishop Dec 2010

Dewey's Pragmatism And The Great Community, Philip Schuyler Bishop

Graduate Theses and Dissertations

In investigating Dewey’s theory of the Great community, it is important to first examine closely Dewey’s theory of scientific inquiry and show how it evades the spectator theory of knowledge common to all modern epistemologies as closed systems. Dewey maintained that through controlled experimentalism we engage, and can solve, existential issues facing us for the purpose of expanding human freedom, promoting the democratic way of life and cultivating the institutions which foster these activities. The usage of inquiry to overcome problematic situations therefore stands as one of the first conditions needed to attain the great community.

Since Dewey ...


African American Athletes And The Negotiation Of Public Spaces: An Examination Of Athletic Capital And African American Perceptions Of Success, Keona Lewis Dec 2010

African American Athletes And The Negotiation Of Public Spaces: An Examination Of Athletic Capital And African American Perceptions Of Success, Keona Lewis

Graduate Theses and Dissertations

This dissertation explores the culture of sport among African American male football players as well as African American perspectives on sport and success. A case study of six African American, Division 1 FBS (Football Bowl Subdivision) collegiate student athletes was conducted along with seventeen supplemental interviews with community members, parents, coaches and former athletes and fans. The participants answered questions that explored education, success, identity construction, ethnicity and sport. Archival data was also reviewed framing the discussion on football in Florida, links between education and sport participation and African American male academic achievement. While many perspectives varied, there were collective ...


Florida's Adolescent Literacy Policy: An Alternative Reading And Response, Diane Kroeger Dec 2010

Florida's Adolescent Literacy Policy: An Alternative Reading And Response, Diane Kroeger

Graduate Theses and Dissertations

In this qualitative case study, I constructed interpretations of the meanings conveyed by state-level discourse communities as they were manifested in the primary and secondary speech genres of Florida’s adolescent literacy policy. Meanings (or values, beliefs and feelings) are highly tacit understandings embedded in the language, actions and objects of policy (Yanow, 2000), and are conveyed through informal and formal speech (Bakhtin, 1986). Results revealed (a) state policy meanings convey multiple versions of literacy with a heavy focus on receptive aspects of literate practice; (b) a typology of students and their fit within the institutional system; and (c) an ...


Advanced Signal Processing Techniques For Single Trial Electroencephalography Signal Classification For Brain Computer Interface Applications, Kun Li Dec 2010

Advanced Signal Processing Techniques For Single Trial Electroencephalography Signal Classification For Brain Computer Interface Applications, Kun Li

Graduate Theses and Dissertations

Brain Computer Interface (BCI) is a direct communication channel between brain and computer. It allows the users to control the environment without the need to control muscle activity [1-2]. P300-Speller is a well known and widely used BCI system that was developed by Farwell and Donchin in 1988 [3]. The accuracy level of the P300-BCI Speller as measured by the percent of communicated characters correctly identified by the system depends on the ability to detect the P300 event related potential (ERP) component among the ongoing electroencephalography (EEG) signal. Different techniques have been tested to reduce the number of trials needed ...


Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen Dec 2010

Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen

Graduate Theses and Dissertations

Altered DNA methylation may lead to suboptimal fetal programming, increasing the risk of adverse pregnancy outcomes such as small for gestational age (SGA); however, few studies have examined the associations between DNA methylation, prenatal exposures, and fetal outcomes. Cross-sectional data from a larger, ongoing study were used to assess the impact of prenatal smoking on gene specific methylation of umbilical cord blood derived DNA and to investigate the association between gene-specific methylation and risk of SGA. The association between gene-specific DNA methylation and birthweight was also assessed. Maternal and infant covariates were abstracted from medical records, cigarette smoke exposure was ...


Aspects Of The Life History Of The Snowy Grouper, Epinephelus Niveatus, In The Gulf Of Mexico, Kelley Kowal Dec 2010

Aspects Of The Life History Of The Snowy Grouper, Epinephelus Niveatus, In The Gulf Of Mexico, Kelley Kowal

Graduate Theses and Dissertations

Knowledge of many life history parameters are essential to properly assess and manage fish species. Although the snowy grouper, Epinephelus niveatus, is a commercially valuable fish, which is harvested throughout the Gulf of Mexico, little is known about its age, growth, and reproduction from this region. In this study, snowy grouper from the northern and eastern regions of the Gulf of Mexico were examined primarily using commercially-derived samples that were collected between 1984 and 2004. A total of 1,200 snowy grouper with fork lengths between 242 and 1,190 mm were collected. Sectioned saggital otoliths were used to determine ...


Discovery Of Novel Viruses From Animals, Plants, And Insect Vectors Using Viral Metagenomics, Terry Fei Fan Ng Dec 2010

Discovery Of Novel Viruses From Animals, Plants, And Insect Vectors Using Viral Metagenomics, Terry Fei Fan Ng

Graduate Theses and Dissertations

Understanding emerging viruses is critical for disease monitoring and prediction; however, surveys of novel viruses are hindered by the lack of a universal assay for viruses. Viral metagenomics, consisting of viral particle purification and shotgun sequencing, is a powerful technique for discovering viruses in a wide variety of sample types. However, current protocols are not effective on tissue samples (e.g., lungs, livers and tumors), where they are hindered by the high amount of host nucleic acids which limits the percentage of sequences that originate from viruses. In this dissertation, a modified viral metagenomics protocol was developed and utilized to ...


Antecedents And Consequences Of Channel Alienation: An Empirical Investigation Within Franchised Channels Of Distribution, Ivan Lapuka Dec 2010

Antecedents And Consequences Of Channel Alienation: An Empirical Investigation Within Franchised Channels Of Distribution, Ivan Lapuka

Graduate Theses and Dissertations

Investigating an important overlooked phase of interorganizational relationship evolution, which is currently hypothesized to progress through five stages of awareness, exploration, expansion, commitment, and dissolution, this dissertation proposes that in the long road between commitment and dissolution, the quintessential interfirm relationship is likely to be characterized by aprolonged period of relationship alienation, which then becomes the immediate precursor to the dissolution stage.

The dissertation utilizes social learning theory, behavior constraint theory, and alienation theory to explain apathetic behaviors of franchisees. The principal proposition is that certain characteristics of the franchise system’s operating environment inadvertently condition franchisee estrangement and failure ...


Continuous Electrowetting Actuation Utilizing Current Rectification Properties Of Valve Metal Films, Corey Lynch Dec 2010

Continuous Electrowetting Actuation Utilizing Current Rectification Properties Of Valve Metal Films, Corey Lynch

Graduate Theses and Dissertations

Electrowetting on dielectric (EWOD) is a technique for reducing the apparent contact angle of a fluid droplet, which has many promising applications in the fields of optics, digital displays, and lab-on-a-chip research. In this thesis, a design is presented for a novel single circuit device for achieving continuous droplet motion, by using the current-rectifying properties of valve metals to create diode-like behavior. This contrasts with existing designs, which require an array of individual electrodes to achieve motion in discrete steps. We are able to demonstrate continuous droplet motion across a 28mm-long test strip with an applied voltage of 303 V ...


Characterization Of The Role Of Nicotine And Delta 9-Thc In Modulation Of Neuroinflammation, Jared Ehrhart Dec 2010

Characterization Of The Role Of Nicotine And Delta 9-Thc In Modulation Of Neuroinflammation, Jared Ehrhart

Graduate Theses and Dissertations

Neuroinflammation is a major driving force in the progression of neurodegenerative disorders. Nicotinic acetylcholine receptors, as well as cannabinoid CB2 receptors, have been shown to have strong anti-inflammatory properties when activated. These effects are shown, in vivo, to be a result of stimulation of α7 nAChRs and CB2 cannabinoid receptors. Microglia cells, an immune cell in the brain, are shown to express both of these receptor subtypes. The studies detailed herein, investigated the ability of two compounds, nicotine and Δ9-THC, in modulation of inflammatory processes. Stimulation of these receptors on microglia using nicotine and Δ9-THC blocked the activation of these ...


A Multi-Level Study Investigating The Impact Of Workplace Civility Climate On Incivility And Employee Well-Being, Raymond Charles Ottinot Dec 2010

A Multi-Level Study Investigating The Impact Of Workplace Civility Climate On Incivility And Employee Well-Being, Raymond Charles Ottinot

Graduate Theses and Dissertations

This study used Zohar‟s (2000) multi-level model of climate to examine the extent to which shared perceptions of workplace civility climate relate to teacher job satisfaction, affective commitment, and counterproductive work behaviors (CWB-abuse) towards other teachers. Workplace civility climate is defined as employee perceptions of how management uses policies, procedures, and practices to maintain a civil workplace. An online-survey was used to assess a cross-sectional sample of K-12 teachers (N = 2222) nested in 207 schools in a large US school district. There was adequate agreement among teacher perceptions of school civility climate for aggregation and between-group variance of civility ...


"We Are The Revolutionaries": Visibility, Protest, And Racial Formation In 1970s Prison Radicalism, Dan Berger Dec 2010

"We Are The Revolutionaries": Visibility, Protest, And Racial Formation In 1970s Prison Radicalism, Dan Berger

Publicly Accessible Penn Dissertations

This dissertation analyzes black and Puerto Rican prison protest in the 1970s. I argue that prisoners elucidated a nationalist philosophy of racial formation that saw racism as a site of confinement but racial identity as a vehicle for emancipation. Trying to force the country to see its sites of punishment as discriminatory locations of repression, prisoners used spectacular confrontation to dramatize their conditions of confinement as epitomizing American inequality. I investigate this radicalism as an effort to secure visibility, understood here as a metric of collective consciousness. In documenting the ways prisoners were symbols and spokespeople of 1970s racial protest ...


1,2,3,4-Tetrahydroacridones As Potential Inhibitors Of Atovaquone-Resistant And Atovaquone- Susceptible P. Falciparum Isolates Tm90-C2b And W2, Lisa Luong Dec 2010

1,2,3,4-Tetrahydroacridones As Potential Inhibitors Of Atovaquone-Resistant And Atovaquone- Susceptible P. Falciparum Isolates Tm90-C2b And W2, Lisa Luong

Outstanding Honors Theses

Malaria is one of the most significant parasitic diseases affecting mankind today, exceeding 200 million annual cases worldwide1. This disease has been a serious issue due to developed resistance to commonly available antimalarial drugs including atovaquone and artemisinin2, the most relevant modern treatment (figure 1.1). This project focuses on the preparation of 1,2,3,4- tetrahydroacridones (figure 1.2) that can be tested for their activity against P. falciparum isolates TM90-C2B (an atovaquone-resistant parasitic strain) and W2 (an atovaquone-susceptible parasite). In the past, studies have shown that endochins (4(1H)-quinolones) 3 and acridines (figure 1.1) have ...


Planning To Make A Difference: A Retrospective Account On Learning How To Organize, Christina Gomez Dec 2010

Planning To Make A Difference: A Retrospective Account On Learning How To Organize, Christina Gomez

Outstanding Honors Theses

No abstract provided.


Robertson, J. Lee, B. 1922 (Fa 535), Manuscripts & Folklife Archives Dec 2010

Robertson, J. Lee, B. 1922 (Fa 535), Manuscripts & Folklife Archives

FA Finding Aids

Finding aid only for Folklife Archives Project 535. Interview with J. Lee Robertson conducted by Kenneth Hines and Gil Calhoun in Bowling Green, Kentucky. Robertson reminisces about the U.S. Army during World war II and his long association with Western Kentucky University.


Sullivan, Brendan J. (Fa 533), Manuscripts & Folklife Archives Dec 2010

Sullivan, Brendan J. (Fa 533), Manuscripts & Folklife Archives

FA Finding Aids

Finding aid and full text (click on "Additional Files" below) for Folklife Archives Project 533. Folklore material classified by genre. Information collected by Brendan J. Sullivan related to folklore genres for a folk studies class at Western Kentucky University.


Davis, Nathan William (Fa 534), Manuscripts & Folklife Archives Dec 2010

Davis, Nathan William (Fa 534), Manuscripts & Folklife Archives

FA Finding Aids

Finding aid only for Folklife Archives Project 534. Folklore material classified by genre. Information collected by Nathan William Davis related to folklore genres for a folk studies class at Western Kentucky University.


The Pragmatic Influences On Thou And Ye In Some Middle English Romances, Aislinn Meyer Dec 2010

The Pragmatic Influences On Thou And Ye In Some Middle English Romances, Aislinn Meyer

Outstanding Honors Theses

The standard explanation of the semantics of power and solidarity for second person Middle English pronoun choice, advanced by Roger Brown and Albert Gilman and accepted by many Middle English scholars since, has proven insufficient to explain many choices between thou and ye that fictional characters make. This paper applies the discourse theories of pragmatics and politeness, developed by Penelope Brown and Stephen C. Levinson, to the relatively untouched data set of non-Chaucerian romances in order to account for some of those anomalies. By examining the pronouns of address in Floris and Blancheflour, Havelok the Dane, Ywain and Gawain, Sir ...


Design, Synthesis And Sar Of A New Class Of Small Molecule Inhibitors Of Β-Secretase., Jordan M. Anderson Dec 2010

Design, Synthesis And Sar Of A New Class Of Small Molecule Inhibitors Of Β-Secretase., Jordan M. Anderson

Outstanding Honors Theses

β-Secretase is the enzyme responsible for the Amyloid-β plaques found in Alzheimer’s disease. Inhibition of this enzyme should prove to be very useful in combating Alzheimer’s disease by preventing this build-up. After a computational screening of the NCID-2 library a molecule was found to possess a 2- propanol structure with aromatic groups on either side. This moiety was replicated by a combinatorial library of 150 compounds. These compounds were screened initially against β-secretase at 100, 50, and then 25 μM to narrow down to 17 structures showing 50% inhibition at 25 μM. The IC50 for each of the ...


Shift To Cesareans As Preferred Birthing Method: Implications, Risks, And Recommendations, Elizabeth Angelica Bernstein Dec 2010

Shift To Cesareans As Preferred Birthing Method: Implications, Risks, And Recommendations, Elizabeth Angelica Bernstein

Outstanding Honors Theses

No abstract provided.