Digital Commons Network^™

Development Of A Lab-On-A-Chip Device For Rapid Nanotoxicity Assessment In Vitro, Pratikkumar Shah

FIU Electronic Theses and Dissertations

Increasing useof nanomaterials in consumer products and biomedical applications creates the possibilities of intentional/unintentional exposure to humans and the environment. Beyond the physiological limit, the nanomaterialexposure to humans can induce toxicity. It is difficult to define toxicity of nanoparticles on humans as it varies by nanomaterialcomposition, size, surface properties and the target organ/cell line. Traditional tests for nanomaterialtoxicity assessment are mostly based on bulk-colorimetric assays. In many studies, nanomaterials have found to interfere with assay-dye to produce false results and usually require several hours or days to collect results. Therefore, there is a clear need for alternative tools that can …

Experimental And Analytical Methodologies For Predicting Peak Loads On Building Envelopes And Roofing Systems, Maryam Asghari Mooneghi

FIU Electronic Theses and Dissertations

The performance of building envelopes and roofing systems significantly depends on accurate knowledge of wind loads and the response of envelope components under realistic wind conditions. Wind tunnel testing is a well-established practice to determine wind loads on structures. For small structures much larger model scales are needed than for large structures, to maintain modeling accuracy and minimize Reynolds number effects. In these circumstances the ability to obtain a large enough turbulence integral scale is usually compromised by the limited dimensions of the wind tunnel meaning that it is not possible to simulate the low frequency end of the turbulence …

A Practical Guideline For Intracranial Volume Estimation In Patients With Alzheimer’S Disease, Saman Sargolzaei, Arman Sargolzaei, Mercedes Cabrerizo, Gang Chen, Mohammed Goryawala, Shirin Noei, Qi Zhou, Ranjan Duara, Warren Barker, Malek Adjouadi

Electrical and Computer Engineering Faculty Publications

Background

Intracranial volume (ICV) is an important normalization measure used in morphometric analyses to correct for head size in studies of Alzheimer Disease (AD). Inaccurate ICV estimation could introduce bias in the outcome. The current study provides a decision aid in defining protocols for ICV estimation in patients with Alzheimer disease in terms of sampling frequencies that can be optimally used on the volumetric MRI data, and the type of software most suitable for use in estimating the ICV measure.

Methods

Two groups of 22 subjects are considered, including adult controls (AC) and patients with Alzheimer Disease (AD). Reference measurements …

A Probabilistic Approach For Pediatric Epilepsy Diagnosis Using Brain Functional Connectivity Networks, Saman Sargolzaei, Mercedes Cabrerizo, Arman Sargolzaei, Shirin Noei, Anas Salah Eddin, Hoda Rajaei, Alberto Pinzon-Ardila, Sergio M. Gonzalez-Arias, Prasanna Jayakar, Malek Adjouadi

Electrical and Computer Engineering Faculty Publications

Background

The lives of half a million children in the United States are severely affected due to the alterations in their functional and mental abilities which epilepsy causes. This study aims to introduce a novel decision support system for the diagnosis of pediatric epilepsy based on scalp EEG data in a clinical environment.

Methods

A new time varying approach for constructing functional connectivity networks (FCNs) of 18 subjects (7 subjects from pediatric control (PC) group and 11 subjects from pediatric epilepsy (PE) group) is implemented by moving a window with overlap to split the EEG signals into a total of …

Design And Development Of Geographical Information System (Gis) Map For Nuclear Waste Streams, Sandhya Appunni

FIU Electronic Theses and Dissertations

A nuclear waste stream is the complete flow of waste material from origin to treatment facility to final disposal. The objective of this study was to design and develop a Geographic Information Systems (GIS) module using Google Application Programming Interface (API) for better visualization of nuclear waste streams that will identify and display various nuclear waste stream parameters. A proper display of parameters would enable managers at Department of Energy waste sites to visualize information for proper planning of waste transport. The study also developed an algorithm using quadratic Bézier curve to make the map more understandable and usable. Microsoft …

An Investigation On Biocompatibility Of Bio-Absorbable Polymer Coated Magnesium Alloys, Sushma Amruthaluri

FIU Electronic Theses and Dissertations

Advances in biomaterials have enabled medical practitioners to replace diseased body parts or to assist in the healing process. In situations where a permanent biomaterial implant is used for a temporary application, additional surgeries are required to remove these implants once the healing process is complete, which increases medical costs and patient morbidity. Bio-absorbable materials dissolve and are metabolized by the body after the healing process is complete thereby negating additional surgeries for removal of implants.

Magnesium alloys as novel bio-absorbable biomaterials, have attracted great attention recently because of their good mechanical properties, biocompatibility and corrosion rate in physiological environments. …

Techniques For Efficient Execution Of Large-Scale Scientific Workflows In Distributed Environments, Selim Kalayci

FIU Electronic Theses and Dissertations

Scientific exploration demands heavy usage of computational resources for large-scale and deep analysis in many different fields. The complexity or the sheer scale of the computational studies can sometimes be encapsulated in the form of a workflow that is made up of numerous dependent components. Due to its decomposable and parallelizable nature, different components of a scientific workflow may be mapped over a distributed resource infrastructure to reduce time to results. However, the resource infrastructure may be heterogeneous, dynamic, and under diverse administrative control. Workflow management tools are utilized to help manage and deal with various aspects in the lifecycle …

Understanding Immigrants' Travel Behavior In Florida: Neighborhood Effects And Behavioral Assimilation, Nishat Zaman

FIU Electronic Theses and Dissertations

The goal of this study was to develop Multinomial Logit models for the mode choice behavior of immigrants, with key focuses on neighborhood effects and behavioral assimilation. The first aspect shows the relationship between social network ties and immigrants’ chosen mode of transportation, while the second aspect explores the gradual changes toward alternative mode usage with regard to immigrants’ migrating period in the United States (US). Mode choice models were developed for work, shopping, social, recreational, and other trip purposes to evaluate the impacts of various land use patterns, neighborhood typology, socioeconomic-demographic and immigrant related attributes on individuals’ travel behavior. …

Movement Effects On The Flow Physics And Nutrient Delivery In Engineered Valvular Tissues, Manuel Salinas

FIU Electronic Theses and Dissertations

Mechanical conditioning has been shown to promote tissue formation in a wide variety of tissue engineering efforts. However the underlying mechanisms by which external mechanical stimuli regulate cells and tissues are not known. This is particularly relevant in the area of heart valve tissue engineering (HVTE) owing to the intense hemodynamic environments that surround native valves. Some studies suggest that oscillatory shear stress (OSS) caused by steady flow and scaffold flexure play a critical role in engineered tissue formation derived from bone marrow derived stem cells (BMSCs). In addition, scaffold flexure may enhance nutrient (e.g. oxygen, glucose) transport. In this …

Neuromuscular Changes In Older Adults During The Lateral Step Task, Tatiana Bejarano

FIU Electronic Theses and Dissertations

Older adults may have trouble when performing activities of daily living due to decrease in physical strength and degradation of neuromotor and musculoskeletal function. Motor activation patterns during Lateral Step Down and Step Up from 4-inch and 8-inch step heights was assessed in younger (n=8, 24.4 years) and older adults (n=8, 58.9 years) using joint angle kinematics and electromyography of lower extremity muscles. Ground reaction forces were used to ascertain the loading, stabilization and unloading phases of the tasks. Older adults had an altered muscle activation sequence and significantly longer muscle bursts during loading for the tibialis anterior, gastrocnemius, vastus …

Aerodynamic Testing Of Variable Message Signs, Debbie Meyer

FIU Electronic Theses and Dissertations

The increasing nationwide interest in intelligent transportation systems (ITS) and the need for more efficient transportation have led to the expanding use of variable message sign (VMS) technology. VMS panels are substantially heavier than flat panel aluminum signs and have a larger depth (dimension parallel to the direction of traffic). The additional weight and depth can have a significant effect on the aerodynamic forces and inertial loads transmitted to the support structure. The wind induced drag forces and the response of VMS structures is not well understood. Minimum design requirements for VMS structures are contained in the American Association of …

Delay-Sensitive Service Request Scheduling For Cloud Computing, Shuo Liu

FIU Electronic Theses and Dissertations

Cloud computing realizes the long-held dream of converting computing capability into a type of utility. It has the potential to fundamentally change the landscape of the IT industry and our way of life. However, as cloud computing expanding substantially in both scale and scope, ensuring its sustainable growth is a critical problem. Service providers have long been suffering from high operational costs. Especially the costs associated with the skyrocketing power consumption of large data centers. In the meantime, while efficient power/energy utilization is indispensable for the sustainable growth of cloud computing, service providers must also satisfy a user's quality of …

Design Of A Small Modified Minkowski Fractal Antenna For Passive Deep Brain Stimulation Implants, Sara Manafi, Hai Deng

Electrical and Computer Engineering Faculty Publications

A small planar modified Minkowski fractal antenna is designed and simulated in dual frequency bands (2.4 and 5.8GHz) for wireless energy harvesting by deep brain stimulation (DBS) devices. The designed antenna, physically being confined inside a miniaturized structure, can efficiently convert the wireless signals in dual ISM frequency bands to the energy source to recharge the DBS battery or power the pulse generator directly. The performance metrics such as the return loss, the specific absorption rate (SAR), and the radiation pattern within skin and muscle-fat-skin tissues are evaluated for the designed antenna. The gain of the proposed antenna is 3.2 …

Optimization Of Cooling Protocols For Hearts Destined For Transplantation, Abas Abdoli

FIU Electronic Theses and Dissertations

Design and analysis of conceptually different cooling systems for the human heart preservation are numerically investigated. A heart cooling container with required connections was designed for a normal size human heart. A three-dimensional, high resolution human heart geometric model obtained from CT-angio data was used for simulations. Nine different cooling designs are introduced in this research. The first cooling design (Case 1) used a cooling gelatin only outside of the heart. In the second cooling design (Case 2), the internal parts of the heart were cooled via pumping a cooling liquid inside both the heart’s pulmonary and systemic circulation systems. …

Numerical Modeling Of The Effects Of Hydrologic Conditions And Sediment Transport On Geomorphic Patterns In Wetlands, Mehrnoosh Mahmoudi

FIU Electronic Theses and Dissertations

This dissertation focused on developing a numerical model of spatial and temporal changes in bed morphology of ridge and slough features in wetlands with respect to hydrology and sediment transport when a sudden change in hydrologic condition occurs. The specific objectives of this research were: (1) developing a two-dimensional hydrology model to simulate the spatial distribution of flow depth and velocity over time when a pulsed flow condition is applied, (2) developing a process-based numerical model of sediment transport coupled with flow depth and velocity in wetland ecosystems, and (3) use the developed model to explore how sediment transport may …

Assessment Of Policies For Innovative Financing In Infrastructure Systems, Ali Mostafavi, Dulcy Abraham, Charlene Sullivan

Infrastructure System-of-Systems (I-SoS ) Research Group

Infrastructure systems are drivers of the economy in the nation. A dollar spent on infrastructure development yields roughly double the initial spending in ultimate economic output in the short term; and over a twenty-year period, and generalized ‘public investment’ produces an aggregated $3.21 of economic activity per $1.00 spent [1]. Thus, formulation of policies pertaining to infrastructure investment and development is of significance affecting the social and economic wellbeing of the nation. The aim of this policy brief is to evaluate innovative financing in infrastructure systems from two different perspectives: (1) through consideration of the current condition of infrastructure in …

Development Of A Methodology That Couples Satellite Remote Sensing Measurements To Spatial-Temporal Distribution Of Soil Moisture In The Vadose Zone Of The Everglades National Park, Luis G. Perez

FIU Electronic Theses and Dissertations

Spatial-temporal distribution of soil moisture in the vadose zone is an important aspect of the hydrological cycle that plays a fundamental role in water resources management, including modeling of water flow and mass transport. The vadose zone is a critical transfer and storage compartment, which controls the partitioning of energy and mass linked to surface runoff, evapotranspiration and infiltration. This dissertation focuses on integrating hydraulic characterization methods with remote sensing technologies to estimate the soil moisture distribution by modeling the spatial coverage of soil moisture in the horizontal and vertical dimensions with high temporal resolution.

The methodology consists of using …

Modeling And Simulation Of Enzymatic Biofuel Cells With Three-Dimensional Microelectrodes, Yin Song, Varun Penmatsa, Chunlei Wang

Department of Mechanical and Materials Engineering

The enzymatic biofuel cells (EBFCs) are considered as an attractive candidate for powering future implantable medical devices. In this study, a computational model of EBFCs based on three-dimensional (3-D) interdigitated microelectrode arrays was conducted. The main focus of this research is to investigate the effect of different designs and spatial distributions of the microelectrode arrays on mass transport of fuels, enzymatic reaction rate, open circuit output potential and current density. To optimize the performance of the EBFCs, numerical simulations have been performed for cylindrical electrodes with various electrode heights and well widths. Optimized cell performance was obtained when the well …

Induced Effects Of Transcranial Magnetic Stimulation On The Autonomic Nervous System And The Cardiac Rhythm, Mercedes Cabrerizo, Anastasio Cabrera, Juan O. Perez, Jesus De La Rua, Niovi Rojas, Qi Zhou, Alberto Pinzon-Ardila, Sergio M. Gonzalez-Arias, Malek Adjouadi

Electrical and Computer Engineering Faculty Publications

Several standard protocols based on repetitive transcranial magnetic stimulation (rTMS) have been employed for treatment of a variety of neurological disorders.Despite their advantages in patients that are retractable to medication, there is a lack of knowledge about the effects of rTMSon the autonomic nervous systemthat controls the cardiovascular system.Current understanding suggests that the shape of the so-called QRS complex together with the size of the different segments and intervals between the PQRST deflections of the heart could predict the nature of the different arrhythmias and ailments affecting the heart. This preliminary study involving 10 normal subjects from 20 to 30 …

Immuno Nanoparticles Integrated Electrical Control Of Targeted Cancer Cell Development Using Whole Cell Bioelectronic Device, Evangelia Hondroulis, Rui Zhang, Chengxiao Zhang, Chunying Chen, Kosuke Ino, Tomokazu Matsue, Chen-Zhong Li

Department of Biomedical Engineering Faculty Publications

Electrical properties of cells determine most of the cellular functions, particularly ones which occur in the cell’s membrane. Manipulation of these electrical properties may provide a powerful electrotherapy option for the treatment of cancer as cancerous cells have been shown to be more electronegative than normal proliferating cells. Previously, we used an electrical impedance sensing system (EIS) to explore the responses of cancerous SKOV3 cells and normal HUVEC cells to low intensity (<2 V/cm) AC electric fields, determining that the optimal frequency for SKOV3 proliferation arrest was 200 kHz, without harming the non-cancerous HUVECs. In this study, to determine if these effects are cell type dependant, human breast adenocarcinoma cells (MCF7) were subjected to a range of frequencies (50 kHz–2 MHz) similar to the previously tested SKOV3. For the MCF7, an optimal frequency of 100 kHz was determined using the EIS, indicating a higher sensitivity towards the applied field. Further experiments specifically targeting the two types of cancer cells using HER2 antibody functionalized gold nanoparticles (HER2-AuNPs) were performed to determine if enhanced electric field strength can be induced via the application of nanoparticles, consequently leading to the killing of the cancerous cells without affecting non cancerous HUVECs and MCF10a providing a platform for the development of a non-invasive cancer treatment without any harmful side effects. The EIS was used to monitor the real-time consequences on cellular viability and a noticeable decrease in the growth profile of the MCF7 was observed with the application of the HER2-AuNPs and the electric fields indicating specific inhibitory effects on dividing cells in culture. To further understand the effects of the externally applied field to the cells, an Annexin V/EthD-III assay was performed to determine the cell death mechanism indicating apoptosis. The zeta potential of the SKOV3 and the MCF7 before and after incorporation of the HER2-AuNPs was also obtained indicating a decrease in zeta potential with the incorporation of the nanoparticles. The outcome of this research will improve our fundamental understanding of the behavior of cancer cells and define optimal parameters of electrotherapy for clinical and drug delivery applications.

A Low-Interaction Automatic 3d Liver Segmentation Method Using Computed Tomography For Selective Internal Radiation Therapy, Mohammed Goryawala, Seza Gulec, Ruchir Bhatt, Anthony J. Mcgoron, Malek Adjouadi

Electrical and Computer Engineering Faculty Publications

This study introduces a novel liver segmentation approach for estimating anatomic liver volumes towards selective internal radiation treatment (SIRT). The algorithm requires minimal human interaction since the initialization process to segment the entire liver in 3D relied on a single computed tomography (CT) slice.The algorithm integrates a localized contouring algorithm with a modified k-means method. The modified k-means segments each slice into five distinct regions belonging to different structures. The liver region is further segmented using localized contouring.The novelty of the algorithm is in the design of the initialization masks for region contouring to minimize human intervention. Intensity based region …

Development Of A Precast Concrete Supertile Roofing System For The Mitigation Of Extreme Wind Events, Brandon L. Mintz

FIU Electronic Theses and Dissertations

Residential roofs have traditionally formed the weakest part of the structure. The connections of roofs to the walls has lacked a clear load path with the result that the structure is weak at this point, leading to the compromise of the structure. Indeed roofs have multiple points of failure that lead to the weakness of the residential structure as a whole. Even if structural failure does not occur, compromise the roofing membrane can lead to high repair costs and property loss. The failure lies in the complex forming of the roof components as the roof aesthetics are placed to protect …

Using Sonic Enhancement To Augment Non-Visual Tabular Navigation, Jonathan M. Cofino, Armando Barreto

FIU Electronic Theses and Dissertations

More information is now readily available to computer users than at any time in human history; however, much of this information is often inaccessible to people with blindness or low-vision, for whom information must be presented non-visually. Currently, screen readers are able to verbalize on-screen text using text-to-speech (TTS) synthesis; however, much of this vocalization is inadequate for browsing the Internet. An auditory interface that incorporates auditory-spatial orientation was created and tested. For information that can be structured as a two-dimensional table, links can be semantically grouped as cells in a row within an auditory table, which provides a consistent …

Exchanging Ohmic Losses In Metamaterial Absorbers With Useful Optical Absorption For Photovoltaics, Ankit Vora, Jephias Gwamuri, Nezih Pala, Anand Kulkarni, Joshua M. Pearce, Durdu Ö. Güney

Electrical and Computer Engineering Faculty Publications

Using metamaterial absorbers, we have shown that metallic layers in the absorbers do not necessarily constitute undesired resistive heating problem for photovoltaics. Tailoring the geometric skin depth of metals and employing the natural bulk absorbance characteristics of the semiconductors in those absorbers can enable the exchange of undesired resistive losses with the useful optical absorbance in the active semiconductors. Thus, Ohmic loss dominated metamaterial absorbers can be converted into photovoltaic near-perfect absorbers with the advantage of harvesting the full potential of light management offered by the metamaterial absorbers. Based on experimental permittivity data for indium gallium nitride, we have shown …

Combined Economic And Emission Dispatch Incorporating Renewable Energy Sources And Plug-In Hybrid Electric Vehicles, Amin Gholami, Mahdi Jamei, Javad Ansari, Arif I. Sarwat

Electrical and Computer Engineering Faculty Publications

Conventional transportation and electricity industries are considered as two major sources of greenhouse gases (GHGs) emission. Improvement of vehicle’s operational efficiency can be a partial solution but it is necessary to employ Plug-In Hybrid Electric Vehicles (PHEVs) and Renewable Energy Sources (RESs) in the network to slow the increasing rate of the GHGs emission. However, it is crucial to investigate the effectiveness of each solution. In this paper, a combination of generation cost and GHGs emission of the two mentioned industries, as economic and environmental aspects of using PHEVs and RESs will be analyzed. The effectiveness of five different scenarios …

A Downsizing Strategy For Combinatorial Pmsg Based Wind Turbine And Micro-Smes System Applied In Standalone Dc Microgrid, Arif I. Sarwat, Amirhasan Moghadasiriseh

Electrical and Computer Engineering Faculty Publications

This paper presents a combinatorial standalone permanent magnet synchronous generator (PMSG) based variable speed wind turbine (VSWT) and small-size superconducting magnetic energy storage (SMES) system into the DC microgrid system. The principal purpose of SMES system is to preserve power balance by absorbing power during peak wind generation and to release it during low power generation. This work accomplished by describing the optimized design of the SMES solenoid coil, ensuring the desired energy storage capacity based on the simulated annealing (SA) algorithm. More importantly, the new control technique is developed for bi-directional DC-DC converter to level output power of the …

Optimal Reliability-Based Placement Of Plug-In Electric Vehicles In Smart Distribution Network, Mohammadhadi Amini, Arif I. Sarwat

Electrical and Computer Engineering Faculty Publications

Distributed renewable resources are one of the major technological inclinations that play a pivotal role in the future green power system. In this context, high penetration of Plug-In Electric Vehicles (PIEVs) may bring many challenges for the smart grid. PIEVs’ unscheduled utilization will cause technical issues for both generation side and demand side. High penetration of PIEVs may lead to reliability deterioration of smart distribution network. In this paper, firstly a PIEV owner behavior model is introduced. The output of this model is the hourly demand of PIEVs per day. Secondly, a comprehensive reliability-based objective function is proposed to allocate …

Lyophilized Kit For The Preparation Of The Pet Perfusion Agent [68ga]-Maa, Alejandro Amor-Coarasa, Andrew Milera, Denny Carvajal, Seza Gulec, Anthony J. Mcgoron

Department of Biomedical Engineering Faculty Publications

Rapid developments in the field of medical imaging have opened new avenues for the use of positron emitting labeled microparticles. The radioisotope used in our research was 68Ga, which is easy to obtain from a generator and has good nuclear properties for PET imaging. Methods. Commercially available macroaggregated albumin (MAA) microparticles were suspended in sterile saline, centrifuged to remove the free albumin and stannous chloride, relyophilized, and stored for later labeling with 68Ga. Labeling was performed at different temperatures and times. 68Ga purification settings were also tested and optimized. Labeling yield and purity of relyophilized MAA microparticles were compared with …

High Pressure And Low Temperature Study Of Ammonia Borane And Lithium Amidoborane, Shah Najiba

FIU Electronic Theses and Dissertations

Hydrogen has been considered as a potentially efficient and environmentally friendly alternative energy solution. However, one of the most important scientific and technical challenges that the “hydrogen economy” faces is the development of safe and economically viable on-board hydrogen storage for fuel cell applications, especially to the transportation sector. Ammonia borane (BH₃NH₃), a solid state hydrogen storage material, possesses exceptionally high hydrogen content (19.6 wt%).However, a fairly high temperature is required to release all the hydrogen atoms, along with the emission of toxic borazine. Recently research interests are focusing on the improvement of H₂ discharge …

Influence Of Chemical Composition And Water On The Bulk Modulus Of Pyrope, Shu Huang

FIU Electronic Theses and Dissertations

Garnets are major silicates from the upper mantle to the transition zone. Elastic properties of garnets are essential to interpret the variation of seismic velocities at different depths and construct a model of the Earth’s composition. Due to the chemical flexibility at octahedron sites of the crystal structures, garnets usually exist with multiple components and have many composition variations. Pyrope is an important member in the garnet group. Fe²⁺-Mg²⁺ substitution in pyrope is one of the common solid solutions. We have synthesized and measured three synthetic solid solutions samples (Py₈₃Alm₁₇, Py₅₄Alm …