Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Aberrant Igg Galactosylation Precedes Disease Onset, Correlates With Disease Activity, And Is Prevalent In Autoantibodies In Rheumatoid Arthritis, Altan Ercan, Jing Cui, Dereck E.W. Chatterton, Kevin D. Deane, Melissa M. Hazen, William Brintnell, Colin I. O'Donnell, Lezlie A. Derber, Michael E. Weinblatt, Nancy A. Shadick, David A. Bell, Ewa Cairns, Daniel H. Solomon, V. Michael Holers, Pauline M. Rudd, David M. Lee
Aberrant Igg Galactosylation Precedes Disease Onset, Correlates With Disease Activity, And Is Prevalent In Autoantibodies In Rheumatoid Arthritis, Altan Ercan, Jing Cui, Dereck E.W. Chatterton, Kevin D. Deane, Melissa M. Hazen, William Brintnell, Colin I. O'Donnell, Lezlie A. Derber, Michael E. Weinblatt, Nancy A. Shadick, David A. Bell, Ewa Cairns, Daniel H. Solomon, V. Michael Holers, Pauline M. Rudd, David M. Lee
Bone and Joint Institute
Objective. To examine the association between aberrant IgG galactosylation and disease parameters in rheumatoid arthritis (RA). Methods. Analysis of N-glycan in serum samples from multiple cohorts was performed. The IgG N-glycan content and the timing of N-glycan aberrancy relative to disease onset were compared in healthy subjects and in patients with RA. Correlations between aberrant galactosylation and disease activity were assessed in the RA cohorts. The impact of disease activity, sex, age, anticyclic citrullinated peptide (anti-CCP) antibody titer, disease duration, and C-reactive protein level on aberrant galactosylation was determined using multivariate analysis. The N-glycan content was also compared between epitope …
Hair Analysis Provides A Historical Record Of Cortisol Levels In Cushing's Syndrome, S. Thomson, G. Koren, L. A. Fraser, M. Rieder, T. C. Friedman, S. H.M. Van Uum
Hair Analysis Provides A Historical Record Of Cortisol Levels In Cushing's Syndrome, S. Thomson, G. Koren, L. A. Fraser, M. Rieder, T. C. Friedman, S. H.M. Van Uum
Paediatrics Publications
The severity of Cushing's Syndrome (CS) depends on the duration and extent of the exposure to excess glucocorticoids. Current measurements of cortisol in serum, saliva and urine reflect systemic cortisol levels at the time of sample collection, but cannot assess past cortisol levels. Hair cortisol levels may be increased in patients with CS, and, as hair grows about 1cm/month, measurement of hair cortisol may provide historical information on the development of hypercortisolism. We attempted to measure cortisol in hair in relation to clinical course in six female patients with CS and in 32 healthy volunteers in 1cm hair sections. Hair …