Digital Commons Network^™

Creating And Hosting Student-Run Research Journals: A Case Study, Adrian K. Ho

Western Libraries Publications

This case study aims to examine an academic library’s roles in facilitating the creation and hosting of open access student-run research journals. In addition to providing an online platform to host the journals, the library acquaints students with scholarly publishing, assists them in securing various resources available on campus, and offers support for content management. There are challenges and opportunities for the library as it undertakes the responsibility of hosting student journals. The article concludes with a discussion of possible topics for future research.

Specific Contributions Of Ventromedial, Anterior Cingulate, And Lateral Prefrontal Cortex For Attentional Selection And Stimulus Valuation., Daniel Kaping, Martin Vinck, R Matthew Hutchison, Stefan Everling, Thilo Womelsdorf

Brain and Mind Institute Researchers' Publications

Attentional control ensures that neuronal processes prioritize the most relevant stimulus in a given environment. Controlling which stimulus is attended thus originates from neurons encoding the relevance of stimuli, i.e. their expected value, in hand with neurons encoding contextual information about stimulus locations, features, and rules that guide the conditional allocation of attention. Here, we examined how these distinct processes are encoded and integrated in macaque prefrontal cortex (PFC) by mapping their functional topographies at the time of attentional stimulus selection. We find confined clusters of neurons in ventromedial PFC (vmPFC) that predominantly convey stimulus valuation information during attention shifts. …

Personality Dimensions And Temperaments Of Engineering Professors And Students – A Survey, Arif Raza, Zaka Ulmustafa, Luiz Fernando Capretz

Electrical and Computer Engineering Publications

This research work aims to study personality profiles and temperaments of Pakistani software engineering professors and students. In this survey we have collected personality profiles of 18 professors and 92 software engineering students. According to the Myers-Briggs Type Indicator (MBTI) instrument, the most prominent personality type among professors as well as among students is a combination of Introversion, Sensing, Thinking, and Judging (ISTJ). The study shows ITs (Introverts and Thinking) and IJs (Introverts and Judging) are the leading temperaments among the professors. About the students’ data, the results of the study indicate SJs (Sensing and Judging) and ISs (Introverts and …

Chronic Maternal Protein Deprivation In Mice Is Associated With Overexpression Of The Cohesin-Mediator Complex In Liver Of Their Offspring, Alfred Balasa, Amarilis Sanchez-Valle, Bekim Sadikovic, Haleh Sangi-Haghpeykar, Jaclyn Bravo, Liang Chen, Wei Liu, Shu Wen, Marta L. Fiorotto, Ignatia B. Van Den Veyver

Paediatrics Publications

Epigenetic mechanisms may play an important role in the developmental programming of adult-onset chronic metabolic diseases resulting from suboptimal fetal nutrition, but the exact molecular mechanisms are incompletely understood. Given the central role of the liver in metabolic regulation, we investigated whether chronic maternal dietary protein restriction has long-term effects on liver gene expression in the offspring. We fed adult C57BL/6J dams ad libitum an 8% maternal lowprotein (MLP) or 20% protein control diet (C) from 4 wk prior to mating until the end of lactation. Male pups were weaned to standard nonpurified diet and singly housed at 21 d …

Perceived Parental Attachment And Achievement Motivation, Mena Bal, Imants Barušs

Psychology

A significant amount of research in attachment theory has been devoted to factors affecting academic achievement, but less attention has been given to the role of attachment in the relation between academic achievement and achievement motivation. The current preliminary study examined the role of perceived parental attachment in achievement motivation. Self-report data obtained from the Parental Attachment Questionnaire, Achievement Goals Questionnaire, and the Performance Failure Appraisal Inventory were collected from 50 university students with a mean age of 18.8 yr. Correlation and regression analyses indicated that parental facilitation of independence correlated significantly and negatively with fear of failure. Results yielded …

Utilization Profile Of The Trauma Intensive Care Unit At The Role 3 Multinational Medical Unit At Kandahar Airfield Between May 1 And Oct. 15, 2009, Kalpa Shah, Steven Pririe, Lisa Compton, Vivian C. Mcalister O.C., Brian Church, Raymond Kao

Office of Military Academic Medicine

Background: In the war against the Taliban, Canada was the lead North Atlantic Treaty Organization (NATO) nation to provide medical and surgical care to NATO soldiers, Afghanistan National Army soldiers, Afghanistan Nation Police, civilians working in and outside Kandahar Airfield and Afghanistan civilians at the Role 3 Multinational Medical Unit (R3MMU) from February 2006 to October 2009.

Methods: We obtained data from the Joint Theatre Trauma Registry between May 1 and Oct. 15, 2009; 188 patients were admitted to the R3MMU intensive care unit (ICU). We analyzed the ICU data according to types and causes of trauma, mechanical ventilation prevalence, …

Academic Libraries Should Consider A Strategic Approach To Promotion And Marketing Of E-Books, Nazi Torabi

Western Libraries Publications

No abstract provided.

Inhibition Of Rho Kinase Regulates Specification Of Early Differentiation Events In P19 Embryonal Carcinoma Stem Cells, Roman J. Krawetz, Jaymi Taiani, Alexis Greene, Gregory M. Kelly, Derrick E. Rancourt

Paediatrics Publications

Background: The Rho kinase pathway plays a key role in many early cell/tissue determination events that take place in embryogenesis. Rho and its downstream effector Rho kinase (ROCK) play pivotal roles in cell migration, apoptosis (membrane blebbing), cell proliferation/cell cycle, cell-cell adhesion and gene regulation. We and others have previously demonstrated that inhibition of ROCK blocks endoderm differentiation in embryonal carcinoma stem cells, however, the effect of ROCK inhibition on mesoderm and ectoderm specification has not been fully examined. In this study, the role of ROCK within the specification and differentiation of all three germ layers was examined. Methodology/Principal Findings: …

From Seven Years To 360 Degrees: Primitive Accumulation, The Social Common, And The Contractual Lockdown Of Recording Artists At The Threshold Of Digitalization, Matt Stahl

FIMS Publications

This article examines the apparent paradox of the persistence of long-term employment contracts for cultural industry ‘talent’ in the context of broader trends toward short-term, flexible employment. While aspirants are numberless, bankable talent is in short supply. Long-term talent contracts appear to embody a durable axiom in employment: labor shortage favors employees. The article approaches this axiom through the lens of recent reconsiderations of the concept of primitive accumulation. In the case of employment, this concept highlights employers’ impetus to transcend legal and customary barriers to and limits on their capacity to capture and compel creative labor, and to appropriate …

Clinical And Genetic Determinants Of Warfarin Pharmacokinetics And Pharmacodynamics During Treatment Initiation, Inna Y. Gong, Ute I. Schwarz, Natalie Crown, George K. Dresser, Alejandro Lazo-Langner, Guang Yong Zou, Dan M. Roden, C. Michael Stein, Marc Rodger, Philip S. Wells, Richard B. Kim, Rommel G. Tirona

Paediatrics Publications

Variable warfarin response during treatment initiation poses a significant challenge to providing optimal anticoagulation therapy. We investigated the determinants of initial warfarin response in a cohort of 167 patients. During the first nine days of treatment with pharmacogenetics-guided dosing, S-warfarin plasma levels and international normalized ratio were obtained to serve as inputs to a pharmacokinetic-pharmacodynamic (PK-PD) model. Individual PK (S-warfarin clearance) and PD (I max) parameter values were estimated. Regression analysis demonstrated that CYP2C9 genotype, kidney function, and gender were independent determinants of S-warfarin clearance. The values for I max were dependent on VKORC1 and CYP4F2 genotypes, vitamin K status …

A Unique Role Of Gata1s In Down Syndrome Acute Megakaryocytic Leukemia Biology And Therapy, Ana C. Xavier, Holly Edwards, Alan A. Dombkowski, Tugce B. Balci, Jason N. Berman, Graham Dellaire, Chengzhi Xie, Steven A. Buck, Larry H. Matherly, Yubin Ge, Jeffrey W. Taub

Paediatrics Publications

Background: Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is uniformly associated with somatic GATA1 mutations, which result in the synthesis of a shorter protein (GATA1s) with altered transactivation activity compared to the wild-type GATA1. It is not fully established whether leukemogenesis and therapeutic responses in DS AMkL patients are due to loss of the wild-type GATA1 or due to a unique function of GATA1s. Methodology: Stable clones of CMK cells with decreased GATA1s or Bcl-2 levels were generated by using GATA1- or BCL-2-specific lentivirus shRNAs. In vitro ara-C, daunorubicin, and VP-16 cytotoxicities of the shRNA stable clones were …

Vitamin D Levels In Peanut Allergic Children, Adam Fowlie, Laura Kim, Trefford Simpson, Harold Kim

Department of Medicine Presentations

Background

The prevalence of peanut allergy is increasing. The reasons for this are not entirely known. A factor may be vitamin D (Vit D).

Methods

This study was performed in a referral allergist’s office in Ontario. Prospectively, all patients (<18 years old) with peanut allergy who were tested for peanut specific IgE (PN IgE) also had Vit D measured. All measurements were done between December 2010 and May 2011. The Vit D measure was 25-hydroxy vitamin D. Patients were divided into three groups: deficient (less than 25 nmol/L), insufficient (25-75 nmol/L) and sufficient (75-250 nmol/L). Vit D levels were compared to PN IgE, sex, age, body mass index (BMI) and other allergies.

Results

Fifty peanut allergic patients were included. The mean Vit D level of the patients was 73.8 nmol/L and the 95% confidence interval was 69.6 - 75.7 nmol/L. One patient (2%) had deficient and thirty-one (62%) of the patients had insufficient Vit D levels. Nineteen (38%) had Vit D levels in the sufficient range. There was no correlation between Vit …

New Zealand’S Bold Strategy For Reducing Health Disparities, N.A.

Aboriginal Policy Research Consortium International (APRCi)

No abstract provided.

Role And Expression Of Frs2 And Frs3 In Prostate Cancer, Tania Valencia, Ajay Joseph, Naveen Kachroo, Steve Darby, Susan Meakin, Vincent J. Gnanapragasam

Paediatrics Publications

Background: FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. Here we investigated FRS2 and FRS3 as a means of disrupting global FGF signalling in prostate cancer.Methods: FRS2 and FRS3 manipulation was investigated in vitro using over-expression, knockdown and functional assays. FRS2 and FRS3 expression was profiled in cell lines and clinical tumors of different grades.Results: In a panel of cell lines we observed ubiquitous FRS2 and FRS3 transcript and protein expression in both benign and malignant cells. We next tested functional redundancy of FRS2 and FRS3 in …

Paradoxical Reversal Learning Enhancement By Stress Or Prefrontal Cortical Damage: Rescue With Bdnf., Carolyn Graybeal, Michael Feyder, Emily Schulman, Lisa M Saksida, Timothy J Bussey, Jonathan L Brigman, Andrew Holmes

Brain and Mind Institute Researchers' Publications

Stress affects various forms of cognition. We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice task. Ventromedial prefrontal cortex (vmPFC) lesions mimicked the effect of stress, whereas orbitofrontal and dorsolateral striatal lesions impaired reversal. Stress facilitation of reversal was prevented by BDNF infusion into the vmPFC. These findings suggest a mechanism by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal) systems.

The Polylogarithm And The Lambert W Functions In Thermoelectrics, Muralikrishna Molli, Kamisetty Venkataramaniah, Sree Ram Valluri

Physics and Astronomy Publications

In this work, we determine the conditions for the extremum of the figure of merit, theta², in a degenerate semiconductor for thermoelectric (TE) applications. We study the variation of the function theta² with respect to the reduced chemical potential mu* using relations involving polylogarithms of both integral and nonintegral orders. We present the relevant equations for the thermopower, thermal, and electrical conductivities that result in optimizing theta² and obtaining the extremum equations. We discuss the different cases that arise for various values of r, which depends on the type of carrier scattering mechanism present in the …

Targeted Inhibition Of Calpain Reduces Myocardial Hypertrophy And Fibrosis In Mouse Models Of Type 1 Diabetes, Ying Li, Jian Ma, Huaqing Zhu, Manpreet Singh, David Hill, Peter A. Greer, J. Malcolm Arnold, E. Dale Abel

Paediatrics Publications

OBJECTIVE - Recently we have shown that calpain-1 activation contributes to cardiomyocyte apoptosis induced by hyperglycemia. This study was undertaken to investigate whether targeted disruption of calpain would reduce myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. RESEARCH DESIGN AND METHODS - Diabetes in mice was induced by injection of streptozotocin (STZ), and OVE26 mice were also used as a type 1 diabetic model. The function of calpain was genetically manipulated by cardiomyocyte-specific knockout Capn4 in mice and the use of calpastatin transgenic mice. Myocardial hypertrophy and fibrosis were investigated 2 and 5 months after STZ injection …

Conflict In The Statutory Elicitation Of Aboriginal Culture In Australia, James F. Weiner

Aboriginal Policy Research Consortium International (APRCi)

In order for Aboriginal rights and interests to be recognised under the Native Title Act (1993), such rights and interests must arise from laws and customs that can be shown to have continuity with the particular set of laws and customs that existed at the time of sovereignty, or, at least, at the time of first European contact. This interpretation of continuity has been applied in Australian native title cases since the High Court’s Yorta Yorta decision (Yorta Yorta v the State of Victoria [2002] HCA 58). Yet today’s Aboriginal native title claim groups are also required to participate in …

Empowering Indigenous Peoples’ Biocultural Diversity Through World Heritage Cultural Landscapes: A Case Study From The Australian Humid Tropical Forests, Rosemary Hill, Leanne C. Cullen-Unsworth, Leah D. Talbot, Susan Mcintyre-Tamwoy

Aboriginal Policy Research Consortium International (APRCi)

Australian humid tropical forests have been recognised as globally significant natural landscapes through world heritage listing since 1988. Aboriginal people have occupied these forests and shaped the biodiversity for at least 8000 years. The Wet Tropics Regional Agreement in 2005 committed governments and the region’s Rainforest Aboriginal peoples to work together for recognition of the Aboriginal cultural heritage associated with these forests. The resultant heritage nomination process empowered community efforts to reverse the loss of biocultural diversity. The conditions that enabled this empowerment included: Rainforest Aboriginal peoples’ governance of the process; their shaping of the heritage discourse to incorporate biocultural …

Type I Collagen Cleavage Is Essential For Effective Fibrotic Repair After Myocardial Infarction, Zengxuan Nong, Caroline O'Neil, Ming Lei, Robert Gros, Alanna Watson, Amin Rizkalla, Kibret Mequanint, Shaohua Li, Matthew J. Frontini, Qingping Feng, J. Geoffrey Pickering

Paediatrics Publications

Efficient deposition of type I collagen is fundamental to healing after myocardial infarction. Whether there is also a role for cleavage of type I collagen in infarct healing is unknown. To test this, we undertook coronary artery occlusion in mice with a targeted mutation (Col1a1 r/r) that yields collagenase-resistant type I collagen. Eleven days after infarction, Col1a1 r/r mice had a lower mean arterial pressure and peak left ventricular systolic pressure, reduced ventricular systolic function, and worse diastolic function, compared with wild-type littermates. Infarcted Col1a1 r/r mice also had greater 30-day mortality, larger left ventricular lumens, and thinner infarct walls. …

Culture Medium, Gas Atmosphere And Mapk Inhibition Affect Regulation Of Rna-Binding Protein Targets During Mouse Preimplantation Development., Michele D Calder, Patricia H Watson, Andrew J Watson

Obstetrics & Gynaecology Publications

During oogenesis, mammalian oocytes accumulate maternal mRNAs that support the embryo until embryonic genome activation. RNA-binding proteins (RBP) may regulate the stability and turnover of maternal and embryonic mRNAs. We hypothesised that varying embryo culture conditions, such as culture medium, oxygen tension and MAPK inhibition, affects regulation of RBPs and their targets during preimplantation development. STAU1, ELAVL1, KHSRP and ZFP36 proteins and mRNAs were detected throughout mouse preimplantation development, whereas Elavl2 mRNA decreased after the two-cell stage. Potential target mRNAs of RBP regulation, Gclc, Slc2a1 and Slc7a1 were detected during mouse preimplantation development. Gclc mRNA was significantly elevated in embryos …

Qu’Est-Ce Que L’Investissement Socialement Responsable?, Diane-Laure Arjaliès

Business Publications

Cet article étudie l’évolution des formes et des objectifs de l’Investissement socialement responsable (ISR) aux États-Unis et en Europe des années 1920 jusqu’à nos jours. En s’intéressant à la fois aux fondements théoriques et aux caractéristiques des fonds ISR au cours du temps, il dresse un panorama des différents types de fonds en fonction de leur appartenance à un référentiel sociétal ou économique. En montrant la complexité et la diversité de l’ISR d’hier et d’aujourd’hui, cet article permet de mieux appréhender les enjeux de définition et de légitimation rencontrés actuellement par les professionnels du secteur de la gestion d’actifs.

This …

Free Fatty Acids And Stroke From Atrial Fibrillation, J. Spence

Department of Medicine Publications

No abstract provided.

Master Transcription Factors Determine Cell-Type-Specific Responses To Tgf-Β Signaling, Alan C. Mullen, David A. Orlando, Jamie J. Newman, Jakob Lovén, Roshan M. Kumar, Steve Bilodeau, Jessica Reddy, Matthew G. Guenther, Rodney P. Dekoter, Richard A. Young

Paediatrics Publications

Transforming growth factor beta (TGF-β) signaling, mediated through the transcription factors Smad2 and Smad3 (Smad2/3), directs different responses in different cell types. Here we report that Smad3 co-occupies the genome with cell-type-specific master transcription factors. Thus, Smad3 occupies the genome with Oct4 in embryonic stem cells (ESCs), Myod1 in myotubes, and PU.1 in pro-B cells. We find that these master transcription factors are required for Smad3 occupancy and that TGF-β signaling largely affects the genes bound by the master transcription factors. Furthermore, we show that induction of Myod1 in nonmuscle cells is sufficient to redirect Smad3 to Myod1 sites. We …

Principles Of Sensorimotor Learning., Daniel M Wolpert, Jörn Diedrichsen, J Randall Flanagan

Brain and Mind Institute Researchers' Publications

The exploits of Martina Navratilova and Roger Federer represent the pinnacle of motor learning. However, when considering the range and complexity of the processes that are involved in motor learning, even the mere mortals among us exhibit abilities that are impressive. We exercise these abilities when taking up new activities - whether it is snowboarding or ballroom dancing - but also engage in substantial motor learning on a daily basis as we adapt to changes in our environment, manipulate new objects and refine existing skills. Here we review recent research in human motor learning with an emphasis on the computational …

A Study Of The Orbits Of The Logarithmic Potential For Galaxies, Sree Ram Valluri, Paul Wiegert, John Drozd, Matt Dasilva

Physics and Astronomy Publications

The logarithmic potential is of great interest and relevance in the study of the dynamics of galaxies. Some small corrections to the work of Contopoulos & Seimenis (1990) who used the method of Prendergast (1982) to find periodic orbits and bifurca- tions within such a potential are presented. The solution of the orbital radial equation for the purely radial logarithmic potential is then considered using the p-ellipse (pre- cessing ellipse) method pioneered by Struck (2006). This differential orbital equation is a special case of the generalized Burgers equation. The apsidal angle is also deter- mined, both numerically as well as …

Resolving The Gully Erosion Problem In Southeastern Nigeria: Innovation Through Public Awareness And Community-Based Approaches, Obidimma Ezezika, Olorunfemi Adetona

Health Studies Publications

The formation of gullies is one of the greatest environmental disasters in Southeastern Nigeria. Large areas of agricultural lands are lost or have become unsuitable for cultivation due to gully erosion. There have been numerous attempts to curb gully erosion in the region; especially through large-scale engineering projects, however, little has been discussed about ways to prevent their onset or the use of community-based low-technology approaches to mitigate their development. We reviewed pertinent literature, interviewed key stakeholders, observed gully erosion sites and had informal discussions with key experts in the field on the causes of gully erosion and community-based approaches …

Environmental Prediction In Canadian Cities, James Voogt

Geography & Environment Presentations

No abstract provided.

Suppression Of The Imprinted Gene Nnat And X-Chromosome Gene Activation In Isogenic Human Ips Cells, Jonathan H. Teichroeb, Dean H. Betts, Homayoun Vaziri

Paediatrics Publications

Genetic comparison between human embryonic stem cells and induced pluripotent stem cells has been hampered by genetic variation. To solve this problem, we have developed an isogenic system that allows direct comparison of induced pluripotent stem cells (hiPSCs) to their genetically matched human embryonic stem cells (hESCs). We show that hiPSCs have a highly similar transcriptome to hESCs. Global transcriptional profiling identified 102-154 genes (>2 fold) that showed a difference between isogenic hiPSCs and hESCs. A stringent analysis identified NNAT as a key imprinted gene that was dysregulated in hiPSCs. Furthermore, a disproportionate number of X-chromosome localized genes were …

Dompep-A General Method For Predicting Modular Domain-Mediated Protein-Protein Interactions, Lei Li, Bing Zhao, Jun Du, Kaizhong Zhang, Charles X. Ling, Shawn Shun Cheng Lishawn

Paediatrics Publications

Protein-protein interactions (PPIs) are frequently mediated by the binding of a modular domain in one protein to a short, linear peptide motif in its partner. The advent of proteomic methods such as peptide and protein arrays has led to the accumulation of a wealth of interaction data for modular interaction domains. Although several computational programs have been developed to predict modular domain-mediated PPI events, they are often restricted to a given domain type. We describe DomPep, a method that can potentially be used to predict PPIs mediated by any modular domains. DomPep combines proteomic data with sequence information to achieve …