Digital Commons Network^™

Total Synthesis Of (+/-)-Goniomitine Via A Formal Nitrile/Donor-Acceptor Cyclopropane [3 + 2] Cyclization., Christian L Morales, Brian L Pagenkopf

Chemistry Publications

The total synthesis of (+/-)-goniomitine has been accomplished in 17 linear steps with 5.2% overall yield starting from commercially available delta-valerolactam. A synthetic highlight includes the first application of a formal [3 + 2] cycloaddition between a highly functionalized nitrile and a donor-acceptor cyclopropane to prepare an indole nucleus. The use of a microwave reactor is shown to greatly improve the reaction times for two steps.

How On Earth Can We Live Together? In Search Of The Common Sense, N.A.

Aboriginal Policy Research Consortium International (APRCi)

Beginning on June 26, 2008 the Tällberg Forum will gather leaders and thinkers from seventy nations for four days of conversations and workshops related to the opportunities and chal- lenges of global interdependence. Tällberg conversations have increasingly focused on the sys- tems problems emerging from the growing imbalance between nature and human activity. Can we design, govern and manage the sustainable interaction between natural systems and the systems of human activity? Can we negotiate among ourselves the resolution of the planetary crisis? Can we find better ways to integrate the work of governments and institutions with the actions of other …

Aboriginal And Non—Aboriginal Australia: The Dilemma Of Apologies, Forgiveness, And Reconciliation, David Mellor, Di Bretherton, Lucy Firth

Aboriginal Policy Research Consortium International (APRCi)

This article presents a qualitative study of the indigenous Australian perspective on reconciliation with nonindigenous Australia, with a focus on the role of an apology for the oppression and violence perpetrated by nonindigenous Australians, and for- giveness on the part of indigenous Australians. A brief historical analysis of the rela- tionship between Aborigines and waves of settlers is presented to demonstrate the ex- tent of the wrong that was perpetrated against Aborigines and the need for social as well as practical reconciliation in the current context. It is argued that negotiated for- giveness is a concept that is pertinent to …

What Makes For Effective Labor Representation On Pension Boards?, Johanna Weststar, Anil Verma

Management and Organizational Studies Publications

This article examines the efficacy of labor representation on pension boards. Using existing literature and interviews with labor trustees, this article develops a model where a more formal approach to recruitment and selection, skill acquisition, and accountability is hypothesized to aid labor trustees in achieving effective integration and representation on pension boards. Data indicate that labor trustees are placed in a challenging environment with insufficient support from their union, other trustees, or the board. These findings have important implications for the selection, training, and integration of labor trustees and the success of a labor agenda on pension issues.

The Stem Cell Debate Continues: The Buying And Selling Of Eggs For Research, Françoise Baylis, Carolyn Mcleod

Philosophy Publications

Now that stem cell scientists are clamouring for human eggs for cloning-based stem cell research, there is vigorous debate about the ethics of paying women for their eggs. Generally speaking, some claim that women should be paid a fair wage for their reproductive labour or tissues, while others argue against the further commodification of reproductive labour or tissues and worry about voluntariness among potential egg providers. Siding mainly with those who believe that women should be financially compensated for providing eggs for research, the new stem cell guidelines of the International Society for Stem Cell Research (ISSCR) legitimise both reimbursement …

Adaptive Radiotherapy Planning On Decreasing Gross Tumor Volumes As Seen On Megavoltage Computed Tomography Images., Curtis Woodford, Slav Yartsev, R. Dar, Glenn Bauman, Jacob Van Dyk

Oncology Publications

PURPOSE: To evaluate gross tumor volume (GTV) changes for patients with non-small-cell lung cancer by using daily megavoltage (MV) computed tomography (CT) studies acquired before each treatment fraction on helical tomotherapy and to relate the potential benefit of adaptive image-guided radiotherapy to changes in GTV.

METHODS AND MATERIALS: Seventeen patients were prescribed 30 fractions of radiotherapy on helical tomotherapy for non-small-cell lung cancer at London Regional Cancer Program from Dec 2005 to March 2007. The GTV was contoured on the daily MVCT studies of each patient. Adapted plans were created using merged MVCT-kilovoltage CT image sets to investigate the advantages …

The Roulette Wheel Is Spinning On A U.S.-Iran War, Erika Simpson

Political Science Publications

No abstract provided.

Assessment Of Human Trabecular Architecture In The Pubis By Three Radiographic Modalities, Andrew D. Wade, Andrew J. Nelson, Gregory J. Garvin, David W. Holdsworth

Anthropology Presentations

This poster discusses technical aspects of an investigation into the use of non-destructive radiological analyses of pubic cancellous bone structure to estimate age-at-death from human skeletal remains. This study stems from findings, in X-ray plain films, of increased rarification and orientation of trabeculae with age [1]; likely in concert with the macroscopic remodelling of the symphyseal surface currently used in estimation of age-at-death.

The study uses three non-destructive X-ray imaging modalities: plain film radiography, computed tomography (CT), and micro-CT (μCT). Plain film radiography has greater spatial resolution than CT [2] and is relatively inexpensive, widely available, and, with portable X-ray …

Donating Fresh Versus Frozen Embryos To Stem Cell Research: In Whose Interests?, Carolyn Mcleod, Françoise Baylis

Philosophy Publications

Some stem cell researchers believe that it is easier to derive human embryonic stem cells from fresh rather than frozen embryos and they have had in vitro fertilization (IVF) clinicians invite their infertility patients to donate their fresh embryos for research use. These embryos include those that are deemed 'suitable for transfer' (i.e. to the woman's uterus) and those deemed unsuitable in this regard. This paper focuses on fresh embryos deemed suitable for transfer - hereafter 'fresh embryos'- which IVF patients have good reason not to donate. We explain why donating them to research is not in the self-interests specifically …

Scholars Portal: The Canadian Experience, Karen Marshall

Western Libraries Presentations

This is a presentation about the Scholars Portal, which is a suite of shared information resources and services centrally managed by a consortium of 20 university libraries in Ontario, Canada (OCUL).

Disorganized Attachment In Adolescent Mother-Infant Dyads: Its Nature, Origins, And Developmental Consequences, Greg Moran, David Pederson

Psychology Presentations

No abstract provided.

Blasted’S Hysteria: Rape, Realism, And The Thresholds Of The Visible, Kim Solga

Department of English Publications

A curious blind spot remains in the critical response to Sarah Kane’s Blasted : the rape of Cate by Ian. In a play famous for its onstage violence, why is this rape, one of its pivotal moments of brutality, left unstaged? My article seeks to worry this lacuna by exploring the theoretical and historical dimensions of the ‘‘missing’’ in Kane’s play. I argue that Kane’s representation of Cate’s rape as missing signals both her engagement with the history of rape’s representation – an elusive, evasive history rather than an outrageous, in-yer-face one – as well as a deft understanding of …

Human Parietal "Reach Region" Primarily Encodes Intrinsic Visual Direction, Not Extrinsic Movement Direction, In A Visual Motor Dissociation Task., Juan Fernandez-Ruiz, Herbert C Goltz, Joseph F X Desouza, Tutis Vilis, J Douglas Crawford

Brain and Mind Institute Researchers' Publications

Posterior parietal cortex (PPC) participates in the planning of visuospatial behaviors, including reach movements, in gaze-centered coordinates. It is not known if these representations encode the visual goal in retinal coordinates, or the movement direction relative to gaze. Here, by dissociating the intrinsic retinal stimulus from the extrinsic direction of movement, we show that PPC employs a visual code. Using delayed pointing and event-related functional magnetic resonance imaging, we identified a cluster of PPC regions whose activity was topographically (contralaterally) related to the direction of the planned movement. We then switched the normal visual-motor spatial relationship by adapting subjects to …

Presenting Libqual+ Results For Action, Margaret Martin Gardiner

Western Libraries Presentations

This is a presentation about how Western Libraries at the University of Western Ontario used LibQUAL+ results to achieve action expected by users.

Reduction Of Esters To Ethers Utilizing The Powerful Lewis Acid Bf2otf·Oet2, Brian Pagenkopf, Nicholas A. Morra

Chemistry Publications

No abstract provided.

Assessment In Crisis, Amresh Srivastava

Psychiatry Presentations

No abstract provided.

First Total Synthesis And Structural Reassignment Of (-)-Aplysiallene., Jian Wang, Brian L Pagenkopf

Chemistry Publications

The first total synthesis of (-)-aplysiallene has been completed in 16 steps and features a key sequential Mukaiyama aerobic oxidative cyclization to prepare the fused bis-THF core. The original stereochemical assignment has been revised as shown.

C-2/C-3 Annulation And C-2 Alkylation Of Indoles With 2-Alkoxycyclopropanoate Esters., Barbora Bajtos, Ming Yu, Hongda Zhao, Brian L Pagenkopf

Chemistry Publications

The annulation reaction between various indoles and 2-alkoxycyclopropanoate esters is reported. Both high efficiency and complete stereochemical control were observed in some cases with this annulation process. A single stereocenter on the cyclopropane controls the diastereoselective formation of up to four new stereocenters. A different reaction course was observed with 3-substituted indole substrates, and an intervening C-3 to C-2-migration process arose that gives synthetically useful C-2 alkylation indole products.

Posttraumatic Stress Disorder And Associated Risk Factors In Canadian Peacekeeping Veterans With Health-Related Disabilities, Don Richardson, James A. Naifeh, Jon D Elhai

MacDonald Franklin OSI Research Centre

Objectives:

This study investigates posttraumatic stress disorder (PTSD) and its associated risk factors in a random, national, Canadian sample of United Nations peacekeeping veterans with service-related disabilities.

Methods:

Participants included 1016 male veterans (age < 65 years) who served in the Canadian Forces from 1990 to 1999 and were selected from a larger random sample of 1968 veterans who voluntarily and anonymously completed a general health survey conducted by Veterans Affairs Canada in 1999. Survey instruments included the PTSD Checklist-Military Version (PCL-M), Center for Epidemiological Studies-Depression Scale (CES-D), and questionnaires regarding life events during the past year, current stressors, sociodemographic characteristics, and military history.

Results:

We found that rates of probable PTSD (PCL-M score > 50) among veterans were 10.92% for veterans deployed once and 14.84% for those deployed more than once. The rates of probable clinical depression (CES-D score > 16) were 30.35% for veterans deployed once and 32.62% for those deployed more than once. We found that, in multivariate analyses, probable PTSD rates and PTSD severity were associated with younger …

Sustainable Antenatal Care Services In An Urban Indigenous Community: The Townsville Experience, Kathryn S. Panaretto, Melvina R. Mitchell, Lynette Anderson, Sarah L. Larkins, Vivienne Manessis, Petra G. Buettner, David Watson

Aboriginal Policy Research Consortium International (APRCi)

Objective: To evaluate the impact of a sustained, community-based collaborative approach to antenatal care services for Indigenous women.

Design: Prospective quality improvement intervention, the Mums and Babies program, in a cohort of women attending Townsville Aboriginal and Islanders Health Service, 1 January 2000 – 31 December 2005 (MB group), compared with a historical control group (PreMB group), 1 January 1998 – 30 June 1999.

Main outcome measures: Proportion of women having inadequate antenatal care and

screening; perinatal indicators. Results: Thenumberofantenatalvisitsperpregnancyincreasedfromthree

(interquartilerange[IQR],twotosix)inthePreMBgrouptosix(IQR,fourtoten)inthe MB group (P < 0.001). There were significant improvements in care planning, completion of cycle-of-care, and antenatal education activities throughout the study period. About 90% of all women attending for antenatal care were screened for sexually transmitted diseases, 89% had measurement of haemoglobin level, and serological tests for hepatitis B and syphilis (minimum antenatal screening). There was increased attendance for dating and morphology scans. In the MB group compared with the PreMB group, there was a significant reduction in perinatal mortality (14 v 60 per 1000 births; P=0.014). Conclusion: Sustained access to a community-based, integrated, shared antenatal service has improved perinatal outcomes among Indigenous women in Townsville.

Pp2cdelta (Ppm1d, Wip1), An Endogenous Inhibitor Of P38 Mapk, Is Regulated Along With Trp53 And Cdkn2a Following P38 Mapk Inhibition During Mouse Preimplantation Development., Jenny A Hickson, Barry Fong, Patricia H Watson, Andrew J Watson

Obstetrics & Gynaecology Publications

Preimplantation embryos utilize mitogen-activated protein kinase signaling (MAPK) pathways to relay signals from the external environment to prepare appropriate responses and adaptations to a changing milieu. It is therefore important to investigate how MAPK pathways are regulated during preimplantation development. This study was conducted to investigate whether PP2Cdelta (Ppm1d, WIP1) is expressed during mouse preimplantation development and to determine the influences of p38 MAPK inhibition on expression of Trp53 (p53), Ppm1d, (WIP1), and Cdkn2a (p16) during mouse preimplantation development. Our results indicate that Trp53, Ppm1d, and Cdkn2a mRNAs and TRP53 and PP2Cdelta proteins are expressed throughout mouse preimplantation development. Treatment …

Spontaneous Low-Frequency Fluctuations In The Bold Signal In Schizophrenic Patients: Anomalies In The Default Network, Robyn L Bluhm, Jodi Miller, Ruth A Lanius, Elizabeth A Osuch, Kristine Boksman, R W J Neufeld, Jean Theberge, Betsy Schaefer, Peter Williamson

Department of Medicine Publications

Spontaneous low-frequency fluctuations in the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (MRI) signal have been shown to reflect neural synchrony between brain regions. A "default network" of spontaneous low-frequency fluctuations has been described in healthy volunteers during stimulus-independent thought. Negatively correlated with this network are regions activated during attention-demanding tasks. Both these networks involve brain regions and functions that have been linked with schizophrenia in previous research. The present study examined spontaneous slow fluctuations in the BOLD signal at rest, as measured by correlation with low-frequency oscillations in the posterior cingulate, in 17 schizophrenic patients, and 17 comparable …

Early Psychosis: A Bridge To Future, Amresh Srivastava

Psychiatry Presentations

No abstract provided.

What Shapes Inner-City Education Policy?, Ben Levin, Jane Gaskell, Katina E. Pollock

Education Publications

This paper is part of a larger study looking at the issues involved as two large urban Canadian school boards, in Winnipeg and Toronto, responded to the demands of poor, inner city areas over the last thirty years of the twentieth century. In this paper we focus our attention on the broader stage on which education policy takes place. We draw from our data three overarching themes that we believe are critical for understanding change in inner-city education over this period. These are: 1) The diminishing role of school boards, as provincial governments took more control of education policy and …

Agent Design Of Smart License Management System Using Gaia Methodology, Qian Zhao, Yu Zhou, Mark Perry

Computer Science Publications

Modern software services and data centers require a license management system to regulate the agreements that have been reached between subscriber and provider. License management helps to track usage and protect service from abuse. License agreements provide the basis for enforcement and regulation. The automation of license agreements is desired by providers and subscribers to improve transaction efficiency, give flexibility, and minimize unwanted cost.

We have proposed a framework, called SmArt (Semantic Agreement) system, that enables agreement automation in the autonomic computing context using ontology and agent technologies. This paper applies the SmArt system to the domain of license management …

An Indigenous Perspective On National Parks And SáMi Reindeer Management In Norway, Jan ÅGe Riseth

Aboriginal Policy Research Consortium International (APRCi)

Protection of nature for biodiversity, and for the material livelihoods of Indigenous peoples, have much in common. Indigenous relations to nature are, however, based on unity between use and protection, implying that human use is necessary for effective protection. Often protected areas include the homelands of Indigen- ous peoples, whose needs and rights are still being ignored to a large extent. This paper explores the effects of a plan for a significant increase of large nature protection areas in Norway, still under implementation. Most of the new protec- tion areas are in the heartland of the Indigenous Sámi, whose core …

Can You Hear Us Now? Voices From The Margin: Using Indigenous Methodologies In Geographic Research, Renee Pualani Louis

Aboriginal Policy Research Consortium International (APRCi)

Indigenous methodologies are an alternative way of thinking about research processes. Although these methodologies vary according to the ways in which different Indigenous communities express their own unique knowledge systems, they do have common traits. This article argues that research on Indigenous issues should be carried out in a manner which is respectful and ethically sound from an Indigenous perspective. This naturally challenges Western research paradigms, yet it also affords opportunities to contribute to the body of knowledge about Indigenous peoples. It is further argued that providing a mechanism for Indigenous peoples to participate in and direct these research agendas …

Alcohol Slows Interhemispheric Transmission, Increases The Flash-Lag Effect, And Prolongs Masking: Evidence For A Slowing Of Neural Processing And Transmission., Sarah A Khan, Brian Timney

Brain and Mind Institute Researchers' Publications

While the alcohol literature is extensive, relatively little addresses the relationship between physiological effects and behavioural changes. Using the visual system as a model, we examined alcohol's influence on neural temporal processing as a potential means for alcohol's effects. We did this by using tasks that provided a measure of processing speed: Poffenberger paradigm, flash-lag, and backward masking. After moderate alcohol, participants showed longer interhemispheric transmission times, larger flash-lags, and prolonged masking. Our data are consistent with the view that alcohol slows neural processing, and provide support for a reduction in processing efficiency underlying alcohol-induced changes in temporal visual processing.

Content Recruitment For Institutional Repositories (Ir’S), Adrian K. Ho, Joe Toth

Western Libraries Publications

No abstract provided.

Copyright: Robertson V Thomson, Margaret Ann Wilkinson

Law Presentations

Members of the CLA Copyright Working Group will provide an update on both the Robertson vs. Thomson Corporation Supreme Court Judgment and the expected copyright legislation, as well as their implications for libraries of all kinds. In addition to analyzing the implications of both the recent Supreme Court Judgment and the proposed copyright legislation, time will be provided to answer copyright questions from the audience.