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Articles 1 - 30 of 155
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Psychometric Properties Of The Farsi Version Of The Eating Pathology Symptoms Inventory (F-Epsi) Among Iranian University Men And Women, Reza N. Sahlan, Kerstin K. Blomquist, Lindsay P. Bodell
Psychometric Properties Of The Farsi Version Of The Eating Pathology Symptoms Inventory (F-Epsi) Among Iranian University Men And Women, Reza N. Sahlan, Kerstin K. Blomquist, Lindsay P. Bodell
Neuroscience Institute Publications
Background: Limited research has validated eating pathology assessments in Iranian men and women. The purpose of the current study was to translate and validate a Farsi version of the Eating Pathology Symptoms Inventory (F-EPSI) in Iranian university students. Methods: Men (n = 279) and women (n = 486) completed questionnaires including the F-EPSI. Results: Confirmatory factor analysis (CFA) indicated that the F-EPSI had an acceptable fit to the data and supported the eight-factor model. The scale was partially invariant across genders. Men reported higher scores on Excessive Exercise and Muscle Building subscales, and women reported higher scores on Body Dissatisfaction …
Microstructural Imaging And Transcriptomics Of The Basal Forebrain In First-Episode Psychosis, Min Tae M. Park, Peter Jeon, Leon French, Kara Dempster, M. Mallar Chakravarty, Michael Mackinley, Julie Richard, Ali R. Khan, Jean Théberge, Lena Palaniyappan
Microstructural Imaging And Transcriptomics Of The Basal Forebrain In First-Episode Psychosis, Min Tae M. Park, Peter Jeon, Leon French, Kara Dempster, M. Mallar Chakravarty, Michael Mackinley, Julie Richard, Ali R. Khan, Jean Théberge, Lena Palaniyappan
Neuroscience Institute Publications
Cholinergic dysfunction has been implicated in the pathophysiology of psychosis and psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The basal forebrain (BF) cholinergic nuclei, defined as cholinergic cell groups Ch1-3 and Ch4 (Nucleus Basalis of Meynert; NBM), provide extensive cholinergic projections to the rest of the brain. Here, we examined microstructural neuroimaging measures of the cholinergic nuclei in patients with untreated psychosis (~31 weeks of psychosis, <2 defined daily dose of antipsychotics) and used magnetic resonance spectroscopy (MRS) and transcriptomic data to support our findings. We used a cytoarchitectonic atlas of the BF to map the nuclei and obtained measures of myelin (quantitative T1, or qT1 as myelin surrogate) and microstructure (axial diffusion; AxD). In a clinical sample (n = 85; 29 healthy controls, 56 first-episode psychosis), we found significant correlations between qT1 of Ch1-3, left NBM and MRS-based dorsal anterior cingulate choline in healthy controls while this relationship was disrupted in FEP (p > 0.05). Case-control differences in qT1 and AxD were observed in the Ch1-3, with increased qT1 (reflecting reduced myelin content) and AxD (reflecting reduced axonal integrity). We found clinical correlates between left NBM …
Dynamic Targeting Enables Domain-General Inhibitory Control Over Action And Thought By The Prefrontal Cortex, Dace Apšvalka, Catarina S. Ferreira, Taylor W. Schmitz, James B. Rowe, Michael C. Anderson
Dynamic Targeting Enables Domain-General Inhibitory Control Over Action And Thought By The Prefrontal Cortex, Dace Apšvalka, Catarina S. Ferreira, Taylor W. Schmitz, James B. Rowe, Michael C. Anderson
Neuroscience Institute Publications
Over the last two decades, inhibitory control has featured prominently in accounts of how humans and other organisms regulate their behaviour and thought. Previous work on how the brain stops actions and thoughts, however, has emphasised distinct prefrontal regions supporting these functions, suggesting domain-specific mechanisms. Here we show that stopping actions and thoughts recruits common regions in the right dorsolateral and ventrolateral prefrontal cortex to suppress diverse content, via dynamic targeting. Within each region, classifiers trained to distinguish action-stopping from action-execution also identify when people are suppressing their thoughts (and vice versa). Effective connectivity analysis reveals that both prefrontal regions …
Bilateral Sequential Theta Burst Stimulation In Depressed Veterans With Service Related Posttraumatic Stress Disorder: A Feasibility Study, Thelepa Vaithianathan, Mervin Blair, Vanessa Soares, Yuri E. Rybak, Lena Palaniyappan, J. Don Richardson, Amer M. Burhan
Bilateral Sequential Theta Burst Stimulation In Depressed Veterans With Service Related Posttraumatic Stress Disorder: A Feasibility Study, Thelepa Vaithianathan, Mervin Blair, Vanessa Soares, Yuri E. Rybak, Lena Palaniyappan, J. Don Richardson, Amer M. Burhan
Neuroscience Institute Publications
Background: Depression comorbid with posttraumatic stress disorder (PTSD) can be disabling and treatment resistant. Preliminary evidence suggests that repetitive transcranial magnetic stimulation (rTMS), may have a role in helping these patients. There are only few published studies using different rTMS paradigms including bilateral intermittent theta burst (iTBS) and low frequency rTMS. Methods: In this small cohort observation study, we examined the efficacy of bilateral sequential theta-burst stimulation (bsTBS) in 8 treatment resistant depression (TRD) military veterans with PTSD comorbidity stemming from military service experience. Results: bsTBS was generally well tolerated and resulted in 25% and 38% remission and response rates …
Progressive Changes In Descriptive Discourse In First Episode Schizophrenia: A Longitudinal Computational Semantics Study, Maria Francisca Alonso-Sánchez, Sabrina D. Ford, Michael Mackinley, Angélica Silva, Roberto Limongi, Lena Palaniyappan
Progressive Changes In Descriptive Discourse In First Episode Schizophrenia: A Longitudinal Computational Semantics Study, Maria Francisca Alonso-Sánchez, Sabrina D. Ford, Michael Mackinley, Angélica Silva, Roberto Limongi, Lena Palaniyappan
Neuroscience Institute Publications
Computational semantics, a branch of computational linguistics, involves automated meaning analysis that relies on how words occur together in natural language. This offers a promising tool to study schizophrenia. At present, we do not know if these word-level choices in speech are sensitive to the illness stage (i.e., acute untreated vs. stable established state), track cognitive deficits in major domains (e.g., cognitive control, processing speed) or relate to established dimensions of formal thought disorder. In this study, we collected samples of descriptive discourse in patients experiencing an untreated first episode of schizophrenia and healthy control subjects (246 samples of 1-minute …
Qmri-Bids: An Extension To The Brain Imaging Data Structure For Quantitative Magnetic Resonance Imaging Data, Agah Karakuzu, Stefan Appelhoff, Tibor Auer, Mathieu Boudreau, Franklin Feingold, Ali R. Khan, Alberto Lazari, Chris Markiewicz, Martijn Mulder, Christophe Phillips, Taylor Salo, Nikola Stikov, Kirstie Whitaker, Gilles De Hollander
Qmri-Bids: An Extension To The Brain Imaging Data Structure For Quantitative Magnetic Resonance Imaging Data, Agah Karakuzu, Stefan Appelhoff, Tibor Auer, Mathieu Boudreau, Franklin Feingold, Ali R. Khan, Alberto Lazari, Chris Markiewicz, Martijn Mulder, Christophe Phillips, Taylor Salo, Nikola Stikov, Kirstie Whitaker, Gilles De Hollander
Neuroscience Institute Publications
The Brain Imaging Data Structure (BIDS) established community consensus on the organization of data and metadata for several neuroimaging modalities. Traditionally, BIDS had a strong focus on functional magnetic resonance imaging (MRI) datasets and lacked guidance on how to store multimodal structural MRI datasets. Here, we present and describe the BIDS Extension Proposal 001 (BEP001), which adds a range of quantitative MRI (qMRI) applications to the BIDS. In general, the aim of qMRI is to characterize brain microstructure by quantifying the physical MR parameters of the tissue via computational, biophysical models. By proposing this new standard, we envision standardization of …
Frontoparietal Connectivity As A Product Of Convergent Evolution In Rodents And Primates: Functional Connectivity Topologies In Grey Squirrels, Rats, And Marmosets, David J. Schaeffer, Kyle M. Gilbert, Miranda Bellyou, Afonso C. Silva, Stefan Everling
Frontoparietal Connectivity As A Product Of Convergent Evolution In Rodents And Primates: Functional Connectivity Topologies In Grey Squirrels, Rats, And Marmosets, David J. Schaeffer, Kyle M. Gilbert, Miranda Bellyou, Afonso C. Silva, Stefan Everling
Neuroscience Institute Publications
Robust frontoparietal connectivity is a defining feature of primate cortical organization. Whether mammals outside the primate order, such as rodents, possess similar frontoparietal functional connectivity organization is a controversial topic. Previous work has primarily focused on comparing mice and rats to primates. However, as these rodents are nocturnal and terrestrial, they rely much less on visual input than primates. Here, we investigated the functional cortical organization of grey squirrels which are diurnal and arboreal, thereby better resembling primate ecology. We used ultra-high field resting-state fMRI data to compute and compare the functional connectivity patterns of frontal regions in grey squirrels …
Differential Impairment Of Cerebrospinal Fluid Synaptic Biomarkers In The Genetic Forms Of Frontotemporal Dementia, Aitana Sogorb-Esteve, Johanna Nilsson, Imogen J. Swift, Carolin Heller, Martina Bocchetta, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, John C. Van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Isabel Santana, Chris R. Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto
Differential Impairment Of Cerebrospinal Fluid Synaptic Biomarkers In The Genetic Forms Of Frontotemporal Dementia, Aitana Sogorb-Esteve, Johanna Nilsson, Imogen J. Swift, Carolin Heller, Martina Bocchetta, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, John C. Van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Isabel Santana, Chris R. Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto
Neuroscience Institute Publications
Background: Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three genes accounting for most of the inheritance: C9orf72, GRN, and MAPT. Impaired synaptic health is a common mechanism in all three genetic variants, so developing fluid biomarkers of this process could be useful as a readout of cellular dysfunction within therapeutic trials. Methods: A total of 193 cerebrospinal fluid (CSF) samples from the GENetic FTD Initiative including 77 presymptomatic (31 C9orf72, 23 GRN, 23 MAPT) and 55 symptomatic (26 C9orf72, 17 GRN, 12 MAPT) mutation carriers as well as 61 mutation-negative controls were measured using a …
Elevated Csf And Plasma Complement Proteins In Genetic Frontotemporal Dementia: Results From The Genfi Study, Emma L. Van Der Ende, Carolin Heller, Aitana Sogorb-Esteve, Imogen J. Swift, David Mcfall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G.P. Dopper, Martina Bocchetta, Emily Todd, David Cash, Caroline Graff, Matthis Synofzik, Fermin Moreno, Elizabeth Finger, Raquel Sanchez-Valle, Rik Vandenberghe, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Chris Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek
Elevated Csf And Plasma Complement Proteins In Genetic Frontotemporal Dementia: Results From The Genfi Study, Emma L. Van Der Ende, Carolin Heller, Aitana Sogorb-Esteve, Imogen J. Swift, David Mcfall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G.P. Dopper, Martina Bocchetta, Emily Todd, David Cash, Caroline Graff, Matthis Synofzik, Fermin Moreno, Elizabeth Finger, Raquel Sanchez-Valle, Rik Vandenberghe, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Chris Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek
Neuroscience Institute Publications
Background: Neuroinflammation is emerging as an important pathological process in frontotemporal dementia (FTD), but biomarkers are lacking. We aimed to determine the value of complement proteins, which are key components of innate immunity, as biomarkers in cerebrospinal fluid (CSF) and plasma of presymptomatic and symptomatic genetic FTD mutation carriers. Methods: We measured the complement proteins C1q and C3b in CSF by ELISAs in 224 presymptomatic and symptomatic GRN, C9orf72 or MAPT mutation carriers and non-carriers participating in the Genetic Frontotemporal Dementia Initiative (GENFI), a multicentre cohort study. Next, we used multiplex immunoassays to measure a panel of 14 complement proteins …
Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox
Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox
Neuroscience Institute Publications
Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected …
Associations Between Polygenic Risk, Negative Symptoms, And Functional Connectome Topology During A Working Memory Task In Early-Onset Schizophrenia, Mengjie Deng, Zhening Liu, Wen Zhang, Zhipeng Wu, Hengyi Cao, Jie Yang, Lena Palaniyappan
Associations Between Polygenic Risk, Negative Symptoms, And Functional Connectome Topology During A Working Memory Task In Early-Onset Schizophrenia, Mengjie Deng, Zhening Liu, Wen Zhang, Zhipeng Wu, Hengyi Cao, Jie Yang, Lena Palaniyappan
Neuroscience Institute Publications
Working memory (WM) deficit in schizophrenia is thought to arise from a widespread neural inefficiency. However, we do not know if this deficit results from the illness-related genetic risk and influence the symptom burden in various domains, especially in patients who have an early onset illness. We used graph theory to examine the topology of the functional connectome in 99 subjects (27 early-onset schizophrenia (EOS), 24 asymptomatic siblings, and 48 healthy subjects) during an n-back task, and calculated their polygenic risk score (PRS) for susceptibility to schizophrenia. Linear regression analysis was used to test associations of the PRS, clinical symptoms, …
Whole-Brain Modelling Identifies Distinct But Convergent Paths To Unconsciousness In Anaesthesia And Disorders Of Consciousness, Andrea I. Luppi, Pedro A.M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard, Guy B. Williams, Michael M. Craig, Paola Finoia, Alexander R.D. Peattie, Peter Coppola, Adrian M. Owen, Lorina Naci, David K. Menon, Daniel Bor, Emmanuel A. Stamatakis
Whole-Brain Modelling Identifies Distinct But Convergent Paths To Unconsciousness In Anaesthesia And Disorders Of Consciousness, Andrea I. Luppi, Pedro A.M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard, Guy B. Williams, Michael M. Craig, Paola Finoia, Alexander R.D. Peattie, Peter Coppola, Adrian M. Owen, Lorina Naci, David K. Menon, Daniel Bor, Emmanuel A. Stamatakis
Neuroscience Institute Publications
The human brain entertains rich spatiotemporal dynamics, which are drastically reconfigured when consciousness is lost due to anaesthesia or disorders of consciousness (DOC). Here, we sought to identify the neurobiological mechanisms that explain how transient pharmacological intervention and chronic neuroanatomical injury can lead to common reconfigurations of neural activity. We developed and systematically perturbed a neurobiologically realistic model of whole-brain haemodynamic signals. By incorporating PET data about the cortical distribution of GABA receptors, our computational model reveals a key role of spatially-specific local inhibition for reproducing the functional MRI activity observed during anaesthesia with the GABA-ergic agent propofol. Additionally, incorporating …
Prenatal And Postpartum Maternal Mental Health And Neonatal Motor Outcomes During The Covid-19 Pandemic, Alissa Papadopoulos, Emily S. Nichols, Yalda Mohsenzadeh, Isabelle Giroux, Michelle F. Mottola, Ryan J. Van Lieshout, Emma G. Duerden
Prenatal And Postpartum Maternal Mental Health And Neonatal Motor Outcomes During The Covid-19 Pandemic, Alissa Papadopoulos, Emily S. Nichols, Yalda Mohsenzadeh, Isabelle Giroux, Michelle F. Mottola, Ryan J. Van Lieshout, Emma G. Duerden
Neuroscience Institute Publications
Background: Rates of prenatal and postpartum stress and depression in pregnant individuals have increased during the COVID-19 pandemic. Perinatal maternal mental health has been linked to worse motor development in offspring, with motor deficits appearing in infancy and early childhood. We aimed to evaluate the relationship between prenatal and postpartum stress and depression and motor outcome in infants born during the COVID-19 pandemic. Methods: One hundred and seventeen participants completed an online prospective survey study at two timepoints: during pregnancy and within 2 months postpartum. Depression was self-reported using the Edinburgh Perinatal/Postpartum Depression Scale (EPDS), and stress via the Perceived …
National Identity Predicts Public Health Support During A Global Pandemic, Jay J. Van Bavel, Aleksandra Cichocka, Valerio Capraro, Hallgeir Sjåstad, John B. Nezlek, Tomislav Pavlović, Mark Alfano, Michele J. Gelfand, Flavio Azevedo, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Robert Malcolm Ross, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, Biljana Gjoneska, June Gruber, Estrella Gualda
National Identity Predicts Public Health Support During A Global Pandemic, Jay J. Van Bavel, Aleksandra Cichocka, Valerio Capraro, Hallgeir Sjåstad, John B. Nezlek, Tomislav Pavlović, Mark Alfano, Michele J. Gelfand, Flavio Azevedo, Michèle D. Birtel, Aleksandra Cislak, Patricia L. Lockwood, Robert Malcolm Ross, Koen Abts, Elena Agadullina, John Jamir Benzon Aruta, Sahba Nomvula Besharati, Alexander Bor, Becky L. Choma, Charles David Crabtree, William A. Cunningham, Koustav De, Waqas Ejaz, Christian T. Elbaek, Andrej Findor, Daniel Flichtentrei, Renata Franc, Biljana Gjoneska, June Gruber, Estrella Gualda
Neuroscience Institute Publications
Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 …
Maternal Immune Activation And Adolescent Alcohol Exposure Increase Alcohol Drinking And Disrupt Cortical-Striatal-Hippocampal Oscillations In Adult Offspring, Angela M. Henricks, Emily D.K. Sullivan, Lucas L. Dwiel, Judy Y. Li, Diana J. Wallin, Jibran Y. Khokhar, Wilder T. Doucette
Maternal Immune Activation And Adolescent Alcohol Exposure Increase Alcohol Drinking And Disrupt Cortical-Striatal-Hippocampal Oscillations In Adult Offspring, Angela M. Henricks, Emily D.K. Sullivan, Lucas L. Dwiel, Judy Y. Li, Diana J. Wallin, Jibran Y. Khokhar, Wilder T. Doucette
Neuroscience Institute Publications
Maternal immune activation (MIA) is strongly associated with an increased risk of developing mental illness in adulthood, which often co-occurs with alcohol misuse. The current study aimed to begin to determine whether MIA, combined with adolescent alcohol exposure (AE), could be used as a model with which we could study the neurobiological mechanisms behind such co-occurring disorders. Pregnant Sprague-Dawley rats were treated with polyI:C or saline on gestational day 15. Half of the offspring were given continuous access to alcohol during adolescence, leading to four experimental groups: controls, MIA, AE, and Dual (MIA + AE). We then evaluated whether MIA …
Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard
Cognitive Composites For Genetic Frontotemporal Dementia: Genfi-Cog, Jackie M. Poos, Katrina M. Moore, Jennifer Nicholas, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Lize C. Jiskoot, Emma Van Der Ende, Esther Van Den Berg, Janne M. Papma, Harro Seelaar, Yolande A.L. Pijnenburg, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre De Mendonça, Pietro Tiraboschi, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard
Neuroscience Institute Publications
Background: Clinical endpoints for upcoming therapeutic trials in frontotemporal dementia (FTD) are increasingly urgent. Cognitive composite scores are often used as endpoints but are lacking in genetic FTD. We aimed to create cognitive composite scores for genetic frontotemporal dementia (FTD) as well as recommendations for recruitment and duration in clinical trial design. Methods: A standardized neuropsychological test battery covering six cognitive domains was completed by 69 C9orf72, 41 GRN, and 28 MAPT mutation carriers with CDR® plus NACC-FTLD ≥ 0.5 and 275 controls. Logistic regression was used to identify the combination of tests that distinguished best between each mutation carrier …
Progression Of Atherosclerosis With Carnitine Supplementation: A Randomized Controlled Trial In The Metabolic Syndrome, Amer M. Johri, Marie France Hétu, Daren K. Heyland, Julia E. Herr, Jennifer Korol, Shawna Froese, Patrick A. Norman, Andrew G. Day, Murray F. Matangi, Erin D. Michos, Stephen A. Lahaye, Fraser W. Saunders, J. David Spence
Progression Of Atherosclerosis With Carnitine Supplementation: A Randomized Controlled Trial In The Metabolic Syndrome, Amer M. Johri, Marie France Hétu, Daren K. Heyland, Julia E. Herr, Jennifer Korol, Shawna Froese, Patrick A. Norman, Andrew G. Day, Murray F. Matangi, Erin D. Michos, Stephen A. Lahaye, Fraser W. Saunders, J. David Spence
Neuroscience Institute Publications
Background: L-carnitine (L-C), a ubiquitous nutritional supplement, has been investigated as a potential therapy for cardiovascular disease, but its effects on human atherosclerosis are unknown. Clinical studies suggest improvement of some cardiovascular risk factors, whereas others show increased plasma levels of pro-atherogenic trimethylamine N-oxide. The primary aim was to determine whether L-C therapy led to progression or regression of carotid total plaque volume (TPV) in participants with metabolic syndrome (MetS). Methods: This was a phase 2, prospective, double blinded, randomized, placebo-controlled, two-center trial. MetS was defined as ≥ 3/5 cardiac risk factors: elevated waist circumference; elevated triglycerides; reduced HDL-cholesterol; elevated …
Corrigendum To "Dissemination In Time And Space In Presymptomatic Granulin Mutation Carriers: A Spatial Chronnectome Study" [Neurobiology Of Aging Volume 108, December 2021, Pages 155-167, Enrico Premi, Marcello Giunta, Armin Iraji, Srinivas Rachakonda, Vince D. Calhoun, Stefano Gazzina, Alberto Benussi, Roberto Gasparotti, Silvana Archetti, Martina Bocchetta, Dave Cash, Emily Todd, Georgia Peakman, Rhian Convery, John C. Van Swieten, Lize Jiskoot, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B. Rowe, Mario Masellis, Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre De Mendonça, Fabrizio Tagliavini, Chris R. Butler
Corrigendum To "Dissemination In Time And Space In Presymptomatic Granulin Mutation Carriers: A Spatial Chronnectome Study" [Neurobiology Of Aging Volume 108, December 2021, Pages 155-167, Enrico Premi, Marcello Giunta, Armin Iraji, Srinivas Rachakonda, Vince D. Calhoun, Stefano Gazzina, Alberto Benussi, Roberto Gasparotti, Silvana Archetti, Martina Bocchetta, Dave Cash, Emily Todd, Georgia Peakman, Rhian Convery, John C. Van Swieten, Lize Jiskoot, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, James B. Rowe, Mario Masellis, Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre De Mendonça, Fabrizio Tagliavini, Chris R. Butler
Neuroscience Institute Publications
No abstract provided.
Environmental Influences On Affect And Cognition: A Study Of Natural And Commercial Semi-Public Spaces, Kathryn E. Schertz, Jillian E. Bowman, Hiroki P. Kotabe, Elliot A. Layden, Jenny Zhen, Tanvi Lakhtakia, Muxuan Lyu, Olivia A. Paraschos, Stephen C. Van Hedger, Nak Won Rim, Kathleen D. Vohs, Marc G. Berman
Environmental Influences On Affect And Cognition: A Study Of Natural And Commercial Semi-Public Spaces, Kathryn E. Schertz, Jillian E. Bowman, Hiroki P. Kotabe, Elliot A. Layden, Jenny Zhen, Tanvi Lakhtakia, Muxuan Lyu, Olivia A. Paraschos, Stephen C. Van Hedger, Nak Won Rim, Kathleen D. Vohs, Marc G. Berman
Neuroscience Institute Publications
Research has consistently shown differences in affect and cognition after exposure to different physical environments. The time course of these differences emerging or fading during exploration of environments is less explored, as most studies measure dependent variables only before and after environmental exposure. In this within-subject study, we used repeated surveys to measure differences in thought content and affect throughout a 1-h environmental exploration of a nature conservatory and a large indoor mall. At each survey, participants reported on aspects of their most recent thoughts (e.g., thinking of the present moment vs. the future; thinking positively vs. negatively) and state …
Blood Pressure Trajectories Over 35 Years And Dementia Risk: A Retrospective Study: The Hunt Study, Geir Selbaek, Josephine Stuebs, Knut Engedal, Vladimir Hachinski, Knut Hestad, Cathrine Selnes Trevino, Håvard Skjellegrind, Yehani Wedatilake, Bjørn Heine Strand
Blood Pressure Trajectories Over 35 Years And Dementia Risk: A Retrospective Study: The Hunt Study, Geir Selbaek, Josephine Stuebs, Knut Engedal, Vladimir Hachinski, Knut Hestad, Cathrine Selnes Trevino, Håvard Skjellegrind, Yehani Wedatilake, Bjørn Heine Strand
Neuroscience Institute Publications
High blood pressure is a well-established risk factor of dementia. However, the timing of the risk remains controversial. The aim of the present study was to compare trajectories of systolic blood pressure (SBP) over a 35-year follow-up period in the Health Survey in Trøndelag (HUNT) from study wave 1 to 4 in people with and without a dementia diagnosis at wave 4 (HUNT4). This is a retrospective cohort study of participants aged ≥ 70 years in HUNT4, where 9,720 participants were assessed for dementia. In the HUNT study all residents aged ≥ 20 years have been invited to four surveys: …
Stroke–Heart Syndrome: Recent Advances And Challenges, Jan F. Scheitz, Luciano A. Sposato, Jeanette Schulz-Menger, Christian H. Nolte, Johannes Backs, Matthias Endres
Stroke–Heart Syndrome: Recent Advances And Challenges, Jan F. Scheitz, Luciano A. Sposato, Jeanette Schulz-Menger, Christian H. Nolte, Johannes Backs, Matthias Endres
Neuroscience Institute Publications
After ischemic stroke, there is a significant burden of cardiovascular complications, both in the acute and chronic phase. Severe adverse cardiac events occur in 10% to 20% of patients within the first few days after stroke and comprise a continuum of cardiac changes ranging from acute myocardial injury and coronary syndromes to heart failure or arrhythmia. Recently, the term stroke– heart syndrome was introduced to provide an integrated conceptual framework that summarizes neurocardiogenic mechanisms that lead to these cardiac events after stroke. New findings from experimental and clinical studies have further refined our understanding of the clinical manifestations, pathophysiology, and …
Effects Of Oral Contraceptives On Spatial Cognition Depend On Pharmacological Properties And Phase Of The Contraceptive Cycle, Elizabeth Hampson, Erin E. Morley, Kelly L. Evans, Cathleen Fleury
Effects Of Oral Contraceptives On Spatial Cognition Depend On Pharmacological Properties And Phase Of The Contraceptive Cycle, Elizabeth Hampson, Erin E. Morley, Kelly L. Evans, Cathleen Fleury
Neuroscience Institute Publications
The central nervous system effects of oral contraceptives (OCs) are not well-documented. In a set of 3 studies, we investigated a specific cognitive function, mental rotation, in healthy women currently using OCs for contraceptive purposes (n = 201) and in medication-free controls not using OCs (n = 44). Mental rotation was measured using a well-standardized and extensively validated psychometric test, the Vandenberg Mental Rotations Test (MRT). In an initial study (Study 1), current OC users (n = 63) were tested during the active or inactive phases of the contraceptive cycle in a parallel-groups design. Studies 2 and 3 were based …
Frequency And Longitudinal Course Of Motor Signs In Genetic Frontotemporal Dementia, Sonja Schönecker, Francisco J. Martinez-Murcia, Boris Stephan Rauchmann, Nicolai Franzmeier, Catharina Prix, Elisabeth Wlasich, Sandra V. Loosli, Katja Bochmann, Juan Manuel Gorriz Saez, Robert Laforce, Simon Ducharme, Maria Carmela Tartaglia, Elizabeth Finger, Alexandre De Mendonça, Isabel Santana, Raquel Sanchez-Valle, Fermin Moreno, Sandro Sorbi, Fabrizio Tagliavini, Barbara Borroni, Markus Otto, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, John Van Swieten, Christopher Butler, Alexander Gerhard, Caroline Graff, Adrian Danek, Jonathan D. Rohrer
Frequency And Longitudinal Course Of Motor Signs In Genetic Frontotemporal Dementia, Sonja Schönecker, Francisco J. Martinez-Murcia, Boris Stephan Rauchmann, Nicolai Franzmeier, Catharina Prix, Elisabeth Wlasich, Sandra V. Loosli, Katja Bochmann, Juan Manuel Gorriz Saez, Robert Laforce, Simon Ducharme, Maria Carmela Tartaglia, Elizabeth Finger, Alexandre De Mendonça, Isabel Santana, Raquel Sanchez-Valle, Fermin Moreno, Sandro Sorbi, Fabrizio Tagliavini, Barbara Borroni, Markus Otto, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, John Van Swieten, Christopher Butler, Alexander Gerhard, Caroline Graff, Adrian Danek, Jonathan D. Rohrer
Neuroscience Institute Publications
Background and ObjectivesFrontotemporal dementia (FTD) is a highly heritable disorder. The majority of genetic cases are caused by autosomal dominant pathogenic variants in the chromosome 9 open reading frame 72 (c9orf72), progranulin (GRN), and microtubule-associated protein tau (MAPT) gene. As motor disorders are increasingly recognized as part of the clinical spectrum, the current study aimed to describe motor phenotypes caused by genetic FTD, quantify their temporal association, and investigate their regional association with brain atrophy.MethodsWe analyzed baseline visit data of known carriers of a pathogenic variant in the c9orf72, GRN, or MAPT gene from the Genetic Frontotemporal Dementia Initiative cohort …
Is Collaborative Open Science Possible With Speech Data In Psychiatric Disorders?, Lena Palaniyappan, Maria F. Alonso-Sanchez, Brian Macwhinney
Is Collaborative Open Science Possible With Speech Data In Psychiatric Disorders?, Lena Palaniyappan, Maria F. Alonso-Sanchez, Brian Macwhinney
Neuroscience Institute Publications
No abstract provided.
The Apathy, Gait Impairment, And Executive Dysfunction (Aged) Triad Vascular Variant, Vladimir Hachinski, Elizabeth Finger, Frederico Pieruccini-Faria, Manuel Montero-Odasso
The Apathy, Gait Impairment, And Executive Dysfunction (Aged) Triad Vascular Variant, Vladimir Hachinski, Elizabeth Finger, Frederico Pieruccini-Faria, Manuel Montero-Odasso
Neuroscience Institute Publications
Apathy, gait disturbances, and executive dysfunction (AGED) often occur together. Although they can arise independently, the presence of one might portend another. This recognition suggests the possible etiology. We focus on the most common, the vascular. We explain the AGED vascular mechanism through the ambibaric brain concept. The brain contains two complementary blood pressure systems: One high in the primitive brain (brainstem, basal ganglia, and thalamus) and a low-pressure system in the Homo sapiens brain (cerebral hemispheres). Hypertension inflicts the most damage on the primitive brain. The frontal systems connect to the basal ganglia, then the thalamus and back to …
Ensuring The Permanent Cessation Of Brain Function During Normothermic Regional Perfusion, Marat Slessarev, Teneille Gofton, Sam D. Shemie
Ensuring The Permanent Cessation Of Brain Function During Normothermic Regional Perfusion, Marat Slessarev, Teneille Gofton, Sam D. Shemie
Neuroscience Institute Publications
No abstract provided.
Evaluating Brain Parcellations Using The Distance-Controlled Boundary Coefficient, Da Zhi, Maedbh King, Carlos R. Hernandez-Castillo, Jörn Diedrichsen
Evaluating Brain Parcellations Using The Distance-Controlled Boundary Coefficient, Da Zhi, Maedbh King, Carlos R. Hernandez-Castillo, Jörn Diedrichsen
Neuroscience Institute Publications
One important approach to human brain mapping is to define a set of distinct regions that can be linked to unique functions. Numerous brain parcellations have been proposed, using cytoarchitectonic, structural, or functional magnetic resonance imaging (fMRI) data. The intrinsic smoothness of brain data, however, poses a problem for current methods seeking to compare different parcellations. For example, criteria that simply compare within-parcel to between-parcel similarity provide even random parcellations with a high value. Furthermore, the evaluation is biased by the spatial scale of the parcellation. To address this problem, we propose the distance-controlled boundary coefficient (DCBC), an unbiased criterion …
Understanding The Association Of Childhood Tobacco Use With Neuropathological Outcomes And Cognitive Performance Deficits In Vulnerable Brains, Steven R. Laviolette
Understanding The Association Of Childhood Tobacco Use With Neuropathological Outcomes And Cognitive Performance Deficits In Vulnerable Brains, Steven R. Laviolette
Neuroscience Institute Publications
No abstract provided.
Widespread Cortical Thinning, Excessive Glutamate And Impaired Linguistic Functioning In Schizophrenia: A Cluster Analytic Approach, Liangbing Liang, Angélica M. Silva, Peter Jeon, Sabrina D. Ford, Michael Mackinley, Jean Théberge, Lena Palaniyappan
Widespread Cortical Thinning, Excessive Glutamate And Impaired Linguistic Functioning In Schizophrenia: A Cluster Analytic Approach, Liangbing Liang, Angélica M. Silva, Peter Jeon, Sabrina D. Ford, Michael Mackinley, Jean Théberge, Lena Palaniyappan
Neuroscience Institute Publications
Introduction: Symptoms of schizophrenia are closely related to aberrant language comprehension and production. Macroscopic brain changes seen in some patients with schizophrenia are suspected to relate to impaired language production, but this is yet to be reliably characterized. Since heterogeneity in language dysfunctions, as well as brain structure, is suspected in schizophrenia, we aimed to first seek patient subgroups with different neurobiological signatures and then quantify linguistic indices that capture the symptoms of “negative formal thought disorder” (i.e., fluency, cohesion, and complexity of language production). Methods: Atlas-based cortical thickness values (obtained with a 7T MRI scanner) of 66 patients with …
Three Dimensions Of Association Link Migraine Symptoms And Functional Connectivity, Samuel R. Krimmel, Danielle D. Desouza, Michael L. Keaser, Bharati M. Sanjanwala, Robert P. Cowan, Martin A. Lindquist, Jennifer A. Haythornthwaite, David A. Seminowicz
Three Dimensions Of Association Link Migraine Symptoms And Functional Connectivity, Samuel R. Krimmel, Danielle D. Desouza, Michael L. Keaser, Bharati M. Sanjanwala, Robert P. Cowan, Martin A. Lindquist, Jennifer A. Haythornthwaite, David A. Seminowicz
Neuroscience Institute Publications
Migraine is a heterogeneous disorder with variable symptoms and responsiveness to therapy. Because of previous analytic shortcomings, variance in migraine symptoms has been inconsistently related to brain function. In the current analysis, we used data from two sites (n = 143, male and female humans), and performed canonical correlation analysis, relating restingstate functional connectivity (RSFC) with a broad range of migraine symptoms, ranging from headache characteristics to sleep abnormalities. This identified three dimensions of covariance between symptoms and RSFC. The first dimension related to headache intensity, headache frequency, pain catastrophizing, affect, sleep disturbances, and somatic abnormalities, and was associated with …