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Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility, Raymond Tak Cheung
Neurochemical Changes Following Stroke: Role In Neuroprotection And Cardiac Susceptibility, Raymond Tak Cheung
Digitized Theses
The mechanisms mediating neuronal recovery and cardiovascular complications after ischemic stroke are not completely known. In these investigations, I examined changes in neuropeptides and a catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), following middle cerebral artery occlusion (MCAO) in adult male Wistar rats.;Five days following MCAO, the immunoreactivity for TH and neuropeptide Y (NPY) increased in the insular cortex (IC) within the peri-infarct zone. NPY also increased ipsilaterally in the basolateral nucleus of the amygdala, whereas leucine-enkephalin, dynorphin and neurotensin increased ipsilaterally in the central nucleus of the amygdala. Sham MCAO was ineffective.;Neurochemical changes were assessed 5 days after localized excitotoxic …
Structural Basis For Human Anti-Dna Antibody Specificity, Mahmoud Mahmoudi
Structural Basis For Human Anti-Dna Antibody Specificity, Mahmoud Mahmoudi
Digitized Theses
Anti-DNA antibodies are hallmarks of SLE both in human and inbred lupus prone mice. The role of these antibodies in disease pathogenesis, particularly in glomerulonephritis has been documented. It is now well accepted that the genetic potential to generate anti-DNA antibodies also exists in the normal B cell immune repertoire. This genetic potential has been revealed by detection of anti-DNA antibodies in serum of normal individuals and by immortalizing DNA reactive B cells as hybridomas and as transformed cell lines. There is growing evidence that anti-DNA antibodies from the normal B cell repertoire and disease-associated anti-DNA antibodies share V region …
Characterization Of Intestinal Epithelial Cells In Acute Intestinal Allograft Rejection, Xian-Chang Li
Characterization Of Intestinal Epithelial Cells In Acute Intestinal Allograft Rejection, Xian-Chang Li
Digitized Theses
Intestinal transplantation (IT) remains highly experimental compared to other solid organ transplants because of poorly defined mechanisms of graft rejection. In this project, the role of luminal bacteria-derived endotoxin and inflammatory cytokines (IL-1, IL-6, TNF-{dollar}\alpha){dollar} in intestinal epithelial damage during acute graft rejection was examined. In a novel mouse model of IT, the acute intestinal rejection was associated with elevated levels of endotoxin, IL-6, and TNF-{dollar}\alpha{dollar} in the peripheral blood. The progressive increase in endotoxin and TNF-{dollar}\alpha{dollar} levels correlated well with the histologic severity of epithelial damage. To further define the role of endotoxin and inflammatory cytokines on intestinal epithelial …
Host And Viral Determinants Influencing The Pathogenesis Of Coronavirus-Induced Neurological Disease In Rodents, John M. Pasick
Host And Viral Determinants Influencing The Pathogenesis Of Coronavirus-Induced Neurological Disease In Rodents, John M. Pasick
Digitized Theses
Host and viral determinants influencing the outcome of coronavirus JHM infections of the CNS of rodents were investigated using intact animals and primary neural cell cultures. Two problems pertinent to the process of pathogenesis were addressed. The first was concerned with elucidating host factors responsible for controlling the age dependent nature for induction of the demyelinating form of disease in suckling rats. In the second, the basis of the relative resistance exhibited by inbred SJL/J mice to JHMV was examined in relation to both host and viral determinants.;Using primary, dissociated neural cultures from perinatal rats, several interesting aspects of host …
The Generation Of Cytotoxic Tumour Infiltrating Lymphocyte Clones Against Head And Neck Squamous Cell Carcinoma, Henry J. Lapointe
The Generation Of Cytotoxic Tumour Infiltrating Lymphocyte Clones Against Head And Neck Squamous Cell Carcinoma, Henry J. Lapointe
Digitized Theses
73 samples of H&NSCCa were processed for these studies. An enzymatic disaggregation protocol for the flow cytometric analysis of DNA content of tumour whole cell preparations was developed. Analysis of the tumour cell component without the need for incorporation of reference controls provided a more accurate assessment of DNA content of tumour cell populations. Six lines of H&NSCCa were established in vitro from fresh tumour samples. Tumour cell effects on PHA- or IL-2 stimulated proliferation of PBMNCs ranged from 61% and 45% suppression to 4% and 121% enhancement of the proliferative responses respectively. Flow cytometric analysis revealed a down regulation …
An Immunobiological Study Of Natural Killer Cells, Marien J. Zanyk
An Immunobiological Study Of Natural Killer Cells, Marien J. Zanyk
Digitized Theses
The innate ability of the immune system to prevent the onset of cancer involves an intricate network of defense known as the natural killer (NK) cell system. As reactive elements in tumour defense and essential components of adoptive immunotherapy, NK cells represent a relatively new field of study that holds immeasurable potential in our struggle against cancer. Although their anti-tumour potential has been realized, NK cells and many of their regulatory processes, remain a scientific challenge. In order to exploit this system to its fullest potential, the functional mechanisms of NK-mediated tumour cell recognition and destruction must be fully understood …
Postmenopausal Osteoporosis: Characterisation Of An Animal Model And The Effects Of Dietary Calcium, Darien-Alexis Veronica Lazowski
Postmenopausal Osteoporosis: Characterisation Of An Animal Model And The Effects Of Dietary Calcium, Darien-Alexis Veronica Lazowski
Digitized Theses
Postmenopausal osteoporosis is a debilitating condition which affects 25% of Caucasian women. To date, neither prophylaxis nor treatment have met with any great success. Calcium supplementation (CaSuppl) has been widely advocated in the prevention and treatment of osteoporosis despite the paucity of scientific evidence suggesting that calcium has any beneficial effect. We have employed an oophorectomised rat model to investigate the effects of oestrogen deficiency on the skeleton and bone marrow. In this laboratory approach it was also possible to examine the effects of calcium in this model.;Adult female rats were either oophorectomised or sham operated, and fed either a …
The Effects Of Environmental Pollutants On Bone Remodelling, Kenneth David Danylchuk
The Effects Of Environmental Pollutants On Bone Remodelling, Kenneth David Danylchuk
Digitized Theses
No abstract provided.
Morphometry And Morphology Of Fetal Stem Arteries Of Human Placenta In Hypertensive Diseases ("Toxemia") Of Pregnancy, Heras Jorge Las
Morphometry And Morphology Of Fetal Stem Arteries Of Human Placenta In Hypertensive Diseases ("Toxemia") Of Pregnancy, Heras Jorge Las
Digitized Theses
No abstract provided.
Ultrastructural Studies Of Experimental Haematogenous And Lymphogenous Metastases, Robert Lewis Josephson
Ultrastructural Studies Of Experimental Haematogenous And Lymphogenous Metastases, Robert Lewis Josephson
Digitized Theses
No abstract provided.
The Ultrastructure Of Fibrin And Fibrinolysis, Sabiha Perveen Khan
The Ultrastructure Of Fibrin And Fibrinolysis, Sabiha Perveen Khan
Digitized Theses
No abstract provided.
Alkylation Carcinogenesis--A Comparative Study Of N-Methyl-N-Nitrosourea And Methyl-Methanesulfonate, Subhas Chandra Maitra
Alkylation Carcinogenesis--A Comparative Study Of N-Methyl-N-Nitrosourea And Methyl-Methanesulfonate, Subhas Chandra Maitra
Digitized Theses
No abstract provided.
Ultrastructure Of Muscle In Typical And Atypical Duchenne Muscular Dystrophy A Comparative Study, Felix Teodoro Oteruelo
Ultrastructure Of Muscle In Typical And Atypical Duchenne Muscular Dystrophy A Comparative Study, Felix Teodoro Oteruelo
Digitized Theses
No abstract provided.
The Morphogenesis Of The Experimental Poststenotic Dilatation Of The Canine Carotid And Femoral Arteries, Alberto Trillo
The Morphogenesis Of The Experimental Poststenotic Dilatation Of The Canine Carotid And Femoral Arteries, Alberto Trillo
Digitized Theses
No abstract provided.
Ultrastructural Studies Of Metastases: Functions Of Fibrin And Platelets, Eng Ching Chew
Ultrastructural Studies Of Metastases: Functions Of Fibrin And Platelets, Eng Ching Chew
Digitized Theses
No abstract provided.
Pathogenesis Of Chemically Induced Malignant Lymphoma In Mice, Vijay Vinayak Joshi
Pathogenesis Of Chemically Induced Malignant Lymphoma In Mice, Vijay Vinayak Joshi
Digitized Theses
No abstract provided.
The Occurrence Of Fibrin In Association With Tumours, David Stevens Jones
The Occurrence Of Fibrin In Association With Tumours, David Stevens Jones
Digitized Theses
No abstract provided.