Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Osteoblast And Chondrocyte Specific Contribution Of The Runx2 Gene During The Development Of Cleidocranial Dysplasisa, Kayla Renee King
Osteoblast And Chondrocyte Specific Contribution Of The Runx2 Gene During The Development Of Cleidocranial Dysplasisa, Kayla Renee King
All ETDs from UAB
The Runx2 transcription factor is essential for the differentiation of mesenchymal stem cells into functional chondrocytes and osteoblasts. In humans, the haploinsufficiency of the Runx2 gene is associated with cleidocranial dysplasia (CCD). The CCD is characterized by short stature, open sutures and fontanels in the skull, hypoplastic clavicles and supernumerary teeth. Skeletal elements disrupted in CCD patients are developed by intramembranous and/or endochondral ossification. However, the cell type specific roles of the Runx2 gene in the development of CCD-associated skeletal defects remain unknown. The main goal of this research was to define the specific role of the Runx2 gene in …