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Stimulation Of Anterior Thalamic Nucleus Protects Hippocampus Neural Injury In Kainic Acid-Induced Epileptic Rats, Na Yan, Ning Chen, Wei Gao, Wei Wang
Stimulation Of Anterior Thalamic Nucleus Protects Hippocampus Neural Injury In Kainic Acid-Induced Epileptic Rats, Na Yan, Ning Chen, Wei Gao, Wei Wang
Research outputs 2014 to 2021
Anterior nucleus of thalamus (ANT) stimulation has been proved to be effective in the treatment of refractory epilepsy, but the underlying mechanisms remain to be elucidated. We examined the role of ANT stimulation on hippocampal neuron death after seizures induced by kainic acid (KA). Our data showed that ANT stimulation could significantly rescue neurons from death induced by seizures, by reducing the release of cytochrome c (cyto c) and also via apoptosis-inducing factor (AIF) induced by seizures through inhibiting the activated caspase-9 and caspase-3. Our data suggest that ANT stimulation may protect against neuronal loss and reduce neuronal injury in …