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Bmp2 Enhances Osteogenesis Of Gingival Stem Cells In Peptide Hydrogel, Annapurna Bondalapati
Bmp2 Enhances Osteogenesis Of Gingival Stem Cells In Peptide Hydrogel, Annapurna Bondalapati
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Purpose: The aim of the study was to investigate effect of the growth factor, Bone Morphogenetic Protein 2 (BMP2), on the differentiation of Human gingiva derived stem cells (HGMSCs) in a self-assembled three-dimensional (3D) peptide hydrogel. The study has two parts; part 1 comprised of optimizing the dose of BMP2 and Part II was investigating the effective delivery method of BMP2 in enhancing the osteogenic differentiation of HGMSCs Methods: Human gingiva derived mesenchymal stem cells (HGMSCs) cultured in the peptide hydrogel (3-D cultures) were treated with 50, 100 and 200 ng/ml BMP2. The cells in the osteogenic differentiation of HGMSCs …