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Articles 1 - 14 of 14
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Relationship Between Self-Reported Oral Health And Self-Esteem In Two Columbia, Sc Populations, Matthew Ablonczy, Elizabeth Smith
Relationship Between Self-Reported Oral Health And Self-Esteem In Two Columbia, Sc Populations, Matthew Ablonczy, Elizabeth Smith
Senior Theses
The importance of oral health to overall health cannot be overstated. For example, oral health can be used for early diagnosis of diseases such as diabetes. Furthermore, it has been well studied that self-esteem is related to oral health. Individuals with proper oral health care have more confidence to interact with others, which results in higher self-esteem. Those who lack the ability to pay for oral healthcare are thus at a great disadvantage. The present study sought to investigate the relationship between oral health and self-esteem in two Columbia, SC populations through surveying. There were two study populations, students at …
Primary Care Of Latino Patients In The United States: A Comparative Analysis Of Personal Experiences In Safety-Net Healthcare Organizations, Grant Douglas Tore
Primary Care Of Latino Patients In The United States: A Comparative Analysis Of Personal Experiences In Safety-Net Healthcare Organizations, Grant Douglas Tore
Senior Theses
This thesis aims to compare two types of healthcare organizations that compose the safety-net healthcare system in the United States with the utilization of both personal experiences and extensive research. The first are community health centers, which receive federal funding in order to serve specific populations with in their communities. In my experience, this population was migrant farmworkers, all who came to the United States legally with H2A visas. The second model is that of the free medical clinic, which operates on a volunteer/staff model, but receives no government funding. Serving primarily uninsured patients, free clinics such as the Good …
The Role Of Cyclin-Dependent Kinase 8 In Vascular Disease, Desiree Leach
The Role Of Cyclin-Dependent Kinase 8 In Vascular Disease, Desiree Leach
Theses and Dissertations
In response to injury, mature vascular smooth muscle cells (SMCs) undergo dedifferentiation, also known as phenotype modulation or switch. This process is characterized by a downregulation or loss of expression of contractile genes and concomitant with an increase in cell proliferation, migration, and extracellular matrix production, thereby leading to vascular lesion formation. However, the underlying molecular mechanism is not fully understood. The objective of my study was to determine whether cyclin-dependent kinase 8 (CDK8), a transcription-regulating kinase, plays a mediator role in vascular SMC dedifferentiation and lesion formation. Our results from immunochemical staining and Western blot revealed that CDK8 expression …
Disability: Becoming An Advocate For Persons With Disabilities And Understanding The History Of The Disability Movement In The United States, Frances Mason Ramsay
Disability: Becoming An Advocate For Persons With Disabilities And Understanding The History Of The Disability Movement In The United States, Frances Mason Ramsay
Senior Theses
The purpose of this thesis is to look at the different facets that make up disability in the United States, with a specific focus on the children with disabilities. These facets include related legislation, the education system, activism, services, and what it means to care for a child with disabilities. Throughout the research process, each of these facets were analyzed to include the most significant events for the section, an overview of each section to provide insight and a small amount of background and history for someone relatively unfamiliar with the history of disability in the United States. Beyond research …
Practicing What You Preach: The Health Behaviors Of Nurses, Catherine Anjali Prabhu
Practicing What You Preach: The Health Behaviors Of Nurses, Catherine Anjali Prabhu
Senior Theses
This research study investigated the relationship between the health behaviors nurses commonly teach to their patients and the behaviors they practice themselves. After receiving the 194 completed surveys, a thorough analysis of variables was completed to determine which educational topics are most frequently included in patient education as well as if these variables are related to the health behaviors nurses practice themselves. It was evident that many nurses who report educating their patients on healthier lifestyles do not implement all of these practices into their own lives. Barriers to implementing such behaviors, employer-provided health programs, and methods of stress reduction …
Individual Differences In Markers Of Cholinergic Signaling Correlating To Fear And Extinction Learning, Grace C. Jones
Individual Differences In Markers Of Cholinergic Signaling Correlating To Fear And Extinction Learning, Grace C. Jones
Theses and Dissertations
Posttraumatic stress disorder (PTSD) results when individuals are exposed to a life threatening event, assault, serious injury, or other traumatic incident. Individuals with PTSD are impaired in their ability to extinguish fear memories, resulting in intrusive symptoms that impair their ability to live otherwise healthy lives. It remains unclear why some individuals exposed to traumatic events develop PTSD while others do not. Acetylcholine has been shown to play a critical role in fear learning, but its role in fear extinction is not well understood. This study utilized a rat model of fear learning and extinction to determine if individual differences …
Muscarinic Acetylcholine Receptor M1’S Impact On Fear Extinction Learning, Joshua R. Mcelroy
Muscarinic Acetylcholine Receptor M1’S Impact On Fear Extinction Learning, Joshua R. Mcelroy
Theses and Dissertations
Post-Traumatic Stress Disorder (PTSD) is a mental health disorder that can occur following a traumatic event like combat, assault, or disaster. Individuals with PTSD are unable to extinguish fear memories which can become chronic and disabling. However, it remains unclear why some individuals exposed to a traumatic event develop PTSD while others are resilient. Acetylcholine plays a critical role in fear learning, but its role in fear extinction is less well understood. In this investigation, we used a rat model of fear extinction to determine if individual differences in extinction learning are correlated with markers of cholinergic signaling. Cholinergic markers …
Developing And Implementing A Quality Assurance Strategy For Electroconvulsive Therapy, Jessa Hollingsworth
Developing And Implementing A Quality Assurance Strategy For Electroconvulsive Therapy, Jessa Hollingsworth
Theses and Dissertations
The literature provides scant guidance in effective quality assurance strategies concerning the use of electroconvulsive therapy (ECT) for the treatment of psychiatric conditions. Numerous guidelines are published that provide guidance in the delivery of care, however, little has been done to determine how a program or facility might ensure compliance to best practice for safety, tolerability, and efficacy in performing ECT. The objective of this project was to create a quality assurance strategy specific to ECT. Determining standards for quality care and clarifying facility policy were key outcomes in establishing an effective quality assurance strategy. An audit tool was developed …
Assessing The Relationship Between Periodontal Disease And Subsequent Inflammatory Responses And Headache Disorders, Bryn E. Davis
Assessing The Relationship Between Periodontal Disease And Subsequent Inflammatory Responses And Headache Disorders, Bryn E. Davis
Theses and Dissertations
Headaches are the sixth leading cause of disability worldwide, and the third leading cause of disability amongst those aged 50 and older. Several headache disorders, including migraines, have been associated with nitric oxide production. It is widely accepted that the pain associated with headache disorders is due to the ability of nitric oxide to function as a vasodilator. While nitric oxide is a known vasodilator and has been linked to headache disorder, it is also produced in response to bacterial infections. Periodontal disease is the result of long term bacterial infections occurring in the gum line and nitric oxide is …
Synergism Of Quercetin And Sodium Butyrate For Controlling Growth Of Glioblastoma, Matthew Alan Taylor
Synergism Of Quercetin And Sodium Butyrate For Controlling Growth Of Glioblastoma, Matthew Alan Taylor
Theses and Dissertations
Glioblastoma multiforme (GBM), or simply glioblastoma, is the most common and aggressive primary brain tumor, with a prevalence of approximately 20,000 new cases per year in the United States and a 3-year survival rate of just 2%. Quercetin (QCT) is a dietary flavonoid that can be found in common foods such as red kidney beans, cilantro, and onions. Despite little evidence showing any benefits through dietary intake of QCT, various studies show its promising anti-cancer results in vitro. In glioblastoma, QCT is able to cause significant amounts of apoptosis through a variety of mechanisms. These include activation of caspase-9 and …
Succination Impairs Protein Folding And Promotes Chop Stability In The Adipocyte During Diabetes, Allison Manuel
Succination Impairs Protein Folding And Promotes Chop Stability In The Adipocyte During Diabetes, Allison Manuel
Theses and Dissertations
Type 2 diabetes mellitus has been diagnosed in ~21 million people in the United States and is closely correlated with obesity, prompting the need for a detailed understanding of adipocyte metabolism in the development of diabetes. The intake of excess nutrients surpasses the energy requirements of the cell and leads to increased mitochondrial stress in the adipocyte. We have shown that this is associated with increased levels of the mitochondrial metabolite fumarate. Fumarate can react with cysteine thiol groups to form the chemical modification S-(2-succino)cysteine (2SC), also termed protein succination. Succination is significantly increased in the adipose tissue of type …
Functional Role Of The Homeobox Transcription Factor Six1 In Neoplastic Transformation Of Human Keratinocytes, Maria Hosseinipour
Functional Role Of The Homeobox Transcription Factor Six1 In Neoplastic Transformation Of Human Keratinocytes, Maria Hosseinipour
Theses and Dissertations
The homeobox transcription factor SIX1 contributes to both tumor development and progression. Numerous studies have determined that the inappropriate expression of embryonic genes, in particular transcription factors, contributes to carcinogenesis. SIX1 is essential for the development of numerous organs including the auditory and olfactory system as well as the kidney, by promoting proliferation, survival and migration of progenitor cells during embryogenesis. SIX1 has also been shown to increase cancer cell proliferation, survival and invasion. The aberrant expression of SIX1 occurs in numerous adult and pediatric cancers. We have previously determined that our in-vitro model system for HPV16-mediated tumorigenesis shares many …
Garlic Inhibits Inflammation During Dengue Infection, Alex R. Hall
Garlic Inhibits Inflammation During Dengue Infection, Alex R. Hall
Theses and Dissertations
Dengue virus (DENV) is a mosquito-borne flavivirus that causes significant human disease and mortality in the tropics and subtropics. There has been a recent global trend of increased epidemic activity, and DENV infection is considered a serious emerging health problem worldwide. A relatively unexplored approach to develop new treatments for dengue virus infection and the prevention of severe disease development is through investigation of natural medicines. Inflammation plays both beneficial and harmful roles during the host response to dengue virus infection. Several studies have proposed that it is the oxidative stress response induced by dengue virus infection that is responsible …
The Role Of Inflammation In Atherosclerosis, Fatma Saaoud
The Role Of Inflammation In Atherosclerosis, Fatma Saaoud
Theses and Dissertations
Atherosclerosis is both a chronic inflammatory disease and lipid deposition disorder characterized by accumulation of lipids, fibrous tissue, and inflammatory cells in the arterial wall. Thus, investigating the role of inflammation and the immune system in the progression of atherosclerosis may help in the development of novel therapeutics for atherosclerotic disease. Current atherosclerosis therapy is aimed at lipid targets and focused primarily on reducing plasma cholesterol levels. Clinical and experimental data support the critical role of inflammation in atherosclerosis and suggest that reducing inflammation even without affecting lipid levels may reduce the event rate of cardiovascular disease. Yet, no pure …