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- Adrenergic Uptake Inhibitors (1)
- Adrenergic alpha-2 Receptor Antagonists (1)
- Age Factors (1)
- Aging (1)
- Alkaloids (1)
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- Anatabine (1)
- Atomoxetine (1)
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- Attention Deficit Disorder with Hyperactivity (1)
- Attention deficit/hyperactivity disorder (1)
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- Conditioned place preference (1)
- Conditioning (Psychology) (1)
- Continine (1)
- Dopamine (1)
- Idazoxan (1)
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- Methylphenidate (1)
- Microdialysis (1)
- Myosmine (1)
- Nicotine (1)
- Norepinephrine (1)
- Nucleus Accumbens (1)
- Prefrontal Cortex (1)
- Prelimbic cortex (1)
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Tobacco's Minor Alkaloids: Effects On Place Conditioning And Nucleus Accumbens Dopamine Release In Adult And Adolescent Rats, Julie A. Marusich, Mahesh Darna, A. George Wilson, Emily D. Denehy, Amanda Ebben, Agripina G. Deaciuc, Linda P. Dwoskin, Michael T. Bardo, Timothy W. Lefever, Jenny L. Wiley, Chad J. Reissig, Kia J Jackson
Tobacco's Minor Alkaloids: Effects On Place Conditioning And Nucleus Accumbens Dopamine Release In Adult And Adolescent Rats, Julie A. Marusich, Mahesh Darna, A. George Wilson, Emily D. Denehy, Amanda Ebben, Agripina G. Deaciuc, Linda P. Dwoskin, Michael T. Bardo, Timothy W. Lefever, Jenny L. Wiley, Chad J. Reissig, Kia J Jackson
Pharmaceutical Sciences Faculty Publications
Tobacco products are some of the most commonly used psychoactive drugs worldwide. Besides nicotine, alkaloids in tobacco include cotinine, myosmine, and anatabine. Scientific investigation of these constituents and their contribution to tobacco dependence is less well developed than for nicotine. The present study evaluated the nucleus accumbens dopamine-releasing properties and rewarding and/or aversive properties of nicotine (0.2-0.8 mg/kg), cotinine (0.5-5.0 mg/kg), anatabine (0.5-5.0 mg/kg), and myosmine (5.0-20.0 mg/kg) through in vivo microdialysis and place conditioning, respectively, in adult and adolescent male rats. Nicotine increased dopamine release at both ages, and anatabine and myosmine increased dopamine release in adults, but not …
Blockade Of Α2-Adrenergic Receptors In Prelimbic Cortex: Impact On Cocaine Self-Administration In Adult Spontaneously Hypertensive Rats Following Adolescent Atomoxetine Treatment, Britahny M. Baskin, Bríd Á. Nic Dhonnchadha, Linda P. Dwoskin, Kathleen M. Kantak
Blockade Of Α2-Adrenergic Receptors In Prelimbic Cortex: Impact On Cocaine Self-Administration In Adult Spontaneously Hypertensive Rats Following Adolescent Atomoxetine Treatment, Britahny M. Baskin, Bríd Á. Nic Dhonnchadha, Linda P. Dwoskin, Kathleen M. Kantak
Pharmaceutical Sciences Faculty Publications
Rationale
Research with the spontaneously hypertensive rat (SHR) model of attention deficit/hyperactivity disorder demonstrated that chronic methylphenidate treatment during adolescence increased cocaine self-administration established during adulthood under a progressive ratio (PR) schedule. Compared to vehicle, chronic atomoxetine treatment during adolescence failed to increase cocaine self-administration under a PR schedule in adult SHR.
Objectives
We determined if enhanced noradrenergic transmission at α2-adrenergic receptors within prefrontal cortex contributes to this neutral effect of adolescent atomoxetine treatment in adult SHR.
Methods
Following treatment from postnatal days 28–55 with atomoxetine (0.3 mg/kg) or vehicle, adult male SHR and control rats from Wistar-Kyoto (WKY) and …