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Development Of A Dna-Liposome Complex For Gene Delivery Applications, Morteza Rasoulianboroujeni, G. Kupgan, F. Moghadam, A. Boughdachi, Payam Khoshkenar, J. J. Ambrose, N. Kiaie, Daryoosh Vashaee, J. D. Ramsey, Lobat Tayebi
Development Of A Dna-Liposome Complex For Gene Delivery Applications, Morteza Rasoulianboroujeni, G. Kupgan, F. Moghadam, A. Boughdachi, Payam Khoshkenar, J. J. Ambrose, N. Kiaie, Daryoosh Vashaee, J. D. Ramsey, Lobat Tayebi
School of Dentistry Faculty Research and Publications
The association structures formed by cationic liposomes and DNA(Deoxyribonucleic acid)-liposome have been effectively utilized as gene carriers in transfection assays. In this research study, cationic liposomes were prepared using a modified lipid film hydration method consisting of a lyophilization step for gene delivery applications. The obtained results demonstrated that the mean particle size had no significant change while the polydispersity (PDI) increased after lyophilization. The mean particle size slightly reduced after lyophilization (520 ± 12 nm to 464 ± 25 nm) while the PDI increased after lyophilization (0.094 ± 0.017 to 0.220 ± 0.004). In addition. The mean particle size …