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The Effects Of Notch Signaling On Functional Recovery Following Traumatic Brain Injury, Jyoti Lodha
The Effects Of Notch Signaling On Functional Recovery Following Traumatic Brain Injury, Jyoti Lodha
Theses and Dissertations
2.5 million people sustain a traumatic brain injury (TBI) annually in the United States. Although there is potential for functional recovery following TBI, there is no definitive treatment to improve recovery after TBI. Our lab has shown that TBI enhances an endogenous neurogenic response in the subventricular zone and hippocampus. TBI-induced neural stem cells (NSCs) can integrate into regions such as the hippocampus and olfactory bulb. Although the mechanism behind TBI-enhanced neurogenesis remains unknown, the Notch signaling pathway has been implicated as a regulator in the maintenance and survival of NSCs.
This thesis explores the effects of Notch pathway manipulation …