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Articles 1 - 30 of 206
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Needs Assessment 2019 In The Department Of Loreto In Perú, Estefania Martinez Limo
Needs Assessment 2019 In The Department Of Loreto In Perú, Estefania Martinez Limo
GW Research Showcase 2021-2024
No abstract provided.
Growing And Sustaining Community Health Workers In Missouri, Jennifer Trott, Jacqueline Baños, Marsha Regenstein
Growing And Sustaining Community Health Workers In Missouri, Jennifer Trott, Jacqueline Baños, Marsha Regenstein
Health Policy and Management Issue Briefs
With funding from the Missouri Foundation for Health, in August 2022 The George Washington University Milken Institute School of Public Health began a 12-month study to assess the Community Health Worker field in Missouri. The resulting report, Growing and Sustaining Community Health Workers in Missouri, provides a landscape of current CHW workforce activity in the state, reviews recent milestones in the development of the profession, and profiles innovative training and practice models being employed in Missouri. The report draws on perspectives about the profession from interviews with 40 individuals from the field, including CHWs and others who supervise or …
Drawing On The Strengths Of Community Health Workers To Address Sexually Transmitted Infections: Roles, Medicaid Reimbursement, And Partnerships, Naomi Seiler, Katie Horton, Paige Organick-Lee, Claire Heyison, Alexis Osei, Greg Dwyer, Aaron Karacuschansky, Mekhi Washington, Amanda Spott
Drawing On The Strengths Of Community Health Workers To Address Sexually Transmitted Infections: Roles, Medicaid Reimbursement, And Partnerships, Naomi Seiler, Katie Horton, Paige Organick-Lee, Claire Heyison, Alexis Osei, Greg Dwyer, Aaron Karacuschansky, Mekhi Washington, Amanda Spott
Health Policy and Management Informal Communications
Rates of bacterial sexually transmitted infections (STIs) in the United States are high and, largely, still soaring. Though chlamydia cases have decreased slightly since 2017, gonorrhea and syphilis have increased by 25% and 68%, respectively, and congenital syphilis has increased by 184%. Bacterial STI can lead to pain, infertility, and even, in the case of syphilis and congenital syphilis, death. With appropriate detection and treatment, all of these STIs are curable. And yet a range of barriers between communities and the healthcare system perpetuate the STI epidemic.
Community health workers (CHWs) could play a key role in helping bridge the …
Managing Conference Posters: A Lifecycle Overview From Printing Service To Digital Repository Discovery, Sarah Weirich
Managing Conference Posters: A Lifecycle Overview From Printing Service To Digital Repository Discovery, Sarah Weirich
Medical Institutional Repositories in Libraries (MIRL)
The Health Sciences and Human Services Library at the University of Maryland, Baltimore (UMB) offers a poster printing service to faculty, students and staff. The printing service is multifaceted. Researchers fill out a submission form to request a large-scale printout of their PDF poster to share at a conference. The same form also includes information about the opportunity to deposit a copy of their poster into the UMB Digital Archive, the University's digital repository, subsequently making their research discoverable beyond a conference venue. Three library departments: Research and Information Services, Resource Development and Access, and Computing and Technology Services work …
Delineating The Field Of Medical Education: Bibliometric Research Approach(Es)., Lauren A Maggio, Anton Ninkov, Jason R Frank, Joseph A Costello, Anthony R. Artino
Delineating The Field Of Medical Education: Bibliometric Research Approach(Es)., Lauren A Maggio, Anton Ninkov, Jason R Frank, Joseph A Costello, Anthony R. Artino
Health, Human Function, and Rehabilitation Sciences Faculty Publications
BACKGROUND: The field of medical education remains poorly delineated such that there is no broad consensus of articles or journals that comprise 'the field'. This lack of consensus indicates a missed opportunity for researchers to generate insights about the field that could facilitate conducting bibliometric studies and other research designs (e.g., systematic reviews) and also enable individuals to identify themselves as 'medical education researchers'. Other fields have utilised bibliometric field delineation, which is the assigning of articles or journals to a certain field in an effort to define that field.
PROCESS: In this Research Approach, three bibliometric field delineation approaches-information …
Non-Elderly Adults On Disability In The Cf Population, Lea Nolan, Semret Seyoum, Julanne Wilson, Marsha Regenstein
Non-Elderly Adults On Disability In The Cf Population, Lea Nolan, Semret Seyoum, Julanne Wilson, Marsha Regenstein
Health Policy and Management Issue Briefs
No abstract provided.
Library Involvement In Health Informatics Education For Health Professions Students And Practitioners: A Scoping Review., Deborah L Lauseng, Kristine M Alpi, Brenda M Linares, Elaine Sullo, Megan Von Isenburg
Library Involvement In Health Informatics Education For Health Professions Students And Practitioners: A Scoping Review., Deborah L Lauseng, Kristine M Alpi, Brenda M Linares, Elaine Sullo, Megan Von Isenburg
Himmelfarb Library Faculty Publications
Objective: The purpose of this scoping review is to evaluate the extent of library or librarian involvement in informatics education in the health domain.
Methods: We searched eight databases from their inception to 2019 for reports of informatics educational activities for health professionals or health professions students that involved library staff or resources. Two reviewers independently screened all titles/abstracts (n=2,196) and resolved inclusion decisions by consensus. From the full text of the 36 papers that met the inclusion criteria, we extracted data on 41 educational activities.
Results: The most frequent coded purposes of activities were "teaching clinical tools" (n=19, 46.3%) …
Medicare Support For Dental And Podiatry Graduate Medical Education Programs., Candice Chen, Yoonkyung Chung, Geoffrey Broadbent, Elizabeth Mertz
Medicare Support For Dental And Podiatry Graduate Medical Education Programs., Candice Chen, Yoonkyung Chung, Geoffrey Broadbent, Elizabeth Mertz
Health Policy and Management Faculty Publications
Importance: Oral health care faces ongoing workforce challenges that affect patient access and outcomes. While the Medicare program provides an estimated $14.6 billion annually in graduate medical education (GME) payments to teaching hospitals, including explicit support for dental and podiatry programs, little is known about the level or distribution of this public investment in the oral health and podiatry workforce.
Objective: To examine Medicare GME payments to teaching hospitals for dental and podiatry residents from 1998 to 2018, as well as the distribution of federal support among states, territories, and the District of Columbia.
Design, Setting, and Participants: This cross-sectional …
Evaluating Patient And Provider Satisfaction With The Use Of Telemedicine For Pediatric Pre-Anesthetic Assessment During The Covid-19 Pandemic, A. Campos, R. Taneja, A. Melwani, C. Challa, C. Vazquez-Colon, J. Cronin, S. Rana, G. Geng-Ramos
Evaluating Patient And Provider Satisfaction With The Use Of Telemedicine For Pediatric Pre-Anesthetic Assessment During The Covid-19 Pandemic, A. Campos, R. Taneja, A. Melwani, C. Challa, C. Vazquez-Colon, J. Cronin, S. Rana, G. Geng-Ramos
GW Research Showcase 2021-2024
No abstract provided.
Advancing And Promoting Community Health: Opportunities For Accountable Communities For Health And Community Health Centers, Helen Mittmann, Jeffrey Levi, Janet Heinrich, Feygele Jacobs, Rebecca Morris, Peter Shin
Advancing And Promoting Community Health: Opportunities For Accountable Communities For Health And Community Health Centers, Helen Mittmann, Jeffrey Levi, Janet Heinrich, Feygele Jacobs, Rebecca Morris, Peter Shin
Geiger Gibson/RCHN Community Health Foundation Research Collaborative
Executive Summary:
Accountable Communities for Health (ACHs) are multi -sector, community-based partnerships that aim to address community health and social needs, and Community Health Centers (CHCs) provide important community-based healthcare services for underserved and medically vulnerable populations. Given the critical role that both ACHs and CHCs play in addressing health-related social needs and social determinants of health, a survey of ACHs on CHC engagement was conducted to better understand opportunities and challenges for CHC participation in ACHs. This survey, along with follow-up conversations with ACH and CHC representatives, confirmed that ACHs and CHCs are natural partners in the effort to …
How To Launch And Continually Enhance An Effective Medical Campus Faculty Development Program: Steps For Implementation And Lessons Learned., Ellen Childs, Christy D. Remein, Robina M Bhasin, Angelique C Harris, Alyssa Day, Lisa M Sullivan, David L Coleman, Emelia J Benjamin
How To Launch And Continually Enhance An Effective Medical Campus Faculty Development Program: Steps For Implementation And Lessons Learned., Ellen Childs, Christy D. Remein, Robina M Bhasin, Angelique C Harris, Alyssa Day, Lisa M Sullivan, David L Coleman, Emelia J Benjamin
Health Sciences Education Research
Purpose: Drawing on the decade of experience of Boston University Medical Campus' Faculty Development Office, this paper reports strategies used to launch and continually improve faculty development programming within an academic health sciences campus.
Patients and Methods: The authors explain the steps that Boston University Medical Campus took to institute their set of faculty development programs, including an overview of resources on how to periodically conduct needs assessments, engage key institutional stakeholders, design and evaluate an array of programming to meet the needs of a diverse faculty, and institute real-time program modifications.
Results: In a step-by-step guide, and by highlighting …
Months Into The Covid-19 Pandemic, Community Health Centers Report Signs Of Improvement, But Face Financial Uncertainty, Jessica Sharac, James Hernandez, Feygele Jacobs, Peter Shin
Months Into The Covid-19 Pandemic, Community Health Centers Report Signs Of Improvement, But Face Financial Uncertainty, Jessica Sharac, James Hernandez, Feygele Jacobs, Peter Shin
Geiger Gibson/RCHN Community Health Foundation Research Collaborative
Executive Summary:
This policy brief reports on the COVID-19 experience of the nation’s community health centers over a six-month period, utilizing data from the Health Resources and Services Administration’s (HRSA’s) weekly Health Center COVID-19 Survey from April 3rd, 2020 to October 2nd, 2020. The data demonstrate that community health centers were immediately responsive to the public health crisis, initiating diagnostic testing for the COVID-19 virus, and adapting care such as telehealth to address patient needs. However, with visits down overall and limited financial relief, the pandemic has taken an enormous financial toll on health centers. Cumulative patient revenue losses over …
Sensors And Wearables In Oncology: A Study Of The Barriers And Facilitators To Adoption, Sam Hanna
Sensors And Wearables In Oncology: A Study Of The Barriers And Facilitators To Adoption, Sam Hanna
Doctor of Philosophy in Translational Health Sciences Dissertations
Innovation, although a subject of considerable debate (e.g., Baregheh et al., 2009; Christensen, 1997), can be defined as the introduction and dissemination of a new or a different idea into use or practice that drives impact (Solis and Sinfield, 2014). Many studies and editorials have highlighted the complexity of the United States health system and detailed the slow speed by which innovative ideas materialize into impactful innovations (Continuing America’s leadership (2017); England & Stewart (2007); Kannampallil, Schauer, Cohen & Patel (2011)). While there are many advances in sensor and wearable technologies in this instance, the adoption rate by oncologists has …
Getting Sexual And Gender Minority Health “Into The Brick And Mortar”: A Mixed Methods Implementation Study, Mandi Pratt-Chapman
Getting Sexual And Gender Minority Health “Into The Brick And Mortar”: A Mixed Methods Implementation Study, Mandi Pratt-Chapman
Doctor of Philosophy in Translational Health Sciences Dissertations
Sexual and gender minorities (SGM) have unique health risks and health care needs, but medical students receive little training on SGM health (Obedin-Maliver, et al., 2011). This mixed methods study sought to learn from curricular champions in diverse settings to apply lessons learned at the George Washington University (GW). Exploratory models that included eight potential predictor variables for six criterion variables were tested using multiple linear regression. Criterion variables were: knowledge, attitudes, and clinical preparedness measured by the Lesbian, Gay, Bisexual, and Transgender Development of Clinical Skills Scale (LGBT-DOCSS; Bidell, 2017); attitudes measured by the Attitudes Toward LGBT Patients Scale …
Improving Nursing Students’ Attitudes And Beliefs About Transgender Clients Through The Use Of A Simulated Clinical Experience, J. Alex Thompson Msn, M.Ed., Rn, Cne
Improving Nursing Students’ Attitudes And Beliefs About Transgender Clients Through The Use Of A Simulated Clinical Experience, J. Alex Thompson Msn, M.Ed., Rn, Cne
Doctor of Nursing Practice Projects
Background: Negative healthcare experiences may lead to poor health outcomes for transgender individuals, but nursing curricula give little attention to transgender healthcare. This study engaged nursing students in a simulated clinical experience (SCE) which featured a young adult transgender male in an acute care setting to determine whether participation would have a significant impact on student nurses’ attitudes and beliefs about transgender individuals.
Methods: The convergent parallel mixed-methods design used a one group pretest-posttest and a post-case debriefing interview to examine undergraduate nursing student attitudes and beliefs toward transgender individuals. Participants (N=27) reported their feelings via the Transgender Attitudes and …
Opioid Administration And Prescribing In Older Adults In U.S. Emergency Departments (2005-2015)., Erin M Marra, Maryann Mazer-Amirshahi, Peter Mullins, Jesse M Pines
Opioid Administration And Prescribing In Older Adults In U.S. Emergency Departments (2005-2015)., Erin M Marra, Maryann Mazer-Amirshahi, Peter Mullins, Jesse M Pines
Emergency Medicine Faculty Publications
Introduction: We assess trends in opioid administration and prescribing from 2005-2015 in older adults in United States (U.S.) emergency departments (ED).
Methods: We analyzed data from the National Hospital Ambulatory Medical Care Survey (NHAMCS) survey from 2005 to 2015. ED visits for painful conditions were selected and stratified by age (18-64, 65-74, 75-84, ≥ 85 years). We analyzed trends in opioid administration in the ED and prescribing at discharge to encounters ≥ 65 and assessed predictors of use using survey-weighted chi-square tests and logistic regression. Trends in the use of five commonly prescribed opioids were also explored.
Results: Opioid administration …
Shelburne And Clark’S Harbour Quit Smoking: A Community-Based Smoking Cessation Initiative Process Evaluation, Georgeann Lois Macdonald Mn: Dnp, Anp, Rn, Accn, Np
Shelburne And Clark’S Harbour Quit Smoking: A Community-Based Smoking Cessation Initiative Process Evaluation, Georgeann Lois Macdonald Mn: Dnp, Anp, Rn, Accn, Np
Doctor of Nursing Practice Projects
Background: The prevalence of Canadian smokers is 14.6%. Clark’s Harbour and Shelburne’s rate of smoking increased from 15.6% in 2012 to 19.4% in 2015 (Propel Centre for Population Health Impact, 2015). It was imperative that innovative ways be found to reduce the smoking prevalence.
Objectives: 1) Identify a difference in the participants’ Stages of Change before and after completing the smoking cessation program. 2) Determine whether the participants quit smoking 3) Assess whether there was satisfaction with the program.
Methods: In this one group pre and post-test design, the participants completed a series of pre and post program questionnaires. The …
Assessing Employee Needs To Enhance A Workplace Wellness Program, Paige Herschend, Dnp, Msn, Bsn, Ba
Assessing Employee Needs To Enhance A Workplace Wellness Program, Paige Herschend, Dnp, Msn, Bsn, Ba
Doctor of Nursing Practice Projects
Background: Workplace wellness programs are increasingly prevalent, but their designs vary dramatically. While successful programs differ, those that are coordinated, comprehensive, and planned intentionally to address specific workplace needs have been found most beneficial.
Objective: This project assessed the perceived health status and wellness needs of employees at one company to determine whether its workplace wellness program could be enhanced.
Methods: This project focused on one site of a large, multi-state company. A retrospective review of data from an employees’ health and wellness survey was performed. Univariate and bivariate statistics were used to analyze the relationships among …
Referral Patterns From Long-Term Care Services To Palliative Care: Perceptions Of Directors Of Nursing, Karen S. Sharrah, Dnp, Msn, Aprn, Fnp-C
Referral Patterns From Long-Term Care Services To Palliative Care: Perceptions Of Directors Of Nursing, Karen S. Sharrah, Dnp, Msn, Aprn, Fnp-C
Doctor of Nursing Practice Projects
Background: Palliative care referrals are important in long-term care facilities because they are the first step in generating the services that the patient may need. This study looked at the phenomena of how Directors of Nursing in long-term care facilities that had access to palliative care services determined if a referral was needed.
Objectives: The purpose of this study was to gain a deeper understanding of the decision- making process used by Directors of Nursing for referrals. The study’s aims were to determine what factors prompt a referral in long-term care settings. The primary research question was: How …
Acute Cardiac Air Embolism, Leslie Billello, Brian Gacioch, James P. Phillips
Acute Cardiac Air Embolism, Leslie Billello, Brian Gacioch, James P. Phillips
Emergency Medicine Faculty Publications
No abstract provided.
Adoptive T Cell Therapy For Epstein-Barr Virus Complications In Patients With Primary Immunodeficiency Disorders, L Mclaughlin, Catherine Bollard, Michael D. Keller
Adoptive T Cell Therapy For Epstein-Barr Virus Complications In Patients With Primary Immunodeficiency Disorders, L Mclaughlin, Catherine Bollard, Michael D. Keller
Pediatrics Faculty Publications
Patients with primary immunodeficiency disorders (PID) have an increased risk from acute and chronic Epstein-Barr Virus (EBV) viral infections and EBV-associated malignancies. Hematopoietic stem cell transplantation (HSCT) is a curative strategy for many patients with PID, but EBV-related complications are common in the immediate post-transplant period due to delayed reconstitution of T cell immunity. Adoptive T cell therapy with EBV-specific T cells is a promising therapeutic strategy for patients with PID both before and after HSCT. Here we review the methods used to manufacture EBV-specific T cells, the clinical outcomes, and the ongoing challenges for future development of the strategy. …
The Pathology Workforce And Clinical Licensure, Robin Lorenz, Donald S. Karcher, Michael Gautreaux, Melvin Limson, Dani Zander
The Pathology Workforce And Clinical Licensure, Robin Lorenz, Donald S. Karcher, Michael Gautreaux, Melvin Limson, Dani Zander
Pathology Faculty Publications
There has been a recent recognition of the need to prepare PhD-trained scientists for increasingly diverse careers in academia, industry, and health care. The PhD Data Task Force was formed to better understand the current state of PhD scientists in the clinical laboratory workforce and collect up-to-date information on the training and certification of these laboratorians. In this report, we summarize the findings of the PhD Data Task Force and discuss the relevance of the data collected to the future supply of and demand for PhD clinical laboratory scientists. It is clear that there are multiple career opportunities for PhD …
Knowledge Retention Across Curricular Models: An International Collaboration, Rosalyn Jurjus, Abdo Jurjus, Gisela Butera
Knowledge Retention Across Curricular Models: An International Collaboration, Rosalyn Jurjus, Abdo Jurjus, Gisela Butera
Anatomy and Regenerative Biology Faculty Posters and Presentations
Program symposium.
Clinician-Investigator Training And The Need To Pilot New Approaches To Recruiting And Retaining This Workforce., Alison K Hall, Sherry L Mills, P Kay Lund
Clinician-Investigator Training And The Need To Pilot New Approaches To Recruiting And Retaining This Workforce., Alison K Hall, Sherry L Mills, P Kay Lund
Neurology Faculty Publications
Clinician–investigators, also called physician–scientists, offer critical knowledge and perspectives that benefit research on basic science mechanisms, improved diagnostic and therapeutic approaches, population and outcomes medicine, health policy, and health services, yet few clinically trained health professionals pursue a research career. Sustaining this workforce requires attention to the unique challenges faced by investigators who must achieve clinical and research competence during training and their careers. These challenges include the duration of required clinical training, limited or discontinuous research opportunities, high levels of educational debt, balancing the dual obligations and rewards of clinical care and research, competition for research funding, and the …
Gw Nursing, Fall 2017, George Washington University, School Of Nursing
Gw Nursing, Fall 2017, George Washington University, School Of Nursing
GW Nursing Magazine
No abstract provided.
T-Cell Responses Targeting Hiv Nef Uniquely Correlate With Infected Cell Frequencies After Long-Term Antiretroviral Therapy., Allison S Thomas, Kimberley L Jones, Rajesh T Gandhi, Deborah K Mcmahon, Joshua C Cyktor, Dora Chan, Szu-Han Huang, Ronald Truong, Alberto Bosque, Amanda B Macedo, Colin Kovacs, Erika Benko, Joseph J Eron, Ronald J Bosch, Christina M Lalama, Samuel Simmens, Bruce D Walker, John W Mellors, R Brad Jones
T-Cell Responses Targeting Hiv Nef Uniquely Correlate With Infected Cell Frequencies After Long-Term Antiretroviral Therapy., Allison S Thomas, Kimberley L Jones, Rajesh T Gandhi, Deborah K Mcmahon, Joshua C Cyktor, Dora Chan, Szu-Han Huang, Ronald Truong, Alberto Bosque, Amanda B Macedo, Colin Kovacs, Erika Benko, Joseph J Eron, Ronald J Bosch, Christina M Lalama, Samuel Simmens, Bruce D Walker, John W Mellors, R Brad Jones
Microbiology, Immunology, and Tropical Medicine Faculty Publications
HIV-specific CD8+ T-cell responses limit viral replication in untreated infection. After the initiation of antiretroviral therapy (ART), these responses decay and the infected cell population that remains is commonly considered to be invisible to T-cells. We hypothesized that HIV antigen recognition may persist in ART-treated individuals due to low-level or episodic protein expression. We posited that if persistent recognition were occurring it would be preferentially directed against the early HIV gene products Nef, Tat, and Rev as compared to late gene products, such as Gag, Pol, and Env, which have higher barriers to expression. Using a primary cell model of …
Impact Of Larger Sputum Volume On Xpert(®) Mtb/Rif Assay Detection Of Mycobacterium Tuberculosis In Smear-Negative Individuals With Suspected Tuberculosis., Sharlaa Badal-Faesen, Cynthia Firnhaber, Michelle A Kendall, Xingye Wu, Beatriz Grinsztejn, Rodrigo Otavio Da Silva Escada, Michel Fernandez, Evelyn Hogg, Ian Sanne, Pamela Johnson, David Alland, Gerald H Mazurek, Debra A Benator, Anne F Luetkemeyer
Impact Of Larger Sputum Volume On Xpert(®) Mtb/Rif Assay Detection Of Mycobacterium Tuberculosis In Smear-Negative Individuals With Suspected Tuberculosis., Sharlaa Badal-Faesen, Cynthia Firnhaber, Michelle A Kendall, Xingye Wu, Beatriz Grinsztejn, Rodrigo Otavio Da Silva Escada, Michel Fernandez, Evelyn Hogg, Ian Sanne, Pamela Johnson, David Alland, Gerald H Mazurek, Debra A Benator, Anne F Luetkemeyer
Medicine Faculty Publications
As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5–10 mL) were tested with Xpert® MTB/RIF from 176 individuals with smear-negative sputum undergoing tuberculosis evaluation. Despite larger volumes, this strategy had a suboptimal sensitivity of 50% (4/8)
Penile Anaerobic Dysbiosis As A Risk Factor For Hiv Infection, Cindy Liu, Jessica Prodger, Aaron Tobian, Alison Abraham, Godfrey Kigozi, Lance B. Price, +Several Additional Authors
Penile Anaerobic Dysbiosis As A Risk Factor For Hiv Infection, Cindy Liu, Jessica Prodger, Aaron Tobian, Alison Abraham, Godfrey Kigozi, Lance B. Price, +Several Additional Authors
Environmental and Occupational Health Faculty Publications
Sexual transmission of HIV requires exposure to the virus and infection of activated mucosal immune cells, specifically CD4+ T cells or dendritic cells. The foreskin is a major site of viral entry in heterosexual transmission of HIV. Although the probability of acquiring HIV from a sexual encounter is low, the risk varies even after adjusting for known HIV risk factors. The genital microbiome may account for some of the variability in risk by interacting with the host immune system to trigger inflammatory responses that mediate the infection of mucosal immune cells. We conducted a case-control study of uncircumcised participants …
Alternative Splicing Promotes Tumour Aggressiveness And Drug Resistance In African American Prostate Cancer., Bi-Dar Wang, Kristin Ceniccola, Sujin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A Freedman, Jacqueline Olender, Stefan Knapp, Travers Ching, Lana Garmire, Vyomesh Patel, Mariano A Garcia-Blanco, Steven R Patierno, Norman H Lee
Alternative Splicing Promotes Tumour Aggressiveness And Drug Resistance In African American Prostate Cancer., Bi-Dar Wang, Kristin Ceniccola, Sujin Hwang, Ramez Andrawis, Anelia Horvath, Jennifer A Freedman, Jacqueline Olender, Stefan Knapp, Travers Ching, Lana Garmire, Vyomesh Patel, Mariano A Garcia-Blanco, Steven R Patierno, Norman H Lee
Pharmacology and Physiology Faculty Publications
linical challenges exist in reducing prostate cancer (PCa) disparities. The RNA splicing landscape of PCa across racial populations has not been fully explored as a potential molecular mechanism contributing to race-related tumour aggressiveness. Here, we identify novel genome-wide, race-specific RNA splicing events as critical drivers of PCa aggressiveness and therapeutic resistance in African American (AA) men. AA-enriched splice variants of PIK3CD, FGFR3, TSC2 and RASGRP2 contribute to greater oncogenic potential compared with corresponding European American (EA)-expressing variants. Ectopic overexpression of the newly cloned AA-enriched variant, PIK3CD-S, in EA PCa cell lines enhances AKT/mTOR signalling and increases proliferative …
A Novel Micro Cold Atmospheric Plasma Device For Glioblastoma Both In Vitro And In Vivo., Zhitong Chen, Hayk Simonyan, Xiaoqian Cheng, Eda Gjika, Li Lin, Jerome Canady, Jonathan H Sherman, Colin Young, Michael Keidar
A Novel Micro Cold Atmospheric Plasma Device For Glioblastoma Both In Vitro And In Vivo., Zhitong Chen, Hayk Simonyan, Xiaoqian Cheng, Eda Gjika, Li Lin, Jerome Canady, Jonathan H Sherman, Colin Young, Michael Keidar
Pharmacology and Physiology Faculty Publications
: Cold atmospheric plasma (CAP) treatment is a rapidly expanding and emerging technology for cancer treatment. Direct CAP jet irradiation is limited to the skin and it can also be invoked as a supplement therapy during surgery as it only causes cell death in the upper three to five cell layers. However, the current cannulas from which the plasma emanates are too large for intracranial applications. To enhance efficiency and expand the applicability of the CAP method for brain tumors and reduce the gas flow rate and size of the plasma jet, a novel micro-sized CAP device (µCAP) was developed …