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Synthesis, Characterization, Molecular Docking, And Anticancer Activity Of Triazole-Derived Trinuclear Metal Complexes (Tat3), Eman M. Ramadthan, Khansaa Shakir Al-Nama, Ammar H. Al-Sabawi

Baghdad Science Journal

A novel series of trinuclear coordination complexes of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) was synthesized using a triazole-based ligand, namely 4-amino-5-((bis((4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)amino)methyl)-2H-1,2,4-triazole-3(4H)-thione, (TAT3) in an alcoholic medium. The obtained complexes were investigated using a comprehensive set of physicochemical and spectroscopic techniques, including CHNS elemental analysis, Fourier-transform infrared (FT-IR) spectroscopy, UV–visible spectroscopy, proton and carbon-13 nuclear magnetic resonance (¹H and ¹³C-NMR), mass spectrometry, magnetic susceptibility measurements, and molar conductivity. Structural and surface morphology assessments were further carried out using X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). The spectroscopic and analytical data confirmed that …

Synthesis, Spectroscopic Characterization, Biological And Computational Study For Some Metal Ions Complexes With Schiff - Mannich Base Ligand Derived From 1,3,4-Thiadiazole, Israa Rasheed Ghadhban, Shaymaa R. Baqer

Baghdad Science Journal

A new Schiff–Mannich base ligand derived from 1,3,4-thiadiazole was synthesized via the reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with sulfabenzamide and indoline in the presence of formaldehyde, yielding N–(4-((5-(2-oxoindolin-3-ylideneamino)-1,3,4-thiadiazol-2-ylthio)methylamino) phenyl thiolperoxy) benzamide (L). Six multivalent metal complexes were subsequently prepared with Co(II), Ni(II), Cu(II), Pd(II), Pt(IV), and Au(III) ions. The ligand and its complexes were characterized using various spectroscopic techniques, including FT-IR, UV-Vis, ¹H NMR, and ¹³C NMR, while magnetic susceptibility and conductivity measurements were performed for the complexes. Infrared analysis revealed tetradentate coordination of the ligand to all metals, with octahedral geometries for most complexes and square planar geometries for …

Synthesis, Characterization, And Biological Evaluation Of A New Azo Dye Ligand 1-[2,4,6-Trihydroxy-3-(2-Hydroxy-Phenylazo)-Phenyl-Ethanone] And Its Complexes With Co(Ii), Ni(Ii), Cu(Ii), Zn(Ii), And Cd(Ii), Ban Hasan Al-Agele, Areej Kamal Assim Aldabbagh

Baghdad Science Journal

1-[2,4,6-trihydroxy-3-(2-hydroxy-phenylazo)-phenyl-ethanone] is a new azo dye ligand (H₂L), which was used to form a number of new azo dye-metal complexes by reaction with salt chlorides of Co, Ni, Cu, Zn and Cd(II). The complexes were characterized using mass spectroscopy, infrared analysis, ultraviolet-visible spectrophotometry, ¹H-, ¹³C-NMR spectroscopy, conductivity, magnetic susceptibility, DSC, TGA, C.H.N., metal content, and melting point. The results highlighted the ligand's trigonal behavior and that all the complexes yielded tetrahedral geometry, with the exception of Co and Ni, which produced octahedral geometry. They are all non-electrolytic. The compounds' capacity to function as antioxidants was used …

Synthesis, Characterization, And Biological Potentials Of Chalcones Derivatives, Acer Juma Hamad, Hamdia Hateem Jawad, Kadhim Abdulwahid Aadim

Baghdad Science Journal

This work aims at synthesizing chalcone derivatives using Acetophenone and benzaldehyde derivatives as the primary components. The chalcone compounds [1, 2, 3, 4, 5] have been produced through Claisen-Schmidt condensation reaction, which involves combining benzaldehyde derivatives (such as 4-bromobenzaldehyde, 4-hydroxybenzaldehyde, 4-(dimethyl amino)benzaldehyde, and o-Nitro benzaldehyde) with acetophenone or its derivatives. This reaction takes place when an aqueous solution of sodium hydroxide and ethanol are combined at room temperature. The generated products were examined employing carbon-13 nuclear magnetic resonance ¹³C-NMR, proton nuclear magnetic resonance ¹H-NMR, ultraviolet (UV), and infrared (IR) spectroscopic techniques. Each compound was tested to determine how …

Determination Of Trace Pyridoxine Hydrochloride (Vitamin B6) In Dosage Forms And Redbull Samples Using Dispersive Liquid-Liquid Microextraction Technique Coupled With Spectrophotometry, Sally Ghanem Ahmed, Wijdan Shakir Khayoon

Baghdad Science Journal

This paper introduced a sensitive determination method measurement spectrophotometric coupled with dispersive liquid-liquid micro extraction based on charge transfer complex formation between pyridoxine hydrochloride and chloranil using alkaline buffer (pH = 10.5). After that, the extraction of charge transfer complex was conducted by injection a mixture of chloroform and acetone solvents followed by spectrophotometric measurement of tiny organic droplets at λ = 535 nm. The important parameters affecting the formation of the complex and efficiency of DLLME such as concentration of chloranil, volume and pH of buffer solution, reaction time and the optimum conditions of DLLME has been studied and …

Preparation, Characterization, And Antimicrobial Evaluation Of A Cefepime Derivative With Divalent Transition Metals, Zahraa A. Jaber, Israa H. Ibraheem, Sahar S. Hassan

Baghdad Science Journal

The Schiff base ligand (L)- 1-((7-((Z), was recently synthesized 2–(2-((Z)–5,5-diethyl2-(methoxyimino)acetamido)-2-(methoxycarbonyl)-2,6-dioxotetrahydropyrimidin-4(1H)-ylideneamino) thiazol-4-yl8-oxo-5-thia , the next mineral ions, Ni²⁺, Cu²⁺, Zn²⁺, and Co²⁺, are permitted to react with 1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-methylpyrrolidinium, leading to the formation of new metal complexes with distinct geometric shapes. By detecting the shifting in the azomethines band and the appearance of M-N and M-O bands, FT-IR confirmed the occurrence of coordination through N of azobenzene and two O atoms of beta lactam and ester, indicating the development of Schiff base complexes as well as the original Schiff base. Additionally, we can use …

In Silico Study Of N-Pyrazoline Derivate Compounds As Anticancer Through Inhibition Of Pi3k And Pr Expression, Denny Satria, Syukur Berkat Waruwu, Eti Nurwening Sholikhah, Mustofa Mustofa, Pamungkas Bagus Satriyo, Tutik Dwi Wahyuningsih, Hesti L Wiraswati, Ema Damayanti

Baghdad Science Journal

Breast cancer treatment has many options directed at therapeutic targets, but some remain incurable, so new therapies are needed. Pyrazoline has shown various biological activities, one of which is anticancer effectiveness. The purpose of this study was to conduct an in silico analysis of Pyrazoline inhibition of PI3K and PR proteins using docking and MD simulation methods. Predictions of toxicity and pharmacokinetics, including absorption, distribution, metabolism, excretion, and toxicity, were also conducted computationally. The analysis showed that the Pyrazoline compound had interactions with ligands of PI3K proteins and PR proteins. Pharmacokinetic predictions showed that the compound in the human intestine …

Synthesis, Characterization, Antioxidant Content And Antibacterial Study Of New Ligand And Its Complexes From Sulfonic Acid And 2-Phthalaldehyde, Mawlood Khalid Mawlood, Wurood Ali Jaafar

Baghdad Science Journal

The research includes preparation of a new Schiff base from the condensation of sulfonic acid with 2-phthalaldehyde by dissolving (0.2 g, 0.346 mmole) of the ligand (L) in (10 ml) of absolute ethanol, then 0.06 g of potassium hydroxide (KOH) dissolved in 10 ml of distilled water added to it and reacting the product with some binary metal salts (Mn, Co, Ni, Cu, Cd, Zn, Pt, Hg). The biological study was conducted against two types of gram-positive and gram-negative bacteria, Staphylococcus. aureus and Escherichia coli, and the fungus Candida albicans was also used. All the prepared complexes showed …

Synthesis, Characterization And Biological Activity Studies Of New Metal Ion Complexes With Schiff Base Derived From (Z)-3-Hydrazineylidene-1-Phenylpyrazolidine And Evaluating Them As Antioxidants, Zahra Mounir Ahmed, Naser Shaalan

Baghdad Science Journal

The research includes the preparation of several complexes of the transition elements and zinc where M(II) = Co, Ni, Cu, and Zn, containing the 3d shell, with ligand (LH)was synthesized by treating the (Z)-3-hydrazineylidene-1-phenylpyrazolidine and Salicylaldehyde. Ligand (LH) was identified using FT-IR spectra,¹H-¹³C-NMR, UV-Vis spectroscopy, elemental microanalysis CHN and mass spectrometry. The complexes were studied and identified with elemental microanalysis CHN, FT-IR spectroscopy, UV-Vis spectroscopy, conductivity measurement, and magnetic sensitivity. The result showed that, these complexes were classified as homogeneous tridentate complexes with the formula [M(LH) (H₂O)₂Cl] or [M(LH)₂]. xH …

Azo-Schiff Type Ligands Derived From Curcumin And Their Complexes With Transition Metals, Synthesis, Characterization And Bioactivity Studies, Fatima Rasheed Ali, H. A. Hassan

Baghdad Science Journal

In this work the precursor (W1) 2,2'-((1E,1'E)-(4,4'-diamino-5,5'-dimethyl-[1,1'-biphenyl]Diazene-2,1-diyl-3,3’-diyl)-bis((E)-pyridin-3-yldiazenyl)-[1,1'-biphenyl] or (W2) 3,3'-dimethyl-5,5'-bis((E)-pyridin-3-yldiazenyl)-[1,1'-biphenyl] -4,4'-diamine respectively were obtained from the reaction of 2-aminophenol or 2-aminopyridine with toluidine, respectively. Subsequently, these precursors were used for the synthesis of two ligands using the azo compounds (W1) or (W2) and curcumin to produce [H₄L¹] 4,4',4^'', 4^'''-((1E,1'E,6E,6'E)-((3,3'-bis((E)-(2-hydroxyphenyl)diazenyl)-5,5'-dimethyl-[1,1'-bi phenyl]-4,4'-diyl)bis(azaneylylidene))bis(5-hydroxyhepta-1,6-diene-1,7-diyl-3-ylidene))bis(azaneylylidene))bis(aza -neylylidene))tetrakis(2-methoxyphenol) or [H₂L²] 4,4',4^'',4^'''-((3,3'-dimethyl-,4,4'-diyl)bis- (azaneylylidene))bis(5-hydroxyhepta-1,6-diene-1,7-diyl-3-ylidene))tetrakis(2-methoxyphenol). The prepared ligands were characterized by F.T-I.R, U.V, ¹H-NMR,¹³C-NMR spectroscopy. This work also included the preparation of complexes through the reaction of ligands with the metal …

Synthesis, Spectral Characterization, Cytotoxic Assay, And Antimicrobial Evaluation Studies Of Some Transition Metal Complexes Of Schiff Base Derived From Amoxicillin, Alya’A J. Ahmed, Amaal S. Sadiq, Enaam Fadil Mousa, Mahasin Alias

Baghdad Science Journal

Four metal complexes of Schiff base ligand were prepared. To characterize both the ligand and the metal complexes, various techniques were employed, including elemental analysis, FT-IR spectroscopy, UV-Vis spectroscopy, molar conductivity measurements, magnetic moment determination, melting point, mass spectroscopy, ¹H-NMR and ¹³C-NMR spectroscopy. The results showed that the metal complexes formed have the formula [M(L)₂Cl₂]Cl_(n).H₂O, where L= Schiff base ligand and M=Cr(III), Rh(III), Pt(IV) and Au(III), n = 1, 2. Based on spectroscopic analysis, coordination with metal ions involves the ’N’ donor atom of N atoms of the imine and …

Synthesis, Characterization, And Theoretical Investigation Of The Effectiveness As Anti-Corrosion For Chalcone Derivatives, Acer Juma Hamad, Hamdia Hateem Jawad, Kadhim A. Adem

Baghdad Science Journal

In this research, the focus was on preparing a number of chalcone derivatives using the Claisen-Schmidt reaction method through the reaction of some benzaldehyde derivatives with acetophenone substitutes in the presence of a basic medium represented by (NaOH) at a concentration of 10%. The benzaldehyde derivatives and acetophenone derivatives were also dissolved in ethanol at a concentration of 98%. Before starting the preparation, a number of chalcone derivatives were banned, which were prepared and referred to as [Ch1, Ch2,Ch3, Ch4, Ch5]. The substitutes that were used in the preparation were 4-chlorobenzaldehyde, 4-aminoacetophenone, benzaldehyde, 3-Nitroacetophenone, 4-Nitrobenzaldehyde. Acetophenone ,2-4-dichlorobenzaldehyde, and 4-(dimethylamino)benzaldehyde. The …

Synthesis, Characterization, And An Evaluation Of The Biological Activities Of Some New Transition Metal Complexes With Organic Ligand, Ghadeer Alataby, Areej Kamal Assim Aldabbagh

Baghdad Science Journal

The reaction between triethylorthoformate and p-chlorophenyl resulted in formation of N,N'-bis-(p-chlorophenyl)formamidine ligand. Subsequently, this ligand interacted with the following metal ions (Co⁺², Ni⁺², Cu⁺², Cr⁺³ and Ru⁺³) creating air-stable complexes with formula [M(L)₂(H₂O)_n(Cl)_x](X= 0, 1) with distinct octahedral morphologies. The formation of these compounds was identified using mass spectroscopy (MS), which validated the acquired geometries. Fourier transform infrared (FT-IR) spectroscopy analysis demonstrated how the formamidine group formed and how it coordinated with the metal ions. Studies using pyrolysis (Thermogravimetric analysis (TGA) …

Synthesis, Characterization And Studying Biological Activity Of New Schiff Base Compounds Derived From “N-[(4-Hydroxy-3-Methoxyphenyl) Methyl]-8-Methyl-(E)-6-Nonenamide”, Huda Salman Hassan, Sana Hitur Awad

Baghdad Science Journal

This research includes synthesizing new bis-Schiff bases linked to“N-[(4-hydroxy-3-methoxyphenyl) methyl]-8-methyl-(E)-6-nonenamide” derivatives. This work involved ring opening of phathalic anhydride by hydroxyl groups in “N-[(4-hydroxy-3-methoxyphenyl) methyl]-8-methyl-(E)-6-nonenamide” then, they were reacted with thiourea to synthesize Schiff bases by the reaction of different aldehydes. The first step involved the condensation reaction between “N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-(E)-6-nonenamide” (H) and phthalic anhydride to produce(H1). In the second step, compound H1 was reacted with one mol of thiourea to produce maliamic compound (H2). The third step involved the preparing of Schiff bases derivatives, by the reaction of (H2) with different aldehyde to produce compounds (H3 and H4). These compounds …

Synthesis, Characterization And Studying Mass Spectra And Thermal Analysis For Complexes Of Some Metal Ions And Determining Their Activity As Antioxidants, Fatimah Al-Zahraa Sh. H, Abbas Ali Salih Al-Hamdani

Baghdad Science Journal

The new azo dye was prepared from the reaction of the diazonium salt derived from 3-aminophenol with 2-hydroxyquinoline, then it was used to prepare a series of complexes with the chlorides of cobalt, chromium, copper, nickel, platinum, palladium and ammonium molybdate. The ligand was identified by a proton and carbon nuclear magnetic resonance spectroscopy, and the compounds were collected. The prepared materials were subjected to infrared, ultraviolet-visible, and mass spectrometry, as well as thermogravimetric analysis, differential calorimetry, and elemental analysis. Conductivity, magnetic susceptibility, metal content, and chlorine content of the complexes were also measured. The results showed that the ligand …

Green Synthesis, Characterization, Antimicrobial And Anticancer Studies Of Vanadium Oxide Nanoparticles Using Vitex Agnus Castus Extract, Saba H. Mahdi, Lekaa K. Abdul Karem

Baghdad Science Journal

This study, vanadium oxide nanoparticles were synthesized using the biosynthesis method. The resulting VO₂ NPs are characterized by their cost-effectiveness, ease of use, and safety. Vanadium Nano oxide was prepared from vanadium sulfate monohydrate with a plant extract of Vitex agnus castus at a sodium hydroxide concentration of 0.1 M. The reaction was carried out in an alkaline medium at pH range of 8–12, which were characterized by using many techniques such as; Fourier transform IR spectroscopy, ultraviolet-visible spectroscopy, x-ray diffraction XRD, transmission electron microscopy TEM, scanning electron microscopy SEM and EDX pattern. The crystal size of nanoparticles, determined …

Synthesis And Biological Study Of Schiff–Mannich Base Derived From 2-Mercaptobenzimidazole As Chelated Tridentate Ligand With Some Transition Metal Ions Complexes, Thuraya Q. Sabah, Shaymaa R. Baqer

Baghdad Science Journal

To prepare a new ligand, many compounds were used to synthesize Schiff-Mannich base, such as isatin, Para chloro Aniline, 2-mercaptobenzimidazole and indole. The resulting compound 1-((2-((1H-indol-1-ylthio)-1H-benzo[d]imidazol-1-yl)methyl)-3-(4-chlorophenylimino)indolin-2-one (L). (L) was used to create a series of metal ion complexes with Co (II), Ni (II), Cu (II), Pd (II), Pt (IV), and Au (III). C.H.N.S., FTIR, mass spectra UV-ViS, 1H-NMR, 13CNMR, magnetic moment, and molar conductivity were used to characterize all of these compounds. Except for the palladium(II) and gold(III) complexes, all of the produced complexes had an octahedral geometry, according to the data. The antibacterial activity of the produced compounds was …

Preparation And Characterization And Biological Activity Of New Complexes For Some Transition Elements With Schiff Bases Derived From One Antipyrine Substitute, Zeena U. Jasim, Amal M. Ali, Heba A. Mohammed, Maher A. Mohammed

Baghdad Science Journal

A group of divalent complexes was prepared in the formula [M(L)Cl₂] when M=Co⁺², Ni⁺², Cu⁺², Zn⁺², and Cd⁺² L= (Z)-4-((1-(H-indol-3-yl)ethylidene)amino)1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one. The Schiff base ligand is prepared by reacting 4-aminoantipyrine with 3-acetylindol. The prepared ligand and complexes were identified by elemental analysis, an infrared spectrometer, the nuclear magnetic resonance spectrum, molar electrical conductivity, electronic spectra, magnetic susceptibility, atomic absorption of the elements, and biological efficiencies. The measurements showed that the synthesized ligand interacts with the central metal ion through the oxygen carbonyl group and nitrogen azomethine atoms, that the coordination …

Synthesis, Characterization And Biological Activity Of New Ligand Derived From 4-(Dimethylamino) Benzaldehyde And Nano Copper Complex, Enass J. Waheed

Baghdad Science Journal

The general formula of new complexes [M₂(BDS)Cl₄] are resulting from the reaction of a new ligand [N1, N4- bis (1H- benzo [d] imidazol- 2- yl) -N1, N4 -bis(4-(dimethyl amino) benzyl) succinimide] (BDS) with metal ions M(II) = Cd, Co, Hg, Cu and Ni. This ligand was derived from the reaction of the three substances 4-(Dimethyl amino) benzaldehyde, 2-amino benzimidazole, and succinyl chloride. The compounds are characterized by FT-IR, NMR, UV-Vis and Mass spectroscopy. The serine protease SplB of Staphylococcus aureus and the A chain of Rhomboid-protease-GLPG of Escherichia coli were chosen to study the binding strength …

Synthesis, Characterization And Studying Thermal Analysis For Complexes Of Some Metal Ions And Determining Their Activity As Antioxidants, Rasha Khider Hussain Al-Daffay, Abbas Ali Salih Al-Hamdani, Emran Abduljabbar Emran Elluhaibi

Baghdad Science Journal

According to previous studies, a new azo ligand (N-(3-acetyl-2-hydroxy-5-methyl-phenyl)N-(4-carboxy-cyclohexylmethyl)-diazonium salt) was prepared and after verifying the proposed formula according to the results of the analyzes and after using Ligand to prepare a series of complexes using equal molar ratios (1:1) of the ligand and its reaction with each of the salts of manganese, cobalt, nickel, copper and zinc, and after verification according to spectroscopic (ultraviolet and infrared) and diagnostic analysis techniques, which gave tetrahedral shapes for all complexes in a neutral formula, and the ligand is tridentate (NOO) related to azo, ketonic and phenolic hydroxyl group, respectively. Then, the thermal …

Synthesis, Characterization, And Thermal Studying Of Vo(Ii), Cu(Ii), Zn(Ii), Cd(Ii), And Au(Iii) Complexes With Azo Dye And Evaluation As Antioxidants, Areeg Malek Fadhel, Abbas Ali Salih Al-Hamdani, Wail Al Zoubi

Baghdad Science Journal

Complexes of Vanadyl, Copper, Zinc, Cadmium, and Aureate with their double valence and Aureate with its triple valence were prepared using the azo dye (2,4,6-trihydroxy-3-((3-hydroxyphenyl) dixenyl)phenyl)ethane-1-one prepared newly from diazonium salt With 2,4,6-trihydroxyacetophenone, after isolation. The prepared materials were identified by available spectroscopic methods and diagnostic techniques for C.H.N, IR, UV-Vis, ¹H&¹³C-NMR, Mass, thermogravimetric analysis curve, differential scanning calorimetry, and complexes, these techniques included as well as determining the metal percentage, determining the chlorine content, magnetic susceptibility, and molar conductivity. The results showed that the ligand is anionic (negative) tetradentate when coordinated with Vanadyl, Copper, Zinc, Cadmium …

Studies In Natural Product-Inspired Complex Molecule Synthesis: Synthesis Of 26-Norpentacyclic Triterpenoids And Anhydroryanodol, Zachary D. Stempel

Dartmouth College Ph.D Dissertations

Natural products have long served as a stimulus for growth and innovation to advance the field of organic chemistry. This thesis describes efforts in complex molecule synthesis that demonstrate the broad value of programs in natural product total synthesis and natural product-inspired function-oriented synthesis. The first part of this thesis describes a function-oriented synthesis approach to pentacyclic triterpenoids through design of a simplified 26-norpentacyclic triterpenoid platform to promote future medicinal exploration in this area. These studies yielded a divergent asymmetric synthesis of 26-norgermanicol and 26-norlupeol as well as the discovery of a new class of androgen receptor antagonist that is …

Functionalized 1,4-Naphthoquinone-Annulated N-Heterocyclic Carbenes For Biomedical Applications, Dilsha Samanali Wickramasinghe

Browse all Theses and Dissertations

Gold has long been recognized for its medicinal applications, dating back centuries. The use of N-heterocyclic carbenes (NHCs), stable, tunable ligands, has revolutionized the development of metal complexes, particularly those involving gold. Among these, Au-NHC complexes have shown significant promise in treating various diseases, especially arthritis and cancer. More recently, our research has focused on synthesizing dual-targeting naphthoquinone-annulated NHC-based gold(I) complexes, which have demonstrated impressive therapeutic potential in cancer treatment. This emphasizes the growing importance of gold-based complexes in developing more selective and effective cancer therapies. By strategically tuning the electronic and steric properties of these complexes, we have explored …

Synthetic Studies Of Colibactin, A Carcinogenic Gut Microbiome Metabolite, Kevin Mark Wernke

Yale Graduate School of Arts and Sciences Dissertations

The human microbiota is now understood to be intimately linked to host physiology. Recent studies indicate that microbiota species which possess a biosynthetic gene cluster – termed clb – contribute to the development and progression of colorectal cancer. Bacteria possessing the clb gene cluster are correlated to colorectal cancer (CRC) in humans, initiate colonic tumor and polyp formation in murine models, and induce DNA interstrand cross-links in cell models. Furthermore, clb+ bacteria induce a unique mutational signature which has been detected in a number of human tumor samples. Early studies by Oswald and co-workers established that the final product of …

Gene Vectors With Fluorescence Tracking Capabilities, Sophia Despina Angelopoulos

Browse all Theses and Dissertations

This project focuses on the optimization of benzothiazole-based chromophores to utilize them as fluorescent tags functionalized onto stimuli-responsive, or “smart,” polymers as non-viral gene delivery vectors for gene therapy applications. Blue-fluorescent emissive chromophores will allow tracking capabilities for the transfection pathway of the vector to be monitored as it delivers the DNA payload within intercellular space. The most appropriate chromophore must be covalently bound to a free amine within the vector, which is accomplished through NAS chemistry from fluorophenyl-benzothiazoles (F-BTZ-CBz) derivatives to amidated hyperbranched poly(ethyleneimine)(HPEI-IBAm0.61). HPEI is considered to be a synthetic polycation, which promotes tunable solubility through characteristics of …

Imaging The Tumor Microenvironment Using 1,2-Dioxetane Chemiluminescence Agents, Lucas Ryan

Chemistry Theses and Dissertations

As complex organisms, animals and humans rely on a delicate interplay between many connected systems to maintain proper cellular and whole-body function. Oxygen regulation and homeostasis are vital for proper function in healthy cells, as are core components of aerobic metabolism and efficient ATP generation to supply our energy needs. Maintaining pH homeostasis is also of primary importance; cells maintain pH homeostasis through a host of active and passive transporters to maintain pH balance both inside and outside of the cell.

Events of uncontrolled cellular proliferation, also known as cancer, survive and thrive under conditions that perturb the delicate balance …

04. Chemistry, Southwestern Oklahoma State University

Oklahoma Research Day Abstracts

No abstract provided.

9th Annual Postdoctoral Science Symposium, University Of Texas Md Anderson Cancer Center Postdoctoral Association

Annual Postdoctoral Science Symposium Abstracts

The mission of the Annual Postdoctoral Science Symposium (APSS) is to provide a platform for talented postdoctoral fellows throughout the Texas Medical Center to present their work to a wider audience. The MD Anderson Postdoctoral Association convened its inaugural Annual Postdoctoral Science Symposium (APSS) on August 4, 2011.

The APSS provides a professional venue for postdoctoral scientists to develop, clarify, and refine their research as a result of formal reviews and critiques of faculty and other postdoctoral scientists. Additionally, attendees discuss current research on a broad range of subjects while promoting academic interactions and enrichment and developing new collaborations.

Chemiluminescence Imaging Probes For Quantification Of Hno And Ph, Weiwei An

Chemistry Theses and Dissertations

Chemiluminescence is the light emission from a chemical reaction. The excited state is accessed in the course of a chemical reaction and relaxes to the ground state with the emission of a photon. Independence from the need for light excitation gives chemiluminescence several advantages over fluorescence including better signal-to-noise ratio and reduced background at deeper tissue imaging depth. As a result, the sensitivity of chemiluminescent probes for biological analyte detection has been improved significantly. Because of the sensitivity of chemiluminescent probes, we are planning to use this technique to quantify important factors for biological activities.

In this dissertation, two quantification …

Chemical And Biological Studies Of Cannabis Sativa Roots, Mostafa Elhendawy, Amira S. Wanas, Mohamed M. Radwan, N. Azzaz, Elshahat S. Toson, Mahmoud A. Elsohly

Faculty and Student Publications (Open Access)

No abstract provided.