Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (27)
- Physical Sciences and Mathematics (20)
- Medicine and Health Sciences (16)
- Medical Specialties (10)
- Engineering (9)
-
- Medical Sciences (7)
- Oncology (7)
- Biology (6)
- Chemistry (6)
- Environmental Sciences (5)
- Social and Behavioral Sciences (5)
- Animal Sciences (4)
- Arts and Humanities (4)
- Cell and Developmental Biology (4)
- Ecology and Evolutionary Biology (4)
- Bioinformatics (3)
- Biomedical Engineering and Bioengineering (3)
- Biomedical Informatics (3)
- Genetic Phenomena (3)
- Genetics and Genomics (3)
- Medical Genetics (3)
- Microbiology (3)
- Neuroscience and Neurobiology (3)
- Pharmacy and Pharmaceutical Sciences (3)
- Physics (3)
- Statistics and Probability (3)
- Aquaculture and Fisheries (2)
- Biotechnology (2)
- Business (2)
- Cancer Biology (2)
- Institution
-
- The Texas Medical Center Library (8)
- University of Baghdad (7)
- University of Texas at Arlington (6)
- Arkansas State University (4)
- Children's Mercy Kansas City (4)
-
- Duquesne University (4)
- Journal of Dental Sciences (4)
- TÜBİTAK (3)
- University of Alabama at Birmingham (3)
- University of Kentucky (3)
- Edith Cowan University (2)
- Syracuse University (2)
- The British University in Egypt (2)
- University of Central Florida (2)
- University of Memphis (2)
- University of Montana (2)
- University of South Carolina (2)
- Al-Farahidi University (1)
- Blue Economy (1)
- Bryant University (1)
- Bucknell University (1)
- Butler University (1)
- CINEC Campus (1)
- Chapman University (1)
- Chulalongkorn University (1)
- Claremont Colleges (1)
- Clemson University (1)
- Cleveland State University (1)
- Department of Primary Industries and Regional Development, Western Australia (1)
- Design Research Society (1)
- Keyword
-
- Chemistry (7)
- Animals (5)
- Molecular docking (4)
- Female (3)
- Humans (3)
-
- Mice (3)
- Biological activity (2)
- Deep Learning (2)
- Invasive species (2)
- Male (2)
- Ovary (2)
- Schiff base (2)
- Thermogravimetric analysis (2)
- 2-Amino-5-mercapto-1 (1)
- 3 (1)
- 3-d]pyrimidine (1)
- 4 thiadiazol (1)
- ADMET prediction (1)
- AI agents (1)
- AI;Bioengineering;Cardiomyocyte;Deep Learning;Machine Learning;Stem Cell (1)
- AP-1 transcription factor (1)
- Accelerated Failure Time Models (1)
- Accelerated Gap Time Models (1)
- Acceptance of the insolubility of pain (1)
- Adolescent (1)
- Adult (1)
- Agentic AI (1)
- Aging (1)
- Aging; Periodontal ligament; Bioinformatics; RNA Sequencing; Regeneration (1)
- Aging;Biology;Endocrinology;Inflammation (1)
- Publication
-
- Baghdad Science Journal (7)
- All Approved Curriculum (4)
- Creative Nonfiction Magazine (4)
- Faculty, Staff and Student Publications (4)
- Journal of Dental Sciences (4)
-
- ETDs from 2020-2029 (3)
- Faculty, Staff and Students Publications (3)
- Fast Capitalism (3)
- Manuscripts, Articles, Book Chapters and Other Papers (3)
- Electronic Theses and Dissertations Archive (2)
- Graduate Studies Theses and Dissertations 2026 (2)
- Research outputs 2022 to 2026 (2)
- Theses (2)
- Theses and Dissertations (2)
- Turkish Journal of Chemistry (2)
- University of Montana Course Syllabi, 2026-2030 (2)
- A with Honors Projects (1)
- Al-Farahidi Biomedical Journal (1)
- All Graduate Theses and Dissertations, Fall 2023 to Present (1)
- All Theses (1)
- Applied Environmental Research (1)
- Archival Material (Undated) (1)
- Articles (1)
- Arts & Sciences Faculty Publications (1)
- Arts & Sciences Graduate Student Theses and Dissertations (1)
- Biological Sciences Faculty Publications (1)
- Biological Sciences: Faculty Publications (1)
- Biological and Biomedical Sciences Department Faculty Journal Articles (1)
- Biology Faculty Publications (1)
- Biology Honors Projects (1)
- Publication Type
Articles 1 - 30 of 114
Full-Text Articles in Entire DC Network
Integrating Technologies For Synthetic, Systems, And Spatial Approaches In Cancer Research, Karmella A. Haynes, Kolade Adebowale, Belinda S. Akpa, Joel S. Bader, Trisha Bansal, Joshua Breunig, Ran Brosh, Lukasz J. Bugaj, George M. Burslem, Awalpreet Chadha, Moumita Das, Tara Deans, Cole A. Deforest, Lawrence J. Dooling, Zev Gartner, Laura M. Heiser, Alex Hughes, Melissa L. Kemp, Kirill S. Korolev, Chunru Lin, Timothee Lionnet, Xin Lu, Alison P. Mcguigan, Hamid Reza Mirzaei, Ajit J. Nirmal, Marina Pasca Di Magliano, Alexandros Poulopoulos, Kunal Rai, José Reyes, Dagan Segal, Mary Kathryn Sewell-Loftin, Evegeniya V. Shmeleva, Adam Stevens, Subbaya Subramanian, Thea Tlsty, Jennifer Totonchy, Alexander Vlahos, Pei Wang, Ioannis K. Zervantonakis, Yanding Zhao
Integrating Technologies For Synthetic, Systems, And Spatial Approaches In Cancer Research, Karmella A. Haynes, Kolade Adebowale, Belinda S. Akpa, Joel S. Bader, Trisha Bansal, Joshua Breunig, Ran Brosh, Lukasz J. Bugaj, George M. Burslem, Awalpreet Chadha, Moumita Das, Tara Deans, Cole A. Deforest, Lawrence J. Dooling, Zev Gartner, Laura M. Heiser, Alex Hughes, Melissa L. Kemp, Kirill S. Korolev, Chunru Lin, Timothee Lionnet, Xin Lu, Alison P. Mcguigan, Hamid Reza Mirzaei, Ajit J. Nirmal, Marina Pasca Di Magliano, Alexandros Poulopoulos, Kunal Rai, José Reyes, Dagan Segal, Mary Kathryn Sewell-Loftin, Evegeniya V. Shmeleva, Adam Stevens, Subbaya Subramanian, Thea Tlsty, Jennifer Totonchy, Alexander Vlahos, Pei Wang, Ioannis K. Zervantonakis, Yanding Zhao
Pharmacy Faculty Articles and Research
Emerging tools for spatial analysis, systems biology, and synthetic biology offer opportunities to observe, dissect, and perturb cancer mechanisms, to design strategies for the prevention of oncogenesis, and to identify therapies that lead to durable tumor control. Here, we summarize perspectives from the virtual Innovation Lab on “Synthetic and Systems Approaches to Interrogate Spatiotemporal Processes in Cancer” (S3) hosted by the National Institutes of Health (NIH), which assembled interdisciplinary experts to discuss cancer spatial organization and dynamic cellular interactions and how they can be addressed by leveraging novel synthetic and systems biology approaches. These discussions focused especially on cancer initiation, …
Examining The Challenges Of Providing Mental Health Treatment In Female Correctional Facilities From The Perspective Of Mental Health Professionals, Lacretia Williams
Examining The Challenges Of Providing Mental Health Treatment In Female Correctional Facilities From The Perspective Of Mental Health Professionals, Lacretia Williams
Walden Dissertations and Doctoral Studies
Women in correctional settings frequently experience significant mental health issues that are linked to histories of trauma, abuse, and victimization. Despite increased attention to trauma-informed and gender-responsive approaches, numerous obstacles continue to affect the delivery of mental health treatment within female correctional facilities. Existing literature focuses on systemic and policy concerns, overlooking mental health professionals' experiences. Guided by general systems theory, this qualitative study examined the challenges encountered by providers, including how organizational, environmental, and institutional factors influence treatment implementation. Data collected through semistructured interviews with 10 mental health professionals revealed multiple barriers to effective service delivery, including the complex …
Resource Assessment Report No. 10: Southern Nearshore And Estuarine Scalefish Resource: Sandy Sprat (Whitebait) 2026 Assessment, Daniel E. Yeoh, Brett Crisafulli, Rubie Evans-Powell, Sybrand A. Hesp
Resource Assessment Report No. 10: Southern Nearshore And Estuarine Scalefish Resource: Sandy Sprat (Whitebait) 2026 Assessment, Daniel E. Yeoh, Brett Crisafulli, Rubie Evans-Powell, Sybrand A. Hesp
Resource Assessment Reports
Sandy sprat Hyperlophus vittatus (‘whitebait’) is a small-bodied clupeid which occurs in temperate nearshore marine and estuarine waters throughout southern Australia. In Western Australia, this species is almost exclusively caught by the commercial sector on the lower west coast, between Perth and Geographe Bay, where it is considered to comprise a single biological stock. Since 2010, sandy sprat has primarily been caught by the South West Beach Net Fishery (SWBN) in the Bunbury region. This is a shore-based fishery which utilises beach seine nets to target a variety of finfish species in shallow nearshore waters.
Commercial catch is monitored and …
Novel Chitosan-Pyrazole Derivatives: Synthesis, Characterization, And Antimicrobial Potential Assessment, Samar A. Salim, Elrefaie S. Kenawy, Mohamed G. Altamami, Ahmed A. Safaan, Manar M. Emara, Elbadawy A. Kamoun, Atif A. Elgharably
Novel Chitosan-Pyrazole Derivatives: Synthesis, Characterization, And Antimicrobial Potential Assessment, Samar A. Salim, Elrefaie S. Kenawy, Mohamed G. Altamami, Ahmed A. Safaan, Manar M. Emara, Elbadawy A. Kamoun, Atif A. Elgharably
Nanotechnology Research Centre
Double novel chitosan Schiff-base series (I and II) based on heterocyclic moieties were synthesized to improve the pristine antibacterial capabilities of chitosan. Series (I) chitosan Schiff bases were prepared by reacting chitosan with six derivatives of 4-formyl-1H-pyrazole in an acidic medium, whereas series (II) was prepared by reacting chitosan with six derivatives of 1-(4-vinylbenzyl)-3-aryl-1H-pyrazole-4-carbaldehyde in an acidic medium. The chemical configurations of the twelve manufactured Schiff bases were verified using FTIR analysis & TGA measurements. We assessed the antimicrobial efficacy of chitosan and its Schiff base derivatives against four standard bacterial species, Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia …
Baby Fever, Meet Reality Check, Victoria R. Reginaldo
Baby Fever, Meet Reality Check, Victoria R. Reginaldo
Undercurrents: A Journal of Undergraduate Student Composition
Victoria R. Reginaldo is a Biology major from Weymouth, MA; she was born in Brazil and speaks Portuguese. Victoria explains that this essay was meaningful to her because it allowed her to think about an idea she has carried with her since she was young, the desire to have children, and how that dream is shaped and complicated by the realities of today’s society. “As I get older and begin to realize that life isn’t so simple, it made me want to research and write about how society influences the decision to have children,” she shares. Victoria notes that this …
Synthesis, Spectroscopic Characterization, And Biological Evaluation Of Ag(I), Ni (Ii), And Mn(Ii) Complexes With A Tridentate (N, O,O) Hydroxyazo Ligand, Hussein Hayder Abbood, Azal Shakir Waheeb
Synthesis, Spectroscopic Characterization, And Biological Evaluation Of Ag(I), Ni (Ii), And Mn(Ii) Complexes With A Tridentate (N, O,O) Hydroxyazo Ligand, Hussein Hayder Abbood, Azal Shakir Waheeb
Muthanna Medical Journal
Background: HMSA was prepared as a new hydroxyazo ligand with an N, O, O donor arrangement, then used to form Mn (II), Ni (II), and Ag(I) complexes. Objective: The work examined the structural features of HMSA and the prepared metal derivatives and compared their biological responses. Materials and methods: CHNS analysis, FT-IR, UV–Visible and NMR spectroscopy, powder X-ray diffraction (XRD), and FE-SEM were used for characterization. Antibacterial, DPPH antioxidant, and cytotoxicity tests were applied for biological evaluation. Results and conclusion: Spectral changes supported coordination of HMSA through azo nitrogen and phenolic oxygen sites, with a different environment around each studied …
Colorado Mental Health Professionals’ Personal And Professional Perspectives Of Nutrition: A Phenomenological Study, Tanya M. Tyrrell
Colorado Mental Health Professionals’ Personal And Professional Perspectives Of Nutrition: A Phenomenological Study, Tanya M. Tyrrell
Doctoral Dissertations and Projects
Growing evidence supports the relationship between nutrition and mental health. However, little is known about how mental health professionals (MHPs) experience nutrition, perceive its role in relation to mental health, or integrate nutrition into psychotherapy. The purpose of this hermeneutic phenomenological study was to explore Colorado MHPs’ lived experiences with nutrition and examine how those experiences informed their professional perspectives of nutrition. Guided by constructivist epistemology, semi-structured interviews were conducted with 11 MHPs practicing in Colorado, and data were analyzed using reflexive thematic analysis. Analysis generated eight themes. Findings revealed that 1) MHPs experienced nutrition as a lifelong developmental process …
Hhp 529.01: Advanced Exercise Physiology I, Charles L. Dumke
Hhp 529.01: Advanced Exercise Physiology I, Charles L. Dumke
University of Montana Course Syllabi, 2026-2030
No abstract provided.
Schiff Base Synthesis, Characterization And Computational Analysis For Potential Antibacterial Agents, L. N. G. K. Suranjith, M. S. D. Fernando
Schiff Base Synthesis, Characterization And Computational Analysis For Potential Antibacterial Agents, L. N. G. K. Suranjith, M. S. D. Fernando
Journal of Innovation in Science, Engineering and Technology
Schiff bases are an important class of imine compounds known for their structural versatility and biological activities, particularly as potential antimicrobial agents characterized by the azomethine (–C=N–) functional group, are widely recognized for its diverse biological activities. This study focuses on the synthesis and characterization of (E)-N-(3-phenylprop-2-en-1-ylidene)aniline to evaluate its potential as an antibacterial agent. The compound was synthesized via acid-catalyzed condensation of aniline and cinnamaldehyde under reflux for 2 hours in absolute ethanol. After purification through recrystallisation, the structure was confirmed using UV–Visible, FT-IR, 1H-NMR, and 13C-NMR spectroscopy. Thermal stability was assessed with thermogravimetric analysis (TGA), while …
Kinetic Control Of Nuclear-Encoded Mitochondrial Mrna Localization And Local Translation, Surbhi Sharma, Xuemei Wang, Steven Nguyen, Madeline E Rasband, Trinh T Tat, Prabha Chupal, Jen-Yun Chang, Eric L Van Nostrand, Daniel L Kiss, Aidan I Brown, Furqan M Fazal
Kinetic Control Of Nuclear-Encoded Mitochondrial Mrna Localization And Local Translation, Surbhi Sharma, Xuemei Wang, Steven Nguyen, Madeline E Rasband, Trinh T Tat, Prabha Chupal, Jen-Yun Chang, Eric L Van Nostrand, Daniel L Kiss, Aidan I Brown, Furqan M Fazal
Faculty, Staff and Students Publications
Most biological processes are dynamic, yet experimental methods predominantly rely on steady-state measurements to investigate their underlying mechanisms. RNA localization is a fundamental aspect of eukaryotic cell organization and is dynamically regulated by cells. While extensively studied in specialized cell types for a limited number of candidate RNAs, the general principles governing dynamic RNA localization at a transcriptome-wide scale remain largely unexplored. Existing transcriptome-wide studies provide only a static snapshot of RNAs residing in specific cellular locales, in part due to the limited availability of tools for probing cellular spatial organization at biologically relevant scales. Here, we leverage the high …
Developing Field And Spaceflight Microscopy, Nikki Johnston
Developing Field And Spaceflight Microscopy, Nikki Johnston
Dissertations and Theses
Designing for spaceflight favors the reduction of unnecessary features and cost-cutting, whether thisbe computation, hardware, or procedure. Resources are spent toward fortification and mission success over convenience. Such design goals paired with the relatively smaller budgets of academia lead us to do as much as we can in-house and use open-source as much as we can without compromising mission success. We also believe that thoroughly testing technology in extreme environments on earth is necessary for the success of a flight instrument. We focus on microscopy for life detection. I have spent my time here learning methods of hand-building microscopes to …
Folic Acid-Targeted Polymeric Complex Imprinted With Doxorubicin And Quercetin For Controlled Drug Delivery In Cancer Therapy, Ceren Türkcan, Emi̇rhan İşeri̇
Folic Acid-Targeted Polymeric Complex Imprinted With Doxorubicin And Quercetin For Controlled Drug Delivery In Cancer Therapy, Ceren Türkcan, Emi̇rhan İşeri̇
Turkish Journal of Chemistry
Cancer therapy is often limited by the systemic toxicity and dose-dependent adverse effects of conventional chemotherapeutic agents such as doxorubicin (DOX). In this study, a folic acid-functionalized molecularly imprinted polymeric complex based on poly(HEMA) crosslinked with ethylene glycol dimethacrylate was synthesized for the controlled release of DOX in combination with quercetin (QUE), a flavonoid known for its antioxidant and chemosensitizing properties. The aim of this work was to develop and physicochemically characterize a preliminary targeted drug delivery platform at a material-design level. The polymeric complex was synthesized via free-radical polymerization following a DOX–QUE precomplex formation step. Structural characterization was performed …
The Shorthorn: May 2, 1986
The Shorthorn Newspaper Collection: 1980s
No abstract provided.
Viability Assessment Of Bovine Embryos: A Public Dataset And Deep Learning Baselines, Erfan Khayyati
Viability Assessment Of Bovine Embryos: A Public Dataset And Deep Learning Baselines, Erfan Khayyati
All Graduate Theses and Dissertations, Fall 2023 to Present
Improving the success rates of cattle breeding is essential for sustainable agriculture, global food security, and high-quality livestock production. Currently, determining whether a lab-grown bovine embryo is healthy enough for a successful pregnancy requires highly trained experts to manually evaluate days of continuous time-lapse video footage. This process is not only incredibly time-consuming but also highly subjective; human reviewers often suffer from visual fatigue when tracking subtle, microscopic cellular changes over a seven-day period, leading to significant disagreement among even top experts on an embryo’s true potential. Furthermore, assessing bovine embryos is notoriously difficult due to their dark, lipid-dense cellular …
Modeling Intercellular And Intracellular Organization And Dynamics Of The Bacteria Escherichia Coli : From Population Dynamics In The Gut Microbiome, To Condensate Formation In Starved Cells, Alberto Alonso
Theses
Escherichia coli is a predominantly non-pathogenic species of bacteria present in the gut of most healthy adults. It plays a critical role in the health of the gut microbiome and is also widely used as a model organism in microbiology and synthetic biology studies. This thesis discusses results from two ongoing projects on E. Coli organization and emergent biophysical properties at two very distinct length scales. The first project focuses on using genetically modified engineered E. coli bacteria for early detection and intervention in colorectal cancer (CRC), a significant public health issue in the US. The success of these engineered …
Genetic Regulation Of Uterine Organogenesis, Diana A. Machado
Genetic Regulation Of Uterine Organogenesis, Diana A. Machado
Dissertations and Theses (Open Access)
In eutherian and marsupial mammals, the site of embryo implantation and gestation is the uterus. The precursor tissue of the uterus, oviducts, cervix, and upper vagina is the Müllerian duct epithelium and its adjacent mesenchyme. Morphological uterine variation between species is established during embryogenesis by species-specific differences in Müllerian duct fusion at the midline, growth, and differentiation. For example, laboratory mice have a bipartite uterus with two uterine horns and a single cervix, whereas humans have a simplex uterus with a single chamber and single cervix. In humans, variations in the fusion process can alter typical uterine morphology, correlating with …
Bridging Relational And Institutional Accountability: A Mixed Methods Study Of Implementing Sámi Ethical Research Guidelines In Finland’S Public Health Sector, Anna Charlotta Kihlstrom
Bridging Relational And Institutional Accountability: A Mixed Methods Study Of Implementing Sámi Ethical Research Guidelines In Finland’S Public Health Sector, Anna Charlotta Kihlstrom
Theses and Dissertations
The Ethical Guidelines for Research Involving Sámi People in Finland represent a critical step toward ethical Indigenous research; however, a gap remains between these principles and their implementation. This study responds to a research priority identified by the Sámi Social Affairs and Health Committee and examines how ethical research guidelines can be operationalized in the collaboration between the Sámi Parliament and the Finnish Institute for Health and Welfare (THL).
An exploratory sequential mixed methods design was employed, grounded in an Indigenous research paradigm and relational accountability. Extensive community engagement was carried out as a foundational part of the research methodology. …
Assessing Amino Acids And Peptide Adsorption On Pristine Graphene In Aqueous Solution: Nmr Spectroscopy, Budoor S. Al Umairi, Rahma Al Busaidi, Walaa Sameer Aburayan
Assessing Amino Acids And Peptide Adsorption On Pristine Graphene In Aqueous Solution: Nmr Spectroscopy, Budoor S. Al Umairi, Rahma Al Busaidi, Walaa Sameer Aburayan
Sultan Qaboos University Journal For Science
Graphene offers tremendous potential for applications in biomedical and pharmaceutical areas, ranging from molecular diagnostics, biosensors, and prosthetics to implants and drug delivery. However, realising the full potential of graphene is blocked by a limited understanding of the nature and detail of its noncovalent interactions with biological molecules in aqueous dispersion, where such applications can be used. Here, we studied the adsorption of amino acids and peptide on graphene in water utilising Nuclear Magnetic Resonance spectroscopy by observing 1H signals of individual biomolecules when exposed to graphene. The peptide-graphene interactions appeared to be driven by the binding affinity of individual …
Thermoclock:A Novel Automated Temperature Regulation Device That Can Model Circadian Entrainment And Disruption In 2d And 3d In Vitro Models, Kaiyin Kelly Zhang, Cathryn A. Cutia, Chanelle A. Moise, Bhavna Kalyanaraman, Kaitlyn Chhe, Jiexin Wang, Michelle E. Farkas, Ilia N. Karatsoreos, Mary Harrington, Meghan E. Huber, Cathal J. Kearney
Thermoclock:A Novel Automated Temperature Regulation Device That Can Model Circadian Entrainment And Disruption In 2d And 3d In Vitro Models, Kaiyin Kelly Zhang, Cathryn A. Cutia, Chanelle A. Moise, Bhavna Kalyanaraman, Kaitlyn Chhe, Jiexin Wang, Michelle E. Farkas, Ilia N. Karatsoreos, Mary Harrington, Meghan E. Huber, Cathal J. Kearney
Biological Sciences: Faculty Publications
Circadian rhythms are critical for maintaining homeostasis and regulating physiological functions, and consequentially impact disease progression; yet, they remain largely overlooked in in vitro models used in preclinical research. One major barrier to rigorously testing the role of circadian rhythms in these models is the lack of accessible tools that seamlessly integrate into standard culture setups and are capable of sustainably delivering time cues to cells and tissues in long term experiments. Here, we present the ThermoClock, a low-cost, Arduino-based automated temperature control system capable of delivering independent temperature programs to multiple cultures simultaneously. Using circadian reporter U2OS cell lines …
Synthesis, Characterization, Molecular Docking, And Anticancer Activity Of Triazole-Derived Trinuclear Metal Complexes (Tat3), Eman M. Ramadthan, Khansaa Shakir Al-Nama, Ammar H. Al-Sabawi
Synthesis, Characterization, Molecular Docking, And Anticancer Activity Of Triazole-Derived Trinuclear Metal Complexes (Tat3), Eman M. Ramadthan, Khansaa Shakir Al-Nama, Ammar H. Al-Sabawi
Baghdad Science Journal
A novel series of trinuclear coordination complexes of Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) was synthesized using a triazole-based ligand, namely 4-amino-5-((bis((4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)amino)methyl)-2H-1,2,4-triazole-3(4H)-thione, (TAT3) in an alcoholic medium. The obtained complexes were investigated using a comprehensive set of physicochemical and spectroscopic techniques, including CHNS elemental analysis, Fourier-transform infrared (FT-IR) spectroscopy, UV–visible spectroscopy, proton and carbon-13 nuclear magnetic resonance (1H and 13C-NMR), mass spectrometry, magnetic susceptibility measurements, and molar conductivity. Structural and surface morphology assessments were further carried out using X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). The spectroscopic and analytical data confirmed that …
Synthesis, Spectroscopic Characterization, Biological And Computational Study For Some Metal Ions Complexes With Schiff - Mannich Base Ligand Derived From 1,3,4-Thiadiazole, Israa Rasheed Ghadhban, Shaymaa R. Baqer
Synthesis, Spectroscopic Characterization, Biological And Computational Study For Some Metal Ions Complexes With Schiff - Mannich Base Ligand Derived From 1,3,4-Thiadiazole, Israa Rasheed Ghadhban, Shaymaa R. Baqer
Baghdad Science Journal
A new Schiff–Mannich base ligand derived from 1,3,4-thiadiazole was synthesized via the reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with sulfabenzamide and indoline in the presence of formaldehyde, yielding N–(4-((5-(2-oxoindolin-3-ylideneamino)-1,3,4-thiadiazol-2-ylthio)methylamino) phenyl thiolperoxy) benzamide (L). Six multivalent metal complexes were subsequently prepared with Co(II), Ni(II), Cu(II), Pd(II), Pt(IV), and Au(III) ions. The ligand and its complexes were characterized using various spectroscopic techniques, including FT-IR, UV-Vis, 1H NMR, and 13C NMR, while magnetic susceptibility and conductivity measurements were performed for the complexes. Infrared analysis revealed tetradentate coordination of the ligand to all metals, with octahedral geometries for most complexes and square planar geometries for …
Synthesis, Characterization, And Biological Evaluation Of A New Azo Dye Ligand 1-[2,4,6-Trihydroxy-3-(2-Hydroxy-Phenylazo)-Phenyl-Ethanone] And Its Complexes With Co(Ii), Ni(Ii), Cu(Ii), Zn(Ii), And Cd(Ii), Ban Hasan Al-Agele, Areej Kamal Assim Aldabbagh
Synthesis, Characterization, And Biological Evaluation Of A New Azo Dye Ligand 1-[2,4,6-Trihydroxy-3-(2-Hydroxy-Phenylazo)-Phenyl-Ethanone] And Its Complexes With Co(Ii), Ni(Ii), Cu(Ii), Zn(Ii), And Cd(Ii), Ban Hasan Al-Agele, Areej Kamal Assim Aldabbagh
Baghdad Science Journal
1-[2,4,6-trihydroxy-3-(2-hydroxy-phenylazo)-phenyl-ethanone] is a new azo dye ligand (H2L), which was used to form a number of new azo dye-metal complexes by reaction with salt chlorides of Co, Ni, Cu, Zn and Cd(II). The complexes were characterized using mass spectroscopy, infrared analysis, ultraviolet-visible spectrophotometry, 1H-, 13C-NMR spectroscopy, conductivity, magnetic susceptibility, DSC, TGA, C.H.N., metal content, and melting point. The results highlighted the ligand's trigonal behavior and that all the complexes yielded tetrahedral geometry, with the exception of Co and Ni, which produced octahedral geometry. They are all non-electrolytic. The compounds' capacity to function as antioxidants was used …
Biographex: Multi-Level Explainability In Graph Neural Networks For Trustworthy Biomedical Ai, Muhammad Talha Sajid, Ahmad Kamran Malik, Nafees Qamar, Hasnian Abudullah, Aleem Ahmad
Biographex: Multi-Level Explainability In Graph Neural Networks For Trustworthy Biomedical Ai, Muhammad Talha Sajid, Ahmad Kamran Malik, Nafees Qamar, Hasnian Abudullah, Aleem Ahmad
Biological and Biomedical Sciences Department Faculty Journal Articles
In biomedical research and clinical practices, Graph Neural Networks (GNNs) are playing an increasingly important role and have been applied to the problems of disease pathway detection, gene–disease relation prediction, etc. They show great potential for biomedical predictions; however, there are interpretability issues when used on complex datasets like gene expression data. Current explainability methods such as GNNExplainer are designed to explain individual instances, not the whole network. The absence of transparency hinders trust and limits the clinical/biomedical implementation of GNNs. Additionally, more interpretable models like GNN-SubNet and XGDAG do not fulfill the expectation of a clear picture for the …
Caldwell Adaptive Ocular Transport Discovery Platform (Aotdp-1.0) A Modular Open-Hardware Multi-Physics Testbed For Discovering Non-Invasive Posterior Ocular Transport Mechanisms, Michael Victor Caldwell Mr.
Caldwell Adaptive Ocular Transport Discovery Platform (Aotdp-1.0) A Modular Open-Hardware Multi-Physics Testbed For Discovering Non-Invasive Posterior Ocular Transport Mechanisms, Michael Victor Caldwell Mr.
Defensive Publications Series
The Caldwell Adaptive Ocular Transport Discovery Platform (AOTDP-1.0) is an open-hardware experimental research platform designed to investigate, compare, and optimize candidate non-invasive ocular transport mechanisms using standardized laboratory phantom eye models.
The platform does not claim to provide a clinically validated drug-delivery method. Instead, it addresses a fundamental engineering challenge:
How can researchers objectively evaluate competing physical mechanisms for transporting therapeutic agents toward posterior ocular regions without invasive injection approaches?
AOTDP-1.0 provides a modular multi-physics test environment where researchers can independently test and compare:
-
acoustic transport methods,
-
controlled micro-pressure gradients,
-
electromagnetic-assisted approaches,
-
optical stimulation concepts,
-
fluidic transport mechanisms,
-
mechanical interface …
Bivariate Current Status Data With Competing Risks Using Frailty Models, Biswadeep Ghosh
Bivariate Current Status Data With Competing Risks Using Frailty Models, Biswadeep Ghosh
Doctoral Theses
Bivariate current status data with competing risks arises in many application areas, for example, carcinogenicity studies, epidemiological studies, reliability studies, etc..As par of our knowledge, bivariate current status data with competing risks has not received much attention in literature. We initiate this research focusing on modeling and estimation of quantities of interest in absence of any covariate. We model bivariate current status data with competing risks through different frailty structures in order to describe different kinds of association. We consider multiplicative frailty effect on different cause-specific baseline hazard functions. One important part of our analysis is to investigate the identifiability …
Molecular Mechanism Leading To Human Coronary Atherosclerosis Assessed By Proteomic Analysis And Rna Sequences, Sarah J Parker, Chunhong Mao, David L Caudell, Austin Lyle Seals, Yizhi Wang, Thomas D Green, Joseph M Mcclung, Joshua T Maxwell, Jacolby T Roddey, Kiarash Shakeriastani, Chiung-Ting Wu, Yingzhou Lu, Do-Kyun Kim, Justyna Fert-Bober, Dongping Du, Archana Bhat, Niveda Sundararaman, Matthew Ayres, Rakhi Pandey, Saurabh Bhardwaj, Genesio M Karere, Dana Troxclair, Fannie Jackson, Gordon L Love, Richard Vander Heide, James Hixson, Jennifer E Van Eyk, Yue Wang, David Herrington
Molecular Mechanism Leading To Human Coronary Atherosclerosis Assessed By Proteomic Analysis And Rna Sequences, Sarah J Parker, Chunhong Mao, David L Caudell, Austin Lyle Seals, Yizhi Wang, Thomas D Green, Joseph M Mcclung, Joshua T Maxwell, Jacolby T Roddey, Kiarash Shakeriastani, Chiung-Ting Wu, Yingzhou Lu, Do-Kyun Kim, Justyna Fert-Bober, Dongping Du, Archana Bhat, Niveda Sundararaman, Matthew Ayres, Rakhi Pandey, Saurabh Bhardwaj, Genesio M Karere, Dana Troxclair, Fannie Jackson, Gordon L Love, Richard Vander Heide, James Hixson, Jennifer E Van Eyk, Yue Wang, David Herrington
Faculty, Staff and Student Publications
Background and aims: Atherosclerosis results from cellular and extracellular changes in the arterial wall, preceded by molecular shifts that initiate disease and drive tissue conversion, yet these changes are not yet fully described. More data are needed concerning these early changes in the coronary artery molecular landscape that signify the initiation of atherosclerosis and the subsequent tissue pheno-conversion to atherosclerotic plaque. This report summarizes results from a large biorepository of human coronary artery tissue, applying state-of-the-art omics technology, advanced data analytic methods, and an arterial organoid model system to predict molecular dynamics and identify potential regulatory mechanisms that could interrupt …
Synthesis And Evaluation Of Platinum (Iv) Prodrugs And Development Of Localized Drug Delivery Systems, Karla Cisneros Vargas
Synthesis And Evaluation Of Platinum (Iv) Prodrugs And Development Of Localized Drug Delivery Systems, Karla Cisneros Vargas
Electronic Theses and Dissertations Archive
This dissertation outlines the design, synthesis, and characterization of oxaliplatin-derived Pt(IV) prodrugs consisting of biologically active ligands. The stability and coordination behavior of oxaliplatin and a synthesized Pt(IV) derivative are investigated in an aqueous/organic mixed solution. Additionally, cytotoxicity of the compounds was tested using two human osteosarcoma cell lines, MG-63 and SK-ES-1. Notably, the tested drugs exhibited comparable or increased cytotoxicity compared to oxaliplatin. Another aspect of this research outlines the development and optimization of a triple-network hydrogel for the encapsulation and release of the hydrophobic drug Simvastatin. The hydrogel exhibited mechanical stability, biocompatibility, and biodegradability. Furthermore, it details the …
From Introduction To Biomass Dominance: The Invasive Fish Striped Piggy (Pomadasys Stridens) Reshaping Demersal Assemblages In The Eastern Mediterranean, Mehmet Cengi̇z Deval
From Introduction To Biomass Dominance: The Invasive Fish Striped Piggy (Pomadasys Stridens) Reshaping Demersal Assemblages In The Eastern Mediterranean, Mehmet Cengi̇z Deval
Turkish Journal of Zoology
Rapid increases in the abundance and biomass of nonindigenous species have the potential to profoundly reshape demersal fish assemblages in the Eastern Mediterranean Sea, yet quantitative evidence from long-term standardized surveys remains scarce. In the present study, temporal changes in biomass dynamics and community structure were assessed using fishery-independent trawl surveys conducted on the continental shelf of Antalya Bay (GSA 24) during two periods a decade apart (2009–2010 and 2020–2021), with particular focus on the Lessepsian striped piggy Pomadasys stridens. Based on the second survey, in which both daytime and nocturnal sampling were conducted, the biomass index (BI) differed significantly …
Taxing Ai In The Wake Of The Emergence Of Agentic Ai, Reuven S. Avi-Yonah, Herbert Snitz
Taxing Ai In The Wake Of The Emergence Of Agentic Ai, Reuven S. Avi-Yonah, Herbert Snitz
Articles
This article addresses taxation measures to regulate AI agents (i.e., AI that is not fully under the control of humans, including both ANI and AGI). In each case, the focus is on what the agent’s capabilities would be, not on how it becomes capable of successfully performing its tasks (though the latter would likely be relevant to important philosophical questions, e.g., might robots achieve sentience or consciousness, and if so, would they have rights?). Regarding mirroring what we human beings can do, the hallmark of AGI is that it will not be task-specific (like ANI), but will possess broad capabilities, …
Root Chemistry Effects On Soil Organic Matter Fractions Persist In Topsoil And Subsoil Of A Well-Drained Alfisol, Brian Rinehart, Justin Allen, Joeri Kaal, Dave Mcnear, Hanna Poffenbarger
Root Chemistry Effects On Soil Organic Matter Fractions Persist In Topsoil And Subsoil Of A Well-Drained Alfisol, Brian Rinehart, Justin Allen, Joeri Kaal, Dave Mcnear, Hanna Poffenbarger
Plant and Soil Sciences Faculty Publications
Subsoils have been identified as a potential target for building soil C stocks, given the older age and slower cycling of organic matter at depth. Plant roots deliver C deep into the soil profile, but there is limited experimental evidence as to which root traits are most effective at increasing subsoil C. To that end, we conducted a 13C natural abundance study to trace C from roots of differing quality into organic matter fractions in a shallow and deep soil layer of an Alfisol in Lexington, KY. The roots of four species were packed into nylon-wrapped tubes with soil and …