Digital Commons Network^™

Ai & Chemistry, Evelina Jaleniauskiene

Teaching Repository of AI-Infused Learning

"AI & Chemistry" is a four-week language-learning project based on the action-oriented approach. The project asks students to complete two main tasks: prepare an individual Ignite talk and a partnered podcast on any subtopic related to the use of AI in chemistry. Beyond language skills, the project additionally aims to encourage students’ collaboration with AI-powered tools and enhance their AI literacy. All project steps are detailed in an additional PDF file. The integration of the project is not restricted to a language course; it can be adapted for any university-level communicative course.

2007 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Sustained Response To Pan-Braf Inhibitor Plixorafenib (Fore8394, Plx8394) In A Young Adult With Neurodegenerative Langerhans Cell Histiocytosis, Joanna S Yi, Kathleen S Mccarthy, Kate Mazur, Rebecca Kudlaty, Terry Armstrong, Nilesh Desai, Stacie Peacock Shepherd, Daniel Zinn, Jessica Velazquez, Brooks Scull, Carl Allen, Kenneth Mcclain

Faculty, Staff and Students Publications

No abstract provided.

Synthesis, Structure-Activity Relationships, And Antitumor Activities Of Quinoxiline-Containing Inhibitors Of The Protein-Protein Interactions Between Transcription Coactivator Af9/Enl And Dot1l/Af4, Chandra Bhushan Mishra, Xin Li, Bala Krishna Moku, Sehun Kwak, Dnyaneshwar N Garad, Yongcheng Song

Faculty, Staff and Students Publications

Mixed lineage leukemia (MLL) gene rearrangements cause ~75% of acute leukemia in infants and 5-10% in children and adults with poor clinical outcomes. Protein-protein interactions (PPI) between frequent MLL fusion partners AF9/ENL and AF4 or histone methyltransferase DOT1L are drug targets for MLL-rearranged (MLL-r) leukemia. Sixty-seven quinoxiline compounds were synthesized and tested for their ability to inhibit such PPIs. Compounds 16, 17, 59 and 63 were found to be potent inhibitors with IC50 values of 0.35-1.5 μM. Structure-activity relationships are discussed. Potent inhibitors can suppress expression of MLL target genes Myc and Meis1 and selectively block proliferation of MLL-r and …

Proceedings Of The 2025 Berry Summer Thesis Institute, University Of Dayton. University Honors Program, Dorian Borbonus, Nicholas J. Canfield, Triet M. Cao, Thomas Crossman, Jeffrey Huettemann, Aung Myat Khaung, Chase Kinder, Elizabeth Krahe, Anh Duc Nguyen, Quynh Anh Nguyen, Anna M. Petre, Kayden G. Rothery, Anna M. Schmitz, Rachel Zeller

Proceedings of the Berry Summer Thesis Institute (2013-Present)

Thanks to a gift from the Berry Family Foundation and the Berry family, the University Honors Program launched the Berry Summer Thesis Institute in 2012. The institute introduces students in the University Honors Program to intensive research, scholarship opportunities and professional development. Each student pursues a 12-week summer thesis research project under the guidance of a UD faculty mentor. This contains the product of the students' research.

Simulating Chemiluminescence Spectra Of Oh Radical Using Quantum Dynamical Simulations, Triet M. Cao

Research from the Berry Summer Thesis Institute, 2025

Chemiluminescence is a phenomenon of light emission that occurs when molecules transition from an excited state to the ground state. This phenomenon is widely utilized in applications ranging from quantifying product yields in chemical reactions to biological imaging and atmospheric chemistry studies. It has also been used in many crucial applications in the scarce conditions of heat and electricity, such as light sources for astronomy discovery or deep-sea diving. A notable example of such reactions is combustion, where highly reactive hydroxyl radicals (OH) are products. These radicals exhibit a chemiluminescence spectrum because of the interaction between their ground state and …

Designing A Data Collection And Visualization Toolkit For Scalable Tensor Algebra In Quantum Chemistry Applications, Epiya J. Ebiapia

LSU Master's Theses

Large-scale quantum chemistry computations, such as those executed with the Tensor Algebra for Many-body Methods (TAMM) framework, require careful configuration of runtime parameters to achieve high performance and cost efficiency in high-performance computing (HPC) and cloud environments. Without effective performance analysis tools, researchers risk inefficient use of computational resources, leading to longer runtimes and higher costs.

To address this challenge, this thesis presents the design and implementation of a performance profiling and visualization toolkit for TAMM, developed as part of the DOE TEC4 project in collaboration with Pacific Northwest National Laboratory, Microsoft, and Louisiana State University. The toolkit collects detailed …

Insights Into The Radiation Chemistry Of Flash Radiation Therapy, Alan E. Lopez Hernandez

Dissertations and Theses (Open Access)

Purpose: FLASH radiation therapy (FLASH-RT) is an emerging modality that delivers radiation at ultra-high dose rates (UHDR) and has shown consistent normal tissue sparing while preserving tumor control compared to conventional RT—a phenomenon termed the FLASH effect. Despite promising results, the mechanisms behind the FLASH effect remain unclear. Many hypotheses point to radiolytic interactions, but experimental validation is limited. This work aims to develop a robust experimental platform to evaluate the relationship between radiolytic species production and physical beam parameters relevant to FLASH-RT, alongside dosimetry tools for reliable UHDR beam characterization.

Methods: A beam collector (BC) Faraday cup detector was …

Vacuum Consistent Electrochemistry In Ionic Liquid Combined With Oxide Epitaxy, Yuji Matsumoto

Journal of Electrochemistry

We introduce our state-of-the art of “vacuum consistent electrochemistry” to an investigation of the interfaces between oxides and ionic liquid (IL). Pulsed laser deposition (PLD) has been one of the powerful and sophisticated techniques to realize nanoscale preparation of high-quality epitaxial oxide thin films. On the other hand, electrochemistry is a simple, very sensitive, and non-destructive analysis technique for solid-liquid interfaces. To ensure the reproducibility in experiment of the interfaces of such epitaxial oxide films, as well as bulk oxide single-crystals, with IL, we employ a home-built PLD-electrochemical (EC) system with IL as an electrolyte. The system allows one to …

Shallow Water Table In Arid Urban Zone: Preliminary Study At Sultan Qaboos University Campus, Oman, Ali Al-Maktoumi

Journal of Agricultural and Marine Sciences

A shallow water table (SWT) rises up to several centimeters below the soil surface and even exfiltrates making surface impoundments that are common in humid climates. Recently, SWTs emerged even in arid and semi-arid regions of several metropolitan areas of the Arabian Gulf Cooperation Council (GCC) countries with a pernicious impact on the urban infrastructure, health, ecohydrology of parks and gardens, among others. Quantifying SWT’s dynamics and understanding the associated phenomena of water motion and solute transport are vital for finding the proper mitigation techniques and reducing the risks associated with SWT. In this preliminary study, SWT was delineated, its …

Illuminated Magazine - Spring 2025, School Of Graduate Studies, East Tennessee State University

Illuminated: Graduate Student Research Magazine

• 2: Editorial Staff
• 6: Betting on Appalachia: How Appalachian Identity Correlates to Gambling Disorder; Noah Anderson, Psychology, PhD
• 9: Where Are They Now? Featuring Maria Jose Araujo Dias
• 10: Inner Bonds: An Exploration of Emotions through Character Creation, Story, and Design; Cait Maltbie, Studio Art, MFA
• 13: Where Are They Now? Featuring Cynthia Milhorn
• 14: Characterizing the Polymicrobial Interactions of Alcaligenes faecalis; Aly Hargrave, Biology, MS
• 18: Grant Award Recipients
• 20: Discovering a Potentially Novel Bacteriocin from Klebsiella Bacteria; Jasmal Cruz Perez, Biology, MS
• 23: Where Are They Now? Featuring Julianne Hensley
• 24: Assessing How Different Training Programs Affect High-Intensity …

Next-Generation Biomedical Implants And Stimuli Responsive Soft Optical Arrays Via Surface Functionalized Elastomeric Materials, John M. Kapitan

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The demands of emerging technologies, such as soft robotics, stretchable electronics, and next generation biomedical implants, has led to the development of diverse polymeric and hybrid organic/inorganic materials specifically tuned to meet these challenges. These materials typically have low Young’s moduli and are inert with high chemical stability. However, this has led to materials that are static in nature, lacking any meaningful way of responding to changes in their environment and adapting to these changes. This has driven a shift towards the design, manufacturing, and characterization of various stimuli responsive surfaces, relying on precise control of surface chemical coatings and …

Postseismic Groundwater Quality Investigation In Aquifers Following Earthquake-Induced Demolition Wastes: Hatay (Türkiye) Case Study, Pinar Avci, Gali̇p Yüce

Turkish Journal of Earth Sciences

The February 6, 2023 seismic sequence that hit, the Antakya district of Hatay (Türkiye), killed more than 50,000 people and caused extensive structural damages, resulting in the collapse of 80% of the building stock that generated over 100 million tons of debris. Understanding the impact of seismic events on water resources is highly important for ensuring human and environmental health. Herewith, a study was carried out over the Hatay area to assess the post-earthquake sustainable usability of groundwater for drinking, domestic, and irrigation purposes. 17 water points were investigated in September 2023, encompassing alluvial deposits with relatively high hydraulic conductivity …

News From The Chapters 1986-1987, C. Nicholas Raphael

The Geographical Bulletin

During the fall the Gamma Delta Chapter held a series of seminars on topics of controversial nature, such as the causes of glaciation and the extinction of the dinosaurs. The fall picnic was a well-attended success as was the Christmas banquet. During the spring term, the chapter is running a seminar on the Great Plains and is co-sponsoring, with Biology's Tri Beta and Geology's SGE, the visit of Carnegie Museum's Leonard Krishtalka, a paleontologist. The annual spring picnic is held in early May.

Modeling Actinic Flux And Photolysis Frequencies In Dense Biomass Burning Plumes, Jan-Lukas Tirpitz, Santo Fedele Colosimo, Nathaniel Brockway, Robert Spurr, Matt Christi, Samuel Hall, Kirk Ullmann, Johnathan Hair, Taylor Shingler, Rodney Weber, Jack E. Dibb, Richard Moore, Elizabeth Wiggins, Vijay Natraj, Nicolas Theys, Jochen Stutz

Faculty Publications

Biomass burning (BB) affects air quality and climate by releasing large quantities of gaseous and particulate pollutants into the atmosphere. Photochemical processing during daylight transforms these emissions, influencing their overall environmental impact. Accurately quantifying the photochemical drivers, namely actinic flux and photolysis frequencies, is crucial to constraining this chemistry. However, the complex radiative transfer within BB plumes presents a significant challenge for both direct observations and numerical models.

This study introduces an expanded version of the 1D VLIDORT-QS radiative transfer (RT) model, named VLIDORT for photochemistry (VPC). VPC is designed for photochemical and remote sensing applications, particularly in BB plumes …

Chem 361-002: Environmental Chemistry Of Wter And Soil Pollution, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Lung-Delivered Il-10 Mitigates Lung Inflammation Induced By Repeated Endotoxin Exposures In Male Mice, Aaron Schwab, Todd A. Wyatt, Oliver Schanze, Amy J. Nelson, Angela Gleason, Michael J. Duryee, Deanna Mosley, Geoffrey M. Thiele, Ted R. Mikuls, Jill A. Poole

Journal Articles: Environmental, Agricultural & Occupational Health

Therapies capable of resolving inflammatory lung disease resulting from high-consequence occupational/environmental hazards are lacking. This study seeks to determine the therapeutic potential of direct lung-delivered interleukin (IL)-10 following repeated lipopolysaccharide exposures. C57BL/6 mice were intratracheally instilled with LPS (10 μg) and treated with IL-10 (1 μg) or vehicle control for 3 days. Lung cell infiltrates were enumerated by flow cytometry. Lung sections were stained for myeloperoxidase (MPO), CCR2, vimentin, and post-translational protein citrullination (CIT) and malondialdehyde-acetaldehyde (MAA) modifications. Lung function testing and longitudinal in vivo micro-CT imaging were performed. Whole lungs were profiled using bulk RNA sequencing. IL-10 treatment reduced …

Computational Study Of Redox-Active Protein Residues And Biological Proton-Coupled Electron Transfer, Qiwen Zhu

Yale Graduate School of Arts and Sciences Dissertations

Proton-coupled electron transfer (PCET) reactions are essential processes in biological systems, fundamental to various enzymatic functions and redox biology. Key to these reactions are redox-active residues, such as tyrosine and tryptophan, which enhance the efficiency and specificity of electron transfer events. This thesis investigates the thermodynamics, kinetics, and conformational influences of PCET in proteins involving these residues through three projects, each offering significant insights into the mechanisms and broader implications for biological function. The studies have focused on two protein systems: a simple de novo protein system, α3X, and ribonucleotide reductase, an enzyme critical to DNA synthesis. Combining a wide …

Selective Surface Activation And Flotation Of Pyrite For The Recovery Of Tellurium From Sulfide Tailings, Mulenga Mutema Chibesa

Masters Theses

Copper sulfide tailings from past and present mining operations are important secondary sources of critical elements such as tellurium (Te), a key component in cadmium–telluride photovoltaic solar cells. Characterization of tailing streams from copper porphyry (CP) ore flotation revealed that Te-bearing minerals are predominantly hosted in pyrite, which is usually depressed and discarded. Enhancing pyrite recovery is therefore a critical first step toward concentrating Te minerals for downstream extraction. However, pyrite flotation is often hindered by hydrophilic surface complexes formed during prior processing. This research investigated selective flotation of Te-bearing pyrite from CP tailings using micro flotation and bench-scale flotation, …

A Systematic Review Of Environmentally Persistent Free Radical (Epfr) Formation, Characteristics, And Health Effects: Are There Sufficient Data For Risk Assessment?, Avinash Kumar, Divine Nde, Chuqi Guo, Rashmi Pathak, Fox Foley, Syed Ahmad, Prakash Dangal, Farhana Hasan, Myron Lard, Ankit Aryal, Martine E. Mathieu-Campbell, Jennifer Irving, Oluwafeyikemi Ogunmusi, Jennifer Richmond-Bryant, Slawomir Lomnicki, Lavrent Khachatryan, Stephania A. Cormier, Tammy R. Dugas

Faculty Publications

Environmentally persistent free radicals (EPFRs) are stable free radicals formed on particulate matter (PM) through processes such as combustion and pyrolysis. These free radicals are generated on transition metal oxide surfaces in the presence of aromatic precursors. Exposure to EPFRs occurs primarily via inhalation of PM deriving from combustion, traffic, industrial activities, and both indoor and outdoor burning. Other environmental factors that might generate EPFRs are radon, electronic and tobacco cigarettes. EPFRs exhibit unexpectedly long half-lives, ranging from several weeks to, in some cases, several years. EPFRs may be carbon-centered, oxygen-centered or mixed, identified by g-values exhibited in electron paramagnetic …

Stephen J. Lippard: Chemistry Meets Medicine, Radwa Elrouby

Natural Sciences Student Research Presentations

Key Study

In "DNA Sequence Context Modulates the Impact of a Cisplatin 1,2-GpG Intrastrand Cross-Link", Pilch, Todd, and Lippard found that the DNA sequence around the binding site influences how tightly cisplatin binds (Pilch, Todd, and Lippard).

Biophysical techniques like melting temperature and circular dichroism showed that some sequences stabilize DNA more strongly after drug binding (Pilch, Todd, and Lippard).

This explains why cisplatin is more effective in some tumor genomes (Todd and Lippard).

Demystifying Misconceptions In Introductory Undergraduate Chemistry Education With 3d Printed Molecular Orbitals, Hiwot Endeshaw, Daniel J. O'Leary

Pomona Senior Theses

Spatial abilities are invaluable skills for the science, technology, engineering, and mathematics (STEM) subjects. However, women, people from low socioeconomic backgrounds, and ethnic minorities are more likely to have less developed spatial abilities, which is one of the many contributing factors for the lack of diversity in STEM subjects like chemistry. Teaching spatial skills to undergraduate chemistry students may address this issue and help increase the diversity of students who go on to continue their education in the subject. 3D printing technology in higher education has exploded in recent years, presenting a unique opportunity to teach “hard to grasp” concepts …

Cellular And Behavioral Consequences Of Psychedelic Drug Action In The Claustrum, Tanner L. Anderson

Theses and Dissertations--Neuroscience

Psychedelics are rapidly garnering research attention for their ability to successfully treat a variety of psychiatric diseases after one or a handful of treatments in recent clinical research. Among the conditions treated is substance use disorder (SUD), which afflicted 48.5 million (16.7%) Americans aged 12 and older in 2023 (NSDUH). As clinical trial results continue to show lasting positive effects of psychedelic psychotherapy, there remains an enormous gap in knowledge regarding how these drugs cause lasting changes in the brain to achieve these therapeutic effects. It has been suggested that psychedelics must induce rapid and long-lasting neuronal plasticity in order …

Design And Development Of Fluorescent Probes For Sensing And Bioimaging Of Nad(P)H, Intracellular Viscosity, And So2, Dilka Liyana Arachchige

Dissertations, Master's Theses and Master's Reports

Understanding the dynamic biochemical and biophysical changes within living systems is vital for advancing disease diagnosis and therapeutic development. This work presents the design and development of innovative fluorescent probes, based on cyanine and coumarin scaffolds, for the highly sensitive and selective detection of key metabolic and biophysical markers, NAD(P)H, mitochondrial viscosity, and sulfur dioxide (SO₂) in live cells and fruit fly larvae. A series of cyanine-based probes were engineered to undergo strong fluorescence enhancement upon reduction by NAD(P)H, enabling real-time visualization of metabolic fluctuations in cancer cells and Drosophila larvae. These probes exhibit excellent sensitivity, mitochondrial targeting capability, and …

Multiscale Computational Chemistry Studies Of The Catalytic Mechanisms Of Non-Heme Fe(Ii)/2-Oxoglutarate-Dependent Oxygenases, Simahudeen Bathir Jaber Sathik Rifayee

Dissertations, Master's Theses and Master's Reports

Enzymes catalyze complex biological transformations. Non-heme Fe(II)/2-oxoglutarate (2OG)–dependent enzymes are highly versatile catalysts capable of selective C–H oxidation, enabling transformations such as hydroxylation, halogenation, desaturation, demethylation, ring rearrangements, epoxidation, and electrophilic aromatic substitution. These enzymes are involved in various biological processes, including fatty acid metabolism, hypoxic signaling, collagen maturation, and transcriptional regulation. Computational Modeling provides detailed knowledge of the enzymes including atomistic details of the important catalytic species, conformational and electronic effects, which are crucial to enzyme engineering and drug design efforts. This dissertation implements advanced multi-scale molecular modelling techniques including Molecular dynamics and Quantum Mechanic / Molecular Mechanics calculations …

The Roots Of Empire And Industry: The Transnational History Of The Soviet Rubber Industry, Alexander Hinnov Craver

Graduate Research Theses & Dissertations

Global rubber shortages and market instability in the early 20th century drove the United States, Soviet Union, and Nazi Germany to collaborate in an overwhelming drive to secure domestically producible sources of rubber, either from plants that could grow outside the tropics, or from synthetic rubber processes. The Soviet Union was an indispensable part of this converging, transnational “quest for rubber.” Russian scientists created the first factories to produce synthetic rubber, and Russian agronomists had discovered a dandelion in Central Asia that yielded latex suitable for manufacture. Consequently, both discoveries were disseminated across the world. Sometimes they were shared: the …

Increasing Access Through Graduate Teaching Assistant Training: A Udl-Informed, Video-Based Professional Development Approach For Inclusive Chemistry Instruction, Kathleen Lugo Charriez

Graduate Thesis and Dissertation post-2024

STEM courses pose concealed barriers to learning for students with disabilities, a demographic that constitutes a significant portion of postsecondary science and engineering undergraduate student populations. While extensive research has examined access and inclusiveness in K–12 education and, to a more limited extent, in higher education, there remains a critical gap in understanding how to proactively design undergraduate chemistry curricula that are both accessible and inclusive for a diverse range of learners. In particular, limited attention has been given to supporting Graduate Teaching Assistants (GTAs) in adopting inclusive instructional practices in higher education chemistry courses.

In large academic institutions, GTAs …

Investigating The Photophysical Dynamics Of Anthracene And Acridine Derivatives Using Time-Resolved Spectroscopy, Sophia Tiano

Open Access Dissertations

Anthracenes and acridines are among the simplest visible light absorbing heterocyclic and polycyclic aromatic hydrocarbons and as such are extensively used in a variety of applications including photosensitizers and fluorescent sensors. Although the photophysics of some derivatives have been studied in the past, there is still a lot of unknown fundamental information that is vital in order to optimize these molecules for particular applications. Transient absorption spectroscopy was used to study the photophysics of the 9-substituted methyl, hydroxymethyl and formyl derivatives of acridine and anthracene. The growth and decay of the triplet-triplet absorption peak were quantified for each dye in …

Explosions Are Always Entertaining But…: Investigating The Impacts Of Science Shows On High School Students, Shanii Phillips, Miriam Sullivan, Ann Grand

Research outputs 2022 to 2026

Science shows are often posited as a route to encourage young people to engage with science. Using a mixed methods approach, our research investigated the impact of attending a science show on high school students’ intentions to study science or pursue a career in science. We found that while a single visit to a science show has little impact on students’ aspirations, it can reinforce students’ confidence in their ability to succeed in science. In terms of design and performance, the best-received shows included ‘real-world’ content that students could identify as relevant to their lives.