Digital Commons Network^™

Game-Based Learning With Augmented Reality, Kantida Nanon

Dissertations

Augmented Reality (AR) technology provides an effective and controllable learning environment, especially for complicated, potentially dangerous, or critical content. Effective implementation of interaction and platforms for educational tools can maximize learner engagement and optimize the learning experience. This dissertation explores the potential of AR technology to enhance learning experiences across multiple platforms and subject areas, particularly within chemistry and mathematics. The dissertation is grounded in the field of Human-Computer Interaction (HCI) and explores the potential of AR to increase learner engagement, improve learning outcomes, and transform traditional pedagogical practices.

The dissertation is divided into two parts. The first part examines …

Intrinsic Gas-Phase Behavior Of Uranium Species: A Comprehensive Reactivity Study Of [O=U≡Ch]+ And [Uh]+, Justin Terhorst

Electronic Theses and Dissertations

The intrinsic chemistry of actinide elements, particularly uranium, remains a key challenge in understanding f-block reactivity due to the complexity introduced by solvent interactions, counter-ions, and complex equilibria in the condensed phase. In this dissertation, a systematic gas-phase study utilizing preparative tandem ion-trap mass spectrometry (PTMSⁿ) is presented, focusing on the reactivity of uranium-centered species, specifically [OUCH]⁺, an oxy uranium methylidyne species, and [UH]⁺ ions. By stripping away solvent effects and isolating the ions, PTMSⁿ provides a powerful platform to probe the fundamental chemical behavior of uranium species in their intrinsic state.

The …

Surface Chemistry And Adsorption Mechanism Of Orfom® D8 For Cu Depression In Cu-Mo Flotation, Patrick Jeff Mensah

Graduate Theses & Non-Theses

In traditional chalcopyrite-molybdenite (Cu-Mo) flotation separation systems, inorganic depressants such as NaSH and NaCN are used to selectively depress chalcopyrite making it more hydrophilic so molybdenite can be floated and recovered. NaSH and NaCN are highly toxic, have high explosion potential, strong odor, and readily oxidize in air resulting in a high consumption rates. To control oxidation, nitrogen gas, and Nokes reagent are both necessary, making the process even more expensive. In addressing these challenges, attention is fast shifting to disodium carboxymethyl trithiocarbonate (Orfom® D8), a novel organic depressant designed to replace conventional inorganic depressants because it does not easily …

Investigating Student Expectations, Buy-In, And Engagement In Lower Division Undergraduate Chemistry Labs, Elizabeth Blanche Vaughan

Dissertations and Theses

Laboratory courses constitute an integral aspect of chemistry education at the undergraduate level. Despite their prominence, a growing number of researchers have begun to think more critically about the value of laboratory learning experiences. As pedagogical decisions should be based on evidence, it is necessary for chemistry education researchers and practitioners to investigate the claim that teaching laboratories are a valuable part of science education. Therefore, the aim of this dissertation was to address one small section of this gap in the literature by obtaining a more robust understanding of students' expectations, buy-in, and engagement in lower division, undergraduate, chemistry …

Recruitment Sources Of Grass Carp (Ctenopharyngodon Idella) In The Great Lakes, Nicholas Steven Etter

Theses

Grass Carp (Ctenopharyngodon idella) is a species of concern in areas they have invaded, such the Laurentian Great Lakes, due to their potential to substantially reduce aquatic macrophyte coverage. Efforts to control Grass Carp in the Great Lakes have primarily been focused on two tributaries to the western basin of Lake Erie (i.e., Sandusky and Maumee rivers, Ohio) where reproduction has been documented, although other Great Lakes tributaries are known to have thermal and hydrological regimes suitable for Grass Carp spawning. Knowledge of sources contributing to the expanding population of invasive Grass Carp in the Great Lakes is key to …

On The Nature Of Transverse Waves In Marginal Hydrogen Detonation Simulations Using Boundary Layer Loss Modeling And Detailed Chemistry, Joshua Smith, Curran Schmitt, Brian Maxwell

Student Scholarship

Historically, it has been a challenge to simulate the experimentally observed cellular structures and marginal behavior of multi-dimensional, thin-channel hydrogen detonations in the presence of losses, even with detailed chemistry models. Very recently, a quasi-two-dimensional inviscid approach with a calorically perfect gas and two-step chemistry was pursued, where losses due to viscous boundary layers were modeled by the inclusion of an equivalent mass divergence in the lateral direction using Fay's source term formulation with Mirels’ compressible laminar boundary layer solutions. A similar approach was adopted for this study, but with the inclusion of thermally-perfect detailed chemistry in order to capture …

Chem 360-001:Environmental Chemistry, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Removal Of Some Heavy Metals From Polluted Water Using New Schiff Base For Polyacrylamide With Zeolite Nanocomposites, Zainab Sabeer Abdulsada, Sahar S. Hassan, Sanaa Hitur Awad

Baghdad Science Journal

This work involved the preparation of a new Schiff base ligand derived from poly acrylamide and glutaraldehyde [(2S, 2'S) – N, N' - (pentane-1, 5-diylidene) bis (2- methylbutan amide)] (PAAG) with some heavy metals (Cr +3, Mn + 3, Fe + 3, Co + 2, Ni + 2, Cu + 2, Zn + 2, Cd + 2) to produce corresponding complexes. Schiff bases and their metal complexes are characterized using FTIR spectral, Uv-Vis spectroscopy, conductivity, magnetic moments, Thermal gravimetric analysis (TGA), x-ray diffraction, scanning electron microscope (SEM) and atomic force microscope (AFM). The prepared polymer was used with zeolite to …

Effect Of Inulin From Dahlia Tubers (Dahlia Variabilis) Extract On Insulitis Severity And Insulin Expression In Diabetic Rats, Ismawati Ismawati, Saryono Saryono, Mukhyarjon Mukhyarjon, Ilhami Romus, Veni Dayu Putri, Sri Yanti, Fitri Dyna, Nada Idzdihari Adesti

BioMedicine

Background: Dahlia (Dahlia variabilis), a widely cultivated ornamental plant in Indonesia, is known to contain 84.08% inulin in its tubers. Numerous studies have demonstrated the antidiabetic potential of inulin from various plant sources. However, most of the research is in the form of a mixture of inulin with other active substances, and no one has analyzed the effects of inulin derived from dahlia tubers. This study examines the effect of inulin from dahlia tuber extract on blood glucose levels, serum insulin expression, pancreatic tissue insulin expression, homeostatic model assessment of insulin resistance (HOMA-IR), and the extent of …

Synthesis Of Addressable Libraries: New Lessons And The Need For Proper Characterization For Microelectrode Array-Based Reactions, Albert Huang

Arts & Sciences Graduate Student Theses and Dissertations

The Moeller group has been developing synthetic tools for building molecular libraries on microelectrode arrays since 2004. Such a library is intriguing because one can take advantage of the library for biological signaling studies. Microelectrode arrays can serve as a powerful platform for those experiments since every electrode in the array can be addressed individually. Unique members of the library targeting biological receptors that one is interested in can be restricted only above unique electrodes in an array. Thus, high-affinity ligands for those receptors can be identified with this strategy. To make this method work, one has to make sure …

Using Manipulatives As Learning Interventions To Teach Introductory Chemistry Content In The Secondary Classroom And Beyond, John Kenneth Kennon

Electronic Theses and Dissertations Archive

Use of manipulatives to explore concepts qualitatively and quantitatively was investigated in this study. Particle diagrams, enthalpy, VSEPR, and stoichiometry; four classes of students were divided into two groups constituting test group and control group. Control groups received traditional pedagogy (Lewis diagrams) while test groups used manipulatives. Shapiro-Wilks, class means, Kolmogorov-Smirnov, Mann-Whitney U tests, and item-by-item analyses were employed to quantify performance. Particle diagram results suggested that using modeling improves student learning outcomes based on means and Mann-Whitney U-test p-value. Enthalpy results indicated a larger mean for the test group than the control group, but no statistical difference between score …

Pengaruh Perlit Sebagai Adsorben Pada Adsorpsi Zat Warna Metilen Biru, Mardiana Rimba Utami, Kapti Riyani, Tien Setyaningtyas

Chimica et Natura Acta

Aktivitas industri di zaman modern yang berkembang pesat dapat menyebabkan permasalahan lingkungan. Hal ini dikarenakan bertambahnya jumlah limbah yang dihasilkan akibat peningkatan produksi. Limbah zat warna tanpa pengolahan dapat menghambat penetrasi cahaya matahari, aktivitas fotosintesis, dan pertumbuhan biota air. Salah satu limbah zat warna yang sering ditemukan adalah metilen biru. Pengolahan zat warna metilen biru dapat menggunakan metode adsorpsi yang praktis, mudah dilakukan dengan biaya rendah. Penelitian ini menunjukkan aktivitas adsorpsi terbaik metilen biru oleh adsorben perlit terhadap parameter pH, waktu kontak, serta penentuan kinetika dan isoterm adsorpsi. Aktivitas terbaik perlit dalam mengadsorpsi metilen biru adalah pada pH 9 dengan …

Regioselective Hydroamination Of Unactivated Olefins With Diazirine And Total Synthesis Of Nostodione A And Scytonemin, Qingyu Xing

USF Tampa Graduate Theses and Dissertations

As an atom-economic way of carbon-nitrogen bond formation, hydroaminations are great tool for make amines, hydrazines, and other nitrogen-containing heterocycles. Specifically, radical hydroamination is a useful approach for functionalization of unactivated olefins, especially in sterically hindered environments. Diversification remains a challenge for radical hydroaminated products, since the nitrogen sources are carefully designed. In the first chapter of this dissertation, we report a highly diversifiable radical hydroamination reaction with diazirine as a nitrogen source and its potential applications in synthesis of several pharmaceutical interested compounds. Cobalt catalyzed regioselective hydroamination with diazirine shows wide function group tolerance, like phenyl thioether, ketones, esters, …

Enhanced Ctla-4 Blockade Anti-Tumor Immunity With Apg-157 Combination In A Murine Head And Neck Cancer, Daniel Sanghoon Shin, Saroj Basak, Mysore S Veena, Begoña Comin-Anduix, Arjun Bhattacharya, Tien S Dong, Albert Ko, Philip Han, Jonathan Jacobs, Neda A Moatamed, Luis Avila, Matteo Pellegrini, Marilene Wang, Eri S Srivatsan

Faculty, Staff and Student Publications

BACKGROUND: A phase I clinical study for patients with locally advanced H&N cancer with a new class of botanical drug APG-157 provided hints of potential synergy with immunotherapy. We sought to evaluate the efficacy of the combination of APG-157 and immune checkpoint inhibitors.

METHODS: CCL23, UM-SCC1 (human), and SCCVII (HPV-), MEER (HPV+) (murine) H&N cancer cell lines were utilized for in vitro and in vivo studies. We measured tumor growth by treating the mice with APG-157, anti-PD-1, and anti-CTLA-4 antibody combinations (8 groups). The tumor microenvironments were assessed by multi-color flow cytometry, immunohistochemistry, and RNA-seq analysis. Fecal microbiome was analyzed …

Protein Residue Analysis In Archaeology: A Geological Contamination Experiment, Theresa Popp

All Graduate Theses and Dissertations, Fall 2023 to Present

Protein residue analysis has been used by archaeologists for decades to explore ancient diets and hunting behaviors based on proteins deposited on tools and artifacts, however, protein contamination of buried artifacts has been assumed but lacked formal study. Through a contamination experiment testing different geological contexts (e.g. water movement and freeze-thaw), possible routes of protein contamination within soil were identified, adversely impacting protein residue analysis conducted on buried artifacts. Protein was found to move through soil in large enough concentrations to elicit positive protein residue results on sterile artifacts that never made direct contact with the protein source used in …

Valorization Of Date Palm Waste For The Isolation, Characterization, And Surface Chemistry Modification Of Nanocellulose, Mohsin Raza

Dissertations

This dissertation focuses on the utilization of date palm waste, a lignocellulosic material, as a source for the extraction of nanocellulose (NC), a versatile biopolymer with applications in biodegradable composites, bioplastics, and food packaging. Conventional methods of NC production using mineral acids such as sulphuric and hydrochloric acid are reaching their limits of toxicity, so more environmentally friendly alternatives such as ionic liquids (ILs) are being explored. The research focuses on the characterization of different date palm wastes to evaluate their α−cellulose content, lignocellulosic character, and thermal stability. By comparing extraction methods with mineral acids and ILs, the study evaluates …

Discovery Of Strong 3-Nitro-2-Phenyl-2h-Chromene Analogues As Antitrypanosomal Agents And Inhibitors Of Trypanosoma Cruzi Glucokinase, Shane M. Carey, Destiny M. O’Neill, Garrett B. Conner, Julian Sherman, Ana Rodriguez, Edward L. D'Antonio

Natural Sciences Faculty Publications

Chagas disease is one of the world’s neglected tropical diseases, caused by the human pathogenic protozoan parasite Trypanosoma cruzi. There is currently a lack of effective and tolerable clinically available therapeutics to treat this life-threatening illness and the discovery of modern alternative options is an urgent matter. T. cruzi glucokinase (TcGlcK) is a potential drug target because its product, D-glucose-6-phosphate, serves as a key metabolite in the pentose phosphate pathway, glycolysis, and gluconeogenesis. In 2019, we identified a novel cluster of TcGlcK inhibitors that also exhibited anti-T. cruzi efficacy called the 3-nitro-2-phenyl-2H-chromene analogues. This was achieved by performing a target-based …

Drip Water Chemistry Response To Human Activities At Diamond Caverns In Park City, Kentucky, Madison R. High

Honors Theses

This research aims to give insight into factors contributing to seasonal variation of karst cave drip water hydrochemistry relative to surface condition. The study area is a small show cave, Diamond Caverns, located just outside the boundary of Mammoth Cave National Park in Kentucky. Various water chemistry parameters, such as chloride, pH, and temperature were monitored. A YSI EXO2 was deployed to measure the aforementioned parameters at one-hour intervals in a drip water pool starting in November 2023. To discern significant changes in solute concentrations, daily averages were calculated based on the hourly data. Daily averages were then compared to …

Recurrent Lymphoid And Myeloid Relapses Due To Treatment Cessations Reveal Natural History Of Ph-Positive B-All And Pose A Diagnostic Challenge, Shimin Hu, Elias J Jabbour, Collin Y Hu, Guilin Tang, Wei Wang, L Jeffrey Medeiros, Carlos Bueso-Ramos

Faculty, Staff and Student Publications

No abstract provided.

Using Flipped Classroom Modules To Facilitate Higher Order Learning In Undergraduate Organic Chemistry, Lauren R. Holloway, Tabitha Miller, Bryce Da Camara, Paul M. Bogie, Briana L. Hickey, Jack Barbera, Angie L. Lopez, Multiple Additional Authors

Chemistry Faculty Publications and Presentations

In an ongoing effort to incorporate active learning and promote higher order learning outcomes in undergraduate organic chemistry, a hybrid (“flipped”) classroom structure has been used to facilitate a series of collaborative activities in the first two courses of the lower division organic chemistry sequence. An observational study of seven classes over a five-year period reveals there is a strong correlation between performance on the in-class activities and performance on the final exam across all classes; however, a significant number of students in these courses continue to struggle on both the in-class activities and final exam. The Activity Engagement Survey …

Seabird Observations In The Southern Ocean South Of Africa, Summer 1975/1976, M. D. Flora

Marine Ornithology

No abstract provided.

Plasma Chemistry Reference Values In Free-Living Bonelli's Eagle (Hieraaetus Fasciatus) Nestlings, Javier Balbontin, Miguel Ferrer

Journal of Raptor Research

No abstract provided.

Serum Chemistry Values For Nestling Bald Eagles (Haliaeetus Leucocephalus&Rsqb; In Florida Bay, Everglades National Park, Brian Mealey, Greta M. Parks, Carlos M. Pages, Brian A. Millsap, Orin L. Bass, Gregory D. Bossart

Journal of Raptor Research

No abstract provided.

Blood Chemistry, Cytology, And Body Condition In Adult Northern Goshawks (Accipiter Gentilis), Lauri A. Hanauska-Brown, Alfred M. Dufty Jr., Gary J. Roloff

Journal of Raptor Research

No abstract provided.

Design Of Two New Sulfur Derivatives Of Perezone: In Silico Study Simulation Targeting Parp-1 And In Vitro Study Validation Using Cancer Cell Lines, Alejandro Rubiales-Martínez, Joel Martinez, Elvia Mera-Jiménez, Javier Perez-Flores, Guillermo Tellez-Isaias, Rene Miranda Ruvacalba, Maricarmen Hernandez-Rodriguez, Teresa Mancillo Percino, Martha Edith Macia Perez, Maria Ines Nicholas-Vazquez

Poultry Science Faculty Publications and Presentations

Poly-ADP-Ribose Polymerase (PARP-1) is an overexpressed enzyme in several carcinomas; consequently, the design of PARP-1 inhibitors has acquired special attention. Hence, in the present study, three compounds (8–10) were produced through a Michael addition protocol, using phenylmethanethiol, 5-fluoro-2-mercaptobenzyl alcohol, and 4-mercaptophenylacetic acid, respectively, as nucleophiles and perezone as the substrate, expecting them to be convenient candidates that inhibit PARP-1. It is convenient to note that in the first stage of the whole study, the molecular dynamics (MD) simulations and the quantum chemistry studies of four secondary metabolites, i.e., perezone (1), perezone angelate (2 …

Profile: Celebrating Sustainability, Communications And Marketing

Profile (1996-)

In this issue: Zavada is First Morton Gneiss Professor; Cougar Days of Giving Event is Resounding Success; Planned Giving is Way for Alum to Give Significant Support; New at UMN Morris: Degree in Three; Cofer Named Vice Chancellor for Academic Affairs and Dean; Pandemic Challenges Led to Improved Chemistry Lab; Kapemni Program Created with NSF Grant; UMN Morris Archives Receives National Endowment for the Humanities Grant; Morris Model Wins Competition to Energize Rural Communities; UMN Morris Included in Food Justice Initiative Funding; DuHamel Receives McKnight Musician Fellowship Grant; Peters Receives JEDI Award; Brugger Named Fellow of the Geological Society of …

Unusual Eluents, Small Systems, And Digital Signal Processing For Highly Efficient Greener Separations, Troy T. Handlovic

Chemistry & Biochemistry Dissertations - Archive

Separation science is a rapidly evolving field, where routine analyses are now done at speeds and efficiencies not thought to be possible several years ago. The tangential field of green analytical chemistry is evolving at an even faster rate and can be considered to be in its infancy stage. As green analytical chemistry is better understood, the greenness of a method will be considered during standard method development just as resolution, sensitivity, and efficiency are considered now. The first portion of this dissertation focuses on the development of mathematical and pragmatic methods to minimize the analytical method greenness score, and …

Chem 361-002: Environmental Chemistry Ii, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Combined In Silico And Experimental Approaches Of Pharmacognosy To Resolve Complex Natural Product Issues, William Michael Neal

Electronic Theses and Dissertations

Since the identification of useful bioactive natural products can often involve tedious dereplication measures to decipher complex mixtures, much emphasis is placed on methods that can effectively characterize natural products. Several in silico methods, such as quantitative structure-activity relationships (QSARs), molecular docking, and quantum calculations, provide researchers with valuable tools to overcome the challenge of complex natural product mixtures. To exemplify the abilities of computational methodologies to further the field of pharmacognosy, this dissertation elaborates on several research projects involving computational approaches in pharmacognosy, including: (1) global assessment of pregnane X receptor (PXR) agonism via multiple QSAR models, (2) differentiation …

A Phytochemical Analysis Of Secondary Metabolites In Eupatorium Serotinum, Elise Snow

Theses and Dissertations

Phytochemistry, a subset of Natural Products Chemistry, studies chemically derived products from natural substances. Advances in this field have important applications in medicinal research due to the distinctive and unique properties of natural compounds. All metabolites are produced from the metabolic cycle, which is a pathway that provides energy for the organism. These metabolic compounds vary greatly and are classified based on their function within the organism. Primary metabolites are abundant and contribute to organism growth, development, and maintenance of energy. Secondary metabolites are found in lesser quantity and correlate to natural defense mechanisms. For example, salicylic acid is a …