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Robedee, Matthew, Hannah Gorham, Jason White

Querying the Past: LGBTQ Maine Oral History Project Collection

Matthew (Mat) Robedee is a 35-year-old gay man who lives in Portland, Maine. For seven years, he was a health and outreach worker and former prevention programs manager for the Frannie Peabody Center, in Portland. He has also worked with organizations such as Portland Pride and Equality Maine and is currently a real estate agent.

Mat grew up in Buxton, Maine. In elementary school, he revealed to a friend that he thought he was gay. His friend reprimanded him, telling him never to tell anyone about his secret. That event set the tone for years to come, and Mat hid …

Germline Maintenance Through The Multifaceted Activities Of Glh/Vasa In, Elisabeth A Marnik, J Heath Fuqua, Catherine S Sharp, Jesse D Rochester, Emily L Xu, Sarah E Holbrook, Dustin L Updike

Faculty Research 2019

Vasa homologs are ATP-dependent DEAD-box helicases, multipotency factors, and critical components that specify and protect the germline. They regulate translation, amplify piwi-interacting RNAs (piRNAs), and act as RNA solvents; however, the limited availability of mutagenesis-derived alleles and their wide range of phenotypes have complicated their analysis. Now, with clustered regularly interspaced short palindromic repeats (CRISPR/Cas9), these limitations can be mitigated to determine why protein domains have been lost or retained throughout evolution. Here, we define the functional motifs of GLH-1/Vasa in

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

The Short-Term Rental Economy In Rural Maine Communities: An Opportunity For Economic Growth Instead Of A Target For Regulation, Nicholas E. Anania

Maine Law Review

State and local governments across the country are grappling with the rise of short-term housing rentals and how to enact effective regulation regarding their use. The increase of short-term rentals (STRs) is almost entirely the result of online platforms that make STRs easy, efficient, and accessible. While STRs undoubtedly have positive economic outcomes for both property owners and local economies, there are also many negative repercussions which must be effectively regulated. Regulation in this area reflects differing priorities and viewpoints of states and municipalities. Specifically, rural Maine municipalities, many of which are popular seasonal destinations, face not only the challenges …

Finding Novel Therapeutics For Blood Cancer Chemotherapy And Immunotherapy, Jin Li

Doctoral Dissertations

This thesis focuses on identification and development of novel small molecule therapeutics for blood cancer. The studies presented herein examine two classes of novel compounds with different mechanisms: tropolones as chemotherapies (Chapters II and III) and phosphoantigens as immunotherapies (Chapters IV-VII).

A library of α-tropolone derivatives was tested for anti-proliferative effects on a panel of hematological malignancies demonstrating preference towards cells of T cell lineage. Through investigating different compounds, some structure activity relationships for compound potency were determined. As a class, the mechanism of action was reliant upon the caspase pathway, p53 regulation, Akt, mTor, and iron. The α-substituted tropolones …

Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Healthcare, The Environment And Biomedicine, Ahkar Phyo Phyo, Suraj Bala, Mason Barrett, Jack Connelly, Lucy Cummins, Claire Fuller, Hannah Gorga, Jonathan Huang, Dowha Karar, Katrina Kuhn, Elizabeth Lopez-Lopez, Carolina Montoya, Liz Narwold, Lindsay Pett, Shruti Police, Grace Ann Robertson, Rachel Schuman, Virginia Sun, Katie Wall, Ivy Zhong

SSIR Presentations 2019

The final SSIR project aim: To better understand the factors that impact student well-being at the University of Richmond, with a focus on those that raise happiness and reduce stress.

Goals and questions included:

● To find statistically significant data that correlates to who the happiest spidURs are
● Tried to separate student groups to identify individual factors
● Sought out students who had lowest stress, highest happiness

Conserving A Vision: Acadia, Katahdin, And The Pathway From Private Lands To Park Lands, Sean Flaherty, Anthony L. Moffa

Maine Law Review

Although a century separates the official designations, the strategies required to ensure federal protection of Maine’s two National Park Service areas—Acadia National Park and Katahdin Woods and Waters National Monument—closely track one another. In both cases, a handful of enterprising conservationists shared the vision for conservation. Both areas depended on the private acquisition, and donation, of title to the numerous parcels that comprised them before the land could garner federal protection. Politics in the early 20th and 21st centuries had to be overcome. This work tells the stories in parallel, highlighting and analyzing four strands of similarity to not only …

Colby College Catalogue 2019-2020, Colby College

Colby Catalogues

No abstract provided.

Quantification Of Aqp11 Paralog Expression In The Osmoregulatory Organs Of Anguilla Rostrata, Keith C. Kurt

College of Graduate Studies: Theses & Dissertations

Osmoregulation is facilitated by using an assortment of ion and water channels to assist acclimation to changing conditions and to maintain cellular homeostasis. Euryhaline fish can be found in both seawater and freshwater (SW and FW) environments. Expression of ion and water channels have been experimentally demonstrated to change as a fish acclimates to different environmental conditions. Relatively recently, a new group of water channels has been discovered that are primarily intracellular and includes aquaporin 11 (AQP11). Typically, AQPs are located on the cell plasma membrane to allow water to flow in and out of the cell by osmosis to …