Digital Commons Network^™

Efficacy Of Female Rat Models In Translational Cardiovascular Aging Research, Kevin M. Rice, J. C. Fannin, C. Gillette, Eric Blough

Pharmaceutical Science and Research

Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. …

Exploring Individual Differences In Workload Assessment, Danielle K. Boeke

Theses and Dissertations

Air Force missions continue to increase in complexity often imposing higher levels of task load from cognitive tasks on the operators. This increased task load manifests itself in increased cognitive workload and potentially derogated performance. While cognitive workload has been studied for decades, recent advances in objective workload models and physiology monitoring have the potential to provide a more robust understanding of workload, potentially allowing systems to adaptively employ automation to maintain operator peak performance. The current research sought to provide insight into the relationship between subjective workload, task performance, objective workload, and select physiology measures. Analysis of an existing …

Alaska Native Perceptions Of Food, Health, And Community Well-Being: Challenging Nutritional Colonialism, Melanie Lindholm

Arctic and Northern Studies

Alaska Native populations have undergone relatively rapid changes in nearly every aspect of life over the past half century. Overall lifestyles have shifted from subsistence-based to wage-based, from traditional to Western, and from self-sustainability to reliance on Outside sources. My research investigates the effects of these changes on health and well-being. The literature appears to lack concern for and documentation of Native peoples' perceptions of the changes in food systems and effects on their communities. Additionally, there is a lack of studies specific to Alaska Native individual perceptions of health and well-being. Therefore, my research aims to help identify social …

Quantitative Comparison Of Time-Frequency Decomposed Gait Emg Signals, L. Patrick Mitchell

Theses and Dissertations

Falls in the senior population represent an immediate threat to both current and future generations’ quality of life. The results of falls can be disastrous, create a long road to recovery, and in many cases result in death. Hypertension represents a difficult-to-quantify condition which is known to contribute to gait and balance dysfunction. Accurate assessment of conditions such as these represents an area of primary investigative need. In order to meet this need, a new experimental setup is developed which combines time-frequency analysis with surface electromyography (sEMG) signals obtained during ambulation. 3-bit pressure data is acquired using a pressure-sensitive mat, …

Feeling Doctrine: Religious Meanings Of Emotion In Sixteenth-Century German Literature, Georgia Anna Leeper

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation explores the intersections of emotion and Protestant theology in late-16th-century German literature. The project demonstrates the availability of even secular texts to confessional readings through the analysis of representations of emotions. Post-Reformation texts practice an emotional exemplarity that highlights the effects - including the spiritual effects - which emotional experiences have on the individual. I argue that narrative representations of emotions at this moment reflect anxieties about the nebulous nature of faith, and its central role in Protestant salvation. Close readings of widely-read texts such as the 1587 Faustbuch, Melusine, and Hans Sach's Judith: ein Comedi, among others …

Bio-Enhanced Constructivism: Moral Facts For The Naturalistic But Morally Serious Philosopher, Jason Gardner

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACTBio-Enhanced Constructivism: Moral Facts for the Naturalistic but Morally Serious PhilosopherbyJason GardnerDoctor of Philosophy in PhilosophyWashington University in St. Louis, 2014Professor Eric Brown, ChairThere is a tension between being both morally and naturalistically serious because it is doubtful that features philosophers have ascribed to moral facts in order to explain why we should take them seriously can be given a naturalistic accounting. Yet even serious naturalists who think the tension is real and troubling persist in trying to be serious moralists. I do not think they can do so on their own terms. Thus the purpose of this dissertation: to …

Characterization Of Vibrio Vulnificus Strains Using Phenotypic And Genotypic Assays, James Conrad

Masters Theses, 2010-2019

In this study 143 V. vulnificus isolates of clinical and environmental origin, were examined for growth on differential media, identified to species and tested for antibiotic resistance. A multiplex PCR was created and optimized, and phylogenetic analysis was conducted. The first objective was to compare phenotypic methods to identify V. vulnificus. Colony colors of confirmed V. vulnificus isolates on selective media (Vibrio vulnificus agar, thiosulfate citrate bilesalts sucrose agar, CHROMAgar Vibrio (CAV), and colistin polymyxin B cellobiose agar), mostly matched those characteristic of V. vulnificus. To test the ability of these media to select for V. vulnificus, new presumptive V. …

Improved Methods For The Analysis Of Estrogen Residues In Environmental Aqueous Matrices, Sameera Ranmal Gunatilake

Theses and Dissertations

Improved analytical methods using novel cleanup techniques and inexpensive instrumentation for the determination of residue estrogens in municipal wastewater and swine lagoon wastewater have been developed. Presented approaches are less expensive, less time consuming, yet produce comparable detection limits and extraction efficiencies to existing methods. Chapter I provides an overview on environmental estrogens. Chapter II describes a novel method to quantify five estrogens including estriol, estrone, 17alpha-estradiol, 17beta-estradiol, and 17alpha-ethynylestradiol in influent and effluent municipal wastewater. The method includes sample preparation using solid-phase extraction followed by a “QuEChERS” cleanup, dansylation and LC/MS/MS detection. Hydrophilic-lipophilic balance solid phase extraction (SPE) was …

Developing A Wireless Sensor Network Programming Language Application Guide Using Memsic Devices And Labview, Xiao Xie

Master of Technology Management Plan II Graduate Projects

The principal objective of this project is to develop a wireless sensor network (WSN) programming language application guide for junior and senior undergraduate students in College of Technology, Architecture and Applied Engineering in Bowling Green State University. Memsic device, MoteWorks and LabVIEW software are used to conduct experiments in developing WSN applications after both software and hardware platform are verified to be usable with experimental and statistical analysis. The guide is divided into six chapters including both theoretical knowledge and practical experiments in WSN area. Programs, both in nesC language and LabVIEW are improved from previous work, tested to run …

Phosphoinositide 3-Kinase (Pi3k) P11alpha Catalytic Subunit In Adipose Tissue Regulates Systemic Metabolism, Victoria Leigh Boughton

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Adipose tissue is a highly insulin responsive organ that contributes to metabolic regulation. Insulin resistance in the adipose tissue affects systemic lipid and glucose homeostasis. Phosphoinositide 3-kinase (PI3K) mediates downstream insulin signaling in adipose tissue, but its physiological role in vivo remains unclear. Using Cre recombinase driven by the aP2 promoter, we created mice that lack the class 1A PI3K catalytic subunit p110alpha or p110beta specifically in the white and brown adipose tissue. The loss of p11alpha, not p110beta, resulted in increased adiposity, glucose intolerance and liver steatosis. Mice lacking p110alpha in adipose tissue exhibited a decrease in energy expenditure …

Effects Of Nitrate Supplementation On Cognitive And Cerebrovascular Function At Simulated High Altitude, Wesley K. Lefferts

Theses - ALL

Acute high altitude (HA) exposure compromises cognitive function thus posing a significant risk to personnel safety in a HA environment, particularly when performing tasks that requires cognitive vigilance. Normal cerebral function, and thus cognitive function, is dependent upon oxygen supply. At HA there is reduced oxygen availability results in compensatory increases in cerebrovascular blood flow which may be related to nitric oxide (NO), a primary signaling molecule that acts to increase blood flow and ensure an optimal neurovascular coupling (NVC). Upon initial ascent to HA, however, there may be reductions in NO production which may play a role in acute …

Lntegration Of Conventional Lithography And Printing Processes As A Key Enabling Technology For Printed And Flexible Sensing Systems, Binu Baby Narakathu

Dissertations

Sensors, which are used ubiquitously in a wide variety of applications, are revolutionizing the already ever-changing world we live in by providing real-time information about our surroundings. This dissertation focuses on the integration of conventional photolithography and printing processes as a key enabling technology for printed and flexible sensing systems.

Initially, an efficient opto-electrochemical sensing system, for the dual detection of heavy metal compounds was successfully developed. A novel microfluidic flow cell, with a reservoir volume of 25 μl, was designed and fabricated using acrylic. An electrochemical sensor with gold (Au) interdigitated electrodes (IDE) on a glass substrate was photolithographically …

Spectroscopy And Gas-Phase Binding Of Modified Desferrioxamine B Indicator Displacement-Based Sensors, William Scott Jones

Dissertations

A coupling reaction has been used to successfully synthesize two novel probes utilizing coumarin derivatives as fluorophores. The structure, spectroscopy, and thermodynamics of these probes were characterized and studied. These probes, along with a classical probe using a N-methyl-anthranilate fluorophore, are used to take advantage of the ability of siderophores to coordinate Fe³⁺ ions which is coupled with the attractive phosphorescence properties of lanthanide ions. The use of lanthanide metals to create an indicator displacement assays is a novel application of these probes for the detection of Fe³⁺ ions. The use of Tb³⁺ ions as the indicator …

Deveopment Of Explant Registry And Mechanical Testing Of Pristine And Explained Surgical Mesh, Colin Burns-Heffner

All Theses

Abdominal hernia repair is the most commonly performed general surgical procedure, with synthetic surgical mesh commonly used to buttress the defect in the abdominal wall. A majority of surgical mesh is made from Polypropylene (PP), which has been shown to invoke a foreign body response as long as the material remains in the body. Complications such as chronic pain require further investigation of mesh performance in hernia repair to better understand how performance differs for various surgical mesh materials. The broad objective of this thesis is to quantitatively characterize surgical mesh after exposure to human physiology in an in-vivo environment. …

The Relationship Between Attachment, Couple Conflict, And Recovery From Conflict, Nathan C. Taylor

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Advances in technology have opened the door for increased understanding to the physiological changes that influence and are influenced by conflict. The objective of this research was to use these advances in technology to better understand the relationship between attachment and physiological reactivity during conflict, as well as during recovery from couple conflict. Skin conductance equipment was used to measure 10 couples (n = 20) physiological arousal while discussing an area of conflict, and during a recovery section which included a relationship distraction task and discussion. Five multiple regressions were used to analyze physiological reactivity during and after conflict …

Client Selected Music Based Effects On Marital And Couples Therapy, Kevin Matthew Smith

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study was designed to examine the interaction of music-based interventions in the therapeutic process of Martial and Couples Therapy. The use of pre-recorded music was found to be under researched within the literature and created a void within the knowledge that clinicians have about how music might enhance effectiveness of treatment. The inclusion of music in this process is not currently known, which led to this study being conducted. Through a phenomenological lens, the awareness and understanding of how clients react and experience pre-recorded music during the therapeutic process, while still having a selection of options to preserve autonomy, …

High Frequency Devices And Circuit Modules For Biochemical Microsystems, Jiwei Sun

All Dissertations

This dissertation investigates high frequency devices and circuit modules for biochemical microsystems. These modules are designed towards replacing external bulky laboratory instruments and integrating with biochemical microsystems to generate and analyze signals in frequency and time domain. The first is a charge pump circuit with modified triple well diodes, which is used as an on-chip power supply. The second is an on-chip pulse generation circuit to generate high voltage short pulses. It includes a pulse-forming-line (PFL) based pulse generation circuit, a Marx generator and a Blumlein generator. The third is a six-port circuit based on four quadrature hybrids with 2.0~6.0 …

Development Of A Heart Rate Variability Measurement System Using Embedded Electronics, Naresh Kumar Velmurugan

Graduate Theses and Dissertations

Recent advances in embedded electronics have a remarkable influence on the health care system. One of the most important applications is to monitor the health care of the patients at anytime and anyplace. In the last two decades, many researchers have focused mainly on heart rate variability (HRV) measurements. Patient's heart rate variability should be continuously monitored to help them in case of emergency. Under these circumstances, patients are required to have a HRV measuring kit for a constant observation.

The proposed project focuses on the development of a heart rate variability measurement system with the use of embedded electronics. …

Educational Policies Committee Minutes, November 6, 2014, Utah State University

Educational Policies Committee

• Subcommittee Reports
• Curriculum Subcommittee
• Course Approvals
• Program Proposals
• Academic Standards Subcommittee
• General Education Subcommittee

Olfactory Dysfunction Predicts 5-Year Mortality In Older Adults, Jayant M. Pinto, Kristen E. Wroblewski, David W. Kern, L Phillip Schumm, Martha K. Mcclintock

Psychology & Gerontology Faculty Publications

Prediction of mortality has focused on disease and frailty, although antecedent biomarkers may herald broad physiological decline. Olfaction, an ancestral chemical system, is a strong candidate biomarker because it is linked to diverse physiological processes. We sought to determine if olfactory dysfunction is a harbinger of 5-year mortality in the National Social Life, Health and Aging Project [NSHAP], a nationally representative sample of older U.S. adults. 3,005 community-dwelling adults aged 57–85 were studied in 2005–6 (Wave 1) and their mortality determined in 2010–11 (Wave 2). Olfactory dysfunction, determined objectively at Wave 1, was used to estimate the odds of 5-year, …

Octf2014, Robert Kelly

Robert Kelly Manuscripts

From October 2014 Robert Kelly Archive

Notes With Interest: Department Of Finance Newsletter, N03, Fall 2014, University Of Northern Iowa. Department Of Finance.

Department of Finance Newsletter

News about the activities of the Department of Finance

Learning Opportunities 2014/2015, Illinois Mathematics And Science Academy

Course Catalogs

The graduation requirements of the Illinois Mathematics and Science Academy are in concert with those maintained by the State of Illinois with additional requirements as established by the IMSA Board of Trustees. Each semester students must take a minimum of 5 academic courses (2.5 credits) for a grade (not Pass/Fail). Fine Arts, Wellness, and Independent Study courses, or any course taken on a Pass/Fail basis do not count towards the 5 course (2.5 credits) minimum. Most students will take between 5 (2.5 credits) and 7 (3.5 credits) academic courses per semester. Only courses taken for a letter grade will count …

From Medicine To Butterflies And Back Again, C Parmesan

School of Biological and Marine Sciences

My research focuses on the current impacts of climate change on wildlife, from field-based work on butterflies to synthetic analyses of global impacts on a broad range of species across terrestrial and marine biomes. I work actively with governmental agencies and NGOs to help develop conservation assessment and planning tools aimed at preserving biodiversity in the face of climate change.

Development Of A Fatal Noncompressible Truncal Hemorrhage Model With Combined Hepatic And Portal Venous Injury In Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo F. Larsen, William H. Velander, Mark A. Carlson

William H. Velander Publications

Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ,50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34–36 kg) underwent one of three injury types …

Space Radiation: The Number One Risk To Astronaut Health Beyond Low Earth Orbit, Jeffery C. Chancellor, Graham B.I. Scott, Jeffrey P. Sutton

Faculty Publications

Projecting a vision for space radiobiological research necessitates understanding the nature of the space radiation environment and how radiation risks influence mission planning, timelines and operational decisions. Exposure to space radiation increases the risks of astronauts developing cancer, experiencing central nervous system (CNS) decrements, exhibiting degenerative tissue effects or developing acute radiation syndrome. One or more of these deleterious health effects could develop during future multi-year space exploration missions beyond low Earth orbit (LEO). Shielding is an effective countermeasure against solar particle events (SPEs), but is ineffective in protecting crew members from the biological impacts of fast moving, highly-charged galactic …

Regulating Weaponized Nanotechnology: How The International Criminal Court Offers A Way Forward, Lucas D. Bradley

Georgia Journal of International & Comparative Law

No abstract provided.

Repair Of O6-Methylguanine Adducts In Human Telomeric G-Quadruplex Dna By O6-Alkylguanine-Dna Alkyltransferase, Lance M. Hellman, Tyler J. Spear, Colton J. Koontz, Manana Melikishvili, Michael G. Fried

Molecular and Cellular Biochemistry Faculty Publications

O⁶-alkylguanine-DNA alkyltransferase (AGT) is a single-cycle DNA repair enzyme that removes pro-mutagenic O⁶-alkylguanine adducts from DNA. Its functions with short single-stranded and duplex substrates have been characterized, but its ability to act on other DNA structures remains poorly understood. Here, we examine the functions of this enzyme on O⁶-methylguanine (6mG) adducts in the four-stranded structure of the human telomeric G-quadruplex. On a folded 22-nt G-quadruplex substrate, binding saturated at 2 AGT:DNA, significantly less than the ~ 5 AGT:DNA found with linear single-stranded DNAs of similar length, and less than the value found with the …

Bioh 461.80: Tutoring Human Anatomy And Physiology I - Honors, Laurie A. Minns

University of Montana Course Syllabi

No abstract provided.

Bioh 423.80: Human Form And Function Teaching Assistant I - Honors, Heather D. Labbe

University of Montana Course Syllabi

No abstract provided.