Digital Commons Network^™

Long-Term Depression Of Excitatory Inputs To Gabaergic Neurons In The Ventral Tegmental Area, Philip J. Sandoval

Theses and Dissertations

Dopamine cells within the ventral tegmental area of the brain are involved in motivation and reward. Drugs of abuse target these dopamine cells altering their activity and plasticity resulting in addiction. While dopamine cell activity is primarily involved in addiction, the GABA neurons in the VTA have also been shown to have an indirect role. By decreasing the activity of the inhibitory GABA inputs onto dopamine neurons abusive drugs can indirectly increase dopamine cell activity resulting in addictive behaviors. However, although GABA neurons are important in the perception of reward, much less is known about how the excitatory inputs to …

The Adverse Effects Periodontal Disease Has On Women, Jennifer Long

Honors Theses

The Adverse Effects Periodontal Diseases Has on Women Periodontal diseases are challenging to define given the number and variety of different oral diseases. This review sought to answer the question: How does a periodontal disease impact a woman throughout the life span? Specifically, this document discussed how, because of the cycling hormones and the effects those hormones have on the different bacteria, women's periodontal diseases differ from men's. Diseases of the mouth were first discovered during the Egyptian period and the information and knowledge about the different diseases advanced as time progressed. From here, non-surgical and surgical treatments were discussed …

A Symbiotic View Of Life: We Have Never Been Individuals, Scott F. Gilbert, J. Sapp, A. I. Tauber

Biology Faculty Works

The notion of the "biological individual" is crucial to studies of genetics, immunology, evolution, development, anatomy, and physiology. Each of these biological subdisciplines has a specific conception of individuality, which has historically provided conceptual contexts for integrating newly acquired data. During the past decade, nucleic acid analysis, especially genomic sequencing and high-throughput RNA techniques, has challenged each of these disciplinary definitions by finding significant interactions of animals and plants with symbiotic microorganisms that disrupt the boundaries that heretofore had characterized the biological individual. Animals cannot be considered individuals by anatomical or physiological criteria because a diversity of symbionts are both …

Quintessence Of Dust: Cognitive Neuroscience And An Actor's Process, Jason Christopher Davis

Dissertations, Masters Theses, Capstones, and Culminating Projects

This thesis examines theories provided by cognitive neuroscience and applies them to an actor’s process. In particular, this research addresses the subjectivity and intentionality of our consciousness and special as-if states of consciousness, supported by the work of John Searle and Antonio Damasio. The phenomenal feeling of character-model control is discussed and supported by the work of Thomas Metzinger. The paper also considers our relative understanding of mirror neurons and specifically their function in relation to intersubjectivity and their use for an actor’s creation and conveyance of character in rehearsal and performance. It examines Stanislavsky’s notion of emotional memory and …

Building Envelope Wind Pressure Manipulation For Application In Streamlined High-Rise Buildings, Sivaramprasad Sivakumar

Mechanical and Aerospace Engineering - Dissertations

This research investigates methods of manipulating building envelope wind pressure distribution for application in the natural ventilation of high-rise buildings. CFD simulations are employed to predict the wind pressure distribution around the building envelope. First, a 2-D CFD study is conducted to explore various techniques of manipulating the building envelope wind pressure distribution. This study indicates that the use of externally mounted flow-resistance devices is an effective method of manipulating the wind pressure distribution. It is demonstrated that this technique is well suited for application to buildings of streamlined cross-section (e.g. elliptical planform). Next, a 3-D CFD study is conducted …

Life History Variation Of Common Terns In The Gulf Of Maine, Jeffery Bryant Kimmons

Graduate Theses and Dissertations

Life history is the inheritable rules that determine energy and time allocation towards different competing functions in the energy budget of an organism. Reproductive effort varies as organisms make reproductive decisions based on available energy. Factors influencing life histories are those that change energy and time budgets such as diet, competition, and environmental conditions.

Common tern (Sterna hirundo) life history phenotypes vary between islands in the Gulf of Maine. Common terns on offshore islands (>10km from mainland) and nearshore islands (5 to 10km from mainland) lay smaller clutches, hatching chicks with slower growth rates than common terns …

Mrp4 Is A Crucial Regulator Of Testosterone Biosynthesis, Jessica Ann Morgan

Theses and Dissertations (ETD)

The physiological role of multidrug resistance protein 4 (Mrp4) in the testes is unknown. It was discovered that Mrp4 is expressed primarily in mouse and human Leydig cells; however, there is no current evidence that Mrp4 regulates testosterone biosynthesis. The role of Mrp4 was investigated in Leydig cells where testosterone production is regulated by cAMP, an intracellular second messenger formed when the luteinizing hormone (LH) receptor (Lhr) is activated. As Mrp4 regulates cAMP, we compared testosterone levels in our Mrp4 WT and KO mice. Prepubertal KO mice had significantly reduced testicular testosterone, impaired gametogenesis, and disrupted cAMP homeostasis, resulting in …

The Effects Of Energy Beverages In Counteracting The Symptoms Of Mild Hypoxia At Legal General Aviation Altitudes, Daniel Mark Bull

Doctoral Dissertations and Master's Theses

The purpose of this thesis was to conduct preliminary research, in the form of a pilot study, concerning the natural effects of hypoxia compared to the effects of hypoxia experienced after the consumption of an energy beverage. The study evaluated the effects of hypoxia on FAA certificated pilots at a simulated legal general aviation altitude, utilizing the normobaric High Altitude Lab (HAL) located at Embry Riddle Aeronautical University, Daytona Beach, Florida. The researcher tested 11 subjects, who completed three simulated flight tasks within the HAL using the Frasca International Mentor Advanced Aviation Training Device (AATD). The flight tasks were …

Phoneme Weighting And Energy-Based Weighting For Speaker Recognition, Eric Fang

All Dissertations

This dissertation focuses on determining specific vowel phonemes which work best for speaker identification and speaker verification, and also developing new algorithms to improve speaker identification accuracy. Results from the first part of our research indicate that the vowels /i/, /E/ and /u/ were the ones having the highest recognition scores for both the Gaussian mixture model (GMM) and vector quantization (VQ) methods (at most one classification error). For VQ, /i/, /I/, /e/, /E/ and /@/ had no classification errors. Persons speaking /E/, /o/ and /u/ have been verified well by both GMM and VQ methods in our experiments. For …

Design And Development Of A Novel Transcranial Doppler Headset For Assessment Of Cerebral Blood Flow, Brian P. Watt

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Examining physiologic responses of cerebral blood flow (CBF) for subjects in challenging situations requires development of new technology. Challenging circumstances include strenuous physical activity, intensive care, and surgical procedures involving the head, neck and thorax. Headset technology to employ transcranial Doppler (TCD), which is commercially available, fails to meet several requirements for monitoring in these situations. These requirements include stable signal acquisition, non-interference with other physiological monitors, ability to fit all head sizes including infants and children. The design and development of a novel TCD headset was performed to meet these requirements. The new device theoretically allows the user to …

The Effects Of River Sediment, Endosulfan, And Moderate Hypoxia On Blue Crabs (Callinectes Sapidus) From The Tidal, Freshwater James River, Laura Williams

Theses and Dissertations

Juvenile male blue crabs move into the tidal, freshwater James River during warmer months to feed and grow by undergoing molting. In crustaceans, growth and molting are hormonally controlled. The physiological effects of a multiple-stressor environment are determined by comparing the blue crab’s oxygen uptake after exposure to pure sand, James River sediment, or endosulfan-spiked sand. The effect of multiple stressors on molting is measured by the activity level of N-acetyl-ß-glucosaminidase (NAG), an enzyme in epidermal tissue important to molting. The oxygen uptake was decreased by exposure to James River sediment but not for exposure to endosulfan for seven days. …

Transfusion Of Cxcr4-Primed Endothelial Progenitor Cells Reduces Cerebral Ischemic Damage And Promotes Repair In Db/Db Diabetic Mice, Ji Chen, Jianying Chen, Shuzhen Chen, Cheng Zhang, Liangqing Zhang, Xiang Xiao, Avik Das, Yuhui Zhao, Bin Yuan, Mariana Morris, Bin Zhao, Yanfang Chen

Pharmacology and Toxicology Faculty Publications

This study investigated the role of stromal cell-derived factor-1α (SDF-1α)/CXC chemokine receptor 4 (CXCR4) axis in brain and endothelial progenitor cells (EPCs), and explored the efficacy of CXCR4 primed EPCs in treating ischemic stroke in diabetes. The db/db diabetic and db/+ mice were used in this study. Levels of plasma SDF-1α and circulating CD34+CXCR4+ cells were measured. Brain SDF-1α and CXCR4 expression were quantified at basal and after middle cerebral artery occlusion (MCAO). In in vitro study, EPCs were transfected with adenovirus carrying null (Ad-null) or CXCR4 (Ad-CXCR4) followed with high glucose (HG) treatment for 4 days. For pathway block …

Immune Correlates Of Aging In Outdoor-Housed Captive Rhesus Macaques (Macaca Mulatta), Elizabeth S. Didier, Chie Sugimoto, Lisa C. Bowers, Imtiaz A. Khan, Marcelo J. Kuroda

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Background

Questions remain about whether inflammation is a cause, consequence, or coincidence of aging. The purpose of this study was to define baseline immunological characteristics from blood to develop a model in rhesus macaques that could be used to address the relationship between inflammation and aging. Hematology, flow cytometry, clinical chemistry, and multiplex cytokine/chemokine analyses were performed on a group of 101 outdoor-housed captive rhesus macaques ranging from 2 to 24 years of age, approximately equivalent to 8 to 77 years of age in humans.

Results

These results extend earlier reports correlating changes in lymphocyte subpopulations and cytokines/chemokines with increasing …

Different Immersion Temperature's Impact Upon Blood Pressure Of Individuals With Varied Sex And Age, Kasee Hildenbrand, Celestina Barbosa-Leiker, Daniel Melchior

International Journal of Aquatic Research and Education

Warm water immersion is known to have an effect on human cardiovascular function. This study examines how age (young = 18-30 years and older = 31-65 years) and sex influence changes in blood pressure due to submersion in different water temperatures. Fifty-eight individuals sat immersed to the neck in three different water temperature tanks. Blood pressure measurements (systolic/diastolic blood pressure [SBP/DBP], pulse pressure [PP] and heart rate [HR]) were collected every 6 minutes throughout the duration of the test. We observed significant between-group, within-group, and interaction effects for SBP, DBP, and HR. For PP, significant between-group, within-in group and interaction …

Curriculum Subcommittee Agenda, November 1, 2012, Utah State University

Educational Policies Committee

College of Agriculture

• New Course

Department of Agricultural Systems Technology and Education

• New Course
• Add Multiple List
• Add Multiple List, Title Change

Department of Landscape Architecture and Environmental Planning

• University Studies Request, Prerequisite Change

Department of Nutrition, Dietetics and Food Sciences

• New Course
• Credit Hour Change
• Course Number Change
• Credit Hour Change, Prerequisite Change, Course Description Change
• Title Change

Department of Plants, Soils and Climate

• New Course
• Title Change, Course Description Change
• Title Change, Credit Hour Change, Course Description Change

School of Applied Sciences, Technology and Education

• Title Change

School of Veterinary Medicine

• New Course
• Credit Hour Change, Prerequisite Change …

North American Bioactive Plants For Human Health And Performance, Maria Pontes Ferreira, Fidji Gendron, Katrina C. Mcclure, Kelly Kindscher

Nutrition and Food Science Faculty Research Publications

Native and naturalized bioactive plants of the Canadian and American temperate biome are examined for their health and performance enhancement properties. Some of these plants are now being used as natural health products, and many have a long history as traditional foods and/or medicines with indigenous groups. This paper reviews the medicinal/cultural uses and bioactive properties of selected plant families: the Holly family (Aquifoliaceae) as stimulants, the Celery family (Apiaceae) as normoglycemic aids and analgesics, the Ginseng family (Araliaceae) as energy- boosting aids, the Sunflower family (Compositae) as anti-inflammatory aids, and the Legume family (Fabaceae) and Nightshade family (Solanaceae) as …

Undergraduate Curriculum And Academic Policy Committee Minutes, October 17, 2012

Undergraduate Curriculum and Academic Policy Committee Minutes

Minutes from the Wright State University Faculty Senate Undergraduate Curriculum and Academic Policy Committee meeting held on October 17, 2012.

Gβγ Acts At An Inter-Subunit Cleft To Activate Girk1 Channels, Rahul Mahajan

Theses and Dissertations

Heterotrimeric guanine nucleotide-binding proteins (G-proteins) consist of an alpha subunit (Gα) and the dimeric beta-gamma subunit (Gβγ). The first example of direct cell signaling by Gβγ was the discovery of its role in activating G-protein regulated inwardly rectifying K+ (GIRK) channels which underlie the acetylcholine-induced K+ current responsible for vagal inhibition of heart rate. Published crystal structures have provided important insights into the structures of the G-protein subunits and GIRK channels separately, but co-crystals of the channel and Gβγ together remain elusive and no specific reciprocal residue interactions between the two proteins are currently known. Given the absence of direct …

Curriculum Subcommittee Agenda, October 4, 2012, Utah State University

Educational Policies Committee

School of Applied Sciences, Technology and Education

• University Studies Request

School of Veterinary Medicine

• New Course
• Credit Hour Change, Prerequisite Change
• Delete Course

Department of Agricultural Systems Technology and Education

• Reactivate Course, Title Change, Course Description Change

Department of Art and Design

• New Course
• University Studies Request

Department of Music

• Prerequisite Change
• Course Number Change, Prerequisite Change
• Title Change
• Title Change, Course Description Change

Department of Theatre Arts

• New Course
• Prerequisite Change
• Credit Hour Change, Prerequisite Change, Grade Mode Change
• Title Change, Prerequisite Change
• Course Number Change, Prerequisite Change
• Course Number Change, Prerequisite Change, Add Dual List

Department of Economics …

Curriculum Subcommittee Minutes, October 4, 2012, Utah State University

Educational Policies Committee

School of Applied Sciences, Technology and Education

• University Studies Request

School of Veterinary Medicine

• New Course
• Credit Hour Change, Prerequisite Change
• Delete Course

Department of Agricultural Systems Technology and Education

• Reactivate Course, Title Change, Course Description Change

Department of Art and Design

• New Course
• University Studies Request

Department of Music

• Prerequisite Change
• Course Number Change, Prerequisite Change
• Title Change
• Title Change, Course Description Change

Department of Theatre Arts

• New Course
• Prerequisite Change
• Credit Hour Change, Prerequisite Change, Grade Mode Change
• Title Change, Prerequisite Change
• Course Number Change, Prerequisite Change
• Course Number Change, Prerequisite Change, Add Dual List

Department of Economics …

The Relationship Between Heart Rate Variability, Shooting Experience, And Tactical Pistol Performance, Andrew Gerard Thompson

Human Movement Studies & Special Education Theses & Dissertations

PURPOSE: At rest and during a tactical pistol competition classifier, heart rate variability (HRV) time-domain, high frequency (HF), low frequency (LF), total power (TP), and inter-beat-interval (IBI) measurements were examined in 28, healthy subjects (37 ± 11 yr old, 180 ± 7 cm, 90.6 ± 16.9 kg) for correlations to performance. METHODS: Resting measurements were taken supine in a quiet, dimmed room, during metronomic breathing. The shooting task consisted of three stages, comprised of several strings each. The strings were initiated by a starting buzzer and involved several tactical maneuvers, including holster draws, engaging multiple targets, firing on the move, …

Major V. Security Equipment Corp. Appellant's Reply Brief Dckt. 39414

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Sarcopenia, Obesity, And Natural Killer Cell Immune Senescence In Aging: Altered Cytokine Levels As A Common Mechanism, Charles T. Lutz, Lebris S. Quinn

Pathology and Laboratory Medicine Faculty Publications

Human aging is characterized by both physical and physiological frailty. A key feature of frailty, sarcopenia is the age-associated decline in skeletal muscle mass, strength, and endurance that characterize even the healthy elderly. Increases in adiposity, particularly in visceral adipose tissue, are almost universal in aging individuals and can contribute to sarcopenia and insulin resistance by increasing levels of inflammatory cytokines known collectively as adipokines. Aging also is associated with declines in adaptive and innate immunity, known as immune senescence, which are risk factors for cancer and all-cause mortality. The cytokine interleukin-15 (IL-15) is highly expressed in skeletal muscle tissue …

Current, August 27, 2012, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

Introduction, Kevin Curran, James Kearney

Criticism

It might seem strange to devote a collection of essays to "Shakespeare and Phenomenology" in the second decade of the twenty-first century. After all, phenomenology as a philosophical movement had its heyday in the middle of the twentieth century. But phenomenology's demise as a major philosophical movement has enabled it to live on as the approach or method shorn of dogma that its earliest practitioners promised. Far from being a single school of thought, phenomenology now looks more like an intellectual diaspora, a galaxy of related but discreet propositions that share basic assumptions while pursuing different philosophical projects. In early …

Membrane Properties Involved In Calcium-Stimulated Microparticle Release From The Plasma Membranes Of S49 Lymphoma Cells, Lauryl Elizabeth Campbell

Theses and Dissertations

The mechanism of microparticle shedding from the plasma membrane of calcium-loaded cells has been investigated in erythrocytes and platelets. Recent studies have revealed the physiological and clinical importance of microparticle release from nucleated cells such as lymphocytes and endothelium. The experiments of this study were designed to address whether simple mechanisms discovered in platelets and erythrocytes also apply to the more complex nucleated cells. Four such mechanisms were addressed: potassium efflux, transbilayer phosphatidylserine migration, cytoskeleton degradation, and membrane lipid order. The rate and amount of microparticle release in the presence of a calcium ionophore, ionomycin, was assayed by light scatter …

Automatic Generation Of Music For Inducing Emotive And Physiological Responses, Kristine Perry Monteith

Theses and Dissertations

Music and emotion are two realms traditionally considered to be unique to human intelligence. This dissertation focuses on furthering artificial intelligence research, specifically in the area of computational creativity, by investigating methods of composing music that elicits desired emotional and physiological responses. It includes the following: an algorithm for generating original musical selections that effectively elicit targeted emotional and physiological responses; a description of some of the musical features that contribute to the conveyance of a given emotion or the elicitation of a given physiological response; and an account of how this algorithm can be used effectively in two different …

Gut Microbiome Composition Is Linked To Whole Grain-Induced Immunological Improvements, Ines Martinez, James M. Lattimer, Kelcie L. Hubach, Jennifer A. Case, Junyi Yang, Casey G. Weber, Julie A. Louk, Devin J. Rose, Gayaneh Kyureghian, Daniel A. Peterson, Mark D. Haub, Jens Walter

Food for Health: Publications

The involvement of the gut microbiota in metabolic disorders, and the ability of whole grains to affect both host metabolism and gut microbial ecology, suggest that some benefits of whole grains are mediated through their effects on the gut microbiome. Nutritional studies that assess the effect of whole grains on both the gut microbiome and human physiology are needed. We conducted a randomized cross-over trial with four-week treatments in which 28 healthy humans consumed a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB), and characterized their impact on …

The Relationship Between Liv-1 And E-Cadherin (Cdh1) In Prostate Cancer Cells, Lei Cao

Master's Theses

BACKGROUND

The zinc importer LIV-1 is widely distributed, mainly in hormonally controlled tissues. Attention has focused on its role in breast cancer, especially its regulation by estrogen and epidermal growth factor (EGF) and its link to the Epithelial–Mesenchymal Transition (EMT) marker, E-cadherin (CDH1). EMT is important for tumor progression and metastasis. CDH1 expression is under complex control, including by two transcriptional repressors, Snail and Slug. Contrast to CDH1, elevated MMP-9 expression has been linked to increased metastasis and tumor stage.

METHODS

The role of LIV-1 in prostate cancer cell lines, LNCaP and DU145 was investigated. Cells were treated with or …

Radiosynthesis And Bioimaging Of Antibacterial Agents, Li Liu

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

The dose and duration of treatment of antibacterial agents is normally established using plasma pharmacokinetic (PK) data together with information on drug efficacy once treatment has been initiated. Although plasma drug concentration is an important guide for establishing treatment protocols, recent studies indicate that the distribution of antibiotics in tissues is a more critical determinant and predictive factor for their activity. This is because most drugs exert their bactericidal effects at the site of infection rather than in the plasma, and because drug equilibration between plasma and infection site cannot always be achieved Therefore the tissue distribution of front-line TB …