Digital Commons Network^™

Enhancement Of Reactive Oxygen Species Production And Chlamydial Infection By The Mitochondrial Nod-Like Family Member Nlrx1, Ali A. Abdul-Sater, Najwene Saïd-Sadier, Verissa M. Lam, Bhavni Singh, Matthew A. Pettengill, Fraser Soares, Ivan Tattoli, Simone Lipinski, Stephen E. Girardin, Philip Rosenstiel, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Chlamydia trachomatis infections cause severe and irreversible damage that can lead to infertility and blindness in both males and females. Following infection of epithelial cells, Chlamydia induces production of reactive oxygen species (ROS). Unconventionally, Chlamydiae use ROS to their advantage by activating caspase-1, which contributes to chlamydial growth. NLRX1, a member of the Nod-like receptor family that translocates to the mitochondria, can augment ROS production from the mitochondria following Shigella flexneri infections. However, in general, ROS can also be produced by membrane-bound NADPH oxidases. Given the importance of ROS-induced caspase-1 activation in growth of the chlamydial vacuole, we investigated the …

The Introduction Of Alien Aquatic Species By Ships In The Arctic : The Role Of The Polar Code And Other International Legal Instruments, Anne Bouyssou

World Maritime University Dissertations

No abstract provided.

Discovery Of Novel Viruses From Animals, Plants, And Insect Vectors Using Viral Metagenomics, Terry Fei Fan Ng

USF Tampa Graduate Theses and Dissertations

Understanding emerging viruses is critical for disease monitoring and prediction; however, surveys of novel viruses are hindered by the lack of a universal assay for viruses. Viral metagenomics, consisting of viral particle purification and shotgun sequencing, is a powerful technique for discovering viruses in a wide variety of sample types. However, current protocols are not effective on tissue samples (e.g., lungs, livers and tumors), where they are hindered by the high amount of host nucleic acids which limits the percentage of sequences that originate from viruses. In this dissertation, a modified viral metagenomics protocol was developed and utilized to effectively …

Pancytopenia Adult Patients At Baghdad Teaching Hospital, Khudair Abbas Al-Khalisi, Azher Sebieh Al-Zubaidy, Majid Rhaima

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: pancytopnia is a triad of findings caused by different diseases affecting bone marrow primarily or secondarily, causing manifestations of anemia, thrombocytopenia, and/ or leucopenia OBJECTIVE: To identify causes, and presenting symptoms of pancytopnia in patients attending Baghdad teaching hospital. PATIENTS AND METHODS: One hundred and five patients, found on complete blood count having Pancytopenia were included, excluding patients that had been exposed to chemotherapy, and/or radiotherapy RESULTS: Causes in decreasing frequency were acute leukemia (30.47%), aplastic anemia (17.14%), megaloblastic anemia (13.33%), NHL (14.47%), MDS (8.57%), PNH (4.76%), TB, SLE, HD (2.58%) for each, and kalazar, and MM and …

Strategies To Resolve The Three-Dimensional Structure Of The Genome Of Small Single-Stranded Icosahedral Viruses, Eduardo Sanz Garcia

Theses and Dissertations

The aim of this study is the three-dimensional structural characterization of the genome packaging inside viral capsids via cryo-electron microscopy and three-dimensional reconstruction. The genome of some single-stranded viruses can be densely packaged within their capsid shells. Several stretches of the genome are known to adopt stable secondary structures, however, to date, little is known about the three-dimensional organization of the genome inside their capsid shells. Two techniques have been developed to facilitate the structural elucidation of genome packaging: the asymmetric random-model method, and the symmetry-mismatch, random model method. Both techniques were successfully tested with model and experimental data. The …

The Detection Of Neutrophiles In Gastric Mucosa Of Patients Suspected To Be Infected With Helicobacter Pylori Using Leukostix Nassir Enssief Mohsun*,, Suhaila Saadallah, Raji H Al-Hadithi

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Helicobacter pylori has been detected in many populations and associated with inflammation of gastro duodenal mucosa. Colonization of the stomach by Helicobacter pylori occurs in more than half of human population worldwide. It is the principle cause of chronic active gastritis, peptic ulcer and gastric cancer. OBJCTIVE: To detect neutrophiles in homogenates biopsied gastric mucosa semiquantitatively using rapid leukocyte strip test (leukostix). METHODS: A total of 115 patients (74 males, 41 females) referred to The Gastrointestinal Tract Center and Gastroscopy Department of Baghdad Medical City and subjected to gastroscopy were included in this study during the period from …

Energy Expenditure And Physical Activity In Recovering Malnourished Infants, Russell Rising, Gul Tiryaki Sonmez

Publications and Research

Background. Malnourished infants are small for age and weight. Objectives. Determine profiles in 24-hour energy metabolism in recovering malnourished infants and compare to similarly aged healthy controls. Methods. 10 malnourished infants (58.1 ± 5.9 cm, 7.7 ± 5.6 months) were healthy prior to spending 22 hours in the Enhanced Metabolic Testing Activity Chamber for measurement of EE (kcal/min), sleeping metabolic rate (SMR; kcal/min), respiratory quotient (RQ; VCO2/VO2), and physical activity (PA; oscillations in wt/min/kg body weight). Metabolic data were extrapolated to 24 hours (kcal/kg/d). Energy intake (kcal/kg/d) and the proportions (%) of carbohydrate, protein, and fat were calculated. Anthropometrics for …

A Multifactorial Mechanism In The Superior Antimalarial Activity Of Α-C-Galcer, John Schmieg, Guangli Yang, Richard W. Franck, Moriya Tsuji

Publications and Research

We have previously shown that the C-glycoside analog of α-galactosylceramide (α-GalCer), α-C-GalCer, displays a superior inhibitory activity against the liver stages of the rodent malaria parasite Plasmodium yoelii than its parental glycolipid, α-GalCer. In this study, we demonstrate that NK cells, as well as IL-12, are a key contributor for the superior activity displayed by α-C-GalCer. Surprisingly, the diminished production of Th2 cytokines, including IL-4, by α-C-GalCer has no affect on its superior therapeutic activity relative to α-GalCer. Finally, we show that the in vivo administration of α-C-GalCer induces prolonged maturation of dendritic cells (DCs), as well as an enhanced …

The World Health Report 2000: A Case Study On The Indonesia National Health System, Jerico Franciscus Pardosi

Kesmas

Laporan Kesehatan Dunia (LKD) tahun 2000, yang memfokuskan pada program peningkatan kinerja sistem kesehatan, mengundang banyak pro dan kontra. Artikel ini menilai secara kritis laporan tersebut terhadap sistem kesehatan nasional Indonesia. Artikel ini membahas unsur-unsur model evaluasi WHO, pembobotan indikator yang digunakan, ukuran variabel, dan sumber data. Sebanyak 191 negara di dunia, Indonesia telah mencapai total peringkat 106, dengan tingkat kesehatan dan distribusi kesehatan masing-masing pada posisi 103 dan 156. Lebih lanjut, ketanggapan dan keadilan pembiayaan kesehatan masing-masing berada pada peringkat 63-64 dan 73. Sementara itu, indikator pengeluaran kesehatan berada pada peringkat 154 dengan kinerja Sistem Kesehatan Nasional Indonesia untuk …

Role For Sumoylation In Systemic Inflammation And Immune Homeostasis In Drosophila Larvae, Indira Paddibhatla, Mark J. Lee, Marta E. Kalamarz, Roberto Ferrarese, Shubha Govind

Publications and Research

To counter systemic risk of infection by parasitic wasps, Drosophila larvae activate humoral immunity in the fat body and mount a robust cellular response resulting in encapsulation of the wasp egg. Innate immune reactions are tightly regulated and are resolved within hours. To understand the mechanisms underlying activation and resolution of the egg encapsulation response and examine if failure of the latter develops into systemic inflammatory disease, we correlated parasitic wasp-induced changes in the Drosophila larva with systemic chronic conditions in sumoylation-deficient mutants. We have previously reported that loss of either Cactus, the Drosophila (IkB) protein or Ubc9, the SUMO-conjugating …

The Pseudomonas Aeruginosa Magnesium Transporter Mgte Inhibits Transcription Of The Type Iii Secretion System, Gregory G. Anderson, Timothy L. Yahr, Rustin R. Lovewell, George A. O'Toole

Dartmouth Scholarship

Pseudomonas aeruginosa is an opportunistic pathogen that causes life-long pneumonia in individuals with cystic fibrosis (CF). These long-term infections are maintained by bacterial biofilm formation in the CF lung. We have recently developed a model of P. aeruginosa biofilm formation on cultured CF airway epithelial cells. Using this model, we discovered that mutation of a putative magnesium transporter gene, called mgtE, led to increased cytotoxicity of P. aeruginosa toward epithelial cells. This altered toxicity appeared to be dependent upon expression of the type III secretion system (T3SS). In this study, we found that mutation of mgtE results in increased T3SS …

Holy Cross Magazine, Vol. 45, No. 1, Winter 2011, College Of The Holy Cross

Holy Cross Magazine

Syllabus: Catholic Thought and Social Action
with Susan Crawford Sullivan
By Pam Reponen

Haiti’s Struggle
Holy Cross alumni are among those who came to Haiti’s aid when the ground shook and hundreds of thousands were thrown into chaos. Today, almost one year after the quake, men and women from the Hill are standing in solidarity with a devastated country.
By Lisa Armstrong

Rink Master
Figure skating maestro Frank Carroll ’60 has been on the ice as an athlete, a performer and a coach for more than 50 years—with gold-medal results.
By Debra Steilen

Flashback: The Dramatic Society Flies with the …

Trapping Mammals In A Cautious World: The Effect Of Disinfectants On Trap Success, J. A. Wilson, K. E. Mabry

Western North American Naturalist

Disinfecting traps that have captured small mammals is one recommendation for preventing occurrence of hantavirus infection; however, the potential effects of disinfection on small mammal trappability have not been investigated thoroughly. We conducted an experiment to compare the effects of 2 disinfectants (Lysol^® and household bleach) on the trappability of 4 small mammal species (Peromyscus maniculatus, Neotamias spp., and Spermophilus lateralis). We established triplicate trap grids in 2 forest types (red fir and mixed conifer), each consisting of a 6 × 6 array of Sherman live-traps placed at 10-m intervals. Traps were given 1 of 3 treatments: …

Mathematical Modeling, Simulation, And Time Series Analysis Of Seasonal Epidemics., Eric Shu Numfor

Electronic Theses and Dissertations

Seasonal and non-seasonal Susceptible-Exposed-Infective-Recovered-Susceptible (SEIRS) models are formulated and analyzed. It is proved that the disease-free steady state of the non-seasonal model is locally asymptotically stable if R_v < 1, and disease invades if R_v > 1. For the seasonal SEIRS model, it is shown that the disease-free periodic solution is locally asymptotically stable when R̅_v < 1, and I(t) is persistent with sustained oscillations when R̅_v > 1. Numerical simulations indicate that the orbit representing I(t) decays when R̅_v < 1 < R_v. The seasonal SEIRS model with routine and pulse vaccination is simulated, and results depict an unsustained decrease …

Discovery And Characterization Of An Antibiotic From The Soil Bacterium Bacillus Sp., Thomas S. Barber

Electronic Theses and Dissertations

Many important antibiotics have become nearly obsolete due to the rise of antibiotic resistant pathogens. Rhodococcus, an actinomycete related to the prolific antibiotic producing genus Streptomyces, harbors over 30 genes for secondary metabolism that could be involved in antibiotic production. Several antibiotics have already been reported for Rhodococcus, suggesting the genus may be a good source for new inhibitory compounds. Fifty four soil bacteria were isolated using enrichment culture techniques (including 37 Rhodococcus) and screened for antibiotic producers. BTHX2, a species of Bacillus was found to have activity against Micrococcus luteus and Rhodococcus erythropolis. BTHX2 …

The Sir Model When S(T) Is A Multi-Exponential Function., Teshome Mogessie Balkew

Electronic Theses and Dissertations

The SIR can be expressed either as a system of nonlinear ordinary differential equations or as a nonlinear Volterra integral equation. In general, neither of these can be solved in closed form. In this thesis, it is shown that if we assume S(t) is a finite multi-exponential, i.e. function of the form S(t) = a+ ∑ⁿ_k=1 r_ke^-σ_kt or a logistic function which is an infinite-multi-exponential, i.e. function of the form S(t) = c + a/b+e^wt, then …

A Profile Of Rural Southern Appalachian Hiv Patients: Vamc Versus Com., Lauren Brooks

Undergraduate Honors Theses

Although the AIDS epidemic in America began approximately three decades ago, much remains to be learned about the epidemiology of human immunodeficiency virus (HIV) infections in rural America. This study compared profiles of HIV patients at the James H. Quillen Veterans Affairs Medical Center (VAMC) in Mountain Home, TN to those seen at a university-based community HIV care clinic (COM) in Johnson City, TN.

An Exploration Of The College-Educated Female Incarceration Experience, Tanisca Wilson

LSU New Orleans Theses and Dissertations

There has been a significant increase in the nation's female incarceration rate. During 2006, the number of women in prison increased by approximately 4.5 %. The increase of female prisoners from 2005 to 2006 was larger than the average growth rate of 2.9% from 2000 through 2005. Women ages 35 to 39 made up the largest percentage of female prisoners. At the end of 2006, females made up 7.2% of the prison population under State or Federal jurisdiction, up from 6.7% in 2000. Oklahoma had the highest female incarceration rate in the nation, approximately 129, 000 inmates; followed by Louisiana, …

Personality Style And Hiv Risk Behavior Among Adolescent Substance Abusers, Stephanie E. Diamond

Open Access Dissertations

The purpose of this study was to investigate relationships between four personality styles and two important indications of HIV risk behavior, at intake and 3-month follow-up, among a sample of adolescents participating in court-mandated substance abuse treatment in conjunction with an HIV prevention intervention. This study involved a secondary analysis of data from a NIDA funded project (1R01DA011875-01, R. Malow, PI). Predictor variables included levels of antisocial (unruly), dependent(submissive), avoidant (inhibited), and borderline (borderline tendency) personality styles drawn from scales of the Million Adolescent Clinical Inventory (MACI). Criterion variables included number of sexual partners and percentage of sex acts unprotected, …

Psychophysiological Responses To Disgust: Cardiovascular And Facial Muscle Patterns Associated With Different Functional Domains, Robert Oum

Open Access Dissertations

This study examined the distinguishing physiological characteristics of the disgust reaction across different domains. According to an evolutionary analysis, disgust is a heterogeneous emotion with features that are specific to three distinct domains: pathogens, sex, and morality. Each domain is predicted to take as input information specific to the adaptive problem it evolved to solve and regulate behavior accordingly. The goal of the present study was to investigate whether there are any adaptive physiological differences associated with the disgust response across domains. Participants were asked to imagine acts that elicit pathogen, sexual, and moral disgust. It was hypothesized that there …

Intradermal Immunization Of Mice With Radiation-Attenuated Sporozoites Of Plasmodium Yoelii Induces Effective Protective Immunity, Tatiana Voza, Chahnaz Kebaier, Jerome P. Vanderberg

Publications and Research

Background Intravenous injection of mice with attenuated Plasmodium berghei sporozoites induces sterile immunity to challenge with viable sporozoites. Non-intravenous routes have been reported to yield poor immunity. Because intravenous immunization has been considered to be unacceptable for large scale vaccination of humans, assessment was made of the results of intradermal immunization of mice with Plasmodium yoelii, a rodent malaria parasite whose infectivity resembles that of human malaria. Methods Mice were immunized with two injections of isolated, radiation-attenuated P. yoelii sporozoites, either by intravenous (IV) or intradermal (ID) inoculation. In an attempt to enhance protective immunogenicity of ID-injections, one group of …

Dachau—Remembering The Unforgettable, Jennie Gunn Ph.D., Fnp, Carroll Gunn M.A.

Journal of Health Ethics

Ethical research provides great benefit to the public, but ethical research is not guaranteed. Research can go terribly wrong when research subjects are not protected. Egos of scientists and others in power can cause disastrous results, and that is what happened at the Dachau concentration camp in Germany. Because of incidents such as this, medical research at universities is now reviewed by Institutional Review Boards to protect subjects. But not so long ago, in the Dachau concentration camp, researchers were free to impose pain and death upon prisoners in the name of research. Prisoners were mistreated to glean knowledge; many …

Salicylic Acid Diminishes Staphylococcus Aureus Capsular Polysaccharide Type 5 Expression, Lucia P. Alvarez, Maria S. Barbagelata, Mariana Gordiola, A. L. Cheung

Dartmouth Scholarship

Capsular polysaccharides (CP) of serotypes 5 (CP5) and 8 (CP8) are major Staphylococcus aureus virulence factors. Previous studies have shown that salicylic acid (SAL), the main aspirin metabolite, affects the expression of certain bacterial virulence factors. In the present study, we found that S. aureus strain Reynolds (CP5) cultured with SAL was internalized by MAC-T cells in larger numbers than strain Reynolds organisms not exposed to SAL. Furthermore, the internalization of the isogenic nonencapsulated Reynolds strain into MAC-T cells was not significantly affected by preexposure to SAL. Pretreatment of S. aureus strain Newman with SAL also enhanced internalization into MAC-T …

Linking Public Health And Water Utilities To Improve Emergency Response, R. J. Gelting, M. D. Miller

Journal of Contemporary Water Research and Education

No abstract provided.

The Ingredients Of Change: A Political Ecology Approach To Diabetes In The Somali Community Of Minnesota, Mina Tehrani

Geography Capstone Projects

In the early 1990’s, due to political circumstances at home, Somali immigrants and refugees began arriving in the state of Minnesota in large numbers. Over the past two decades, Somali immigrants have come to comprise one of the most populous ethnic groups in the Twin Cities, and are the largest Somali population in the world outside of Eastern Africa. Although quantitative data is unavailable, qualitative evidence and testimonies of healthcare professionals support the conclusion that Somali immigrants in Minnesota suffer from higher rates of diabetes than non-immigrant groups and than they likely did before migration. Why might this be the …

December 13, 2010 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Medical School Watercooler Newsletter - December 12, 2010, Lindsey Lyle

Watercooler Newsletter

This is the December 12, 2010 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Biomedical Librarian Attends Nobel Peace Prize Ceremony in Norway
• Med School Café - Expert Advice for the Community
• UMS-Wright Student Donates Money to USA Family Specialty Clinic
• USA Scientist Featured in Press-Register
• USA Physicians Named Best Doctors for 2011-2012
• USA Surgery Chair to Give Community Lecture

Florida Board Of Governors Meeting : 2010 : 12 : 02 : Minutes, Florida. Board Of Governors., State University System Of Florida.

Statewide Governing Boards: Meeting Minutes and Agendas

3 p. document that includes a resolution to build the University Student Center building.

Research News: 2010, No. 2, University Of Mississippi. School Of Pharmacy

Research News: Grants and Publications (2000-2014)

Grants, publications, technology transfer, special announcements

Educational Policies Committee Program Proposal, College Of Agriculture And Applied Sciences, December 9, 2010, Utah State University

Educational Policies Committee

Utah State University (USU) requests approval to offer, in partnership with Washington State University (WSU) College of Veterinary Medicine, a Doctor of Veterinary Medicine (DVM) degree, effective Summer Semester, 2012.