Digital Commons Network^™

Work-Related Musculoskeletal Disorders Of The Workers In A Child Care Institution, Yi-Shiung Horng, Shih-Fu Hsieh, Hsin-Chi Wu, Chi-Tzu Feng, Ming-Chuan Lin

Rehabilitation Practice and Science

The work-related musculoskeletal disorders among the child care workers could be high given the fact that the workers frequently lift the children and conduct physical actions under inappropriate postures. The objective of this study is to survey the musculoskeletal disorders and potential ergonomic risk factors among the workers in a child care center through an on-site visit and a questionnaire survey. We also used the Chinese Health Questionnaire (CHQ) as a screening questionnaire to detect the emotional distress of the workers.There were 85 workers recruited in our study. Results showed that shoulder pain (57.0%), low back pain (54.7%) and neck …

Analysis Of Adverse Events In Drug Safety: A Multivariate Approach Using Stratified Quasi-Least Squares, Hanjoo Kim, Justine Shults, Scott Patterson, Robert Goldberg-Alberts

UPenn Biostatistics Working Papers

Safety assessment in drug development involves numerous statistical challenges, and yet statistical methodologies and their applications to safety data have not been fully developed, despite a recent increase of interest in this area. In practice, a conventional univariate approach for analysis of safety data involves application of the Fisher's exact test to compare the proportion of subjects who experience adverse events (AEs) between treatment groups; This approach ignores several common features of safety data, including the presence of multiple endpoints, longitudinal follow-up, and a possible relationship between the AEs within body systems. In this article, we propose various regression modeling …

Burden Of Rotavirus Gastroenteritis Among Under Five Years Children At Al-Alwaiya Paediatric Hospital, Sinan Ghazi Mehdi

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Rotavirus is the main cause of diarrhea in 6-12) months which was (31.4%). CONCLUSION: Rotavirus cause 47.4% of acute gastroenteritis cases of the studied sample with no significant statistical difference between rotavirus and other causes of gastroenteritis regarding demographic features (except for gender, more in males), clinical features, and type of treatment and course of disease (except time of onset).Concordance rate between ELISA and Latex was found to be high confirming their validity.

Structure Of A Complete Integrin Ectodomain In A Physiologic Resting State And Activation And Deactivation By Applied Forces, Jianghai Zhu, Bing Hao Luo, Tsan Xiao, Chengzhong Zhang, Noritaka Nishida, Timothy A. Springer

Faculty Publications

The complete ectodomain of integrin αIIbβ3 reveals a bent, closed, low-affinity conformation, the β knee, and a mechanism for linking cytoskeleton attachment to high affinity for ligand. Ca and Mg ions in the recognition site, including the synergistic metal ion binding site (SyMBS), are loaded prior to ligand binding. Electrophilicity of the ligand-binding Mg ion is increased in the open conformation. The β3 knee passes between the β3-PSI and αIIb-knob to bury the lower β leg in a cleft, from which it is released for extension. Different integrin molecules in crystals and EM reveal breathing that appears on pathway to …

Mezirow's Transformational Learning Theory And Alternative Health Therapeutics Of Mind, Body, And Spirit, Lewis Edward Blackwell

Dissertations

An illness, like prostate cancer, brings crisis to our experience and confuses the structure of our reality as well as disturbs our meaning which is upheld by interpretive imagery. Hence, recovery involves a learning experience that consists of a reflective, educational, and spiritual process to rebuild and reconstruct meaning through the use and transformation of our images and themes to create meaning. The purpose of the research was to investigate the meaning of the illness experience through the lens of transformational learning theory. As such, one-on-one interviews were conducted with 10 African American men who lived in large metropolitan areas …

Genotyping And Drug Resistance Patterns Of M. Tuberculosis Strains In Pakistan., Mahnaz Tanveer, Zahra Hasan, Amna R Siddiqui, Asho Ali, Akbar Kanji, Solomon Ghebremicheal, Rumina Hasan

Department of Pathology and Laboratory Medicine

Background:The incidence of tuberculosis in Pakistan is 181/100,000 population. However, information about transmission and geographical prevalence of Mycobacterium tuberculosis strains and their evolutionary genetics as well as drug resistance remains limited. Our objective was to determine the clonal composition, evolutionary genetics and drug resistance of M. tuberculosis isolates from different regions of the country.

Methods:

M. tuberculosis strains isolated (2003-2005) from specimens submitted to the laboratory through collection units nationwide were included. Drug susceptibility was performed and strains were spoligotyped.

Results:

Of 926 M. tuberculosis strains studied, 721(78%) were grouped into 59 "shared types", while 205 (22%) were identified …

Lipid Raft Mediated Lyn Kinase Activation Regulates Host Innate Immune Response Against Pseudomonas Aeruginosa Lung Infection, Shibichakravarthy Kannan

Theses and Dissertations

Pseudomonas aeruginosa (PA) is a common opportunistic pathogen that invades the susceptible host. Alveolar macrophages (AM) play a pivotal role in defending against invading pathogens in the lungs. The effectiveness of AM in combating PA infection has not been studied in detail. The goal was to identify the key components involved in mounting an effective innate immune response using the murine lung infection as a model to understand the host - pathogen interactions. Our most important finding was the involvement of Lyn tyrosine kinase, a member of Src family tyrosine kinases, in orchestrating the host cell response to PA invasion. …

Today - December 22, 2008, Loma Linda University

TODAY

Inside this issue:

-- Loma Linda University, Atlantic Union College explore affiliation possibilities between institutions
-- Senior vice president for development/public affairs named
-- LLUMC, BMC nursing leadership contributes to China academic week
-- Cancer survivors return to Loma Linda
-- 6:10 to the Great Southwest
-- Loma Linda University participates in community emergency response training
-- Good Samaritan awards celebrate employees who fulfill institutional mission
-- Community Christmas Fiesta held at SACHS–Norton
-- Class projects helps chronically ill kids
-- Jan Fisher retires after half a century of service to physical therapy

Bjc Today

BJC Today

No abstract provided.

December 22, 2008 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Habitat Analysis Of North American Sand Flies Near Veterans Returning From Leishmania-Endemic War Zones, David Claborn, Penny Masuoka, Meredith Morrow, Lisa Keep

College of Health and Human Services

Background: Nearly 1300 cases of leishmaniasis have been identified in American military personnel deployed to Iraq and Afghanistan. The symptoms of this disease can range from a mild, self-limiting cutaneous infection to a deadly visceral infection and are not prevented by chemoprophylaxis or immunization. Effective treatments, however, are available. The disease-causing parasite is spread through the bite of the female sand fly. Although the disease occurs in both the Old World and the New World, the parasite species differ between the hemispheres. The large number of cases in military veterans has caused some concern that Old World, temperate-adapted parasite species …

The Weekly Challenger, December 18, 2008, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The December 18, 2008, issue of The Weekly Challenger.

Topical Application Of Entry Inhibitors As "Virustats" To Prevent Sexual Transmission Of Hiv Infection, Michael M. Lederman, Robin L.P. Jump, Heather A. Pilch-Cooper, Scott F. Sieg

Faculty Scholarship

With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future, work to develop a topical strategy to prevent HIV infection is increasingly important. This stated, the track record of large scale "microbicide" trials has been disappointing with nonspecific inhibitors either failing to protect women from infection or even increasing HIV acquisition. Newer strategies that target directly the elements needed for viral entry into cells have shown promise in non-human primate models of HIV transmission and as these agents have not yet been broadly introduced in regions of highest HIV prevalence, they …

The Role Of Msa In Staphylococcus Aureus Biofilm Formation, Karthik Sambanthamoorthy, Antony Schwartz, Vijayaraj Nagarajan, Mohamed O. Elasri

Faculty Publications

Background

Staphylococcus aureus is an important pathogen that forms biofilms. The global regulator sarA is essential for biofilm formation. Since the modulator of sarA (msa) is required for full expression of sarA and regulates several virulence factors, we examined the capacity of the msa mutant to form biofilm.

Results

We found that mutation of msa results in reduced expression of sarA in biofilm and that the msa mutant formed a weak and unstable biofilm. The msa mutant is able to adhere to surfaces and begins to form biofilm but fails to mature indicating that the defect of the …

Whose Business Is Your Pancreas?: Potential Privacy Problems In New York City's Mandatory Diabetes Registry (With N. Gingo Et Al.), Harold J. Krent, Nicholas Gingo, Monica Kapp, Rachel Moran, Mary Neal, Meghan Paulas, Puneet Sarna, Sarah Suma

All Faculty Scholarship

New York City authorities in 2006 formulated a policy requiring that medical data from all diabetics in the City be stored in a centralized registry. This diabetic registry is the first in the nation to require collection of personal testing data for the purpose of monitoring treatments for a noninfectious disease. The registry represents an important step on the path toward better understanding and managing of the disease. Nonetheless, establishment of the registry threatens privacy in a number of ways. Many individuals are open about their diabetes, but others prefer to keep that information to themselves, whether because of concerns …

Confidence Intervals For A Common Mean With Missing Data With Applications In An Aids Study, Hua Liang, Haiyan Su, Guohua Zou

Department of Applied Mathematics and Statistics Faculty Scholarship and Creative Works

In practical data analysis, nonresponse phenomenon frequently occurs. In this paper, we propose an empirical likelihood based confidence interval for a common mean by combining the imputed data, assuming that data are missing completely at random. Simulation studies show that such confidence intervals perform well, even when the missing proportion is high. Our method is applied to an analysis of a real data set from an AIDS clinic trial study.

Biocaster: Detecting Public Health Rumors With A Web-Based Text Mining System, Nigel Collier, Son Doan, Ai Kawazoe, Reiko Matsuda Goodwin, Mike Conway, Yoshio Tateno, Quoc-Hung Ngo, Dinh Dien, Asanee Kawtrakul, Koichi Takeuchi, Mika Shigematsu, Kiyosu Taniguchi

Publications and Research

Summary: BioCaster is an ontology-based text mining system for detecting and tracking the distribution of infectious disease outbreaks from linguistic signals on the Web. The system continuously analyzes documents reported from over 1700 RSS feeds, classifies them for topical relevance and plots them onto a Google map using geocoded information. The background knowledge for bridging the gap between Layman's terms and formal-coding systems is contained in the freely available BioCaster ontology which includes information in eight languages focused on the epidemiological role of pathogens as well as geographical locations with their latitudes/longitudes. The system consists of four main stages: topic …

Evaluation Of The Boys & Girls Clubs Of America Targeted Re-Entry Initiative: Final Report, William H. Barton, G. Roger Jarjoura, André B. Rosay

Reports

In 2003 and early 2004 the Boys and Girls Clubs of America (BGCA) introduced Targeted Re-Entry (TR), a juvenile aftercare approach derived from the Intensive Aftercare Program (IAP) model (Altschuler & Armstrong) into four sites, partnering with state juvenile correctional facilities in Mobile, Alabama; Anchorage, Alaska; Benton, Little Rock, and North Little Rock, Arkansas; and Milwaukee and Wales, Wisconsin. The Targeted Re-entry approach builds closely upon the IAP model, with local Boys & Girls Clubs providing community leadership, case management functions, and close linkages with the correctional system. A key element in all four sites is the introduction of a …

Characterization Of The Genes Involved In Biosynthesis And Transport Of Schizokinen, A Siderophore Produced By Rhizobium Leguminosarum Iari 917., David Jack Hammond

Electronic Theses and Dissertations

Iron is the 4th most abundant metal on the earth's crust and is required by most organisms as a cofactor for many enzymes; however, at physiological pH and aerobic conditions iron forms insoluble ferric oxyhydroxide polymers. Siderophores are low molecular weight compounds that scavenge ferric ions, bind with high affinity, and transport it into the cell via multicomponent transport systems. Rhizobia are soil dwelling organisms that form symbiotic relationships with host plants and fix atmospheric nitrogen, while the bacteria receive nutrients. R. leguminosarum IARI 917 produces a siderophore characterized as 'schizokinen'. In the present study, we have characterized the binding …

The New Hampshire, Vol. 98 [99], No. 24 (Dec. 12, 2008), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 98, but it is the 99th volume in the series. This was corrected in pencil.

Washington University Record, December 11, 2008

Washington University Record

No abstract provided.

The Impact Of Repeated Rounds Of Mass Drug Administration With Diethylcarbamazine Plus Albendazole On Bancroftian Filariasis In Papua New Guinea, Gary J. Weil, Will Kastens, Melinda Susapu, Sandra J. Laney, Steven A. Williams, Christopher L. King, James W. Kazura, Moses J. Bockarie

Biological Sciences: Faculty Publications

Background: This study employed various monitoring methods to assess the impact of repeated rounds of mass drug administration (MDA) on bancroftian filariasis in Papua New Guinea, which has the largest filariasis problem in the Pacific region.

Methodology/Principal Findings: Residents of rural villages near Madang were studied prior to and one year after each of three rounds of MDA with diethylcarbamazine plus albendazole administered per World Health Organization (WHO) guidelines. The mean MDA compliance rate was 72.9%. Three rounds of MDA decreased microfilaremia rates (Mf, 1 ml night blood by filter) from 18.6% pre-MDA to 1.3% after the third MDA (a …

Worm-Web Search: A Content-Based Image Retrieval (Cbir) System For The Parasite Image Collection In The Harold W. Manter Laboratory Of Parasitology, University Of Nebraska State Mueum, Ramalingamurthy Meduri, Ashok Samal, Scott Lyell Gardner

Harold W. Manter Laboratory of Parasitology: Faculty Publications

We have developed a prototype web-accessible content-based image retrieval (CBIR) system that allows internet/web-based sharing of biological collections that contain large numbers of images of archived specimens. This system will enable both researchers and educators to access verified, high quality data on biological collections that are available in any museum with digitized holdings. The CBIR system that we are testing can play an important role in understanding global biodiversity because no knowledge of the specific names of specimens need be known before useful information can be extracted from such databases. Our CBIR framework allows users to search image collections using …

Ada News - 12/08/2008, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

December 8, 2008 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Bjc Today

BJC Today

No abstract provided.

Effects Of Shielding Adenoviral Vectors With Polyethylene Glycol On Vector-Specific And Vaccine-Mediated Immune Responses, Eric A. Weaver, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Many individuals have been previously exposed to human adenovirus serotype 5 (Ad5). This prior immunity has long been known to hinder its use for gene therapy and as a gene-based vaccine. Given these immunogenicity problems, we have tested whether polyethylene glycol (PEG) can blunt immune effects against Ad5 during systemic and mucosal vaccination. Ad5 vectors were covalently modified with 5-, 20-, and 35-kDa linear PEG polymers and evaluated for their ability to produce immune responses against transgene antigen products and the vector itself. We show that shielding Ad5 with different-sized PEGs generally reduces transduction and primary antibody responses by the …

Washington University Record, December 4, 2008

Washington University Record

No abstract provided.

Stony Brook Press, V. 30, N. 06, Stony Brook University. Stony Brook Press.

Stony Brook Press

v. 30, n. 06, v.:ill. ; 38 cm (original analog pub.)

Global Climate Change: Can Human Rights (And Human Beings) Survive This Onslaught?, Sumudu Atapattu

Colorado Environmental Law Journal

No abstract provided.