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2007

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Articles 1 - 30 of 121

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Genotyping Of Human Papilloma Virus Infections And Phenotyping Of Tumor Infiltrating Lymphocytes In Iraqi Patients With Uterine Cervical Neoplasia, Majid Mohammed Mahmmod Al-Jewari Dec 2007

Genotyping Of Human Papilloma Virus Infections And Phenotyping Of Tumor Infiltrating Lymphocytes In Iraqi Patients With Uterine Cervical Neoplasia, Majid Mohammed Mahmmod Al-Jewari

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Among most basic and clinical investigations for detection and genotyping HPV, only In Situ Hybridization (ISH) is effective in studing the relation of HPV genome to that histopathological entity. Tumor Infiltrating Lymphocytes (TILs) represent the local cellular immune response against both cervical cancer and the associated HPV. OBJECTIVE: This study is aimed to investigate ISH in detection and genotyping of HPV and immunohistochemical (IHC) study in phenotyping of TILs in Iraqi women with different grades of cervical neoplasia. MATERIALS AND METHODS: This retrospective research included a total number of 129 cervical tissue blocks , 64 with invasive and …

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Pyridinium Bisretinoids: Synthesis And Photoactivated Cytotoxicity, Junping Gao Dec 2007

Pyridinium Bisretinoids: Synthesis And Photoactivated Cytotoxicity, Junping Gao

Theses and Dissertations

This thesis discusses pyridinium bisretinoid compounds (PBRs), which were prepared for two purposes: 1) to use them as standards for detection of novel fluorophores in human RPE cells, which may be involved in age-related macular degeneration (AMD), and 2) to use them in the development of a targeted and triggered drug delivery system for cancer therapy. We prepared a selection of PBRs using a one-pot biomimetic method; synthesis, mechanisms for formation, and characterization of these compounds is described. We also explored the photoreactivity of three novel PBR compounds and found that these PBRs form oxidation products under blue-light irradiation. The …

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Luminescent Quantum Dots For Cellular Analysis, Lifang Shi Dec 2007

Luminescent Quantum Dots For Cellular Analysis, Lifang Shi

LSU New Orleans Theses and Dissertations

Luminescent quantum dots have attracted great interest in recent years among biological researchers since they provide solutions to problems associated with use of organic fluorophores in cellular studies. Quantum dots show high photostability, high emission quantum yield, narrow and symmetric emission peaks and size-dependent wavelength tunability. The objective of my PhD studies was to develop CdSe/ZnS quantum dot-based probes and utilize them in cellular assays. The first phase of the work was to develop luminescent quantum dot fluorescence resonance energy transfer (FRET) based probes for protease activity. The probes were based on FRET interactions between quantum dots that serve as …

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Metalloporphyrin Catalyzed Degradation Of Pce: Effects Of Reductants, Buffers And Cosolvent Concentration, Sowmya Suryanarayanan Dec 2007

Metalloporphyrin Catalyzed Degradation Of Pce: Effects Of Reductants, Buffers And Cosolvent Concentration, Sowmya Suryanarayanan

All Theses

Reductive dechlorination of chlorinated organic contaminants using metalloporphyrins as catalysts may be an effective approach to treat widespread contamination. However, most previous studies have examined water-soluble rather than insoluble metalloporphyrins despite the fact that the latter category makes up the largest fraction found in nature. Recent studies have shown that addition of different cosolvents to water can activate otherwise non-reactive metalloporphyrin catalysts and facilitate the reduction of tetrachloroethylene (PCE), presumably by the mere process of making the otherwise insoluble metalloporphyrins dissolve in solution. Therefore, solubility has been advanced as a key factor in the ability of metalloporphyrins to catalyze organic …

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Relationship Between Floral Advertisement And Pollinia Removal In Oerstedella Exasperata (Orchidaceae), December 2007, Mary Snayd Dec 2007

Relationship Between Floral Advertisement And Pollinia Removal In Oerstedella Exasperata (Orchidaceae), December 2007, Mary Snayd

Monteverde Institute: Tropical Ecology and Conservation

The purpose of this study was to examine how the floral displays and morphology of Oerstedella exasperata affect reproductive success. This species of orchid is typified by extreme variability in both inflorescence and floral characteristics. In particular there is a wide distribution regarding the degree of symmetry observed in the labellum. The degrees of symmetry are characterized by variations within the fringe symmetry and bilateral symmetry. Furthermore, the surface area of the labellum varies greatly within a population. These remarkably diverse phenotypic morphologies and the summation of the floral traits can enhance or reduce the reproductive success of particular species. …

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Mechanism Of Maintenance Of Cellular Senescence, Sabrina Nunez Dec 2007

Mechanism Of Maintenance Of Cellular Senescence, Sabrina Nunez

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

[to be added]

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A Study Of Avian Nest Predation At Audubon Acres In Chattanooga, Tn, Melea R. Langley Dec 2007

A Study Of Avian Nest Predation At Audubon Acres In Chattanooga, Tn, Melea R. Langley

Masters Theses and Doctoral Dissertations

Predation is believed to be the primary cause of nesting mortality among North American migratory land birds. High rates of nest predation can jeopardize avian reproductive biology by affecting life histories and habitat selection. Artificial nests are commonly used to study nest predation because they allow the researcher to investigate comparative treatments and their impact on predation. Relative nest predation was studied at Audubon Acres in Chattanooga, TN using artificial nests. The study investigated differences in habitat types,nest heights, egg types, and predator types.

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Lipidomic Analysis Of Glioblastoma Multiforme Using Mass Spectrometry, Soo Jung Ha, Gordon Showalter, Shanbao Cai, Haiyan Wang, Wei Michael Liu, Aaron Cohen-Gadol, Jann N. Sarkaria, Jenna Rickus, John Springer, Jiri Adamec, Karen E. Pollok, Kari L. Clase Nov 2007

Lipidomic Analysis Of Glioblastoma Multiforme Using Mass Spectrometry, Soo Jung Ha, Gordon Showalter, Shanbao Cai, Haiyan Wang, Wei Michael Liu, Aaron Cohen-Gadol, Jann N. Sarkaria, Jenna Rickus, John Springer, Jiri Adamec, Karen E. Pollok, Kari L. Clase

Department of Biochemistry: Faculty Publications

Glioblastoma multiforme (GBM) is the most common and malignant form of primary brain tumors. It is highly invasive and current treatment options have not improved the survival rate over the past twenty years. Novel approaches and technologies from systems biology have the potential to identify biomarkers that could serve as new therapeutic targets for GBM. This study employed lipid profiling technology to investigate lipid biomarkers in ectopic and orthotopic human GBM xenograft models. Primary patient cell lines, GBM10 and GBM43, were injected into the flank and the right cerebral hemisphere of NOD/SCID mice. Tumors were harvested from the brain and …

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A Non-Circadian Role For Clock-Genes In Sleep Homeostasis: A Strain Comparison, Paul Franken, Ryan Thomason, H. Craig Heller, Bruce F. O'Hara Oct 2007

A Non-Circadian Role For Clock-Genes In Sleep Homeostasis: A Strain Comparison, Paul Franken, Ryan Thomason, H. Craig Heller, Bruce F. O'Hara

Biology Faculty Publications

BACKGROUND: We have previously reported that the expression of circadian clock-genes increases in the cerebral cortex after sleep deprivation (SD) and that the sleep rebound following SD is attenuated in mice deficient for one or more clock-genes. We hypothesized that besides generating circadian rhythms, clock-genes also play a role in the homeostatic regulation of sleep. Here we follow the time course of the forebrain changes in the expression of the clock-genes period (per)-1, per2, and of the clock-controlled gene albumin D-binding protein (dbp) during a 6 h SD and subsequent recovery sleep in three inbred strains of mice for which …

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The Chlamydomonas Genome Reveals The Evolution Of Key Animal And Plant Functions, Sabeeha S. Merchant, Simon E. Prochnik, Olivier Vallon, Elizabeth H. Harris, Steven J. Karpowicz, George B. Witman, Astrid Terry, Asaf Salamov, Lillian K. Fritz-Laylin, Laurence Maréchal-Drouard, Wallace F. Marshall, Liang Hu Qu, David R. Nelson, Anton A. Sanderfoot, Martin H. Spalding, Vladimir V. Kapitonov, Qinghu Ren, Patrick Ferris, Erika Lindquist, Harris Shapiro, Susan M. Lucas, Jane Grimwood, Jeremy Schmutz, Igor V. Grigoriev, Daniel S. Rokhsar, Arthur R. Grossman, Pierre Cardol, Heriberto Cerutti, Guillaume Chanfreau, Chun Long Chen, Valérie Cognat, Martin T. Croft, Rachel Dent Oct 2007

The Chlamydomonas Genome Reveals The Evolution Of Key Animal And Plant Functions, Sabeeha S. Merchant, Simon E. Prochnik, Olivier Vallon, Elizabeth H. Harris, Steven J. Karpowicz, George B. Witman, Astrid Terry, Asaf Salamov, Lillian K. Fritz-Laylin, Laurence Maréchal-Drouard, Wallace F. Marshall, Liang Hu Qu, David R. Nelson, Anton A. Sanderfoot, Martin H. Spalding, Vladimir V. Kapitonov, Qinghu Ren, Patrick Ferris, Erika Lindquist, Harris Shapiro, Susan M. Lucas, Jane Grimwood, Jeremy Schmutz, Igor V. Grigoriev, Daniel S. Rokhsar, Arthur R. Grossman, Pierre Cardol, Heriberto Cerutti, Guillaume Chanfreau, Chun Long Chen, Valérie Cognat, Martin T. Croft, Rachel Dent

Faculty Publications

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, …

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Mole Street Journal, October 2007, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Oct 2007

Mole Street Journal, October 2007, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Gene Synthesis, Cloning, Expression, Purification And Biophysical Characterization Of The C2 Domain Of Human Tensin, Kiran Sukumar Gajula Oct 2007

Gene Synthesis, Cloning, Expression, Purification And Biophysical Characterization Of The C2 Domain Of Human Tensin, Kiran Sukumar Gajula

Doctoral Dissertations

Tensin is a large "docking" protein found in the adhesive junctions of animal cells and recruited early in the development of cell-substrate contacts. There it binds to the cytoplasmic domain of integrin β1 and caps the barbed ends of filamentous actin. This forms a rational basis for its implication in a direct role in the mechanics of membrane-cytoskeleton interactions. Tensin provides a physical link between the actin cytoskeleton, integrins, and other proteins at the cell-substrate contacts. Its overall biochemical properties are a function of its domain composition and architecture, i.e., the domains that are present and their relative positions in …

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University Of San Diego News Print Media Coverage 2007.10, University Of San Diego Office Of Public Relations Oct 2007

University Of San Diego News Print Media Coverage 2007.10, University Of San Diego Office Of Public Relations

Print Media Coverage (1947-2009)

Printed clippings housed in folders with a table of contents arranged by topic.

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Evaluating The Medicinal Properties Of Mandravasarotra (Cinnamosa Sida) Through Chemical And Pharmacological Screening, Henry J. Bowden Jr. Oct 2007

Evaluating The Medicinal Properties Of Mandravasarotra (Cinnamosa Sida) Through Chemical And Pharmacological Screening, Henry J. Bowden Jr.

Independent Study Project (ISP) Collection

I worked for four weeks at the University of Antananarivo (Ankatso), spending two weeks each in the chemistry and pharmacology laboratories. There I ran a total of eight experiments or “screens” with an alcoholic extract of the medicinal plant Mandravasarotra. This plant is found mainly in northwestern Madagascar, and is often used to stimulate contractions for women having difficulty giving birth. The plant tested positive for three secondary metabolites: tannins, steroids and flavanoids. In the pharmacological tests, the plant exhibited anti-inflammatory properties, and high toxicity in doses exceeding 10ml/kg. Together, conjectures may be made between what is known of the …

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Search For Effective Natural Enemies Of Tetranychus Evansi (Acari: Tetranychidae) In Northwest Argentina, Imeuda P. Furtado, Silvana Toledo, Gilberto J. De Moraes, Serge Kreiter, Markus Knapp Oct 2007

Search For Effective Natural Enemies Of Tetranychus Evansi (Acari: Tetranychidae) In Northwest Argentina, Imeuda P. Furtado, Silvana Toledo, Gilberto J. De Moraes, Serge Kreiter, Markus Knapp

All Peer-Reviewed Publications

The mite Tetranychus evansi Baker & Pritchard (Tetranychidae) probably originated in South America. Because of its importance as a tomato pest in Africa, an extensive project has been conducted to detect potentially effective natural enemies in South America for the classical biological control of the pest in Africa. A search for the natural enemies of T. evansi was conducted in the Province of Tucumán, northwestern Argentina, in December 2004, and this report describes the results. One hundred predatory mites of the family Phytoseiidae referring to 11 species were collected on 11 examined species of solanaceous plants. The most abundant phytoseiid …

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A Simple Array Platform For Microrna Analysis And Its Application In Mouse Tissues, Xiaoqing Tang, Jozsef Gal, Xun Zhuang, Wang-Xia Wang, Haining Zhu, Guiliang Tang Oct 2007

A Simple Array Platform For Microrna Analysis And Its Application In Mouse Tissues, Xiaoqing Tang, Jozsef Gal, Xun Zhuang, Wang-Xia Wang, Haining Zhu, Guiliang Tang

Plant and Soil Sciences Faculty Publications

MicroRNAs (miRNAs) are a novel class of small noncoding RNAs that regulate gene expression at the post-transcriptional level and play a critical role in many important biological processes. Most miRNAs are conserved between humans and mice, which makes it possible to analyze their expressions with a set of selected array probes. Here, we report a simple array platform that can detect 553 nonredundant miRNAs encompassing the entire set of miRNAs for humans and mice. The platform features carefully selected and designed probes with optimized hybridization parameters. Potential cross-reaction between mature miRNAs and their precursors was investigated. The array platform was …

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Benthic Mapping For Habitat Classification In The Peconic Estuary: Phase I Groundtruth Studies, Robert M. Cerrato, Nicole P. Maher Oct 2007

Benthic Mapping For Habitat Classification In The Peconic Estuary: Phase I Groundtruth Studies, Robert M. Cerrato, Nicole P. Maher

School of Marine & Atmospheric Sciences Faculty Publications

Benthic habitat maps of the estuary seafloor will increase our knowledge of range and variability in benthic habitats, will assist managers in their efforts to protect and/or restore commercially and recreationally important finfish and shellfish, will link land usage (e.g. developed vs. undeveloped areas) and water quality data to benthic habitat quality, and will make it possible to utilize faunal data as a long-term indicator of the overall “health” of the estuary. We are developing benthic habitat maps by combining high-resolution remote sensing techniques with detailed study of the physical and faunal characteristics at point locations in different seafloor environments. …

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Benthic Mapping For Habitat Classification In The Peconic Estuary: Phase I Groundtruth Studies, Robert Michael Cerrato, Nicole P. Maher Oct 2007

Benthic Mapping For Habitat Classification In The Peconic Estuary: Phase I Groundtruth Studies, Robert Michael Cerrato, Nicole P. Maher

Working Papers

Special report (State University of New York at Stony Brook, Marine Sciences Center

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Historians And Archaeologists: Proposals For Connecting In A Common Past, Mark E. Harlan Oct 2007

Historians And Archaeologists: Proposals For Connecting In A Common Past, Mark E. Harlan

New Mexico Historical Review

No abstract provided.

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Psodascript: Applying Advanced Language Constructs To Open-Source Phylogenetic Search, Hyrum Carroll, Mark J. Clement, Jonathan Krein, Quinn O. Snell, Adam R. Teichert Oct 2007

Psodascript: Applying Advanced Language Constructs To Open-Source Phylogenetic Search, Hyrum Carroll, Mark J. Clement, Jonathan Krein, Quinn O. Snell, Adam R. Teichert

Faculty Publications

Due to the immensity of phylogenetic tree space for large data sets, researches must rely on heuristic searches to infer reasonable phylogenies. By designing meta-searches which appropriately combine a variety of heuristics and parameter settings, researchers can significantly improve the performance of heuristic searches. Advanced language constructs in the open-source PSODA project—including variables, mathematical and logical expressions, conditional statements, and user-defined commands—give researchers a better framework for the exploration and exploitation of phylogenetic meta-search algorithms. PSODA’s approach to scripting meta-search algorithms is unique among open-source packages and addresses several limitations of other phylogenetic applications.

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Animal Minds, Cognitive Ethology, And Ethics, Colin Allen, Marc Bekoff Sep 2007

Animal Minds, Cognitive Ethology, And Ethics, Colin Allen, Marc Bekoff

Sentience Collection

Our goal in this paper is to provide enough of an account of the origins of cognitive ethology and the controversy surrounding it to help ethicists to gauge for themselves how to balance skepticism and credulity about animal minds when communicating with scientists. We believe that ethicists’ arguments would benefit from better understanding of the historical roots of ongoing controversies. It is not appropriate to treat some widely reported results in animal cognition as if their interpretations are a matter of scientific consensus. It is especially important to understand why loose references to ‘‘cognitive ethology’’ by philosophers can signal ignorance …

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Managing The Recreational Catch Of Demersal Scalefish On The West Coast. Future Management Scenarios For Community Consideration, Jon Ford (Minister For Fisheries; The Kimberley, Pilbara And Gascoyne) Sep 2007

Managing The Recreational Catch Of Demersal Scalefish On The West Coast. Future Management Scenarios For Community Consideration, Jon Ford (Minister For Fisheries; The Kimberley, Pilbara And Gascoyne)

Fisheries Management Papers

This paper discusses the major issues around controlling the total recreational catch. It also considers some of the tools available to manage the catch to specific target levels. The sustainability of fish species must be a key driver. However, the impacts on the social amenity of recreational fishing must also be taken into account. Any particular tool, if used on its own and to its full extent, may be rather “blunt” in its application and its impacts unacceptable to large parts of the community. The most effective and acceptable management package will probably be a mix of tools, supported by …

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Exploring Subseafloor Life With The Integrated Ocean Drilling Program, Steven D'Hondt, Fumio Inagaki, Timothy Ferdelman, Bo Barker Jørgensen, Kenji Kato, Paul Kemp, Patricia Sobecky, Mitchell Sogin, Ken Takai Sep 2007

Exploring Subseafloor Life With The Integrated Ocean Drilling Program, Steven D'Hondt, Fumio Inagaki, Timothy Ferdelman, Bo Barker Jørgensen, Kenji Kato, Paul Kemp, Patricia Sobecky, Mitchell Sogin, Ken Takai

Graduate School of Oceanography Faculty Publications

No abstract provided.

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Fully Codon-Optimized Luciferase Uncovers Novel Temperature Characteristics Of The Neurospora Clock, Van D. Gooch, Arun Mehra, Luis F. Larrondo, Julie Fox, Melissa Touroutoutoudis, Jennifer J. Loros, Jay C. Dunlap Aug 2007

Fully Codon-Optimized Luciferase Uncovers Novel Temperature Characteristics Of The Neurospora Clock, Van D. Gooch, Arun Mehra, Luis F. Larrondo, Julie Fox, Melissa Touroutoutoudis, Jennifer J. Loros, Jay C. Dunlap

Dartmouth Scholarship

We report the complete reconstruction of the firefly luciferase gene, fully codon optimized for expression in Neurospora crassa. This reporter enhances light output by approximately 4 log orders over that with previously available versions, now producing light that is visible to the naked eye and sufficient for monitoring the activities of many poorly expressed genes. Time lapse photography of strains growing in race tubes, in which the frq or eas/ccg-2 promoter is used to drive luciferase, shows the highest levels of luciferase activity near the growth front and newly formed conidial bands. Further, we have established a sorbose medium colony …

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The Benefits Of Bathing Buds: Water Calyces Protect Flowers From A Microlepidopteran Herbivore, Jane E. Carlson, Kyle E. Harms Aug 2007

The Benefits Of Bathing Buds: Water Calyces Protect Flowers From A Microlepidopteran Herbivore, Jane E. Carlson, Kyle E. Harms

Faculty Publications

Protective floral structures may evolve in response to the negative effects of floral herbivores. For example, water calyces - liquid-filled, cup-like structures resulting from the fusion of sepals - may reduce floral herbivory by submerging buds during their development. Our observations of a water-calyx plant, Chrysothemis friedrichsthaliana (Gesneriaceae), revealed that buds were frequently attacked by ovipositing moths (Alucitidae), whose larvae consumed anthers and stigmas before corollas opened. Almost 25% of per-plant flower production was destroyed by alucitid larvae over two seasons, far exceeding the losses to all other floral herbivores combined. Experimental manipulation of water levels in calyces showed that …

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Flight Results From The Genesat-1 Biological Microsatellite Mission, Christopher Kitts, Karolyn Ronzano, Richard Rasay, Ignacio Mas, Phelps Williams, Paul Mahacek, Giovanni Minelli, John Hines, Elwood Agasid, Charlie Friedericks, Matthew Piccini, Macarena Parra, Linda Timucin, C. Beasley, Mike Henschke, Ed Luzzi, Nghia Mai, Mike Mcintyre, Robert Ricks, David Squires, Chris Storment, John Tucker, Bruce Yost, Greg Defouw, Antonio Ricco Aug 2007

Flight Results From The Genesat-1 Biological Microsatellite Mission, Christopher Kitts, Karolyn Ronzano, Richard Rasay, Ignacio Mas, Phelps Williams, Paul Mahacek, Giovanni Minelli, John Hines, Elwood Agasid, Charlie Friedericks, Matthew Piccini, Macarena Parra, Linda Timucin, C. Beasley, Mike Henschke, Ed Luzzi, Nghia Mai, Mike Mcintyre, Robert Ricks, David Squires, Chris Storment, John Tucker, Bruce Yost, Greg Defouw, Antonio Ricco

Small Satellite Conference

The mission of the GeneSat-1 technology demonstration spacecraft is to validate the use of research-quality instrumentation for in situ biological research and processing. To execute this mission, the GeneSat-1 satellite was launched on December 16, 2006 from Wallops Flight Facility as a secondary payload off of a Minotaur launch vehicle. During the first week of operation, the core biological growth test was successfully executed, and by the end of the first month of operation all primary science and engineering test objectives had been successfully performed. In its current phase of operation, a variety of secondary technology characterizations tests are being …

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Nmr Structure And Relaxation Studies Of Dhfr From Haloferax Volcanii At High Salt, Bulent Binbuga Aug 2007

Nmr Structure And Relaxation Studies Of Dhfr From Haloferax Volcanii At High Salt, Bulent Binbuga

Theses and Dissertations

The studies of enzymes from extreme sources have gained significance due to their increasing potential applications. The proteins from halophiles (salt loving) have adapted to challenging environmental conditions and require salt for their structure and function. How halophilic proteins adapt to a hypersaline environment is still an intriguing question. It is important to mimic the environmental conditions of the sample under investigation with experimental techniques. In this study, structure and dynamic features of a halophilic enzyme have been investigated under high salt conditions. The acquisition of NMR data on high salt samples has always been problematic. We have devised a …

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Economic Impacts Of White-Tailed Deer From Hunting In Mississippi, Micah Whittington Whiteside Aug 2007

Economic Impacts Of White-Tailed Deer From Hunting In Mississippi, Micah Whittington Whiteside

Theses and Dissertations

White-tailed deer (Odocoileus virginianus) are an important ecological, social, and economic resource in Mississippi. Studies have been conducted on expenditures by white-tailed deer hunters, but none have administered a research-based, economic impact assessment for white-tailed deer in Mississippi. The economic impacts and associated values of white-tailed deer in Mississippi through a selfministered mail questionnaire were examined to collect white-tailed deer hunter expenditure data during the 2003/2004 hunting season. Expenditures of white-tailed deer hunters were obtained from a mail survey (N = 1,257, 38.6% response rate) and were used in an input-output model to determine economic impacts for the State. Economic …

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Synthesis And Biological Evaluation Of Novel Gbr 12909 Tropane And Azetidine Hybrid Analogues, Shaine A. Cararas Aug 2007

Synthesis And Biological Evaluation Of Novel Gbr 12909 Tropane And Azetidine Hybrid Analogues, Shaine A. Cararas

LSU New Orleans Theses and Dissertations

The high affinity, selective dopamine transporter ligand GBR 12909 has served as a template for the design of two novel classes of dopamine transporter ligands. A series of 3-[2- (diarylmethoxyethyidenyl)]-N-substituted tropane derivatives were synthesized and the binding affinities of these compounds were determined at the dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in rat brain tissue preparations. The tropane derivatives were found to exhibit more potent affinity and selectivity for DAT than GBR 12909. From the SAR of the tropane analogues and GBR 12909, a novel series of 3-[2-(diarylmethoxyethylidenyl)]-Nsubstituted azetidine derivatives has been developed.

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Regulation Of Volume By Spermatozoa And Its Significance For Conservation Biology, Jennifer Barfield Aug 2007

Regulation Of Volume By Spermatozoa And Its Significance For Conservation Biology, Jennifer Barfield

LSU New Orleans Theses and Dissertations

Reproductive science plays an important role in conservation biology. Quantitative studies of basic reproductive biology in wildlife are critical for the development of successful assisted reproductive technologies. Investigation of the volume regulatory mechanism of spermatozoa could produce options to improve the cryopreservation of spermatozoa and provide a non-hormonal contraceptive option for men, both of which could have significant impacts on global biodiversity preservation. Volume regulation of somatic cells involves the movement of osmolytes through various channels, including potassium channels. The potassium channels involved in volume regulation of human, monkey, and murine spermatozoa were investigated. Flow cytometry was used to gauge …

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