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Search For The Basolateral Potassium Channel In The Shark Rectal Gland: Functional And Molecular Identification Of A Task-1 Channel Coupled To Chloride Secretion, Conner Telles

Yale Medicine Thesis Digital Library

In the shark rectal gland (SRG), apical Cl- secretion through CFTR channels is tightly coupled to a basolateral K+ conductance. The identity of this K+ conductive pathway is unknown. Studies were performed in the isolated perfused SRG with 16 K+ channel inhibitors at their IC50 and with acidic perfusate. During maximal chloride secretion stimulated by forskolin and IBMX, secretion was inhibited >90% by barium chloride, a non-selective inhibitor of K+ channels. Specific inhibitors of calcium sensitive, voltage sensitive, ATP sensitive, and inward rectifying K+ channels had no effect on chloride secretion. The inhibitors quinidine, quinine, bupivicaine, anandamide, and low perfusate …

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Seal Bounty And Seal Protection Laws In Maine, 1872 To 1972: Historic Perspectives On A Current Controversy, Barbara Lelli, David E. Harris

Natural Resources Journal

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Temperature Tolerance In Crustaceans: Critical Temperatures And The Heart, Lindsay Haupt (Murray-Miller)

All Theses And Dissertations

At certain upper and lower threshold temperatures (critical temperatures (Tc) crustaceans switch to anaerobic metabolism despite sufficient oxygen availability in the environment. I tested the hypothesis that failure of the heart at critical temperatures leads to insufficient oxygen delivery and subsequent anaerobiosis in peripheral tissues.

I exposed rock crabs, Cancer irroratus, as whole animals, and their buffer-perfused semi-isolated hearts to a progressive temperature increase, while monitoring heart rate and lactate accumulation. The whole animals heart rate increased with temperature following a Q₁₀ of 2.8. An abrupt decline in heart rate occurred at 25°C and lactate accumulation occurred between …

Origin And Mechanism Of Terpene Biosynthesis In Pseudopterogorgia Spp, Jennifer M. Boehnlein

Electronic Theses and Dissertations 2000 - 2009

The goal of this work was to investigate the biosynthetic origins of diterpene natural products (pseudopterosins, kallolides, bipinnatins, and cembrenes) from corals of the genus Pseudopterogorgia as well as the biosynthetic pathways by which they are produced. These studies have shown that the pseudopterosins from Pseudopterogorgia elisabethae are biosynthesized within the algal symbiont (or possibly a bacterium or fungus associated with the symbiont), are not inducible by manipulation of light levels, and do not change as a result of transplantation to new locations. Studies on Pseudopterogorgia bipinnata revealed that only one chemotype is capable of biosynthesizing the kallolide family of …