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Evaluating The Occurrence Of Age-Related Peripheral Neuropathy In Het3 Mice And Development Of A Whole Tissue Imaging Technique For Analyzing Total Innervation In The Subcutaneous Adipose Depot, Jake Willows

Electronic Theses and Dissertations

Adipose tissue can be characterized as either being a white (energy storing) depot or a brown (energy expending) depot and both have been found to contain dense networks of neural innervation. This adipose nerve supply regulates numerous metabolic functions and likely plays an important role in the function of adipose blood vessels. Recently our lab has shown in the C57BL/6 mouse model that peripheral neuropathy, or the dying back and dysfunction of the nerves in the superficial tissues such as the skin, can extend into the subcutaneous adipose tissue in conditions commonly associated with the neuropathic phenotype (i.e. diabetes, obesity, …

Aging Intimately, Niamh Mcdonnell, Giulia Hjort

Capstones

We’re both familiar with grief after the loss of family members over 75. This project is our way of giving back in a small way by listening, but also as a way of remembering the people we unexpectedly lost. Each person we’ve met on this journey has inspired us in their own way, with their stories of resilience through grief and aging. All of our collaborators on this project are constantly learning, taking risks, and moving forward through loss and pain. They aren’t defined by their age. Rather, they embrace it with a willingness to reinvent their approach to romance …

Inclusion Of Kinetic Proteomics In Multi-Omics Methods To Analyze Calorie Restriction Effects On Aging, Richard Hajime Carson

Theses and Dissertations

One of the greatest risk factors for disease is advanced age. As the human lifespan has increased, so too have the burdens of caring for an increasingly older population suffering from rising rates of cardiovascular disease, kidney disease, diabetes, and dementia. The need for improving medical technology and developing new therapies for age-related diseases is manifest. Yet our understanding of the processes of aging and how to attenuate the effects of aging remains incomplete. Various studies have established calorie restriction as a robust method for extending lifespan in laboratory organisms; however the mechanism is a topic of much debate. Advancing …

Oxidative And Adsorbent Impacts On Selenide Based Transition Metal Dichalcogenides, Anna Hoffman

Doctoral Dissertations

This paper covers an overview of the transition metal dichalcogenides, TMD, class of materials. Their layered van der Waals chemical structure and unique electrical and optical properties, such as an indirect in the bulk to direct band gap in the monolayer transition, has brought research focus to their potential role in nanoelectronics. This paper goes over general TMD properties then focuses on WSe₂. While TMDs posses useful and promising characteristics in their pristine state, without precise control over electrical behavior real world application will never occur. Defect engineering is discussed as a method to tune TMD properties, specifically the effects …

Help-Seeking For Cognitive Impairment By The Patient : The Role Of Self-Compassion., Allison J. Midden

Electronic Theses and Dissertations

Older adults represent one of the fastest growing population groups with estimates predicting global growth from 617 million in 2015 to 1.6 billion in 2050. As the aged population increases, incidence of Alzheimer’s disease (AD) and other dementias will also increase. Professionals agree that early intervention is essential for therapeutic and quality of life purposes. However, many older adults wait several months or years to seek medical help after first noticing signs of cognitive impairment. The present study seeks to identify the predictors of help-seeking for cognitive impairment by an individual for him/herself and the role that self-compassion may play …

Age And Seasonal Change In The Chronobiology Of A Spider With An Exceptionally Long-Period Circadian Clock, Shae Crain

Electronic Theses and Dissertations

This study examines locomotor activity in samples of Frontinella pyramitela collected over its active season (April-October) to investigate whether seasonality and/or age may help explain the exceptional variability typically found in spider clock systems. Despite its noteworthy variability (%CV= 7.7), we have found that Frontinella has a mean free-running period of 28.4±2.18 hours that does not significantly vary over time. There is no correlation between day length and free-running period, indicating that varying length of FRP is not a function of photoperiod length. In LD 12:12 h, the window of activity is significantly smaller in April, gradually widening as the …

Identification Of Chromatin Regulators Perturbed In Hematopoietic Stem And Progenitor Cell Aging, Eraj S. Khokhar

Electronic Theses and Dissertations

As lifespan is increasing globally, there is a critical need to identify strategies to extend healthspan and prevent chronic diseases into older age. The long-term goal of my research is to identify novel strategies to ameliorate aging-induced decline in hematopoietic stem cell (HSC) function. HSCs give rise to all mature blood and immune cells. With age, HSCs undergo defects in their differentiation ability which correlates with a decline in immune function. Comprehensive knowledge of gene regulatory and epigenetic mechanisms underlying this defect is a barrier to developing therapies to ameliorate aging-associated decline in HSC function. Therefore, my project focuses on …

The Role Of The Environmental Context In Advance Care Planning Among Older Adults, Brittany E. Gaines

Graduate Doctoral Dissertations

Research has focused on various individual characteristics associated with advance care planning (ACP), but little is known about how the environment context is associated with ACP. This study examined the role of environmental characteristics in ACP by addressing three key aims: 1) examine the independent effects of environmental factors on ACP, 2) assess the moderating effects of environmental factors on the associations between ACP and individual household income and educational attainment, and 3) conduct a longitudinal examination of ACP and environmental characteristics. I combined individual ACP information from the 2004 and 2011 waves of the Wisconsin Longitudinal Study with county …

Rural Aging: The Geographic Reach Of Service Access In Utah, Identifying Barriers And Solutions, Alexandra T. Schiwal

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This dissertation includes two studies of rural age-related services in the state of Utah. The first study combines geospatial, demographic data (number of people over 55) and age-related services (hospitals, hospice providers, nursing homes, senior centers, and Areas Agencies on Aging) at the county level and census-tract level to determine localized differences in proportional access to age-related services. Higher and lower proportions are then predicted by contextual factors including rural/urban gradient, economic industry, and broadband access. Results demonstrate that broadband access was significantly associated with higher access to age-related services, but being a retirement destination (increase in people over 65 …

Serum Myostatin And Igf-1 As Biomarkers Of Sarcopenia: A Proof-Of-Concept Design, Ashley Binns

Graduate Theses and Dissertations

The population comprising older adults is growing exponentially, as are healthcare related costs. Nearly $20 billion is annually expensed by older adults for health-related issues affiliated with age-related decline in skeletal muscle mass. Yet, diagnostic criteria are not readily utilized in clinical practice. PURPOSE: Therefore, the purpose of this study was to provide evidence for use of blood biomarkers (myostatin, IGF-1) to predict appendicular skeletal muscle mass (ASM) among middle-aged and older adults. METHODS: A cross-sectional study was conducted among 106 individuals (n = 68 females; n = 38 males) aged ≥ 40 years of age (60.1 ± 11.1 y) …

Emotional Response To Negative Mood Induction In Mild Cognitive Impairment And Cognitively-Intact Older Adults, Gennarina Diane Santorelli

Doctoral Dissertations

Older adults with mild cognitive impairment (MCI) report greater rates of psychiatric symptoms than cognitively-intact older persons. This may be associated with emotion dysregulation, which is prevalent in cognitively-impaired populations. No research to date has investigated responses to emotionally-provocative stimuli in persons with MCI. Aim 1 of this study determined differences in emotional reactivity to and recovery from negative mood induction in older persons with amnestic MCI (aMCI) and cognitively-healthy older adults. Moreover, emotion dysfunction in MCI may be linked to impairment in executive function (EF), a common feature of MCI. Theoretical models postulate that EF is essential to the …

How Specific Is Domain-Specific Slowing? Evidence For A General Form Of A Domain-Specific Mechanism, Cynthia C. Flores

Arts & Sciences Electronic Theses and Dissertations

Faces are special not just because our ability to quickly and accurately process faces is integral for social functioning throughout our lives, but also because faces are considered a unique class of visual stimuli (i.e., faces rely more on holistic processing than objects and there exist specialized, face-specific regions in the brain). Behavioral and neuropsychological research point to face processing as dissociable from other kinds of visuospatial processing. Although there is evidence that neural specificity for faces is retained in older adults, there is also evidence that age-related impairments are greater in face processing, relative to object processing. Using a …

Dimensions Of Depression And Cerebellar Subregion Volumes In Older Adults, Hannah R. Michalak

Psychology Theses

The present study examined the relationship between subthreshold depressive symptoms and gray matter volume in subregions of the posterior cerebellum in middle-aged to older adults. Structural magnetic resonance imaging data from 38 adults aged 51 to 80 years were analyzed along with participants’ responses to the Center for Epidemiologic Studies Depression Scale. Subscale scores for depressed mood, somatic symptoms, and lack of positive affect were calculated, and multiple regression analyses were used to examine the relationship between symptom dimensions and cerebellar volumes. Greater somatic symptoms of depression were significantly related to larger vermis VI volumes, as were total depressive scores. …

The Impact Of Traumatic Brain Injury On Neuropsychological Functioning And Tau Accumulation Later In Life In Military Veterans, Lindsay Eatman

Dissertations

Abstract The following study examines aging veterans that experience a TBI while in service and

compares to older veteran without a history of TBI. The objective is to look at cognitive profile later in life for military veterans with moderate to severe TBI different and compared to older veterans with no history of TBI. Is there a difference in tau accumulations on neuroimaging in military veterans with moderate to severe TBI compared to older veterans without a history of TBI? What is the relationship between the cognitive profile and tau imaging correlates for military veterans with moderate to severe TBI …

Comparing Independent Approaches To Estimate Age At Size Of The Jonah Crab (Cancer Borealis): Corroborating Gastric Mill Band Counts As A Direct Aging Method, Carlton Huntsberger

Electronic Theses and Dissertations

Knowing the age of an organism is essential in understanding the dynamics and management of wild populations. Age determination has been an especially long-standing challenge in the study of crustaceans, since they posed a unique challenge, shedding all calcified structures with each molt. The Jonah crab (Cancer borealis), is one of many commercially harvested crustaceans for which no absolute aging method has yet been established. It is an ecologically important species and a newly managed fishery in New England and Atlantic Canada. The recent increase of commercial fisheries for this species has highlighted the large data gap of …

Investigation Of The Effect Of Age On Regenerative Outcomes Following Treatment Of Volumetric Muscle Loss Injuries, John Taehwan Kim

Graduate Theses and Dissertations

Volumetric muscle loss (VML) is a traumatic injury in skeletal muscle resulting in the bulk loss of more than 20% of the muscle’s volume. Included in the bulk loss of muscle is the skeletal muscle niche comprised of nerve bundles, vasculature, local progenitor cells, basal lamina, and muscle fibers, overwhelming innate repair mechanisms. The hallmark of VML injury is the excessive accumulation of non-contractile, fibrotic tissue and permanent functional deficits. Though predominant in the younger demographic, the elderly population is also captured within VML injuries. There are many factors that change with aging in skeletal muscle that may further hinder …

Dissociable Effects Of Monetary, Liquid, And Social Incentives On Motivation Across The Adult Life Span, Jennifer Crawford

Arts & Sciences Electronic Theses and Dissertations

Humans are social creatures and, as such, can be motivated by aspects of social life, like approval from others, to guide decision-making in everyday life. Indeed, a common view in the aging literature is that older adults have a stronger orientation towards socioemotional goals or incentives, relative to other incentive modalities, like money, because of changing motivational priorities in older adulthood. In prior work, however, we found that older adults actually showed greater effects of monetary relative to primary (liquid) incentives, suggesting alternative interpretations of impaired motivational integration and/or slower adaptation to incentive conditions. The current study tested these alternatives, …

New Public Service: Gray Matters In The Delivery Of Public Added Value Through Creative Governance Practices – A Silver Lining To Managing The Effects Of A Changing Demographic, Salvador Portillo

Public Affairs Dissertations

The baby boomer generation, those people born worldwide between 1946 and 1964 are now making their mass exodus from the workforce and are on the imminent road to retirement. Or maybe they are not. The road to retirement is shrouded in uncertainty for countless older Americans. The financial crisis in 2008 left many reeling with debts and inadequate payments from their hard earned pensions. In addition to this, research has shown poor planning has left a significant portion of baby boomers facing financial insecurity, requiring them to work longer than anticipated. Nevertheless, large swaths of older adults are having difficulty …

One Year Change In Cognitive Function In Male And Female Common Marmosets (Callithrix Jacchus), Brianna Healey

Masters Theses

Long term cognitive studies in humans and nonhuman primates such as macaques are difficult because of their long lifespan. The common marmoset (Callithrix jacchus) is a non-human primate who shares with humans many features characteristic of primates, including a complex brain and cognitive function. They also have a short lifespan (~10 years) that makes them a great model in studies of cognitive aging. This study focuses on the rate of decline in cognitive function in male and female marmosets based on performance on reversal learning tasks over 2 years of testing.

We found that marmosets improved their overall …

Home-Based Cognitive Monitoring: The Role Of Personality And Predictors Of Adherence And Satisfaction, Nasreen A. Sadeq

USF Tampa Graduate Theses and Dissertations

Over the last several decades, a growing awareness of the benefits of regular screening for common health conditions, such as cancer and cardiovascular diseases, has paved the way for preventative screenings to become routine in medical settings. Given that cognitive impairment is frequently reported as the number one worry of older adults, home-based cognitive monitoring may be an innovative solution that allows middle aged and older adults to take an active role in monitoring an important aspect of their health. Although several home-based cognitive monitoring programs have been validated for use in clinical and home-based settings, the Cogstate Brief Battery …

Examining The Effects Of Stress And Age On Neural Reward Processing: Considerations For The Role Of Individual Differences In Autonomic Reactivity, William Mccuddy

Dissertations (1934 -)

Acute stress is unavoidable and may hinder basic reward processing underlying adaptive decision-making. Additionally, older adults may be at an increased risk of poor decision-making after exposure to acute stress due to age-related changes in cognitive and autonomic functioning. The current study assessed the influence of acute stress, autonomic reactivity, and age on a simple behavioral task during fMRI. Specifically, old and young adults completed a basic reward processing paradigm (i.e., where participants received monetary rewards and punishments) after exposure to acute stress (i.e., social evaluative cold pressor) or control procedure between-subjects. In the young group, differential responses for monetary …

Aging In The Workplace: A Cross Case Analysis In Jamaica's Finance Sector, Malaika Tahirah Edwards

LSU Doctoral Dissertations

Along with the increase in the number of older people globally, is an increase in the number of older people in the labor force. Older adults increasingly represent a large segment of the working population. The purpose of this study was therefore to explore workplace aging, with specific reference to Jamaica’s finance sector, in relation to organizational preparedness for the aging workforce.

This study examined aging from an organizational perspective, a national perspective, and an individual perspective, through the lens of Baby Boomers. The study was framed through the lens of the Four Frames Model, and the Metaperspectives Theory, which …

Socioeconomically Disadvantaged Neighborhoods, Stroke Risk, And Cognition In Older Adults: A Focus On Violent Crime, Linda D. Ruiz

College of Science and Health Theses and Dissertations

Living in socioeconomically disadvantaged neighborhoods, i.e., neighborhoods with lower incomes, lower education/occupational levels, and/or higher crime, increases one’s risk of developing chronic health problems, including cardiovascular disease risk factors and stroke. These health problems are associated with reduced cognition and dementia and may help to explain disparities in brain aging. We investigated the association of neighborhood socioeconomic characteristics on stroke risk and cognitive outcomes hypothesizing that stroke risk mediates the association between the socioeconomic environment and cognitive functioning. Participants were non-demented community-dwelling older adults (N=121), ~67 years of age (50% male, 44% non-Latino Black) who underwent cognitive and medical assessments. …

Informal Caregivers’ Of Adults With Autism Spectrum Disorder: Experiences Of Social Inclusion Policy In The Province Of Ontario, Heather L.M. Church

Electronic Thesis and Dissertation Repository

Social inclusion for people with Autism Spectrum Disorder (ASD) is a widely

accepted social value. Policy implementation impacts on health, experience of inclusion and on individuals and caregivers.

Method. This study used a qualitative directed content analysis to analyse the needs, care, services and policy which influence the care and support of adults with ASD in the Province of Ontario. Caregivers of adults with ASD were interviewed to determine: a) how the Services and Supports to Promote the Social Inclusion of Persons with Developmental Disabilities Act, 2008, is experienced and b) has influenced how they and their loved ones with …

Comorbidities And Medication Adherence Among Older Individuals Living With Hiv In The United States, Amanda M. Kong

Dissertations and Theses

The number of people living with HIV (PLWH) ≥65 years old is increasing in the United States (US) as PLWH live longer. In 2015, there were nearly 1 million people living with diagnosed HIV in the US and under 10% were age ≥65. By 2035, the proportion of PLWH in this age group is projected to be 27%. Like the general population of elderly individuals, as they age, PLWH face age-related comorbidities, many of which require routine medical care and daily medications, in addition to daily antiretroviral therapy (ART) for treatment of HIV. Previous research has found that PLWH develop …

Effects Of Life-Long Wheel Running Behavior On Plantar Flexor Contractile Properties, Alexander Nicholas Beechko

Electronic Theses, Projects, and Dissertations

Aging in skeletal muscle is characterized by a loss in muscular performance. This is in part related to the direct loss of muscle mass due to senescence, known as sarcopenia. With age, skeletal muscles lose force production, contractile speed, and power production. The force velocity relationship of muscle is a product of force production and contraction speed, both of which decline with age; however, the mechanisms and trajectory of this decline are not well understood. Exercise has positive effects on muscle, and thus may assist in maintaining performance in old age. However, few long-term studies have been performed to examine …

The Revelation Effect In Autobiographical Memory, Vincent A. Medina

Seton Hall University Dissertations and Theses (ETDs)

The revelation effect is a memory illusion in recognition memory where items are more likely to be considered old if they are immediately preceded by a cognitive task (for a review, see Abfalg, Bernstein, & Hockley, 2017). Recent research has shown that the revelation effect appears in past and future episodic judgments so long as the tasks are autobiographical in nature (Westerman, Miller, & Lloyd, 2017). Aging is a factor that has not yet been studied in the revelation effect literature in terms of autobiographical memory. It has implications because of aging’s significant impact on mental time travel. During this …

Exploring Age-Related Metamemory Differences Using Modified Brier Scores And Hierarchical Clustering, Chelsea Parlett

Computational and Data Sciences (MS) Theses

Older adults (OAs) typically experience memory failures as they age. However, with some exceptions, studies of OAs’ ability to assess their own memory functions– Metamemory (MM)– find little evidence that this function is susceptible to age-related decline. Our study examines OAs’ and young adults’ (YAs) MM performance and strategy use. Groups of YAs (N = 138) and OAs (N = 79) performed a MM task that required participants to place bets on how likely they were to remember words in a list. Our analytical approach includes hierarchical clustering, and we introduce a new measure of MM—the modified Brier—in order to …

Mechanics Of Phenotypic Aging Trajectories In C. Elegans And Humans, William Zhang

Arts & Sciences Electronic Theses and Dissertations

Overall, my dissertation integrates longitudinal measurements of physiology to investigate the aging process. In the first half, I examine the surprising and largely unexplained degree of variation in lifespan within even homogeneous populations. I sought to understand how physiological aging differs between long- and short-lived individuals within a population of genetically identical C. elegans reared in a homogeneous environment. Using a novel culture apparatus, I longitudinally monitored aspects of aging physiology across a large population of isolated individuals. Aggregating several measures into an overall estimate of senescence, I find that long- and short-lived individuals start adulthood on an equal physiological …

Overactive Bladder: Shortcomings Of Current Diagnostic And Treatment Approaches And A New Etiological Paradigm, Nina L. Franzen

Master's Theses

Aims: To examine the effectiveness of the current diagnostic and treatment approach of overactive bladder (OAB) and the relative impact of cognition on what is currently a bladder-centric condition. Methods: A review of the literature on OAB from the population to organ/brain level was conducted. The impact of age-induced bladder dysfunction via cognitive changes to sensory integration and attention control are discussed. Results: OAB uses bladder-centric terminology to represent a collection of symptoms with inconsistent and often unknown pathology. Proposed etiologies and therapeutic models for overactive bladder focus on the bladder organ, but evidence suggests that age-related degradation to inhibitory …