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Purification Of Protoporphyrin Ix Using The Fplc, Ken Overway, Laura Narby May 2027

Purification Of Protoporphyrin Ix Using The Fplc, Ken Overway, Laura Narby

Honors Projects

Protoporphyrin IX (PPIX) is the main pigment in brown eggshells, and it is embedded in the shell gland of hens during the final stages of the egg-making process. This natural dye can be used as a substitute for organic sensitizers in dye-sensitized solar cells (DSSCs). One benefit of PPIX is that it is a natural resource and has a high absorption coefficient in the visible and near-infrared region (NIR). Purified PPIX is extremely helpful in dye-sensitized solar cells because it improves electron injection efficiency, can be chemically modified to improve its absorption efficiency, and can be mixed with nanomaterials such …

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Avian Influenza And The Approach To Designing An H5n1 Vaccine, Lauren N. Hickey May 2027

Avian Influenza And The Approach To Designing An H5n1 Vaccine, Lauren N. Hickey

Honors Program: Senior Projects (Public)

The Avian influenza virus (AIV) H5N1 has been responsible for the culling and deaths of millions of birds since 2022 with concern for wildlife, livestock, and human infections occurring as well. With eggs flying off the shelves in grocery stores, even individuals not involved in the agricultural industry have seen the drastic effects of this disease first-hand. For chickens, this virus works quickly and overpowers the innate immune system before the adaptive immune system has time to properly respond. Therefore, a safe and effective vaccine could reduce the number of poultry deaths and prevent the continuous spread of the infection. …

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The Contractual Womb: U.S. Surrogacy Reform Through A Federal Bioethical Framework, Yasmine A. Quinones Jan 2027

The Contractual Womb: U.S. Surrogacy Reform Through A Federal Bioethical Framework, Yasmine A. Quinones

Student Works

No abstract provided.

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Addressing The Challenges Of Cognitive Decline In The Physician Workforce, Sharona Hoffman Jan 2027

Addressing The Challenges Of Cognitive Decline In The Physician Workforce, Sharona Hoffman

Faculty Publications

This book chapter examines the growing challenge of cognitive decline among aging physicians and analyzes various approaches to addressing it. In 2024, twenty percent of working physicians were sixty-five or older, and evidence suggests that 12-14% of older clinicians have cognitive deficits that may affect job performance. The chapter evaluates two primary approaches to cognitive assessment: employer-initiated programs and programs operated by state medical boards. Employer "late career practitioner policies" (LCPP) that require older physicians to undergo testing are becoming increasingly popular among health care organizations. But they are vulnerable to challenge under disability and age discrimination laws, as evidenced …

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Revising The Role Of Minors And Their Participation In Their End-Of-Life Care: An Argument For A Shared Decision-Making Model Rooted In Pediatric Patients’ Decision-Making Capacity, Taylor Talcott Jan 2027

Revising The Role Of Minors And Their Participation In Their End-Of-Life Care: An Argument For A Shared Decision-Making Model Rooted In Pediatric Patients’ Decision-Making Capacity, Taylor Talcott

Student Works

No abstract provided.

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Work-Life Balance Of Parents: Comparing The Parental Leave Systems And Their Legal Structures In The United States And European Union, Michelle C. Hunter Jan 2027

Work-Life Balance Of Parents: Comparing The Parental Leave Systems And Their Legal Structures In The United States And European Union, Michelle C. Hunter

Student Works

No abstract provided.

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Optimizing Human Fcrn Mouse Models To Improve Pharmacokinetic Evaluation Of Antibody Drug Candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, Elena Gonzalo-Gil Dec 2026

Optimizing Human Fcrn Mouse Models To Improve Pharmacokinetic Evaluation Of Antibody Drug Candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, Elena Gonzalo-Gil

Faculty Research 2026

The use of animal models that can reliably predict drug performance in human patients is critical to antibody therapeutic development. Along with assessing toxicity and efficacy, determining the pharmacokinetic (PK) properties of therapeutics in Tg32 and Tg276 mice is essential to preclinical characterization. While Tg32 mice have been well established as indispensable in their ability to model the PK properties of antibody therapeutics, their intact immunity leaves them capable of mounting anti-drug antibody responses that interfere with PK interpretation. Here, we demonstrate the negative impact anti-drug responses can have on PK parameters derived from Tg32 mice, and provide strong evidence …

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Optimizing Human Fcrn Mouse Models To Improve Pharmacokinetic Evaluation Of Antibody Drug Candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, Elena Gonzalo-Gil Dec 2026

Optimizing Human Fcrn Mouse Models To Improve Pharmacokinetic Evaluation Of Antibody Drug Candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, Elena Gonzalo-Gil

Faculty Research 2026

The use of animal models that can reliably predict drug performance in human patients is critical to antibody therapeutic development. Along with assessing toxicity and efficacy, determining the pharmacokinetic (PK) properties of therapeutics in Tg32 and Tg276 mice is essential to preclinical characterization. While Tg32 mice have been well established as indispensable in their ability to model the PK properties of antibody therapeutics, their intact immunity leaves them capable of mounting anti-drug antibody responses that interfere with PK interpretation. Here, we demonstrate the negative impact anti-drug responses can have on PK parameters derived from Tg32 mice, and provide strong evidence …

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Limosilactobacillus Reuteri Promotes Melatonin Release From Human Intestinal Organoids Via 5′Ectonucleotidase Activity, Micah D Forshee, Erika J Nachman, Esha R Shenoy, Heather A Danhof, Ludwig Ermann Lundberg, Stefan Roos, Robert A Britton Dec 2026

Limosilactobacillus Reuteri Promotes Melatonin Release From Human Intestinal Organoids Via 5′Ectonucleotidase Activity, Micah D Forshee, Erika J Nachman, Esha R Shenoy, Heather A Danhof, Ludwig Ermann Lundberg, Stefan Roos, Robert A Britton

Faculty, Staff and Students Publications

Strains of Limosilactobacillus reuteri have been used to prevent or treat various conditions; however, the mechanisms by which they exert beneficial effects are not completely understood. Infant colic is one example in which L. reuteri DSM 17938 reduces clinical symptoms. While the etiology of colic is unknown, abnormal melatonin levels in infants have been suggested as a possible contributor. L. reuteri DSM 17938 has been shown to produce adenosine from AMP via production of the extracellular enzyme 5′ectonucleotidase (5′NT). Adenosine is a potent signaling molecule that impacts several important aspects of host physiology, including the release of melatonin from the …

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Steroid Receptor Coactivator 3-Deficient Regulatory T Cells Eradicate Multiple Solid Tumors In Syngeneic Mouse Models, Nuri Sung, Eunsu Kim, Yosef Gilad, Yuri Park, Adam M Dean, Yan Xia, Jianming Xu, Clifford C Dacso, David M Lonard, Sang Jun Han Dec 2026

Steroid Receptor Coactivator 3-Deficient Regulatory T Cells Eradicate Multiple Solid Tumors In Syngeneic Mouse Models, Nuri Sung, Eunsu Kim, Yosef Gilad, Yuri Park, Adam M Dean, Yan Xia, Jianming Xu, Clifford C Dacso, David M Lonard, Sang Jun Han

Faculty, Staff and Students Publications

Steroid receptor coactivator 3 (SRC-3) is highly expressed in regulatory T cells (Tregs) and is important for their immunosuppressive activity. Recently, we demonstrated that disrupting SRC-3 expression in Tregs eliminates triple-negative breast cancer (TNBC) and prostate cancer in syngeneic animal models by generating an anti-tumor immune microenvironment without inducing immune-related adverse events (irAEs). Further analysis of these mice revealed that SRC-3 knockout (KO) Tregs infiltrated breast tumors and facilitated the infiltration of CD8

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When Probiotics Guidelines Differ: A Practical Guide For Clinicians And Researchers, Geoffrey A Preidis, Hania Szajewska, Marla Cunningham, Howard Bauchner, Daniel J Merenstein Dec 2026

When Probiotics Guidelines Differ: A Practical Guide For Clinicians And Researchers, Geoffrey A Preidis, Hania Szajewska, Marla Cunningham, Howard Bauchner, Daniel J Merenstein

Faculty, Staff and Students Publications

Many professional organizations publish clinical practice guidelines for the use of probiotics in gastrointestinal disorders. Generally, no two guidelines align perfectly, and some differ markedly. These discrepancies occur because clinical practice guidelines are not purely mechanical outputs of data synthesis. They are shaped by structured interpretation, value judgments, and predefined thresholds for uncertainty. These elements become particularly visible when effect sizes are small, heterogeneity is high, and outcomes vary in clinical relevance-as is the case with probiotic research. This article examines why discordance among probiotic guidelines is predictable and provides practical guidance for clinicians who must decide among conflicting recommendations …

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Is Your Cyst Really A Ganglion Cyst? A Case Report Of Angioleiomyoma Mimicking A Plantar Fascia Cystic Lesion, Christopher Anjorin Ms Dpmc, Joseph Bender Dpm Dec 2026

Is Your Cyst Really A Ganglion Cyst? A Case Report Of Angioleiomyoma Mimicking A Plantar Fascia Cystic Lesion, Christopher Anjorin Ms Dpmc, Joseph Bender Dpm

School of Podiatric Medicine - Student Research

Ganglion cysts are among the most common benign soft tissue masses encountered in podiatric clinical practice, and their diagnosis is often presumed based on location, clinical observation, and transillumination. However, this case highlights a diagnostic idiosyncrasy: a lesion clinically presumed to be a ganglion cyst within the plantar fascia was ultimately identified as an angioleiomyoma following surgical excision and histopathological evaluation. This finding underscores the importance of maintaining a broad differential diagnosis when assessing cystic lesions, particularly those that transilluminate, as benign vascular tumors may closely mimic more common entities in both clinical presentation and imaging. More importantly, what if …

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Social Procurement As A Catalyst For Dei In Construction: Some Takeaways For Hrm?, Jennifer Waterhouse, Robyn Keast, Judy Lundy, Martin Loosemore Dec 2026

Social Procurement As A Catalyst For Dei In Construction: Some Takeaways For Hrm?, Jennifer Waterhouse, Robyn Keast, Judy Lundy, Martin Loosemore

Research outputs 2022 to 2026

Purpose: Diversity, equity and inclusion (DEI) initiatives aim to foster workplaces where all employees feel valued and can add value. Increasingly, the success of these initiatives is influenced by environments and interactions beyond organisational boundaries, including recent backlash. Despite this, most DEI research remains focused on intra-organisational aspects and human resource management (HRM) activities. The purpose of this paper is to introduce social procurement as a novel and promising framework for advancing DEI in theory and practice through a collaborative, inter-organisational approach that has the potential to overcome institutional barriers and mitigate backlash. Design/methodology/approach: Data were collected through 15 in-depth …

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Associations Between Trpm4 Gene Variants And Intracranial Pressure Dynamics Following Traumatic Brain Injury, Emily H. Saweris Dec 2026

Associations Between Trpm4 Gene Variants And Intracranial Pressure Dynamics Following Traumatic Brain Injury, Emily H. Saweris

Summer Research Program Abstracts

No abstract provided.

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Stocks And Fluxes Of Carbon And Nitrogen In Northeastern Brazil Coastal Seascapes, Antoniwal A. Jatobá-Junior, Pere Masque, Carlos Eduardo De Rezende, Vanessa Hatje Dec 2026

Stocks And Fluxes Of Carbon And Nitrogen In Northeastern Brazil Coastal Seascapes, Antoniwal A. Jatobá-Junior, Pere Masque, Carlos Eduardo De Rezende, Vanessa Hatje

Research outputs 2022 to 2026

Quantifying carbon and nitrogen dynamics is essential for understanding the role of coastal ecosystems in climate change mitigation and habitat connectivity. We assessed organic carbon (OC) and total nitrogen (TN) stocks, accumulation rates, and isotopic composition (δ13C and δ15N) in sediment across diverse seascapes in northeastern Brazil, including high- and low-salinity mangroves, a tidal flat, a freshwater marsh, and an inundated forest. OC stocks in the upper meter of sediment were highest in the freshwater marsh (283 ± 64 Mg OC ha−1) and tidal flat (266 ± 27 Mg OC ha−1), and …

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Over A Century Of Global Decline In The Growth Performance Of Marine Fishes, Helen F. Yan, Hannah V. Watkins, Alexandre C. Siqueira, David R. Bellwood Dec 2026

Over A Century Of Global Decline In The Growth Performance Of Marine Fishes, Helen F. Yan, Hannah V. Watkins, Alexandre C. Siqueira, David R. Bellwood

Research outputs 2022 to 2026

Human-driven pressures are causing large-scale changes in the ecologies and life histories of fishes. Growth performance is a composite life-history trait that captures the trade-off between two fundamental traits: growth and body size. Here, we assess the impacts of fishing and temperature on the growth performance of marine teleost fishes globally over the last century. Using 7683 growth curves encompassing 1479 species, we find a global pattern of decline in growth performance from 1908 onwards, with the greatest declines in commercially valuable fishes. Indeed, managed fisheries experienced a 9% decline in growth performance over the last century, which can equate …

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Coastal Land Uplift And Intensified Land-Use Influence Seagrass Carbon And Nitrogen Sink Capacity Over Millennial Timescales, Martin Dahl, Sara Braun, Maria E. Asplund, Mats Björk, Joeri Kaal, Hans W. Linderholm, Elinor Andrén, Thomas Andrén, Žilvinas Ežerinskis, Madhavu Vidya Faizal, Sara C. Forsberg, Andrius Garbaras, Malin E. Kylander, Pere Masqué, Miguel A. Mateo, Justina Šapolaitė, Oscar Serrano, J. Robin Svensson, Olena Vinogradova, Martin Gullström Dec 2026

Coastal Land Uplift And Intensified Land-Use Influence Seagrass Carbon And Nitrogen Sink Capacity Over Millennial Timescales, Martin Dahl, Sara Braun, Maria E. Asplund, Mats Björk, Joeri Kaal, Hans W. Linderholm, Elinor Andrén, Thomas Andrén, Žilvinas Ežerinskis, Madhavu Vidya Faizal, Sara C. Forsberg, Andrius Garbaras, Malin E. Kylander, Pere Masqué, Miguel A. Mateo, Justina Šapolaitė, Oscar Serrano, J. Robin Svensson, Olena Vinogradova, Martin Gullström

Research outputs 2022 to 2026

Seagrass meadows store sedimentary carbon and nitrogen and thus play an important role in climate change mitigation and nutrient retention globally. Here we reconstruct the impact of land-use and coastal land uplift on millennial–scale seagrass (Zostera marina) blue carbon and nitrogen accumulation in the Baltic Sea based on a multiproxy paleoreconstruction approach. We show that increased landscape clearance resulted in higher terrestrial runoff and increased accumulation of carbon and nitrogen, whereas land uplift led to hydrodynamically sheltered environments facilitating seagrass colonization, occurring 1700 and > 4000 years ago. The establishment of the seagrass meadows resulted in enhancement of the quality of …

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Genetic Drivers Of Progression In Alzheimer’S Disease Are Distinct From Disease Risk, Celeste E. Cohen, Shane Fernandez, Umran Yaman, Ahmad R. Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O’Brien, Paul Maruff, Alexi Nott, John A. Hardy, Simon M. Laws, Dervis A. Salih, Maryam Shoai Dec 2026

Genetic Drivers Of Progression In Alzheimer’S Disease Are Distinct From Disease Risk, Celeste E. Cohen, Shane Fernandez, Umran Yaman, Ahmad R. Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O’Brien, Paul Maruff, Alexi Nott, John A. Hardy, Simon M. Laws, Dervis A. Salih, Maryam Shoai

Research outputs 2022 to 2026

Background: Recent trials in Alzheimer’s disease (AD) demonstrate encouraging outcomes. These trials target risk mechanisms identified through genetic analysis whilst directly aiming to reduce progression rates. Evidence from other neurodegenerative diseases suggests the genetics of progression is distinct from risk of disease. To expand these initial successes and improve clinical outcomes further we need to understand genetics of progression of disease. These can be deduced through rigorous analysis of meticulously phenotyped longitudinal cohorts. In this study we first looked at known genetic drivers of risk, namely polygenic risk scores for AD and APOE‑ε4, to assess their role in progression. This …

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Methods For Tagging Whale Sharks: Insights Into Performance And Best Practices With A Focus On Clamp Attachments, Freya C. Womersley, Sofia Green, Alberto Garcia-Baciero, Ronan Conlon, Amy L. Jeffries, Matt J. Waller, Sara S. Ratão, Nuno Queiroz, Pedro Afonso, Gonzalo Araujo, Adam Barnett, Christine Barry, Michael L. Berumen, Farukhkha Bloch, Ginevra Boldrocchi, Camrin D. Braun, Ryan Caillouet, Constance Chapman, Jesse E.M. Cochran Dec 2026

Methods For Tagging Whale Sharks: Insights Into Performance And Best Practices With A Focus On Clamp Attachments, Freya C. Womersley, Sofia Green, Alberto Garcia-Baciero, Ronan Conlon, Amy L. Jeffries, Matt J. Waller, Sara S. Ratão, Nuno Queiroz, Pedro Afonso, Gonzalo Araujo, Adam Barnett, Christine Barry, Michael L. Berumen, Farukhkha Bloch, Ginevra Boldrocchi, Camrin D. Braun, Ryan Caillouet, Constance Chapman, Jesse E.M. Cochran

Faculty Publications

Background: Biologging and telemetry have transformed our understanding of marine megafauna movement ecology. Yet, methodological constraints continue to limit data quality and deployment duration. Devices recording whale shark (Rhincodon typus) behaviours and movements have been used for decades, but they remain challenging to deploy and vary in success. Recently, spring-loaded clamp-based systems have emerged as one of the most widely used approaches to attach electronic tags to the fins of this globally endangered species. Currently, however, no consensus guidelines exist as to how to optimise this approach, potentially leading to continued underperforming deployments limiting analysis potential. Here, we synthesise experiences …

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Evaluating The Impact Of Research Equipment Availability On Scientific Rigor, Reproducibility, And Innovation Across Stem Disciplines, Lyndi G. Hraban Dec 2026

Evaluating The Impact Of Research Equipment Availability On Scientific Rigor, Reproducibility, And Innovation Across Stem Disciplines, Lyndi G. Hraban

Honors Program: Senior Projects (Public)

Research infrastructure plays a central role in shaping the quality and innovative capacity of scientific research. This study evaluates how the availability of research equipment influences scientific rigor, reproducibility, and innovation across STEM disciplines. Drawing on literature from science-to-science research, policy studies, and discipline-specific analyses, this project synthesizes existing scholarship to explore the relationship between access to infrastructure and key research outcomes. Findings across the literature indicate that access to advanced and well-maintained equipment can strengthen scientific rigor by enabling more precise measurements, improved experimental control, and the implementation of standardized research protocols. Shared and centralized facilities are also associated …

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Reduced Mediators Released By Cyanobacteria During Exoelectrogenesis Detected Using Differential Pulse Voltammetry, Laura T. Wey, Monica Brachi, Yagut Allahverdiyeva, Shelley D. Minteer Dec 2026

Reduced Mediators Released By Cyanobacteria During Exoelectrogenesis Detected Using Differential Pulse Voltammetry, Laura T. Wey, Monica Brachi, Yagut Allahverdiyeva, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

Cyanobacteria generate electrical current through exoelectrogenesis (extracellular electron transfer) downstream of photosynthesis, yet the identity of the endogenous redox mediator(s) responsible remains unresolved. Here, we apply differential pulse voltammetry (DPV) to detect and characterise redox-active species released by Synechocystis sp. PCC 6803 under illumination. To enable sensitive detection, we developed an electrolyte intermediate between BG11 (Blue-Green-11) growth medium and MOPS (3-(N-morpholino)propanesulfonic acid) buffer that minimises background electrochemical interference while maintaining short-term cellular functionality. DPV revealed multiple light-enhanced oxidation peaks (0.1–0.65 V vs. saturated calomel electrode (SCE)) that were not resolvable using cyclic voltammetry, providing evidence that cyanobacteria release reduced compounds …

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A Global High-Resolution Comprehensive Heat Indices Dataset From 1950 To 2024, Abdul Malik, Sateesh Masabathini, Mohsin Ahmed Shaikh, Qinqin Kong, Muhammad Usman, Dasari Hari Prasad, Ibrahim Hoteit Dec 2026

A Global High-Resolution Comprehensive Heat Indices Dataset From 1950 To 2024, Abdul Malik, Sateesh Masabathini, Mohsin Ahmed Shaikh, Qinqin Kong, Muhammad Usman, Dasari Hari Prasad, Ibrahim Hoteit

All Works

Heatwaves are becoming more intense and frequent as global temperatures rise, affecting vulnerable populations, particularly in low-income communities. Addressing the impacts of heatwaves requires high-resolution data to assess their influence on labour productivity, public health, and climate risk. We introduce the Comprehensive Heat Indices (CHI) dataset, a high-resolution (0.1° × 0.1°) hourly dataset from 1950 to 2024, derived from the ERA5 and ERA5-Land reanalyses. The CHI dataset encompasses thirteen heat stress indices, including wet-bulb temperature, universal thermal climate index, mean radiant temperature, wind chill, and lethal heat stress index (Ls). Thresholds for Ls are empirically linked to mortality, enabling the …

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A Critical Review Of Pharmaceutical Pollutants In Soil And Air: Ecotoxicological Impacts On Animal, Plant And Microbial Communities - Health Hazards And Waste Management, Md Faisal Amin, Md. Saydur Rahman Dec 2026

A Critical Review Of Pharmaceutical Pollutants In Soil And Air: Ecotoxicological Impacts On Animal, Plant And Microbial Communities - Health Hazards And Waste Management, Md Faisal Amin, Md. Saydur Rahman

School of Integrative Biological & Chemical Sciences Faculty Publications

Pharmaceutical contamination in soil and air has become a critical environmental concern due to its widespread sources, complex behavior, and long-lasting ecological impacts. This review comprehensively explores the presence, fate, and effects of pharmaceutical compounds in soil, highlighting their entry routes, environmental persistence, and biological consequences. Pharmaceuticals infiltrate terrestrial and aquatic environments through various pathways, including agricultural application, pharmaceutical manufacturing waste, sewage sludge, hospital and household discharges, irrigation with contaminated water, and atmospheric deposition. A wide range of drug classes, such as antibiotics, analgesics, non-steroidal anti-inflammatory drugs, antidepressants, anticancer drugs, and hormones, have been identified in both soil and air …

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A Global Image-Based Data Repository Of Killer Whale Interactions With Elasmobranchs, Emma Luck, Isabella L. Reeves, Maeva Terrapon, Rebecca Wellard, Stephanie K. Venables, Alison V. Towner, Alison A. Kock, Charlotte Hussain, Molly Altschwager, Rosie Ballard, Evans Baudin, Nancy Black, Evan Brodsky, Jade Cantrall, Julio Cardoso, Matt I.D. Carter, Oliver Clarke, Santiago Diaz-Pazmino, David Donnelly, Georgina Cabayol Ferraz, Arlaine Francisco, Laura González García, Mark Jackman, Aimee Jan, Eric Martin, Dane Mcdermott, James Moskito, Blair Ranford, Jesús Erick Higuera Rivas, Jasmin O’Brien, Anton Oleynik, Hernán Orellana-Vásquez, Daniela Alarcón Ruales, Gemma Sharp, Jade Sharp, Alisa Schulman-Janiger, Colleen M. Talty, Paul Tixier, John A. Totterdell, Steve Truluck, Jennah Tucker, Tara Weberg, M. Fernanda Urrutia-Osorio, Machi Yoshida, Jochen R. Zaeschmar, Lauren Meyer Dec 2026

A Global Image-Based Data Repository Of Killer Whale Interactions With Elasmobranchs, Emma Luck, Isabella L. Reeves, Maeva Terrapon, Rebecca Wellard, Stephanie K. Venables, Alison V. Towner, Alison A. Kock, Charlotte Hussain, Molly Altschwager, Rosie Ballard, Evans Baudin, Nancy Black, Evan Brodsky, Jade Cantrall, Julio Cardoso, Matt I.D. Carter, Oliver Clarke, Santiago Diaz-Pazmino, David Donnelly, Georgina Cabayol Ferraz, Arlaine Francisco, Laura González García, Mark Jackman, Aimee Jan, Eric Martin, Dane Mcdermott, James Moskito, Blair Ranford, Jesús Erick Higuera Rivas, Jasmin O’Brien, Anton Oleynik, Hernán Orellana-Vásquez, Daniela Alarcón Ruales, Gemma Sharp, Jade Sharp, Alisa Schulman-Janiger, Colleen M. Talty, Paul Tixier, John A. Totterdell, Steve Truluck, Jennah Tucker, Tara Weberg, M. Fernanda Urrutia-Osorio, Machi Yoshida, Jochen R. Zaeschmar, Lauren Meyer

Research outputs 2022 to 2026

Killer whales (Orcinus orca) are cosmopolitan apex predators that interact with numerous species, including sharks, skates, and rays (subclass Elasmobranchii). Interactions between killer whales and elasmobranchs have garnered attention from the scientific community, but the dynamics of these events are poorly understood, as interactions are often challenging to observe. In this study, we collated imagery of interactions between killer whales and elasmobranchs to create the first image-based repository of interspecific interactions between marine predators. A total of 320 photos and videos from 82 unique interactions were collected from 12 countries. A minimum of 18 elasmobranch species across 16 genera were …

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Radio Frequency Tagging–Enabled Patient Monitoring: Integrating Mobility Tracking With Early Warning Systems For Enhanced Safety, Ahed Abugabah, Prashant Kumar Shukla, Piyush Kumar Shukla, Abhishek Dwivedi Dec 2026

Radio Frequency Tagging–Enabled Patient Monitoring: Integrating Mobility Tracking With Early Warning Systems For Enhanced Safety, Ahed Abugabah, Prashant Kumar Shukla, Piyush Kumar Shukla, Abhishek Dwivedi

All Works

Ensuring patient safety in healthcare environments requires continuous monitoring systems capable of identifying early warning signs of clinical risk. Traditional surveillance methods often fail to capture meaningful patterns in patient movement, limiting their ability to prevent incidents such as falls, prolonged immobility, or unnoticed health deterioration. Radio Frequency Tagging technology has been increasingly adopted for real-time patient tracking; however, existing systems are generally limited to location detection and lack predictive insights into patient behaviour. To overcome these limitations, this study presents a Radio Frequency Tagging-based patient monitoring framework that integrates mobility tracking with an early warning mechanism to enable proactive …

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Mtorc2-Nav1.2 Signaling Drives Early Hyperexcitability In Alzheimer’S Disease Mouse Model, Nolan M Dvorak, Jeffrey L Noebels Dec 2026

Mtorc2-Nav1.2 Signaling Drives Early Hyperexcitability In Alzheimer’S Disease Mouse Model, Nolan M Dvorak, Jeffrey L Noebels

Faculty, Staff and Students Publications

Hyperexcitability is a biomarker of early-stage Alzheimer’s Disease (AD) and hastens cognitive decline later in its course. Mechanistic target of rapamycin (mTOR) signaling contributes to the slope of this trajectory, as evidenced by early increased brain expression and the rescue of hyperexcitability by genetic deletion of mTOR complex 2 (mTORC2); however, a molecular mechanism directly linking mTOR signaling to membrane hyperexcitability in early-stage AD remains elusive. Here, we show that hyperactive mTOR signaling stimulates the voltage-gated Na+ channel 1.2 (Nav1.2), a previously identified downstream phosphorylation target of mTORC2 and a key regulator of membrane electrogenesis. Augmented Nav1.2 channel function induced …

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Long-Term Analysis Of Pm2.5 Elemental Composition And Source Contributions In Coastal Urban Environments Of Corpus Christi And Houston In Texas, Sai Deepak Pinakana, Jeremy A. Sarnat, Amit U. Raysoni Dec 2026

Long-Term Analysis Of Pm2.5 Elemental Composition And Source Contributions In Coastal Urban Environments Of Corpus Christi And Houston In Texas, Sai Deepak Pinakana, Jeremy A. Sarnat, Amit U. Raysoni

School of Earth, Environmental, & Marine Sciences Faculty Publications

Long-term assessments of fine particulate matter play a key role in identifying persistent and emerging emission contributors. Coastal urban areas are highly susceptible to transboundary dust and wildfire events in addition to local pollution sources. Multi-decadal assessments in these regions using chemical speciation data could offer insights into major pollutant sources and their trends. This study utilizes nearly two decades of PM2.5 elemental composition data at two major coastal cities in Texas: Houston and Corpus Christi. Fourteen trace elements were analyzed to characterize the seasonal variability and long-term source evolution using a combination of Spearman’s correlation analysis, principal component analysis, …

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Evaluating The Transformation Of Land Cover, Land Surface Temperature, And Urban Heat Island In Sylhet Division Through Geospatial Analysis, Md Fazle Rabbi Joy, Md Abdur Rahim, Md Mahfuzar Rahman, Sumiaya Amin Preota Dec 2026

Evaluating The Transformation Of Land Cover, Land Surface Temperature, And Urban Heat Island In Sylhet Division Through Geospatial Analysis, Md Fazle Rabbi Joy, Md Abdur Rahim, Md Mahfuzar Rahman, Sumiaya Amin Preota

School of Earth, Environmental, & Marine Sciences Faculty Publications

Rapid and unplanned urbanization has significantly transformed land use/land cover (LULC), contributing to increased land surface temperature (LST) and the emergence of urban heat islands (UHIs), especially in ecologically fragile regions. This study focuses on the Sylhet Division of Bangladesh, assessing LULC changes, LST dynamics, and UHI expansion from 1994 to 2024 using Landsat satellite imagery, normalized difference vegetation index (NDVI), normalized difference water index (NDWI) indices, and field-based LST validation. Unsupervised classification reveals a 191.75% increase in settlement areas and a 25.65% loss in forest cover. Correspondingly, the highest LST zones (> 30 °C) were absent in 1994 but …

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In-Hospital Mortality Patterns And Readmissions In Patients With Chronic Obstructive Pulmonary Disease: An Analysis Of The Role Of Pulmonary Hypertension, Saad Afzal Khan, Trishna Parikh, Adishwar Rao, Akriti Agrawal, Aarohi Parikh, Farah Kazzaz, Sarah Shin, Harry Karmouty-Quintana, Maulin Patel, Kha Dinh, Bela Patel, Bindu Akkanti Dec 2026

In-Hospital Mortality Patterns And Readmissions In Patients With Chronic Obstructive Pulmonary Disease: An Analysis Of The Role Of Pulmonary Hypertension, Saad Afzal Khan, Trishna Parikh, Adishwar Rao, Akriti Agrawal, Aarohi Parikh, Farah Kazzaz, Sarah Shin, Harry Karmouty-Quintana, Maulin Patel, Kha Dinh, Bela Patel, Bindu Akkanti

Faculty, Staff and Student Publications

Chronic obstructive pulmonary disease (COPD) may be complicated by pulmonary hypertension (PH). We aimed to understand the impact of PH on in-hospital mortality and quantify the 30-day readmission rate among patients with COPD. For this cross-sectional study, we used the Nationwide Readmissions Database from 2017-2020 to identify adults ≥18 years with COPD. Patients were stratified according to PH diagnosis. Baseline characteristics between groups were compared using the Pearson chi-square test and two-sample t-test. Predictors of in-hospital mortality were determined using multivariate logistic regression analysis adjusted for demographics and confounders. The 30-day readmission rate and prevalence of PH subgroups by baseline …

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Methylated Cfdna May Distinguish Between High- And Intermediate-Risk Uveal Melanoma: A Pilot Study, Mike Wu, Daniël P. De Bruyn, Ruben G. Boers, Aaron B. Beasley, Daan M. Hazelaar, Stavros Makrodimitris, Joachim B. Boers, Jolanda Vaarwater, Ronald O.B. De Keizer, Robert M. Verdijk, Nicole C. Naus, Dion Paridaens, Saskia M. Wilting, Elin S. Gray, Wilfred F.J. Van Ijcken, Joost Gribnau, Annelies De Klein, Erwin Brosens, Emine Kiliç Dec 2026

Methylated Cfdna May Distinguish Between High- And Intermediate-Risk Uveal Melanoma: A Pilot Study, Mike Wu, Daniël P. De Bruyn, Ruben G. Boers, Aaron B. Beasley, Daan M. Hazelaar, Stavros Makrodimitris, Joachim B. Boers, Jolanda Vaarwater, Ronald O.B. De Keizer, Robert M. Verdijk, Nicole C. Naus, Dion Paridaens, Saskia M. Wilting, Elin S. Gray, Wilfred F.J. Van Ijcken, Joost Gribnau, Annelies De Klein, Erwin Brosens, Emine Kiliç

Research outputs 2022 to 2026

Background: Uveal melanoma (UM) is a highly aggressive malignancy with a metastatic risk that depends on the molecular subclass. This subclass can be determined through molecular characterization of tumor-derived tissue. With eye-sparing treatments, tumor tissue is rarely available for molecular testing. We hypothesized that minimal invasive biomarkers such as methylated cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) can be used for prognosis and monitoring of patients. Methods: Plasma cfDNA was isolated from healthy blood donors (HBDs, N = 19) and UM patients (N = 22). Plasma was collected at baseline (localized disease, N = 13) and during follow-up (metastatic …

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