Digital Commons Network^™

Avian Influenza And The Approach To Designing An H5n1 Vaccine, Lauren N. Hickey

Honors Program: Senior Projects (Public)

The Avian influenza virus (AIV) H5N1 has been responsible for the culling and deaths of millions of birds since 2022 with concern for wildlife, livestock, and human infections occurring as well. With eggs flying off the shelves in grocery stores, even individuals not involved in the agricultural industry have seen the drastic effects of this disease first-hand. For chickens, this virus works quickly and overpowers the innate immune system before the adaptive immune system has time to properly respond. Therefore, a safe and effective vaccine could reduce the number of poultry deaths and prevent the continuous spread of the infection. …

The Contractual Womb: U.S. Surrogacy Reform Through A Federal Bioethical Framework, Yasmine A. Quinones

Student Works

No abstract provided.

Optimizing Human Fcrn Mouse Models To Improve Pharmacokinetic Evaluation Of Antibody Drug Candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, Elena Gonzalo-Gil

Faculty Research 2026

The use of animal models that can reliably predict drug performance in human patients is critical to antibody therapeutic development. Along with assessing toxicity and efficacy, determining the pharmacokinetic (PK) properties of therapeutics in Tg32 and Tg276 mice is essential to preclinical characterization. While Tg32 mice have been well established as indispensable in their ability to model the PK properties of antibody therapeutics, their intact immunity leaves them capable of mounting anti-drug antibody responses that interfere with PK interpretation. Here, we demonstrate the negative impact anti-drug responses can have on PK parameters derived from Tg32 mice, and provide strong evidence …

Optimizing Human Fcrn Mouse Models To Improve Pharmacokinetic Evaluation Of Antibody Drug Candidates., Gregory J. Christianson, Zachary M Howard, Samantha Kenney, Emily Lowell, Nijaguna Bethur, Derry C. Roopenian, Elena Gonzalo-Gil

Faculty Research 2026

The use of animal models that can reliably predict drug performance in human patients is critical to antibody therapeutic development. Along with assessing toxicity and efficacy, determining the pharmacokinetic (PK) properties of therapeutics in Tg32 and Tg276 mice is essential to preclinical characterization. While Tg32 mice have been well established as indispensable in their ability to model the PK properties of antibody therapeutics, their intact immunity leaves them capable of mounting anti-drug antibody responses that interfere with PK interpretation. Here, we demonstrate the negative impact anti-drug responses can have on PK parameters derived from Tg32 mice, and provide strong evidence …

Establishing A Patient-Resolved Single-Cell And Perturbational Framework For Cisplatin-Resistance Mapping And Candidate Drug Prioritization In Oral Squamous Cell Carcinoma, Chih-Yuan Fang

Articles in Press

No abstract provided.

Global Burden Of Enteric Infectious Diseases, Diarrhoeal Diseases, And Corresponding Aetiologies, 1990–2023: A Systematic Analysis For The Global Burden Of Disease Study 2023, Gbd 2023 Diarrhoeal Disease And Enteric Infectious Diseases Collaborators, Kathryn H. Jacobsen

Health Studies Faculty Publications

Summary

Background

Molecular Epidemiology Of Mycobacterium Tuberculosis In The Middle East And North Africa: A Systematic Review And Meta-Analysis, Tsegaye Shamebo, Aboma Zewude, Temesgen Mohammed, Atef Oreiby, Mohammed Saleh Albreiki, Yassir Mohammed Eltahir, Robert Barigye, Markos Tibbo, Ali Artaman, Gobena Ameni

All Works

Objective The objective of this article was to conduct a comprehensive systematic review and meta-analysis on the molecular epidemiology of Mycobacterium tuberculosis in the Middle East and North Africa. Methods PubMed, Scopus, Web of Science, Embase, and Google Scholar databases were used for literature search on the molecular epidemiology, clustering rate and recent transmission index of Mycobacterium tuberculosis complex (MTBC) published between 1 January 2000 to 31 December 2025. The study quality was assessed using the Newcastle-Ottawa Scale (NOS) and meta-analysis was carried out using R statistics version 4.5.3. Results Fifty-nine studies reported 13,194 Mycobacterium tuberculosis (M. tuberculosis) isolates of …

Building A Mini Medical School: An Evidence-Based Framework For Health Science Education Outreach, Alexandra S. Hausmann, Shirley F. Delair, Liliana P. Bronner

Medical Student Summer Research Program

No abstract provided.

Dipl 6276 Global Health Governance, Yanzhong Huang Ph.D.

Diplomacy Syllabi

Public health challenges — pandemic influenza, HIV and AIDS, COVID-19, obesity, neglected diseases, tobacco use, climate change, and underperforming health systems — increasingly shape and are shaped by the political, economic, and social dimensions of globalization. At the same time, international rules that fall outside the traditional health sphere, such as those governing intellectual property, trade, and greenhouse gas emissions, can have profound consequences for human health. Strong national health systems remain essential, but the reach of health threats and the capacity to respond often extend beyond any single state and beyond the health sector itself. Translating development goals into …

The Lender Center For Social Justice Bibliography 2025-2026, The Lender Center For Social Justice

The Lender Center for Social Justice

The Lender Center for Social Justice Bibliography (2025-2026) is a document containing all Lender-Center scholarship written between 2020-2026. The title references the newest entries, which were created in the 2025-2026 academic year.

Faculty Authors & Achievers Bibliography 2026, Luke Vilelle

WRL: Faculty Authors & Achievers Bibliographies

The office of Academic Affairs and the Wyndham Robertson Library congratulate all Hollins faculty who published or presented creative or scholarly works from Fall 2024 - Fall 2026. These pages comprise a list of that work.

Efficacy And Safety Of Frail Patients Treated With Ciltacabtagene Autoleucel In The Real World: A Center For International Blood And Marrow Transplant Research Analysis., Hira Mian, Muhammad Salman Faisal, Tiening Chen, Ruta Brazauskas, Temitope Oloyede, Nausheen Ahmed, Aimaz Afrough, Larry D Anderson, Rahul Banerjee, Jesus Berdeja, Aram Bidikian, Jakob Devos, Binod Dhakal, Ajoy Dias, Danai Dima, Yvonne A Efebera, Lohith Gowda, Doris K Hansen, Hamza Hashmi, Heather J Landau, Lazaros Lekakis, Abu-Sayeef Mirza, Ravi Narra, Krina Patel, Ashley E Rosko, Mark Schroeder, Surbhi Sidana, Saad Usmani, Marcelo C Pasquini, Taiga Nishihori, Othman Salim Akhtar, Meera Mohan

Oncology Articles

Background: Ciltacabtagene autoleucel (cilta-cel), an anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR-T) therapy, is approved for relapsed/refractory multiple myeloma (RRMM).

Methods: Using the Center for International Blood and Marrow Transplant Research registry, this study evaluated outcomes of frail patients receiving commercial cilta-cel from March 2022 to December 2023. Frailty was defined by an adapted simplified score incorporating age, performance status, and comorbidities.

Results: Among 541 patients with available frailty status, 183 (33.8%) were frail and 358 (66.2%) were nonfrail. Overall response rates were comparable (frail 82.8% vs. nonfrail 88.5%). However, frail patients had inferior progression-free survival (PFS) (12-month …

Annual Campus Safety And Fire Report 2026, University Of Nebraska Police And Public Safety Department

Public Safety Reports

This 2026 Annual Safety and Fire Report was compiled for enrolled or prospective students and employed or prospective faculty and staff. Its purpose is to communicate the safety of the University of Nebraska Omaha campus.

Individual Host Variation In Single-Cell Responses To Enteroaggregative Escherichia Coli Infection Modeled With Human Colon Organoids, Ling Qiu, Tajhal D Patel, Hannah E Jones, Cristian Coarfa, Anthony W Maresso

Faculty, Staff and Students Publications

Enteroaggregative Escherichia coli (EAEC) is a leading cause of diarrhea worldwide. Interestingly, EAEC disease outcomes vary dramatically among infected individuals, ranging from asymptomatic colonization to acute and chronic diarrhea. While previous research has focused on EAEC virulence factors, emerging evidence suggests that host genetic and cellular background may be equally important in determining disease susceptibility. To understand host-driven disease heterogeneity, we performed single-cell RNA sequencing on human colon organoids (HCOs) derived from three healthy adult donors following EAEC 042 infection. Surprisingly, despite comparable EAEC adherence across donors, we observed striking donor-specific responses to infection at multiple levels. A total of …

Dysentery: Sanitation, Inequality, And Conflict Shaping Human Suffering, Rumeysa B. Ivgen

Undergraduate Research Symposium

Dysentery, historically termed the "bad gut" by Hippocrates, remains one of the most persistent and devastating infectious diseases in human history. While often viewed through a purely biological lens, this research argues that the spread of dysentery is fundamentally driven by social and structural failures. By examining historical accounts and modern data, this study explores how dysentery thrives on poor sanitation, armed conflict, and systemic inequality. Historically, the disease was synonymous with a "shameful death," as primitive, street-side latrines stripped many of their privacy and dignity. This loss of dignity was more extreme in military history, where makeshift trench sanitation …

From Advisory To Action: The Case For Preserving Paccarb In The Fight Against Antimicrobial Resistance, Leila S. Hojat, Muhammad Dhanani, Amy Y. Kang, Salome O. Chitavi, Robert A. Weinstein, Edward Stenehjem

Pharmacy Faculty Articles and Research

The Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) was established to advise the government on strategies to mitigate antimicrobial resistance (AMR) and its increasing threat to public health and national security. Its members included experts from diverse disciplines such as healthcare, veterinary medicine, industry, public health, and agriculture who were positioned to interface with key stakeholders and the public in an aspirational multidisciplinary approach to combating AMR. The council was successful in elevating AMR as a national priority and played a crucial role in watershed events for antimicrobial stewardship (AS) such as the development of the second National Action …

Therapeutic Outcomes Of Oral Antibiotics For The Treatment Of Methicillin-Resistant Staphylococcus Aureus Urinary Tract Infections: A Multisite, Retrospective Cohort Study Of Linezolid, Trimethoprim–Sulfamethoxazole And Doxycycline, Ryan Mccall, Elena Gatskevich, Steven E. Fiester, Michael Floren, Elisabeth Chandler

Chemistry Publications

Background: Methicillin-resistant Staphylococcus aureus (MRSA) urinary tract infections (UTIs), while relatively uncommon, pose a unique challenge in treatment as only specific intravenous (IV) options are typically utilized, with the efficacy of oral antimicrobials being poorly defined. Methods: The multi-site retrospective cohort study described herein therefore aims to characterize outcomes associated with oral administration of linezolid, trimethoprim-sulfamethoxazole (TMP-SMX), or doxycycline for the treatment of MRSA UTIs. Study participants were adults with culture-positive MRSA UTIs receiving one of the three oral therapies. Exclusion criteria included polymicrobial UTI, concomitant MRSA outside the urinary tract, receipt of non-study anti-MRSA agents for greater than or …

Epidemic Dynamics Under Pulse Population Exchange, Hannah Kravitz, Christina Durón, Moysey Brio

Mathematics and Statistics Faculty Publications and Presentations

Many epidemiological models assume either closed populations or continuous demographic turnover. We consider an intermediate setting in which exchange occurs through discrete pulses. In this paper, we introduce a population-conserving compartmental epidemiological model with pulse population exchange at a set of prescribed times. At each pulse, a fraction of the population in each compartment is replaced by a combination of susceptible and immunized individuals. In contrast to typical pulse birth or pulse vaccination models where only a single compartment undergoes a pulse population change, the pulses in this model have competing effects: removing infectious individuals reduces the force of infection, …

Dr. Contrarian: A Persona-Driven Conversational Ai Agent For Coaching Argumentative Reasoning In Infectious Disease Classroom Debates, Khayriyyah Mohd Hanafiah

Biology Faculty/Staff Publications

Critical thinking and persuasive communication are essential for biology graduates navigating socioscientific dilemmas. While debate pedagogy fosters problem-solving, autonomy, competence, and relatedness aligned with adult learning and self-determination theories, inexperienced students often struggle with the cognitive load and anxiety from this format. To bridge this gap, “Dr. Contrarian,” a persona-based conversational AI agent, was developed to function as an adversarial coach during debate preparation. Survey data (n = 21) adapted from the Technology Acceptance Model show that 85.7% of students found the tool easy to use, and 71.4% would use it again. Thematic analysis of metacognitive reflections suggests that while …

Microbiome Dynamics During Translocation Of The Critically Endangered Frog Craugastor Ranoides, Xavier A. Harrison, Katherine Herborn, Gilbert Alvarado, Maria Marta Chavarria, Kirtsy J. Marsh, Alexander Wilson, Alexandra North, Vikki Wakeham, Roberto Fernández Ugalde, Héctor Zumbado-Ulate, Jon Bielby, Robert Puschendorf

School of Biological and Marine Sciences

Amphibian populations are declining, and species are going extinct due to habitat loss, climate change, and emerging infectious disease, prompting the increasing use of translocations as a conservation tool. Skin-associated bacterial communities play a key role in amphibian health, particularly in protecting hosts from pathogenic infection. However, to date weknow relatively little about the impact of translocation on the dynamics of skin-associated bacteria, or the consequences oftranslocation-mediated disturbance of the microbiome for amphibian health. We investigated the skin microbiome of the critically endangered frog Craugastor ranoides, now restricted to a fraction of its historical range in Costa Rica. We first …

Emergency Departments And The Return Of Vaccine-Preventable Diseases: Closing The Preparedness Gap, Eve A. Spear, Steven J. Spear

URGENT Matters

No abstract provided.

When Steroids Backfire: Tinea Incognito Following Treatment For Presumed Psoriasis, Nicole Skalka, Nathaniel Marroquin, Jay Nguyen, Panagiotis Mitropoulos, Patrick Dominguez

GME Publications

Tinea incognito is an altered clinical presentation of a dermatophyte infection that develops following treatment with topical or systemic corticosteroids or other immunosuppressive agents. Suppression of inflammation temporarily improves the appearance of the eruption while masking the characteristic annular, scaly appearance of the infection, making diagnosis more challenging. If a fungal infection is suspected, a potassium hydroxide (KOH) preparation should be performed to evaluate for an underlying fungal etiology. A 43-year-old male presented to dermatology after treatment with clobetasol propionate 0.05% cream and roflumilast 0.3% cream for presumed psoriasis. His eruption initially improved but subsequently recurred and progressively worsened over …

Comparison Of Preenrichment And Screening Methods For The Detection Of Salmonella Enterica Serovar Agona In Meat Analog Products, Kylie Sacapano, Amanda Tabb, Biola Fatusin, Samantha M. Covaia, Isha Shingre, Lieuchi Phan, Kyson Chou, Jamie Du, Beilei Ge, Donna Williams-Hill, Rosalee S. Hellberg

Food Science Faculty Articles and Research

With the growing demand and variety of meat analogs on the commercial market, there is a need to revisit testing methods for foodborne pathogens in these products. The U.S. Food and Drug Administration (FDA) regulatory methods for Salmonella enterica detection in meat analogs follow the Bacteriological Analytical Manual and are relatively time-consuming. Therefore, this study aimed to compare preenrichment and screening methods for the detection of Salmonella in meat analogs by evaluating current FDA reference methods alongside alternative preenrichment broths and rapid molecular screening techniques. Meat analog samples were inoculated with S. enterica serovar Agona at three levels: (1) uninoculated …

Historical Chaos Among Tetrabothriideans (Eucestoda) Of Odontocetes (Artiodactyla)—Revising Generic Taxonomy And Species Diversity For Cestodes Among Oceanic Dolphins, Eric P. Hoberg, Kaylen Marie Soudachanh, Robert L. Rausch

MANTER: Journal of Parasite Biodiversity

Explorations over the past 150 years that have defined the diversity and structure of the tetrabothriidean cestode fauna among Odontocete cetaceans (Artiodactyla) are summarized and reviewed. Persistent errors in interpretation of comparative morphological characters, inconsistent taxonomic decisions, and an understanding of generic-level and species diversity are addressed. We outline a revision of the Tetrabothriidea, which now encompasses 8 genera. Prosthecocotyle is resurrected from synonymy with Tetrabothrius, and Cetaceobothridius n. gen is proposed. A clear basis is outlined for differentiation of generic and species diversity among Cetaceobothridius, Priapocephalus, Prosthecocotyle, Strobilocephalus, Tetrabothrius, and Trigonocotyle that constitute the tetrabothriidean fauna of odontocetes; species …

The Effect Of Job Enlargement Programs On The Wellbeing Of United States Air Force Personnel, Joseph Earl Stone

Doctoral Dissertations and Projects

The purpose of this study was to examine the relationship between job enlargement programs and overall wellbeing among active-duty United States Air Force personnel using a mixed method, convergent parallel approach. Utilizing a sample of 125 active-duty personnel, these two variables were examined for a predictive relationship while controlling for eight covariates utilizing multiple regression analysis (quantitative) and assessed for contextual purposes using thematic analysis (qualitative), employing survey data from all participants. The study was framed by self-determination theory (SDT), which posits that the wellbeing of individuals is affected by three core needs of competence, autonomy, and relatedness. Quantitatively, no …

Re-Education On Chlorhexidine (Chg) Bathing Protocol Affects Patient Chg Bathing Compliance And Surgical Site Infection (Ssi) Rates, Mary Samantha Ross

Doctoral Dissertations and Projects

Surgical site infections (SSI) are considered a hospital-acquired infection, leading to increased hospital length of stay (LOS), readmission rates, increased cost, morbidity, mortality rates, and poor postoperative outcomes. The literature review demonstrated the benefits of preoperative Chlorhexidine (CHG) bathing, but called for standardized protocols, improved education, and patient compliance. Research and clinical experience supported the need for improved patient compliance with CHG bathing. Consistent SSI rates even after protocol changes called for re-education of nursing staff in addition to addressing patient compliance issues. Therefore, providing re-education on the updated protocol, which addresses patient compliance issues, can lead to a reduction …

The Exploration Of Nutrition And Mental Health Among Retired Female Sergeant Majors, Renee Michelle Mcmillan

Doctoral Dissertations and Projects

This qualitative study investigated the nutrition and mental health of seven retired female United States Army Command Sergeant Majors (CSM) and four retired United States Army Sergeant Majors (SGMs). Transcendental phenomenology was used in this study along with George Engel’s Biopsychosocial Theory (BPST). The study examined how dietary food choices converged with cognitive behavior, body image, restrictive eating, and the stress accompanied with transitioning from military to civilian life. Four themes and 11 subthemes emerged from this study. The findings indicated an integration with nutritional interventions, mental health services, family-focus education, and faith-based programs. These findings may help retired female …

A Health Card Is Not Healthcare Why Coverage Does Not Always Become Care And How Institutions Can Close The Gap, Deepak Aggarwal

Defensive Publications Series

Universal healthcare is usually measured through two questions: can people obtain the care they need, and can they afford it without financial hardship? Both matter. Neither tells us whether care actually reached the patient.

A person may hold a health card. The treatment may be covered. The ambulance, hospital, specialist and payer may each follow their own rules correctly. Yet the patient may still wait too long, arrive at a hospital that cannot treat them, or be lost between institutions.

This paper examines that gap through Decision Engineering™. It follows a person suffering a heart attack along the Decision Integrity …

The C3-C3ar Axis Modulates Trained Immunity In Alveolar Macrophages, Alexander P Earhart, Rafael Aponte Alburquerque, Marick Starick, Lorena Garnica, Ayse Naz Ozanturk, Rahul Kumar Maurya, Xiaobo Wu, Jeffrey Haspel, Hrishikesh S Kulkarni, Et Al.

2020-Current year OA Pubs

Complement protein C3 is crucial for immune responses in mucosal sites such as the lung, where it aids in microbe elimination, and enhances inflammation. While trained immunity - enhanced secondary responses of innate immune cells after prior exposure - is well-studied, the role of the complement system in trained immune responses remains unclear. We investigated the role of C3 in trained immunity and found that alveolar macrophage (AM)

Skin Carotenoid Scores Reflect Immune Status Among Children Living With Hiv In Tanzania, Wilbert Mbuya, Thobias Boniphace, Michael Mwagala, Peter Agrea, Nazareth M Mbilinyi, Nancy E Moran, Andrew R Dinardo, Mkunde Chachage

Children’s Nutrition Research Center Staff Publications

Many individuals living with HIV experience persistent inflammation despite antiretroviral treatment, increasing their risk for cardiovascular diseases, cognitive decline, and other noncommunicable diseases. Carotenoids can inhibit this inflammation by reducing lipid peroxidation. Carotenoid intake and plasma concentrations can be approximated using a noninvasive cutaneous spectrophotometer. This study quantified skin carotenoid levels in Tanzanian children ages 5 to 15 years old (N = 185) both with and without HIV. Over 95% had low to moderate skin carotenoid scores (< 400 units). In children living with HIV, higher viral loads were linked to lower skin carotenoid scores (rho = -0.57, P < 0.001), whereas higher CD4 counts correlated with increased skin carotenoid scores (rho = 0.52, P < 0.001). Overall, carotenoid levels were low and associated with immune status, suggesting that elevated carotenoid scores correlate with lower inflammation in children living with HIV. Future studies investigating dietary carotenoid interventions to support immune function are warranted.