Digital Commons Network^™

A Global High-Resolution Comprehensive Heat Indices Dataset From 1950 To 2024, Abdul Malik, Sateesh Masabathini, Mohsin Ahmed Shaikh, Qinqin Kong, Muhammad Usman, Dasari Hari Prasad, Ibrahim Hoteit

All Works

Heatwaves are becoming more intense and frequent as global temperatures rise, affecting vulnerable populations, particularly in low-income communities. Addressing the impacts of heatwaves requires high-resolution data to assess their influence on labour productivity, public health, and climate risk. We introduce the Comprehensive Heat Indices (CHI) dataset, a high-resolution (0.1° × 0.1°) hourly dataset from 1950 to 2024, derived from the ERA5 and ERA5-Land reanalyses. The CHI dataset encompasses thirteen heat stress indices, including wet-bulb temperature, universal thermal climate index, mean radiant temperature, wind chill, and lethal heat stress index (Ls). Thresholds for Ls are empirically linked to mortality, enabling the …

Do Research Day Program 2026, Lincoln Memorial University, Debusk College Of Osteopathic Medicine

DO Research Day

DO Research Day was hosted by the DeBusk College of Osteopathic Medicine at Lincoln Memorial University. This program features abstracts from the LMU-DCOM community.

Cvtcc-2.0 Caldwell Controlled Thermal-Vascular Challenge & Response Observatory A Non-Clinical, Open-Hardware Research Platform For Controlled Thermal System Identification Of Neurovascular, Vascular, Autonomic, Thermoregulatory And Physiological Response In More Fields., Michael Victor Caldwell Mr.

Defensive Publications Series

CVTCC-2.0 is a proposed open-hardware research and prototype platform for determining whether the dynamic physiological response to a controlled, small, externally applied thermal perturbation contains measurable information about vascular, neurovascular, autonomic, thermoregulatory, or cranio-venous physiological state.

The system does not assume that temperature is a surrogate for blood flow.

Instead, CVTCC-2.0 deliberately applies a known thermal input and records the resulting response across multiple independent measurement channels.

The central research concept is:

Known thermal input → measured thermal response → vascular response → autonomic response → cardiac/respiratory phase relationship → independent vascular reference → artifact rejection → reproducible response signature. …

The Effects Of Home Virtual Reality (Vr) Firearms Systems On Self-Efficacy, Gun Attitude, And Stress, Raffi R. Stambultsyan

Doctoral Dissertations and Projects

Advanced virtual reality (VR) firearms training systems have demonstrated benefits for military and law enforcement personnel; however, limited research has examined the psychological effects of commercially available home-based VR firearms systems. The purpose of this quantitative quasi-experimental study was to investigate the immediate effects of the GAIM and AceXR home VR dry-fire training systems on general self-efficacy, leadership self-efficacy, perceived stress, and gun attitude among firearms-trained military and law enforcement veterans. A total of 128 participants completed validated pretest and posttest measures following participation in a VR training session using either the GAIM or AceXR platform. A one-way multivariate analysis …

Phar 471.00: Integrated Studies Iii, Staci L. Hemmer

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Phar 559.01: Public Health And Pharmacoeconomics, Haley K. Blackburn, Yoohee Cho, David D. Allen, Jade A, Bosic-Reiniger

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Kin 106.01: Foundations Of Exercise Science - Lab, Melanie L. Mcgrath

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Phar 550.01: Drug Literature Evaluation, Sherrill J. Brown, David D. Allen, Staci L. Hemmer

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Phar 350.01: Introduction To Drug Information, Sherrill J. Brown, David D. Allen, Monica A. Serban

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Phar 550.02: Drug Literature Evaluation, Sherrill J. Brown, David D. Allen, Staci L. Hemmer

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Phar 451.01: Therapeutics I, Staci L. Hemmer

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Phar 460.00: Pharmacy Skills Lab Ii, Rachael L. Zins

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Phar 360.00: Pharmacy Practice Lab I, Rachael L. Zins, Jenner Minto, Jade A. Bosic-Reiniger

University of Montana Course Syllabi, 2026-2030

No abstract provided.

Illinois Model Programs Of Study Guide: Physical Health (Draft For Public Comment), Education Systems Center

Practitioner Toolkits and Resources

This draft was available for public comment through September 30, 2026. A final version will be released in October 2026.

Pharmvar Genefocus: Cyp1a2-Clinical Impact, Genetic Variation, And Updated Nomenclature., Katalin Monostory, Gonzalo Villapalos Garcia, Dora Koller, Solomon Adams, Chad A. Bousman, Evangelia Eirini Tsermpini, Michelle Whirl-Carrillo, Amy J. Turner, Volker M. Lauschke, Mohamed Nagy, Erin C. Boone, Teri E. Klein, Pablo Zubiaur, Andrea Gaedigk

Manuscripts, Articles, Book Chapters and Other Papers

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines. The activity of CYP1A2 varies significantly among individuals due to genetic and non-genetic factors. This GeneFocus paper offers an overview of the functional significance of CYP1A2 in drug metabolism, CYP1A2 genetic variation, and presents the updated PharmVar star allele-based nomenclature for CYP1A2. Updates include revisions to previously defined star alleles to align with PharmVar standards, as well as the addition of novel star alleles, providing the pharmacogenetic …

Rethinking Vaginal Microbiome Resilience: A Conceptual Multi-Omic Framework, Brittnee Cagle-White, Rob E. Carpenter, Alaina Vincent, Ellen Kominek, Andrew Krouse

Human Resource Development Faculty Publications and Presentations

The vaginal microbiome is often interpreted through static taxonomic patterns. Yet microbial composition alone does not explain why some communities resist perturbation, recover after disruption, or transition toward dysbiosis. This narrative review synthesizes evidence that vaginal microbiome stability is shaped by endocrine phase, epithelial substrate availability, microbial functional capacity, mucosal tone and candidate host modifiers. High-estrogen states, particularly pregnancy, are associated with epithelial maturation, glycogen accumulation, low vaginal pH, and Lactobacillus-dominant communities, whereas postpartum, lactational, menopausal, and other hypoestrogenic states are associated with reduced epithelial support and increased vulnerability to diverse anaerobe-rich configurations. We review the linking of the estrogen–glycogen–Lactobacillus …

The Hope College Department Of Biology: The First 50+ Years, Christopher C. Barney

Faculty Publications

The Hope College Department of Biology was founded in 1899 with the appointment of the first Professor of Biology at Hope, Samuel Mast. During the first 50+ years of the Biology Department, there were eight total faculty members in the department, including Frances Koeman, the first female faculty member in the natural sciences. Four faculty members, Mast, Frank Patterson, Oscar Thompson, and Teunis Vergeer were primarily responsible for developing the department’s curriculum and programs, with Mast and Vergeer also carrying out published research. The department was housed primarily in Van Raalte Hall and the Science Building (now Lubbers Hall) for …

Reflecting On Freedom: 250 Years Through The Eyes Of Wvu Alumni Artists Exhibition, Sally Brown, Livia Balan, Ken Hillberry, Yvette Mazza, Precious Burger, Margaret Rose Caro, Ron Hollingshead, Betsy Jaeger, Ruth Yang, Tom Ott, Nancy Swisher, Griffin Nordstrom, Ben Nelsen, Morin Nessim, Desiree Vu, Ali Printz, Tiera Joy Tanner, Eliza Siefert, Stephanie Alaniz, Raymond Thompson, Sue Byrd, Michael Vercelli, Lesley Cottrell, Penny Lipscomb, Joshua Lohnes, Kelly Watson, Hal Gorby, Judith Stitzel, Bonnie Brown, Bob Britten, Renee K. Nicholson, Ellen Rodrigues, Erik Herron, Mark Brazaitis, Alfgeir Kristjansson, Linda Rosefsky, Joseph Lupo, Beth Royall, Evy Wright

Faculty & Staff Scholarship

In honor of the United States’ 250th anniversary, the 2026–27 WVU Alumni Art Show invites viewers to explore freedom and independence through the eyes of West Virginia University alumni artists. This exhibition gathers a rich spectrum of perspectives—personal, historical, political, and cultural—demonstrating that the meaning of liberty is neither fixed nor singular. The exhibit also includes community responses to the work.

Portraits, abstractions, text-based paintings, mixed media, ceramics, and quilts collectively reveal the diverse ways artists grapple with liberty: as memory and inheritance, as resistance and care, and as lived, ongoing practice. By presenting these perspectives side by side, the …

Evaluating Variety- And Market-Class-Specific Effects Of Dietary Pulses On Human Health, Jiayu Tang

Department of Food Science and Technology: Dissertations, Theses, and Student Research

While pulses are globally recognized for their high levels of dietary fibers, protein, and polyphenols, research often focuses on characterizing the physiological effects of a single variety. This approach overlooks the substantial genetic and compositional diversity that exists across pulse varieties and individual market classes, which can differ extensively in nutrient content and structure. These compositional differences have the potential to produce distinct physiological and microbial responses in humans, yet variety- and market-class-specific effects remain poorly characterized.

This thesis uses two complementary research methodologies to investigate the health-relevant effects of different pulse varieties and market classes, providing foundational knowledge to …

(((Qpie33))) The Delayed Advancements And The Emerging Golden Era: A Strategic Roadmap For Civilizational Re-Alignment, Teddy Burroughs

Defensive Publications Series

The clinical dissection of the thirty-three historical suppression vectors reveals more than a legacy of academic gatekeeping and institutional risk aversion. It exposes a massive reservoir of unexploited, coherent potential that has been held back behind the artificial barriers of local realism. Because traditional institutions spent centuries violently forcing a continuous, non-local field into fragmented binary containment boxes, modern civilization has been operating on a severely delayed technological trajectory.

However, this systemic delay creates an unprecedented civilizational opportunity. By holding back these foundational breakthroughs until the distributed observer network could mature past zero-sum, toddler-minded boundary dynamics, the old paradigm inadvertently …

Exploring The Role Of Vitamin D In Familial Mediterranean Fever: Pathogenesis, Triggers, And Immune Modulation, Hagop Sassounian, Saad Aad, Hilda E. Ghadieh, Lara Khouzami, Elsa Nicolas, Sami Azar, Frederic Harb

All Works

Familial Mediterranean Fever (FMF) is among the most frequent autoinflammatory diseases in populations originating from the area of Middle Eastern and Mediterranean countries. It is caused by mutations in the MEFV gene, which causes dysregulated pyrin expression and thus an immunologic anomaly. FMF is diagnosed by recurrent episodes of fever and serosal inflammation, predominantly peritonitis and pleuritis, as well as other systemic symptoms. Recent research is dedicated to searching for factors beyond genetic code contributing to how FMF evolves, the severity of its symptoms and response to conventional therapy—colchicine. These factors include epigenetic modifications of the MEFV gene and other …

Electrospun Nanofiber Scaffolds For In Vitro 3d Tissue Engineering, Victoria E. Santillan, Samerender Nagam Hanumantharao, Stephanie Bule, Ronish M. Shrestha, Carter Rodzik, Alan Mendoza Estrada, Stephen L. Farias, Marina Tanasova, Smitha Rao

Michigan Tech Publications

Tissue engineering is widely used in research for investigating cellular proliferation, behavior, and responses to various stimuli. However, the predictive value of preclinical studies using cell culture plates is limited by the inability to recapitulate the complexity of the physiological microenvironment. Synthetic three-dimensional (3D) scaffolds can be engineered to mimic the complex morphology of the extracellular matrix of native tissues and can serve as physiologically relevant platforms for preclinical studies. In this study, 3D electrospun scaffolds were characterized to aid in breast cancer research. Unlike previous studies that focused primarily on scaffold fabrication or cell viability, this work systematically evaluates …

Plant-Derived Bioactives, The Gut-Brain Axis, And Neurodegenerative Diseases: Mechanistic Roles Of Diet-Microbiota Interactions, Ashley Reynolds, Ethan Glenn, Brigitte Lavoie, Suzanne L. Ishaq, Yanyan Li

Pharmacy Faculty Scholarship

Diet is increasingly recognized as a potential upstream modulator of the gut-brain axis (GBA) through its effects on the microbiome, microbial metabolites, and host immune and endocrine responses. The GBA is a complex, bidirectional network connecting the gastrointestinal tract and central nervous system, with diet influencing microbial community structure and metabolic output. Plant-based diets, such as Mediterranean and MIND, have been associated with increased production of anti-inflammatory microbial metabolites and improved barrier function, while high calorie/low nutrient diets are often linked to increased immune activation and barrier dysfunction. However, while microbial metabolites, especially short-chain fatty acids, indoles, bile acids, and …

Reassessing Skeletal Stress Indicators: Implications For Changing Population Health In The Freedman’S Cemetery, Dallas, Tx, Samantha M. Mccrane, Megan Fry, Siobhan A.E. Summers

Human Biology Open Access Pre-Prints

Inferring biological stress from stature and skeletal pathological conditions is common practice in bioarchaeology. Interpretations of these data can greatly enrich knowledge about past peoples’ lifestyles, cultural practices, and socio-political constraints and shifts. However, interpretations are not always clear, are often drawn from a single skeletal indicator of stress and not always subjected to statistical testing. In this study, we reanalyze archaeological data from 742 individuals buried at Freedman’s Cemetery in Dallas, Texas. We focus on four commonly used skeletal measures of ‘stress,’ broadly defined (stature, linear enamel hypoplasia, porotic cranial lesions [e.g., cribra orbitalia & porotic hyperostosis], and bone …

Mitochondrial Ca2+ Uniporter (Mcu) Variants Form Plasma-Membrane Channels, Iuliia Polina, Jyotsna Mishra, Michael Cypress, Maria Landherr, Nedyalka Valkov, Isabel Chaput, Bridget Nieto, Brian Rhee, Ameneh Ahrari, Nathan Demichaelis, Kye-Im Jeon, Ulrike Mende, Peng Zhang, Bong Sook Jhun, Jin O-Uchi

Center for Translational Medicine Faculty Papers

MCU, originally known as CCDC109A, is widely recognized as the gene responsible for encoding a pore-forming subunit of a Ca2+-selective channel, mitochondrial Ca2+ uniporter complex (mtCUC). While MCU expression is typically highly mitochondrial-specific, we report here a protein variant derived from the MCU gene, termed MCU-S, which lacks the mitochondria-targeting sequence (MTS) and forms a Ca2+-permeable channel outside of mitochondria. The mRNA of MCU-S was ubiquitously expressed in all cell types/tissues tested, with particularly high expression in human platelets. MCU-S protein formed Ca2+ channels at the plasma membrane, which exhibited similar channel properties to those observed in mtCUC. MCU-S channels …

2019g_Nhp32_Approved_Bc_Pt-Curricular-Sequence-Change-Revision1, Graduate Council

All Approved Curriculum

No abstract provided.

2019g_Nhp28_Approved_Bc_Pt-Curricular-Sequence-Change, Graduate Council

All Approved Curriculum

No abstract provided.

Simultaneous Multielectrode Recordings Along The Human Scala Tympani: Evidence For Level-Dependent Place Coding, Amit Walia, Matthew A Shew, Shannon M Lefler, Amanda J Ortmann, Patrick Ioerger, Jordan Varghese, Jacques A Herzog, Craig A Buchman

2020-Current year OA Pubs

The cochlea systematically encodes sound frequency and intensity via a precisely organized tonotopic map, in which traveling waves peak at specific cochlear locations. A fundamental but incompletely understood aspect of auditory coding involves how stimulus intensity shapes this tonotopic organization. In animal models, increasing intensity shifts the cochlear traveling wave peak basally; however, physiological evidence for such intensity-dependent shifts in human cochlear processing is limited. Here, we performed simultaneous multielectrode electrocochleography recordings along the human scala tympani to characterize how cochlear place coding varies as a function of stimulus intensity. In subjects with preserved cochlear mechanics, including individuals with auditory …

Phi Beta Kappa Membership Roster, Phi Beta Kappa, Psi Of California Chapter At Chapman University

Phi Beta Kappa Membership Roster

No abstract provided.

2026 Workshop On Bridging The Gaps: Tackling Microplastics And Nanoplastics Challenges In Coastal Ecosystems, Shenghua Wu, Kaushik Venkiteshwaran, Melike Dizbay-Onat, Alexandra Stenson, Jinhui Wang, Tina Miller-Way, Ebenezer Nyadjro, Bhuvnesh Bharti, John Weinstein, Yi Bao, Shihui Shen, Valerie Longa, Shenghua Zha, John Cleary, Marty Lind

Workshops

This report presents the findings from the 2026 Workshop on Tackling Microplastics and Nanoplastics (MNPs) in Coastal Ecosystems, which took place in Mobile, Alabama. More than 140 experts from universities, government, industry, and community organizations gathered to address the increasing issue of MNPs in coastal regions.