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Multidisciplinary Practices (Mdps) In Elder Law, Bryan Koslow Jan 2027

Multidisciplinary Practices (Mdps) In Elder Law, Bryan Koslow

Student Works

No abstract provided.


Perspectives On Person‐Centred End‐Of‐Life Care In Care Homes: Findings From A Qualitative Secondary Analysis, Gary Hodge, Susie Pearce Oct 2026

Perspectives On Person‐Centred End‐Of‐Life Care In Care Homes: Findings From A Qualitative Secondary Analysis, Gary Hodge, Susie Pearce

School of Nursing and Midwifery

No abstract provided.


The Lender Center For Social Justice Bibliography 2025-2026, The Lender Center For Social Justice Oct 2026

The Lender Center For Social Justice Bibliography 2025-2026, The Lender Center For Social Justice

The Lender Center for Social Justice

The Lender Center for Social Justice Bibliography (2025-2026) is a document containing all Lender-Center scholarship written between 2020-2026. The title references the newest entries, which were created in the 2025-2026 academic year.


Faculty Authors & Achievers Bibliography 2026, Luke Vilelle Oct 2026

Faculty Authors & Achievers Bibliography 2026, Luke Vilelle

WRL: Faculty Authors & Achievers Bibliographies

The office of Academic Affairs and the Wyndham Robertson Library congratulate all Hollins faculty who published or presented creative or scholarly works from Fall 2024 - Fall 2026. These pages comprise a list of that work.


Age Differences In Perceived Individual And Community Recovery After Tornadoes: Implications For Community-Centered Recovery Policy In An Aging Society, Sizhuo Chen, Zhen Cong Sep 2026

Age Differences In Perceived Individual And Community Recovery After Tornadoes: Implications For Community-Centered Recovery Policy In An Aging Society, Sizhuo Chen, Zhen Cong

Health Sciences and Kinesiology Faculty Articles

"This study examines perceived individual recovery and perceived community recovery among tornado survivors across three waves spanning four years. Using three-wave longitudinal survey data from survivors in Dallas, Texas; Nashville, Tennessee; and Birmingham, Alabama collected in 2021, 2022, and 2025, we estimate recovery trajectories using linear mixed-effects growth models. We link respondents to tract-level SVI 2020 component measures to examine whether tract-level social vulnerability contextualizes age differences in recovery perceptions. We ask: (1) How do perceived individual recovery and perceived community recovery change over time? (2) Do these trajectories differ by age group? (3) Do community social vulnerability measures contextualize …


Unlocking Effective Evaluations: Lessons From Media Literacy And Digital Skills Intervention Studies In Estonia, Finland, And Poland, Natalia Edisherashvili, Marit Puusepp, Veronika Kalmus, Margus Pedaste, Sini Tiihonen, Fatemeh Irani, Łukasz Tomczyk, Leen D'Haenens, Tania Azadi, Chao Wang Sep 2026

Unlocking Effective Evaluations: Lessons From Media Literacy And Digital Skills Intervention Studies In Estonia, Finland, And Poland, Natalia Edisherashvili, Marit Puusepp, Veronika Kalmus, Margus Pedaste, Sini Tiihonen, Fatemeh Irani, Łukasz Tomczyk, Leen D'Haenens, Tania Azadi, Chao Wang

Journal of Media Literacy Education Pre-Prints

This study examines factors that enable and hinder the evaluation of Media Literacy (ML) and Digital Skills (DS) interventions across three countries and four contexts: in-service teachers in Estonia, elderly populations in Jyväskylä (Finland), vocational students in Helsinki (Finland), and pre-service teachers in Poland. Guided by the Logic Model framework, it explores barriers and enablers across Inputs, Activities, Outputs, and Outcomes to reveal structural and contextual elements shaping evaluation effectiveness. Findings cluster into four domains: organisational and administrative factors, intervention design, evaluation processes, and participant engagement. Organisational challenges such as staff turnover disrupted alignment between intervention and evaluation goals, while …


Changes In Physical Activity And Sleep In Relation To Reductions In Body Weight And Cholesterol Levels Among Adults With Ptsd, Jeffery Kibler, Karla Patricia Molina Valenzuela, Shalynn Murphy, Claudia Ocholski, Valeria Rangel Cunha, Dania Dabbagh, Blaise Desautels, Alexis B. Tola, Mindy Ma Sep 2026

Changes In Physical Activity And Sleep In Relation To Reductions In Body Weight And Cholesterol Levels Among Adults With Ptsd, Jeffery Kibler, Karla Patricia Molina Valenzuela, Shalynn Murphy, Claudia Ocholski, Valeria Rangel Cunha, Dania Dabbagh, Blaise Desautels, Alexis B. Tola, Mindy Ma

Faculty Articles

There is evidence of strong relationships between posttraumatic stress and cardiovascular disease (CVD) risk. Interventions focused on healthy behaviors may promote CVD risk-reduction in posttraumatic stress disorder (PTSD). The present study includes analysis of the associations among key outcomes from an intervention study of a cognitive behavioral healthy lifestyle intervention in PTSD, treated as an adjunct to standard trauma therapy. Specifically, we examined whether changes in physical activity and sleep efficiency were associated with changes in body weight and cholesterol. The health behavior intervention is conducted in 12 weekly sessions and includes four overlapping modules (physical activity, nutrition, sleep, and …


Harmonies Of Healing: A Secondary Data Analysis On Music Engagement And Quality Of Life In Older Adults, Theophilus Eben Nartey Sep 2026

Harmonies Of Healing: A Secondary Data Analysis On Music Engagement And Quality Of Life In Older Adults, Theophilus Eben Nartey

Doctoral Dissertations and Projects

The purpose of this quantitative, cross-sectional secondary data analysis was to examine the relationship between music engagement and self-reported quality of life among adults aged 60 years and older, using data from the Health and Retirement Study (HRS). Guided by the Biopsychosocial-Spiritual (BPSS) framework, the study explored whether music engagement significantly predicted perceived well-being in later adulthood while accounting for chronic health conditions. Secondary data from the HRS public-use dataset were analyzed using IBM SPSS Statistics Version 29. The final analytical sample consisted of 1,582 adults aged 60 years or older with complete data on all variables included in the …


Gender Differences In The Association Between Marriage And Epigenetic Age, Theo O. Moran, Alina M. Kushner, Theodore F. Robles, Jennifer W. Robinette Sep 2026

Gender Differences In The Association Between Marriage And Epigenetic Age, Theo O. Moran, Alina M. Kushner, Theodore F. Robles, Jennifer W. Robinette

Psychology Faculty Articles and Research

Introduction:

Being married is related to better health, but many studies reveal greater health benefits among men relative to women. Some research has indicated that married individuals exhibit decelerated epigenetic age relative to individuals who are not married, but questions remain regarding gender differences therein. The purpose was to investigate gender differences in associations of marital status to epigenetic age (ing) assessed on three clocks/algorithms (PhenoAge, GrimAge, and DunedinPACE).

Methods:

Data from 762 participants in the national Midlife in the United States Study (MIDUS II; men N = 382, women N = 380) were used. Weighted linear regressions were conducted …


Implementation Of A Learning Module To Reduce Advanced Practice Provider Preceptor Burden, Michelle Bloom Sep 2026

Implementation Of A Learning Module To Reduce Advanced Practice Provider Preceptor Burden, Michelle Bloom

Doctor of Nursing Practice (DNP) Student Projects

The transition of advanced practice providers (APPs) from student to provider, or from an experienced provider to a new organization or location, has been identified as a high-stress period with potential turnover for new-hire APPs. APP preceptors play a key role in this transition. Limited time to teach during the clinical day and a limited knowledge base among new hires were two of many factors associated with increased preceptor burden. A brief online educational module that provided pre-clinical, organization-specific education was proposed to improve new-hire APPs’ knowledge base and reduce preceptor burden, among APP preceptors working in a 36-bed surgical/burn/trauma …


Messages From The Provost, Georgia Southern University Sep 2026

Messages From The Provost, Georgia Southern University

Messages from the Provost

  • Message from the Provost
  • GS continues to address critical health care needs with new Physician Assistant Program

  • GS study finds link between breastfeeding and COVID-19 outcomes across Georgia

  • GS receives historic funding to curb isolation among older adults and people with disabilities


Gene-Environment Interactions In Cardiovascular Aging: Volunteering, Polygenic Risk, And Biomarker Change In European And African Ancestry Populations, Seoyoun Kim, Byeongju Ryu, Erin Ware, Koichiro Shiba, Cal J. Halvorsen Sep 2026

Gene-Environment Interactions In Cardiovascular Aging: Volunteering, Polygenic Risk, And Biomarker Change In European And African Ancestry Populations, Seoyoun Kim, Byeongju Ryu, Erin Ware, Koichiro Shiba, Cal J. Halvorsen

Brown School Faculty Publications

Volunteering has been associated with better cardiovascular health, but whether this association varies by genetic susceptibility to cardiovascular disease remains unclear. This study examined associations between volunteering and cardiovascular biomarkers, assessed associations between biomarker-specific polygenic scores (PGSs) and these outcomes, and tested whether polygenic risk moderated volunteering–biomarker associations among U.S. adults aged 51 years and older.


Sedentary Behaviors And Functional Disability Among Chinese Older Adults (2008–2018): Evidence Including Mahjong, Yen-Han Lee, Yen-Chang Chang, Minzhi Ye, Cai Xu Sep 2026

Sedentary Behaviors And Functional Disability Among Chinese Older Adults (2008–2018): Evidence Including Mahjong, Yen-Han Lee, Yen-Chang Chang, Minzhi Ye, Cai Xu

School of Social Work Faculty Publications

Purpose: This study examined how different types of sedentary behavior relate to changes in functional disability, measured by activities of daily living (ADL) and instrumental activities of daily living (IADL), among Chinese older adults.

Major findings: Using data from 17,939 participants in four waves (2008–2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), sedentary behavior was categorized into four types: none, playing mahjong only, combining these with other sedentary activities, and other activities alone (e.g., reading and watching TV). Cox two-state regression models estimated the hazard of transitioning in ADL and IADL disability. Engaging in sedentary behaviors was generally …


Neuronal Expression Of Bromodomain Proteins Alters Neuronal Health And Peripheral Protein Homeostasis To Promote Longevity, Naibedya Dutta, Daniel Hicks, Edgar Esparza, Anna Entin, Priyadharshini Vijayakumar, Caitlin M Lange, Tripti Nair, Elijah A Roditi, Athena Alcala, Maxim Averbukh, Matthew Vega, Rebecca Aviles Barahona, Caitlin Mctygue, Veronica Kuo, Juri Kim, Herbert Anson, Aeowynn J Coakley, George Wang, Steven E Pilley, Max A Thorwald, Whitaker Cohn, Sean P Curran, Nicolas Brouilly, Caroline Kumsta, Rachel N Arey, Peter J Mullen, Gilberto Garcia, Ryo Higuchi-Sanabria Aug 2026

Neuronal Expression Of Bromodomain Proteins Alters Neuronal Health And Peripheral Protein Homeostasis To Promote Longevity, Naibedya Dutta, Daniel Hicks, Edgar Esparza, Anna Entin, Priyadharshini Vijayakumar, Caitlin M Lange, Tripti Nair, Elijah A Roditi, Athena Alcala, Maxim Averbukh, Matthew Vega, Rebecca Aviles Barahona, Caitlin Mctygue, Veronica Kuo, Juri Kim, Herbert Anson, Aeowynn J Coakley, George Wang, Steven E Pilley, Max A Thorwald, Whitaker Cohn, Sean P Curran, Nicolas Brouilly, Caroline Kumsta, Rachel N Arey, Peter J Mullen, Gilberto Garcia, Ryo Higuchi-Sanabria

Faculty, Staff and Students Publications

Longevity and stress resilience require precise coordination of gene expression programs across tissues. Here, we demonstrate that overexpression of the chromatin reader bet-1 specifically in neurons of Caenorhabditis elegans promotes organismal longevity and stress resistance via cell-nonautonomous signaling. Neuronal bet-1 elicits a neurotransmitter-dependent signal that activates the conserved stress-responsive transcription factor HSF-1 in the intestine, enhancing proteostasis, oxidative stress resistance, metabolic remodeling, and immune defense. Life span extension by neuronal bet-1 requires both hsf-1 and daf-16 in neurons but only requires hsf-1 in peripheral tissues. Using bulk RNA sequencing, we reveal distinct prolongevity pathways that include enhanced heat-shock response, proteostasis, …


Joseph Herschel Mckissick, Jr. Papers, 1947-2014, Joseph Herschel Mckissick Jr. Aug 2026

Joseph Herschel Mckissick, Jr. Papers, 1947-2014, Joseph Herschel Mckissick Jr.

Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids

No abstract provided.


Frailty As A Framework To Understand Tuberculosis Severity, Recovery, And Sequelae, Yoscelina Estrella Martinez-Lopez, Benjamin W. Black, Jessica Lee, Brian J. Buta, Lisa Y. Armitige, William A. Fountain, Rafael Samper, Aanand D. Naik, Joanne Turner, Blanca I. Restrepo Aug 2026

Frailty As A Framework To Understand Tuberculosis Severity, Recovery, And Sequelae, Yoscelina Estrella Martinez-Lopez, Benjamin W. Black, Jessica Lee, Brian J. Buta, Lisa Y. Armitige, William A. Fountain, Rafael Samper, Aanand D. Naik, Joanne Turner, Blanca I. Restrepo

School of Medicine Publications

Tuberculosis (TB) causes profound systemic illness, and many survivors experience long-term sequelae associated with disability and premature mortality. Current TB severity indicators capture isolated aspects of disease and may not reflect the integrated physiological impact of infection on the host. Frailty, a multidimensional syndrome characterized by reduced physiological reserve and increased vulnerability to stressors, predicts adverse outcomes and guides clinical management in geriatrics. We propose frailty as an integrative framework for understanding the systemic effects of TB across the life course, encompassing disease severity, recovery, and long-term sequelae. We discuss biological mechanisms through which Mycobacterium tuberculosis infection may erode physiological …


University Of Central Florida Undergraduate Catalog, 2025-2026, University Of Central Florida Aug 2026

University Of Central Florida Undergraduate Catalog, 2025-2026, University Of Central Florida

UCF Catalogs

No abstract provided.


When Your Neighbours Are A Reminder Of Your Ageing, Cynthia Tan, Yi Wen (Chen Yiwen) Tan Aug 2026

When Your Neighbours Are A Reminder Of Your Ageing, Cynthia Tan, Yi Wen (Chen Yiwen) Tan

ROSA Journal Articles and Publications

In a commentary, Cynthia Tan, a retired senior corporate leader, and Tan Yi Wen, a Senior Research Fellow at SMU’s Centre for Research on Successful Ageing (ROSA), questioned whether the low demand for community care apartments is because seniors do not want only other seniors for company. They noted that most older people do not spend their days dwelling on ageing until everyone around them reminds them that they are growing old. They added that prolonged exposure to such an environment may carry subtle emotional and psychological consequences. Citing a national survey by ROSA, the writers mentioned that eight in …


Remote Assessment And Management Of Physical Function In Older Adults (Ramp): An International Expert Delphi Process, Jack Dalla Via, Hurst, Elsa Dent, Jackson J. Fyfe, Paul Jansons, Eleanor J. Hayes, Marc Sim, Mylene Aubertin-Leheudre, Alex Barreto De Lima, Lucimere Bohn, Sabine Britting, Fanny Buckinx, Gavin Connolly, Lora Giangregorio, Duarte Henriques-Neto, Jennifer R.A. Jones, Robert Kob, Suzanne N. Morin, Girish N, Lucas B.R. Orssatto, Maria Pearson, Daniel Pinto, Esmee M. Reijnierse, Catherine M. Said, Mohamed Salem, Gary Skinner Aug 2026

Remote Assessment And Management Of Physical Function In Older Adults (Ramp): An International Expert Delphi Process, Jack Dalla Via, Hurst, Elsa Dent, Jackson J. Fyfe, Paul Jansons, Eleanor J. Hayes, Marc Sim, Mylene Aubertin-Leheudre, Alex Barreto De Lima, Lucimere Bohn, Sabine Britting, Fanny Buckinx, Gavin Connolly, Lora Giangregorio, Duarte Henriques-Neto, Jennifer R.A. Jones, Robert Kob, Suzanne N. Morin, Girish N, Lucas B.R. Orssatto, Maria Pearson, Daniel Pinto, Esmee M. Reijnierse, Catherine M. Said, Mohamed Salem, Gary Skinner

Research outputs 2022 to 2026

Background: Remote methods may help older adults improve their physical function, but understanding the perspectives of experts who deliver this care is critical. This modified Delphi process aimed to develop expert consensus on effectiveness, feasibility and implementation of remote assessment and management of physical function in older adults. Methods: This online Delphi process included experts involved in supporting older adults to maintain or improve their health. The Round 1 survey presented 33 Delphi statements assessed using an 11-point Likert scale (0–10; ≥7 indicated agreement). Statements with strong (≥80 %), moderate (50–<80 %) and low (<50 %) agreement were accepted, revised, or rejected, respectively. Revised statements were presented in Round 2, and accepted statements were consolidated into key messages. Results: In total, 108 respondents (67 % female; mean [SD] age 41.4 [10.9] years) from 16 countries (five continents) completed Round 1. Fourteen statements were accepted (88–100 % agreement) and 10 were rejected (8–39 % agreement). The remaining nine statements (52–69 % agreement) were revised, and two new statements were developed for Round 2, which was completed by 89 (82 %) respondents. Five Round 2 statements were accepted (82–93 % agreement). Seven key messages were developed from 19 accepted statements, highlighting that remote care should be accessible to older adults with requisite capabilities, is feasible for older adults and health professionals with adequate support and training, and requires guidelines, policies, and further research to support wider adoption. Conclusions: The findings of this Delphi process can inform the implementation of remote care approaches for assessing and managing physical function in older adults.


Dnp Final Report: Community-Based Advance Care Planning Education For Older Adults: A Quality Improvement Project, Teresa Hill Jul 2026

Dnp Final Report: Community-Based Advance Care Planning Education For Older Adults: A Quality Improvement Project, Teresa Hill

DNP Final Reports

Background: Advance care planning (ACP) supports patient autonomy and promotes care aligned with individual values and preferences. Despite these benefits, fewer than half of adults aged 50–80 have completed formal ACP documentation, and community-dwelling older adults rarely engage in ACP before serious illness, representing a persistent gap in early engagement.

Purpose: This quality improvement (QI) project evaluated the effectiveness of a community-based ACP educational intervention in improving ACP knowledge, confidence, and engagement among older adults.

Methods: A nurse facilitator trained in the Five Wishes framework delivered a structured, 60-minute ACP workshop at a senior center in North Texas. A pre–post …


Using Polygenic Risk Scores To Evaluate Definitions Of Self-Reported Sleep Phenotypes Across Cohorts, Annah B Wyss, Michael Brown, Xiang Li, Brian W Spitzer, Zhijie Huang, Heming Wang, Richa Saxena, Linda Gallo, Qibin Qi, Wassim Tarraf, Robert Kaplan, Melissa Lamar, Hector M González, Charles Decarli, Myriam Fornage, Jerome I Rotter, Stephen S Rich, Kent D Taylor, Xiuqing Guo, Alexis C Wood, Peter Y Liu, Susan R Heckbert, Chloé Sarnowski, Jan Bressler, Alanna C Morrison, Bing Yu, Pamela L Lutsey, Carmen R Isasi, Susan Redline, Tamar Sofer Jul 2026

Using Polygenic Risk Scores To Evaluate Definitions Of Self-Reported Sleep Phenotypes Across Cohorts, Annah B Wyss, Michael Brown, Xiang Li, Brian W Spitzer, Zhijie Huang, Heming Wang, Richa Saxena, Linda Gallo, Qibin Qi, Wassim Tarraf, Robert Kaplan, Melissa Lamar, Hector M González, Charles Decarli, Myriam Fornage, Jerome I Rotter, Stephen S Rich, Kent D Taylor, Xiuqing Guo, Alexis C Wood, Peter Y Liu, Susan R Heckbert, Chloé Sarnowski, Jan Bressler, Alanna C Morrison, Bing Yu, Pamela L Lutsey, Carmen R Isasi, Susan Redline, Tamar Sofer

Faculty, Staff and Students Publications

Study objectives: Since genome-wide association studies (GWAS) of sleep phenotypes have been conducted in differing populations and definitions of sleep phenotypes vary across studies, we investigated associations between several polygenic risk scores (PRSs) and potential sleep definitions among multiethnic cohorts.

Methods: Using data from four cohorts (HCHS/SOL, ARIC, MESA, BHS, N = 16 895), we considered multiple definitions of short and long sleep, insomnia, and excessive daytime sleepiness (EDS). PRSs were developed based on summary statistics from GWAS in European ancestry individuals from the UK Biobank (UKB) and from GWAS conducted in a multiethnic population from the Million Veteran Program …


Visual-Motor Coordination In Automated Driving: Effects Of Temporal Urgency And Motor Demand On Intervention Behavior, Kailin Cui, Jonathan Chiu, Pranav Meda, Gaojian Huang, Yue Luo Jul 2026

Visual-Motor Coordination In Automated Driving: Effects Of Temporal Urgency And Motor Demand On Intervention Behavior, Kailin Cui, Jonathan Chiu, Pranav Meda, Gaojian Huang, Yue Luo

Faculty Research, Scholarly, and Creative Activity

Occupational Applications: This study shows that time-critical automation intervention requests increase drivers’ visual-motor demands, reflected in measurable changes in driving performance and posture (i.e., limb engagement and trunk positioning) during transitions of control. These responses indicate that maneuver urgency and takeover timing can place elevated biomechanical and coordination demands on drivers, particularly in work-based automated driving. For ergonomics and human factors practice, the findings underscore the need to design automated transportation systems (e.g., ridesharing services) that align request timing with operators’ physical and perceptual capabilities. In occupational settings such as automated shuttles and fleet-supervised vehicles, intervention requests should provide adequate …


Borin Kim Named Fellow Of Gerontological Society Of America, Aaron Sanborn Jul 2026

Borin Kim Named Fellow Of Gerontological Society Of America, Aaron Sanborn

UNH Today Archive

No abstract provided.


Older Adults' Caregiving Expectations For The Future, Smita Ekka Dewan, Derek Tice-Brown, Janna C. Heyman, Henry J. Davis, Colette Phipps, Joanne Mcmahon, Laura Sutter, Ye Feng, Jacqueline Heyde Jul 2026

Older Adults' Caregiving Expectations For The Future, Smita Ekka Dewan, Derek Tice-Brown, Janna C. Heyman, Henry J. Davis, Colette Phipps, Joanne Mcmahon, Laura Sutter, Ye Feng, Jacqueline Heyde

Publications and Research

The purpose of this cross-sectional study was to explore older adults' perception of caregiver stress and their anticipation of becoming a caregiver (N = 723). Bivariate analyses revealed that perceived caregiving stress was higher among older adults who were females, White/Non-Hispanics, with chronic health conditions, who had experienced prior physical and financial caregiving burdens and was lower among those with just a high school degree. Multivariate analyses revealed that perceived caregiving stress levels remained higher only for those with past experience with physical caregiving, those with chronic health conditions, older females and White/Non-Hispanic older adults. The overall model was …


A Comparative Study Of Aging And Cortical Folding In Chimpanzees And Olive Baboons, William D. Hopkins, Angela M. Achorn, Michele M. Mulholland, Elizabeth R. Magden, Steven J. Schapiro, Courtney L, Fults, Jean‐Francois Mangin, Adrien Meguerditchian Jul 2026

A Comparative Study Of Aging And Cortical Folding In Chimpanzees And Olive Baboons, William D. Hopkins, Angela M. Achorn, Michele M. Mulholland, Elizabeth R. Magden, Steven J. Schapiro, Courtney L, Fults, Jean‐Francois Mangin, Adrien Meguerditchian

Anthropology Faculty Publications

In light of the evidence that nonhuman primates naturally develop Alzheimer's disease neuropathologies, there is a renewed interest in research on the comparative biology of aging, including neurological changes across the age groups in species with diverse lifespans. In this paper, we examined age‐related differences in two measures of cortical folding, mean depth and fold opening, in a sample of chimpanzees (Pan troglodytes) and olive baboons (Papio anubis). We found significant species differences in the slope and pattern of age‐related changes in cortical folding. As predicted, chimpanzees showed negative linear associations between age and mean depth and …


Uti, Delirium, And Dementia: A Conceptual Bioinformatics Framework For Clinical Attribution, Rob E. Carpenter, Andrew Krouse Jul 2026

Uti, Delirium, And Dementia: A Conceptual Bioinformatics Framework For Clinical Attribution, Rob E. Carpenter, Andrew Krouse

Human Resource Development Faculty Publications and Presentations

Urinary tract infection (UTI) is frequently invoked to explain delirium, confusion, and functional decline in persons with dementia. Yet urine positivity in this population often reflects asymptomatic bacteriuria, colonization, chronic pyuria, contamination, or sampling noise rather than clinically attributable infection. For biomedical informatics and computational diagnostics readers, this narrative review contributes an integrative conceptual bioinformatics framework for probabilistic clinical attribution of suspected UTI in dementia under uncertainty. We formalizes the attribution problem by distinguishing organism detection from a clinically plausible infection-related contribution to neurocognitive decline. The framework integrates clinical, laboratory, biological, and longitudinal data to clarify whether urinary findings are …


The Most Age-Diverse Society In Our Country's History, Cal J. Halvorsen, Logan Fox, Tim B. Zielonko Jul 2026

The Most Age-Diverse Society In Our Country's History, Cal J. Halvorsen, Logan Fox, Tim B. Zielonko

Harvey A. Friedman Center for Aging

The public narrative is that the United States population is getting older. This is, indeed, true. We have more people over age 50 than we have ever had in our country—both in total numbers and in the share of the population. The numbers of older people will continue to grow, all the way up until the projections stop at the year 2100. Many have asked, “What will we do with all of these older people?”


Replacing Surrogate Decision-Making With Supported Decision-Making For Minimal Risk Research, Jennifer Hawkins, Aaron Eli Segal, David Wendler, Dana Howard Jul 2026

Replacing Surrogate Decision-Making With Supported Decision-Making For Minimal Risk Research, Jennifer Hawkins, Aaron Eli Segal, David Wendler, Dana Howard

Faculty and Staff Publications

We advocate for a change in the way individuals with cognitive impairment are enrolled in minimal risk clinical research. We do so in the hope that such a change will lead to more cognitively impaired individuals being enrolled in research. Our proposal applies only to cases where would-be participants retain some interest in decision-making as well as the ability to express a decision. In these cases, we argue that the common practice whereby researchers either obtain consent from the individual or consent from a surrogate and assent from the individual, is ethically unnecessary. Instead, a process of facilitated decision-making based …


Inflammation Associated With Obesity, Aging, And Amyloid Burden In Adults With Down Syndrome, Victoria L. Fleming-Batayneh, Brian C. Helsel, Lauren T. Ptomey, Benjamin L. Handen, Mark Mapstone, Melissa Petersen, Sharon J. Krinsky-Mchale, Christy L. Hom, Davneet Minhas, Weiquan Luo, Charles Laymon, Joseph H. Lee, Annie Cohen, Beau M. Ances, Adam M. Brickman, Margaret Pulsifer, H. Diana Rosas, Florencia Lai, Shahid H. Zaman, Elizabeth Head, Dana Tudorascu, Julie Price, Fredrick Schmitt, Bradley T. Christian, Ozioma Okonkwo, Sigan L. Hartley, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus M. Birn, Adam M. Brickman Jul 2026

Inflammation Associated With Obesity, Aging, And Amyloid Burden In Adults With Down Syndrome, Victoria L. Fleming-Batayneh, Brian C. Helsel, Lauren T. Ptomey, Benjamin L. Handen, Mark Mapstone, Melissa Petersen, Sharon J. Krinsky-Mchale, Christy L. Hom, Davneet Minhas, Weiquan Luo, Charles Laymon, Joseph H. Lee, Annie Cohen, Beau M. Ances, Adam M. Brickman, Margaret Pulsifer, H. Diana Rosas, Florencia Lai, Shahid H. Zaman, Elizabeth Head, Dana Tudorascu, Julie Price, Fredrick Schmitt, Bradley T. Christian, Ozioma Okonkwo, Sigan L. Hartley, Beau M. Ances, Howard F. Andrews, Karen Bell, Rasmus M. Birn, Adam M. Brickman

Neurology Faculty Publications

Objective: Adults with Down syndrome (DS) often show elevated systemic inflammation, but the association with obesity, aging, and Alzheimer's disease (AD) pathology is not well understood. Methods: Data were drawn from 188 nondemented adults with DS participating in the Alzheimer Biomarkers Consortium-DS (ABC-DS). Participants completed clinical assessments, blood draws, and neuroimaging. Plasma biomarkers included indicators of general, pro-, and anti-inflammation. Mixed linear models tested associations between BMI, age, PET-measured amyloid burden, and inflammatory biomarkers, adjusting for sex, trisomy type, and collection site. False discovery rate correction was applied. Results: The majority of the participants met criteria for obesity. Higher BMI …


Discordance Between Self-Report And Performance-Based Measures Among At-Risk Older Adults: A Secondary Data Analysis, Chiung-Ju Liu, Wen-Pin Chang, Inga Wang Jul 2026

Discordance Between Self-Report And Performance-Based Measures Among At-Risk Older Adults: A Secondary Data Analysis, Chiung-Ju Liu, Wen-Pin Chang, Inga Wang

Occupational Therapy Faculty Publications

Importance: Subtle, age-related declines in occupational performance among at-risk older adults may go undetected when assessed solely with self-report measures, potentially leading to missed intervention opportunities. Understanding discrepancies between self-reported and performance-based occupational performance outcomes can inform assessment selection and interpretation.

Objective: To examine the discrepancies between the two types of measure among community-dwelling older adults at risk for losing independence.

Design: Cross-sectional study using secondary data analysis.

Participants: Seventy-one community-dwelling older adults (M age = 74 yr, SD = 9) who showed muscle weakness and reported difficulty with activities of daily living.

Outcomes and measures: Canadian Occupational Performance Measure …