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Articles 1 - 5 of 5
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Cftr From Divergent Species Respond Differently To The Channel Inhibitors Cftrinh-172, Glibenclamide, And Glyh-101, Marie Suzy Bewley
Cftr From Divergent Species Respond Differently To The Channel Inhibitors Cftrinh-172, Glibenclamide, And Glyh-101, Marie Suzy Bewley
Yale Medicine Thesis Digital Library
Studies of widely diverse species of a protein are a powerful tool to gain information on the structure and function of the protein. We investigated the response of human, pig, shark and killifish cystic fibrosis trans-membrane conductance regulator (CFTR) to specific inhibitors of the channel: CFTRinh-172, GlyH-101, and glibenclamide. In several expression systems, including isolated perfusions of the rectal gland, primary cell cultures of rectal gland tubules and oocyte expression, we observed fundamental differences in the sensitivity to inhibition by these CFTR blockers. We used primarily two-electrode voltage clamping of cRNA microinjected Xenopus laevis oocytes. In oocyte studies, shark CFTR …
A Prognostic Index For Predicting Lymph Node Metastasis In Minor Salivary Gland Cancer, Shane Lloyd
A Prognostic Index For Predicting Lymph Node Metastasis In Minor Salivary Gland Cancer, Shane Lloyd
Yale Medicine Thesis Digital Library
We hypothesized that lymph node involvement in minor salivary gland cancers is associated with clinical and pathological factors commonly available to the clinician after a typical initial workup. Our aim was to identify these factors using a dataset that allowed us to compile the largest series of minor salivary gland cancers in the published literature. Using this dataset we also aimed to characterize the distribution of histological types by primary site, identify the predictors of the use of external beam radiation therapy and neck dissection, and examine the effect of lymph node involvement on survival. Using the SEER database, we …
Search For The Basolateral Potassium Channel In The Shark Rectal Gland: Functional And Molecular Identification Of A Task-1 Channel Coupled To Chloride Secretion, Conner Telles
Yale Medicine Thesis Digital Library
In the shark rectal gland (SRG), apical Cl- secretion through CFTR channels is tightly coupled to a basolateral K+ conductance. The identity of this K+ conductive pathway is unknown. Studies were performed in the isolated perfused SRG with 16 K+ channel inhibitors at their IC50 and with acidic perfusate. During maximal chloride secretion stimulated by forskolin and IBMX, secretion was inhibited >90% by barium chloride, a non-selective inhibitor of K+ channels. Specific inhibitors of calcium sensitive, voltage sensitive, ATP sensitive, and inward rectifying K+ channels had no effect on chloride secretion. The inhibitors quinidine, quinine, bupivicaine, anandamide, and low perfusate …
Calcium Dependent Chloride Transport In The Rectal Gland Of The Dogfish Shark Squalous Acanthias, Barbara Ann Ross
Calcium Dependent Chloride Transport In The Rectal Gland Of The Dogfish Shark Squalous Acanthias, Barbara Ann Ross
Yale Medicine Thesis Digital Library
No abstract provided.
Corticosteroid Induction Of Na-K-Atpase In The Fresh Water Eel (Anguilla Rostrata), Michael Cynamon
Corticosteroid Induction Of Na-K-Atpase In The Fresh Water Eel (Anguilla Rostrata), Michael Cynamon
Yale Medicine Thesis Digital Library
No abstract provided.