Digital Commons Network^™

The Characterization Of Sleep Quality In Pediatric Cancer Survivors With Overweight/Obesity, Erin M. Brennan

USF Tampa Graduate Theses and Dissertations

Advances in cancer treatment have improved survival rates among pediatric cancer survivors (PCS), shifting the focus toward long-term quality of life. Despite this progress, PCS remain at elevated risks of chronic health issues, including disrupted sleep and obesity. The purpose of this study was to characterize the sleep of PCS with overweight/obesity and to identify predictors of sleep quality. Guided by Merz and Tomfohr-Madsen’s (2018) conceptual framework for sleep disruption in children impacted by cancer, this secondary analysis of data examined disease parameters, family and environmental factors, and physical activity as potential predictors of sleep quality. Participants were enrolled between …

Statistical Challenges And Simulation Results For Pilot Clinical Trials, Weiliang Cen

USF Tampa Graduate Theses and Dissertations

Background: The effect size estimated from a pilot trial is often an inaccurate reflection of the true effect size observed in a large trial, leading to either underestimation or overestimation. Published data suggest that effect sizes from large trials are typically smaller than those reported in their corresponding pilot trials. To address this discrepancy, conservative or discount adjustment methods are widely recommended to modify pilot trial effect sizes when calculating sample sizes, thereby maintaining adequate statistical power. This study aims to assess effect sizes from both pilot and large trials and to evaluate the performance of existing adjustment methods.

Methods: …

Improving Coral Restoration Outcomes Through Novel Molecular Applications, Matthew H. Gamache

USF Tampa Graduate Theses and Dissertations

Coral reef ecosystems are declining globally from numerous stressors, including localized pollution, disease, and marine heatwaves induced by climate change. To preserve these ecosystems, it is critical to identify corals that can withstand stressors—primarily future marine heatwaves—and prioritize them for coral restoration efforts until these stressors are mitigated. Coral responses to thermal stress can be influenced by several partners, including mutualistic microalgae and a vast prokaryotic community. Here, I use advanced molecular techniques to examine which partners (coral host, algal symbiont, and microbial communities) are associated with coral health, how they contribute to holobiont physiology, and their potential to increase …

Exploring Perceived Parental Vulnerability In Pediatric Cancer Survivors: A Comparative Thematic Analysis Of English And Spanish-Speaking Families., Yusnavi Martinez Pineiro

USF Tampa Graduate Theses and Dissertations

This study examined how perceived parental vulnerability is expressed among parents of pediatric cancer survivors and explored potential differences between Spanish-speaking and English-speaking families. Data were drawn from an existing ongoing clinical trial in the IHOPE lab of the University of South Florida, who collaborates with over 10 pediatric cancer survivorship clinics across the country. The study used a total of 26 (13 Spanish-speaking and 13 English-speaking) structured interview transcripts from parent participants. The transcripts were the first session with the parent participant, the interventionist spoke the parent’s preferred language (English or Spanish), perceived parental vulnerability was one of six …

The Ruling Relations Of Care: An Institutional Ethnography Of High-Risk Prenatal Care Experiences, Nicole L. Harris

USF Tampa Graduate Theses and Dissertations

Disrespect during pregnancy, labor, and delivery is common in the United States. The Centers for Disease Control and Prevention has estimated that approximately one in five women overall, and over 30% of Black women, report being ignored, dismissed, or verbally mistreated during their care. Public health efforts have primarily focused on individual-level interventions to improve patient-provider communication or reduce provider bias; however, these strategies have been critiqued for their limited scope and effectiveness in shifting outcomes. Instead, researchers and advocates have called for an examination of the structures that shape clinical encounters, including policies, protocols, workflows, and organizational culture. This …

Myfoodrx: A Personalized Food-As-Medicine Mhealth Application For Food-Insecure Adults With Chronic Conditions, Jay Hiteshkumar Jariwala

USF Tampa Graduate Theses and Dissertations

Food insecurity (FI) remains a persistent public health challenge in the United States, disproportionately affecting underserved populations and contributing to higher rates of chronic conditions such as diabetes, hypertension, and obesity. Traditional Food-as-Medicine programs have emerged as promising interventions, but often follow a generalized, non-personalized approach that limits long-term effectiveness, especially among diverse, high-risk communities. This thesis presents MyFoodRx, a personalized mobile health (mHealth) application designed to address the intersection of food insecurity and chronic disease through tailored nutritional guidance, real-time pantry integration, and adaptive educational content.

Developed through a User-Centered Design (UCD) process, MyFoodRx leverages a modular client–server architecture, …

Marigold-Silver Nanoparticles (Agnps) Complex: Characterization, Therapeutic Potential, And Future Approaches For Lung Injury Via Antioxidant And Anti-Inflammatory Effects, Navdeep Kaur

USF Tampa Graduate Theses and Dissertations

Chronic respiratory diseases (CRDs) and other lung conditions are a key cause of the problems facing global health, as they greatly increase morbidity, death, and the financial burden. In order to achieve the third Sustainable Development Goal of the United Nations, which is to reduce premature mortality from non-communicable illnesses by one-third by 2030, updated epidemiological statistics are crucial for directing prevention, control, and treatment measures. One of the major reasons of illness and death globally is chronic obstructive pulmonary disease (COPD). Lung damage and the emergence of CRDs, such as asthma, emphysema, COPD, and other respiratory disorders, are largely …

A Multidimensional Perspective Of Patterns Of Functioning And Well-Being, Lendi Nicole Joy

USF Tampa Graduate Theses and Dissertations

The Center for Behavioral Health Statistics and Quality estimates that 79.4% of U.S. adults will remain free from mental illness each year, but this does not necessarily mean they will enjoy positive psychological health and well-being. Well-being has been associated with positive outcomes such as greater health, longevity, work productivity, and increased social engagement. Thus, it is important for researchers to understand factors contributing to the development of well-being and optimal functioning. The current study used latent profile analysis to classify individuals based on their levels of well-being at ages 23 to 26 years and explored functioning indexes assessed when …

Healthy Bodies, Moral Minds, And Rural Ideals: Contextualizing Interwar British Childhood And Citizenship Through Children's Country Holidays Fund Vacations, Paula J. Pack

USF Tampa Graduate Theses and Dissertations

This dissertation uses the Children’s Country Holidays Fund (CCHF) as a critical lens to examine how philanthropy, childhood, class, public health, and rural nostalgia intersected within the broader context of citizen formation in interwar Britain. Founded in 1884 to provide country holidays for poor London schoolchildren, the CCHF evolved from a philanthropic response to Victorian slum life into an informal arm of welfare governance by the end of the interwar period. Through its country holidays, the Fund became an active participant in shaping ideals of health, morality, and civic responsibility in a period marked by heightened concern over national vitality …

Food For Thought: Binge Planning Cognitions And Behaviors Within An Online Sample Of Adults With Binge-Type Eating Disorders, Rose H. Miller

USF Tampa Graduate Theses and Dissertations

Research has begun exploring the phenomenon of binge planning, wherein individuals who binge eat do so with forethought, rather than impulsively. What specific thought processes and behaviors comprise binge plans remains unexamined. How, or if, the eating disorder presentations of individuals who plan binges ahead of time differ from those who binge impulsively is also still unknown. The present study sought to explore the thoughts, emotions, and behaviors associated with binge planning, and to identify how the motivations, symptomologies, and personality traits (i.e., impulsivity) differ between binge eaters who do or do not plan their binges. An online study using …

Branching Corals Modulate Their Hydrodynamic Environment, Enhancing Capture Rates Of Evasive Prey, Kelsey Daniels

USF Tampa Graduate Theses and Dissertations

Reef-building corals obtain nutrients through two primary means: autotrophy (via mutualism with photosynthetic zooxanthellae) and heterotrophy (via feeding). The latter form of resource acquisition is understudied and many aspects of predator-prey interactions between coral and naturally occurring prey species remain unexplored. In this thesis, I elucidate the role of branching coral morphology in shaping the colony’s local hydrodynamic environment and describe how this environment impacts prey capture, particularly among evasive and hydrodynamically sensitive, but highly abundant prey such as copepods. I used acrylic cylinders of three sizes in aquaria to model the structure of coral branches across the range of …

Understanding The Interplay Between Nutritional Status And Depression Among Community-Dwelling Older Adults, Mary R. Goldsworthy

USF Tampa Graduate Theses and Dissertations

By the year 2050, it is projected that the population of individuals aged 60 years and older will increase by 47 percent, reaching a total of 82 million in the United States. Many older adults experience depressive symptoms, and some never recover from it. Depression is one of the most common psychiatric disorders among older adults. Approximately 3.2% of community-dwelling older adults experience major depressive disorder in a 12-month period, although many more experience clinically significant depressive symptoms, with a recent estimate of 35% based on a global meta-analysis. In addition to physical functioning and depressive symptoms, another domain in …

Essays In Development Economics, Karina Gabitova

USF Tampa Graduate Theses and Dissertations

This dissertation investigates how environmental shocks and early-life health conditions influence child and adolescent development in low- and middle-income countries, using longitudinal data from the Young Lives survey in Ethiopia, India, Peru, and Vietnam. The two chapters address distinct but interrelated dimensions of human capital formation: the effect of environmental shocks on adolescent self-esteem and the causal impact of birth weight on cognitive and non-cognitive outcomes.

Chapter 1 analyzes how shocks such as droughts, floods, and crop failures affect adolescent selfesteem, a key non-cognitive skill linked to long-term well-being. Using a fixed-effects model, the study finds heterogeneous effects: environmental shocks …

Murine Studies On Ketogenic Modulation Of Metabolism And Epigenetics In Olfaction- Based Learning, Lps Inflammatory Response, And Sex Dimorphisms In Dietary Response, Sara E. H. Moss

USF Tampa Graduate Theses and Dissertations

Ketogenic diets are well-established therapeutic interventions for epilepsy, with documented neuroprotective effects arising from their metabolic, antioxidant and anti-inflammatory properties. Beyond epilepsy, ketogenic therapies are under investigation for various conditions including Alzheimer disease, cancer, diabetes, and cardiovascular disease. These diets suppress insulin levels and shift metabolic physiology toward fat and ketone body metabolism. This elevates circulating levels of ketone bodies, namely beta-hydroxybutyrate, acetoacetate, and acetone, which serve as both energy substrates and signaling molecules. The state of elevated ketone bodies (ketosis) can be achieved with various formulations of a ketogenic diet as well as exogenous ketone supplementation, though the signaling …

Growing The Future: Community Gardens In Hillsborough County, Florida, Nicole M. Kennady

USF Tampa Graduate Theses and Dissertations

This project was an evaluation on community gardens in Hillsborough County, Florida from May 2024 to November 2024, built off of Homegrown Hillsborough’s first year evaluation of the current Hillsborough County food system. Homegrown Hillsborough is a network of community members with a mission to grow a strong food system in Hillsborough County by assisting in all areas of the food system from food production to food waste. Homegrown Hillsborough plans to act as a development initiative focused on community nutrition. Over the next two years, Homegrown Hillsborough plans to focus on food production, food access, and economic development. Through …

An Exploration Of The Experiences Of Perinatal Depression And Anxiety Among Pregnant And Parenting Adolescents In The Tampa Bay Area Of Florida, Olajumoke Adetoun Ojeleye

USF Tampa Graduate Theses and Dissertations

Perinatal depression (PND) and perinatal anxiety (PNA) are increasing among pregnant and parenting adolescents (PPAs), with PNA often underrecognized. This leads to significant socioeconomic costs and adverse maternal consequences if untreated. Hence, this dissertation explores the experiences of PND and PNA among PPAs, focusing on their knowledge gaps, perception, mental health needs, care preferences, and access to PMH care. The research employs a qualitative design (free-listing and in-depth interviews) to gather participant insights. Key findings reveal that many PPAs possess limited knowledge about PNA when compared to PND. Lack of support from partners, family, and peers emerged as the topmost …

Linking Education And Work: Understanding The Influence Of Community Schooling Models On Student Pathways, Takiyah N. Dixon

USF Tampa Graduate Theses and Dissertations

This dissertation explores the integration of work-study programs, mentorship, and support systems at Cristo Rey Tampa Salesian High School (CRTSHS) and their role in preparing underrepresented students for post-secondary education and professional careers. Utilizing a case study methodology, this research centers on an in-depth analysis of a single participant's experience, which provides a qualitative insight into the impacts of these educational components. The study examines how the school's work-study program equips students with practical skills, how mentorship shapes their academic and personal development, and how support systems contribute to their readiness for higher education and employment.

The data for this …

Cultivating Coastal Communities: An Exploration Of Synergies And Tradeoffs To The Colocation Of Stormwater Ponds And Urban Agriculture In Tampa Bay, Estenia Ortiz

USF Tampa Graduate Theses and Dissertations

Cultivating resilience in coastal communities such as Tampa Bay is becoming increasingly important as urbanization continues to fuel complex environmental and social challenges further exacerbated by sea level rise, habitat degradation, and more intense storm events. Food and water systems are particularly vulnerable under these circumstances, jeopardizing residents’ quality of life. This research explored the nexus of stormwater detention ponds and urban agriculture, namely community and residential gardens, this research reveals factors to consider in the colocation of these systems to build local community resilience and protect waterways.

Focusing on East Tampa, a historic Black community in Florida, and the …

“It’S Essential We Learn How To Grow For Ourselves”: The Legacies Of Black Gardening In Racialized Food Systems., Funmi Odumosu

USF Tampa Graduate Theses and Dissertations

In this thesis, I aim to investigate the impact of food racism on Black communities, with a specific focus on the importance of gardening in combatting food apartheid and fostering holistic connections to nature and community in school-aged children. Inequitable access to major retail supermarkets and unequal distribution of healthy food options are intentionally occurring patterns in the food spaces of predominately Black communities. These food system inequities exacerbate a lack of consumption and potential consequences on the health and well-being of children of color particularly during critical physical and cognitive developmental periods.

Many solutions to these inequities entail implementing …

Γ -Aapeptides Targeting Amyloid-Β Pathway And Neural Repair For Alzheimer’S Disease Treatment, Ning Shen

USF Tampa Graduate Theses and Dissertations

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and progressive neuronal degeneration. Despite extensive research, no treatments have been able to effectively halt or reverse the progression of the disease. This study aimed to evaluate the therapeutic potential of two novel γ-AApeptides, HW-C9 and 125-6b, in AD treatment, assessing both their individual and combined effects. HW-C9 was designed to inhibit Aβ aggregation, while 125-6b was developed to promote neuronal growth and repair. Initially, the therapeutic effects of HW-C9 and 125-6b were assessed both in vitro and in vivo. The results showed that HW-C9 …

Evaluating How Malaria Transmission Season, Residency, And Travel History Modify The Association Between Vector Control Method Use And P. Falciparum Infection In Accra, Ghana., Anna Beltrame

USF Tampa Graduate Theses and Dissertations

Background. Urbanization and population movements increase urban malaria risk, necessitating adjustments to traditional control strategies. Data on vector control methods in urban African settings and their association with malaria risk remain limited.

Objectives. To evaluate the association between vector control methods and Plasmodium falciparum infection in Accra, Ghana, and how this association varies by malaria transmission season, residency, and travel history.

Methods. This observation study utilized data from two cross-sectional household surveys conducted in March-April and June-July 2024 as part of the MUSE study. Participants were household members over six months old who gave consent, randomly selected from 13 health …

Navigating Change: Youth Civic Engagement At Tampa Heights Junior Civic Association, Alex R. Whitacre

USF Tampa Graduate Theses and Dissertations

This study examines the impact of gentrification on the Tampa Heights community in Florida, focusing on the role of Tampa Heights Junior Civic Association (THJCA) in fostering civic engagement and youth empowerment amidst urban transformation. Using a mixed-methods ethnographic approach, including participant observation, archival review, spatial analysis, surveys, and interviews, the research investigates how THJCA affiliates conceptualize and respond to gentrification, space, and community change. Employing urban place theories and social capital frameworks, the research challenges deficit-oriented narratives in examining the experiences of current and former residents, the effects of gentrification on youth educational services, and THJCA's strategies for maintaining …

Cactus Infused Beads For Off-Flavor Mitigation In Aquaculture Systems, Rama Mahita Kambhampati

USF Tampa Graduate Theses and Dissertations

Aquaculture has become a vital component of global food production, now providing 50% of the world's fish supply. However, the industry encounters major challenges due to off-flavor compounds like Geosmin and 2-Methylisoborneol (MIB), which give fish an unpleasant earthy or musty smell. These compounds are detectable by humans at extremely low levels 0.7 parts per billion (ppb) for MIB and ten parts per trillion (ppt) for Geosmin—making them a persistent problem. Their presence not only reduces the sensory quality of aquaculture products but also results in significant economic losses, with U.S. catfish production incurring an additional $15–$23 million annually due …

Infiltration Of Immune Cells And Lipid Nanoparticle-Mediated Drug Delivery In A Skin Cancer Model, Aynur Sanem Yilmaz

USF Tampa Graduate Theses and Dissertations

Melanoma, the deadliest form of skin cancer, is notorious for its rapid mutation rate and high potential for metastasis, making effective treatment particularly challenging. Immunotherapy has emerged as a significant advancement in melanoma therapy, leveraging the immune system to target and eliminate cancer cells. These achievements have motivated further investigation into immune system-based strategies for this aggressive cancer. Cell-based drug delivery has been primarily achieved by either using immune cells as direct carriers for therapeutics or by employing active molecules through drug delivery systems, most often nanoparticles. While immune cells exhibit innate tumor-homing abilities, they face challenges such as limited …

Pseudomonas Aeruginosa Aggregate Formation In The Cystic Fibrosis Airway, Alexa D. Gannon

USF Tampa Graduate Theses and Dissertations

Bacterial aggregates are observed in both natural and artificial environments. In the context of disease, aggregates have been isolated from both chronic and acute infections. Pseudomonas aeruginosa (Pa) aggregates contribute significantly to chronic infections, particularly in the lungs of people with cystic fibrosis (CF). Unlike the large biofilm structures observed in vitro, Pa in CF sputum forms smaller aggregates (~10-1000 cells), and the mechanisms behind their formation remain underexplored. This study aims to identify genes essential and unique to Pa aggregate formation in a synthetic CF sputum media (SCFM2). We cultured Pa strain PAO1 in SCFM2 and LB, both with …

A Phenotypic Characterization Of Staphylococcus Aureus Bacteremia Clinical Isolates, Sara Dj Daniels

USF Tampa Graduate Theses and Dissertations

Staphylococcus aureus is a human pathogen of serious concern because of its ability to cause serious and wide-ranging disease. Of particular concern is the ability of S. aureus to cause bacteremia (SAB), allowing the bacteria to disseminate and spread to various organs. This study addressed this issue through the phenotypic characterization of two methicillin-resistant S. aureus (MRSA) clinical isolates taken from patients with sustained complicated bacteremia at Tampa General Hospital, referred to as SA1097 and SA1098. A battery of phenotypic tests was conducted on these strains, including a growth curve, hemolysis and proteolysis screenings, cytotoxicity assays using human neutrophils, blood …

The Association Between Oral Microbiome, Oral Inflammation, Periodontal Disease, And Systemic Metabolism In Individuals With/Without Type 1 Diabetes, Mianli Xiao

USF Tampa Graduate Theses and Dissertations

This study explores the associations between oral microbiomes, periodontal disease (PD), and systemic metabolism in individuals with and without Type 1 diabetes (T1D). Data were obtained from 208 participants (99 with T1D, 109 non-diabetic) in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) pilot study and 283 participants from the Oral Microbiome ancillary cohort study. Both studies included the collection of saliva or subgingival plaque samples. Microbial DNA was extracted, and the V4 region of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. Machine learning models, including Random Forest (RF) and Multi-layer Perceptron (MLP), were applied …

Unravelling The Impact Of Blood Metabolites, And Lifestyle Factors On Periodontal Disease Using Mendelian Randomization, Rhea Charles

USF Tampa Graduate Theses and Dissertations

Periodontal disease remains a global public health concern. Despite the availability of preventive and therapeutic strategies, the multifactorial nature of periodontitis complicates its understanding and management. Periodontal disease is associated with an increased risk of chronic conditions, including ischemic heart disease (IHD), gestational hypertension, respiratory diseases such as COPD and bronchitis, and various cancers, including kidney and pancreatic cancers. Moreover, individuals with diabetes, autoimmune diseases like lupus and Crohn’s disease, and osteoporosis are more likely to develop periodontitis. The ambiguity in the direction of causality between periodontal disease and its associated conditions poses challenges for effective treatment. Mendelian randomization offers …

A Shield-Bearer’S Tale: Elucidating The Roles Of Estradiol And Choline In Mitigating Chemotherapy-Related Cognitive Impairment, Robert W. Botelho Jr.

USF Tampa Graduate Theses and Dissertations

Chemotherapy-Related Cognitive Impairments (CRCIs) are significant consequences of chemotherapy that affect a substantial portion of breast cancer survivors, potentially persisting long after treatment cessation. This series of studies investigated the neuroprotective roles of estradiol and choline against CRCIs induced by cyclophosphamide and doxorubicin (CYP/DOX), commonly known as Adriamycin/Cytoxan (AC) chemotherapy. Utilizing the MMTV-PyVT mouse model of breast cancer, this body of work spans several experimental studies, the first of which evaluates the impact of dietary choline supplementation on spatial memory and cholinergic function in tumor-bearing mice undergoing chemotherapy. The subsequent study tests whether impaired ovarian function and resulting reductions in …

An Evaluation Of The Premack Contingency To Increase Physical Activity In Teenagers With Autism Spectrum Disorder, Shreeya S. Deshmukh

USF Tampa Graduate Theses and Dissertations

The United States Department of Health and Human Services (2018) recommends that teenagers engage in physical activity to improve their cardiovascular health and muscle and bone strength. Yet, most teenagers with and without autism spectrum disorder do not meet the recommended guidelines for physical activity. Research related to promoting physical activity has evaluated group contingencies, reinforcement-based interventions, and antecedent interventions; however, these interventions are time-intensive, require many resources, or are ineffective. The purpose of this study was to extend Allen and Iwata (1980) by reinforcing completion of a low-probability exercise to a specified criterion with access to a high-probability exercise. …