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Comparative Toxicity Of Diphacinone To Northern Bobwhite (Colinus Virginianus) And American Kestrels (Falco Sparverius), Barnett A. Rattner, Katherine E. Horak, Sarah E. Warner, Daniel D. Day, John J. Johnston
Comparative Toxicity Of Diphacinone To Northern Bobwhite (Colinus Virginianus) And American Kestrels (Falco Sparverius), Barnett A. Rattner, Katherine E. Horak, Sarah E. Warner, Daniel D. Day, John J. Johnston
USDA Wildlife Services: Staff Publications
The acute oral toxicity of the anticoagulant rodenticide diphacinone was found to be about 20 times greater to American kestrels (LD50=97 mg/kg) than to northern bobwhite (LD50=2,014 mg/kg). Several precise and sensitive clotting assays (prothrombin time, Russell’s Viper venom time, thrombin clotting time) were adapted for use in these species, and this combination of assays is recommended to detect effects of diphacinone and other rodenticides on coagulation. Oral administration of diphacinone over a range of doses (sublethal to the extrapolated LD15) prolonged prothrombin time and Russell’s Viper venom time within 24 to 48 hrs …
Acute Toxicity Of Diphacinone In Northern Bobwhite: Effects On Survival And Blood Clotting, Barnett A. Rattner, Katherine E. Horak, Sarah E. Warner, John J. Johnston
Acute Toxicity Of Diphacinone In Northern Bobwhite: Effects On Survival And Blood Clotting, Barnett A. Rattner, Katherine E. Horak, Sarah E. Warner, John J. Johnston
USDA Wildlife Services: Staff Publications
The anticoagulant rodenticide diphacinone was slightly toxic (acuteoralLD50 2014 mg/kg) to Northern bobwhite (Colinus virginianus) in a 14-day acute toxicity trial. Precise and sensitive assays of blood clotting (prothrombin time, Russell’s Viper venom time, and thrombin clotting time) were adapted for use in quail, and this combination of assays is recommended to measure the effects of anticoagulant rodenticides. A single oral sub lethal dose of diphacinone (434mg/kg body weight) prolonged clotting time at 48 h post-dose compared to controls. At 783 mg/kg (approximate LD02), clotting time was prolonged at both 24 and 48 h post-dose. …