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Digital Maturity In The Administrative Prosecution In Egypt, Asmaa A. Hassan
Digital Maturity In The Administrative Prosecution In Egypt, Asmaa A. Hassan
Theses and Dissertations
The growing deployment of information and communication technologies in public service delivery, in general, and in the judiciary in particular, underscores the need for an assessment tool to evaluate digital maturity. Understanding digital maturity, a state in which an organization has completed digital development, helps diagnose the status quo, identify enablers, and address challenges, and consequently provide a roadmap for efficient improvements. This study aims to examine key factors affecting digital maturity within the Administrative Prosecution (AP) in Egypt, a pillar of the judicial authority and mandated to investigate financial and administrative violations committed by public servants. A mixed-methods approach …
From Planned To Lived: Street-Level Transformation And The Production Of Urban Space In New Cairo, Seba Abouyoussef
From Planned To Lived: Street-Level Transformation And The Production Of Urban Space In New Cairo, Seba Abouyoussef
Theses and Dissertations
Egypt's new cities program has produced four generations of satellite developments, yet none have been systematically evaluated for how they perform once inhabited. Each is planned as a prototype — functionally zoned, automobile-oriented, image-driven — with little regard for the social, cultural, and behavioral dynamics that will shape it. This thesis examines the gap between the planned city and the lived city by tracing how three streets in New Cairo transformed over a fifteen-year period (2010–2025) through everyday use, stakeholder interaction, and pivotal trigger events.
The research follows a qualitative, multi-phase methodology — combining historical and physical mapping, behavioral observation, …
Effect Of Casting Conditions On Interface Formation In Aluminum–Brass Bimetal Produced By Compound Die Casting, Farida Boulos
Effect Of Casting Conditions On Interface Formation In Aluminum–Brass Bimetal Produced By Compound Die Casting, Farida Boulos
Theses and Dissertations
This research work investigates compound die casting of aluminum-brass hybrid metal. AA7075 and AA1050 were cast around a cylindrical brass substrate and the interface region is studied. Casting temperature as well as substrate diameter were varied with the objective of studying their influence on the structure of the interface and the thickness of the intermetallic layers (IMLs). Light Optical Microscopy (LOM) overview images and high magnification images were obtained, and the interface was characterized by Scanning Electron Microscopy equipped with Energy Dispersive X-ray Spectroscopy (SEM-EDS). Moreover, nano-indentation hardness measurements were conducted. Results showed that porosity significantly affected the integrity of …
Nanoscale Water Confinement And Coordination-Driven Ion Transport In Eutectogel Electrolytes For Electrochemical Energy Storage Applications, Abdallah Akar
Theses and Dissertations
The rapid expansion of renewable energy systems, portable electronics, electric vehicles, and smart grid technologies has intensified the demand for advanced electrochemical energy storage devices capable of delivering high power density, long cycling life, operational safety, and environmental sustainability. Among these technologies, supercapacitors have attracted considerable attention because of their rapid charge-discharge capability, excellent cycling stability, and high-power performance. However, their relatively low energy density remains a critical limitation that restricts their broader practical application. Since the energy density of supercapacitors scales with the square of the operating voltage, expanding the electrochemical stability window of the electrolyte represents one of …
Unearthing Potential: Impact Investors’ Perspectives On Egypt’S Social Enterprise Market, Yousef Hesham Shoukry
Unearthing Potential: Impact Investors’ Perspectives On Egypt’S Social Enterprise Market, Yousef Hesham Shoukry
Theses and Dissertations
This thesis examines impact investing in Egypt from the vantage point of the impact investors, revealing that Egypt's constraint is not the availability of capital but its direction, as the absence of legal recognition, coordinated intermediaries, and a shared impact-measurement standard keeps capital out of a market otherwise rich in social enterprise potential. The study employed a constructivist grounded theory approach, drawing on eleven semi-structured interviews with impact fund managers, ecosystem enablers, and public-sector policy advisors operating in or considering Egypt's social enterprise market. Data revealed that practitioners converge on the founding principles of impact investment (combined financial and social …
Policy Coherence And Private Sector Development In Egypt: Aligning Governance Reforms With Development Finance, Shereef El Tanahi
Policy Coherence And Private Sector Development In Egypt: Aligning Governance Reforms With Development Finance, Shereef El Tanahi
Theses and Dissertations
Despite record volumes of development finance flowing into Egypt, the private sector, particularly its micro, small, and medium enterprises, has yet to experience the broad-based growth these investments were designed to catalyze. Between 2020 and 2025, international development partners committed more than 15.6 billion dollars to Egypt's private sector, yet private investment remains a modest share of the national economy, and most domestic firms continue to face severe barriers to credit.
This thesis argues that the answer lies not in the volume of capital mobilized, but in the coherence of the policies that govern how that capital reaches firms. The …
Simulation-Based Assessment Of Operational And Retrofit Solutions For Effluent Compliance Of A Capacity-Limited Oxidation Ditch Wwtp, Ahmed Sameh Harash
Simulation-Based Assessment Of Operational And Retrofit Solutions For Effluent Compliance Of A Capacity-Limited Oxidation Ditch Wwtp, Ahmed Sameh Harash
Theses and Dissertations
Oxidation-ditch wastewater treatment plants (WWTPs) across Egypt's Nile Delta are increasingly carrying hydraulic and organic loads beyond what they were designed for. This work can be considered pioneering as this work compared operational and structural retrofit alternatives for such a plant within a single verified simulation framework. The present study fills that gap by building a digital twin of the Qaha WWTP, a dual-train Carrousel oxidation ditch in Qalyubia Governorate, calibrated to a baseline flow of 7,420 m³/day in the SUMO24 platform (a third-generation, open-source wastewater treatment process simulation software) using the SUMO2c biokinetic model (a simplified variant of Activated …
Circulating Futures: Infrastructure, Value, And The Making Of Contemporary Egypt, Yasmine Abdeldayem
Circulating Futures: Infrastructure, Value, And The Making Of Contemporary Egypt, Yasmine Abdeldayem
Theses and Dissertations
Since 2014, Egypt has undertaken an unprecedented expansion of its road network as part of a broader project of territorial development and national renewal. Roads are presented in this project as the connective infrastructure through which new cities, investment zones, and desert territories are brought into circulation. Yet their developmental effects are often difficult to discern: infrastructure is rapidly built but unevenly maintained, while projects justified in terms of mobility, growth, and public benefit can produce dispossession, exclusion, and new forms of risk. This thesis argues that roads cannot be understood solely through the developmental outcomes they are intended to …
Dynamic Baseline Schedule Updates Using Digital Twinning: A Case Study On Aluminum Formwork Construction, Ahmed Hamdi Sweilam
Dynamic Baseline Schedule Updates Using Digital Twinning: A Case Study On Aluminum Formwork Construction, Ahmed Hamdi Sweilam
Theses and Dissertations
Repetitive high-rise construction using aluminum formwork couples consecutive floor cycles through a reused panel set and a floor-level inspection and pour barrier, so productivity loss compounds upward rather than being absorbed locally. The baseline schedule is nevertheless fixed before execution and is not revised as evidence of realized productivity accumulates. This thesis develops a simulation-based digital twin that updates the baseline from observed as-built durations and acts on its own forecast. A discrete-event simulation of a ten-story residential tower is built in AnyLogic® and verified analytically at 180.00 hours per floor. After each completed floor the twin infers activity productivity …
A Maximum Energy Release Rate Computational Framework For Fatigue Crack Trajectory And Life Prediction Under Mixed-Mode Proportional And Nonproportional Loading, Nahla Helmy Matar
A Maximum Energy Release Rate Computational Framework For Fatigue Crack Trajectory And Life Prediction Under Mixed-Mode Proportional And Nonproportional Loading, Nahla Helmy Matar
Theses and Dissertations
The problem of mixed-mode fatigue crack growth has been a persistent research challenge. The determination of fatigue crack propagation direction directly impacts the safety and integrity of components and structures, making it crucial in various industrial applications, including welded drilling pipes, aerospace, and automotive engineering. Unlike uniaxial loading, mixed-mode cracks tend to change direction frequently (kinking), and nonproportional loading adds to the complexity of the problem. This research aims to estimate the crack propagation direction and fatigue crack life in linear elastic materials subjected to mixed-mode (I+II) loading conditions under proportional or non-proportional cyclic loading. Numerical software was developed based …
Enhancing User Engagement In Heritage Sites Through Interactive Digital Design: Development And Evaluation Of A Web-Based Application At The Qalawun Complex, Hend Bazeed
Theses and Dissertations
This study develops and evaluates a web-based interactive application for the Qalawun Complex in Cairo, a fourteenth-century Mamluk monument of significant tangible and intangible cultural heritage value, with the aim of enhancing visitor engagement beyond the passive observation that characterizes most heritage visits. The research is structured within an Asset-Design-Evaluate (ADE) framework and grounded in Radical Constructivism, Situated Learning theory, and the Design-Dynamics-Experience (DDE) framework, positioning the physical architecture of the site as the primary source of visitor knowledge through observation-based interaction tasks.
The application, titled "Qalawun's Treasure," comprises eight spatially anchored hotspots across the mausoleum, madrasa, and bimaristan of …
Technology, Power, And Colonial Modernity: The Making Of The Egyptian Railways, Ahmed Mohamed Rahmy
Technology, Power, And Colonial Modernity: The Making Of The Egyptian Railways, Ahmed Mohamed Rahmy
Theses and Dissertations
This thesis examines Egyptian railways as a technology of power through which modern temporal order was gradually formed, reorganized, and contested. Focusing on the period from 1850 to 1920, it argues that railway infrastructure did more than facilitate mobility, economic exchange, and imperial administration: it reorganized the temporal relations through which social life was governed and experienced. Timetables, standardized schedules, fares, penalties, stations, and administrative procedures made punctuality, regularity, and measurable time appear as neutral requirements of life, while positioning existing ecological, agricultural, religious, and communal rhythms as signs of backwardness.
The thesis draws on British official correspondence, parliamentary debates, …
Sustainable – Low-Cost - Upgrade Of Activated Sludge Process For Nitrogen And Phosphorus (N&P) Removal From Wastewater, Abanoub N. Basta
Sustainable – Low-Cost - Upgrade Of Activated Sludge Process For Nitrogen And Phosphorus (N&P) Removal From Wastewater, Abanoub N. Basta
Theses and Dissertations
Many municipal wastewater treatment plants (WWTPs) in developing countries were designed primarily for organic matter and suspended solids removal and therefore face increasing difficulty in meeting modern nitrogen (N) and phosphorus (P) discharge requirements. Conventional biological nutrient removal upgrades commonly require additional reactor volume, recirculation systems, aeration energy, and capital investment. Accordingly, sustainable retrofit strategies that improve nutrient removal within existing treatment footprints are increasingly needed, particularly in water-scarce and land-constrained regions.
This study investigated the integration of water hyacinth (Eichhornia crassipes) into the aeration stage of an activated sludge process as a hybrid nature-based enhancement for nitrogen and phosphorus …
A Comparative Study: Force Majeure And The Theory Of Unforeseen Circumstances Across Different Jurisdictions In The Middle East, Omar Hamed Sawan
A Comparative Study: Force Majeure And The Theory Of Unforeseen Circumstances Across Different Jurisdictions In The Middle East, Omar Hamed Sawan
Theses and Dissertations
The motivation behind this study stems from recent global disruption events that impact construction projects worldwide. These events vary across a wide spectrum, whether they are political events such as the Russo-Ukraine war or the war in the Middle East, economic events such as inflation or currency devaluations; or environmental events such as climate change and the emergence of public health crises like the Covid-19 pandemic. These series of events underscore the growing importance of understanding how the different legal frameworks address unforeseeable events in the construction industry. In this context, force majeure and the theory of unforeseen circumstances (also …
Knowledge, Attitudes, And Practices (Kap) Of Parents Regarding The Prevention And Control Of Childhood Iron Deficiency Anemia In Egypt: A Cross-Sectional Study, Omnia Soliman
Theses and Dissertations
Childhood Iron Deficiency Anemia (IDA) remains a major public health challenge in Egypt, where its persistently high and rising prevalence carries substantial consequences for child growth, cognitive development, immunity, and long-term health outcomes. Globally, approximately 40% of children aged 6–59 months are affected by anemia (World Health Organization, 2025), and Egypt mirrors this burden, with national data showing a worsening trend in recent years. In Egypt, national strategies have traditionally focused on biomedical interventions such as iron supplementation and food fortification, while less attention has been directed toward behavioral and household-level determinants, particularly parental knowledge, attitudes, and practices (KAP) related …
Extending Geometric Acoustic Ray Tracing To Multi-Room Environments: A Case Study On Gunshot Sound Transmission Between Adjacent Rooms, Tyler Ton
Theses and Dissertations
Accurate localization of gunshots in multi-room building environments remains a challenging problem in acoustic forensics and public safety applications. Existing approaches model sound propagation within a single room, neglecting the transmission of acoustic energy through walls and other building materials. This thesis presents a study on modeling multi-room gunshot acoustic transmission, combining geometric ray tracing with structural acoustic transmission-loss modeling to generate impulse responses for two horizontally adjacent rooms separated by a shared wall, providing a foundation for future inter-room gunshot localization work. The proposed system uses GSound-SIR, a geometric acoustics engine, to simulate sound propagation in both of the …
A Data-Driven Koopman Framework For Station-Keeping On Near Rectilinear Halo Orbit, Anusha Sharma Malladi
A Data-Driven Koopman Framework For Station-Keeping On Near Rectilinear Halo Orbit, Anusha Sharma Malladi
Theses and Dissertations
Cislunar missions have gained significant attention in recent decades, motivating the need for efficient modeling and reliable control. In this work a Koopman operator based framework is developed for approximating the error dynamics around a reference Near Rectilinear Halo Orbit (NRHO) in the Earth-Moon Circular Restricted Three-Body Problem (CR3BP). A decoder free neural network is used to learn a lifted linear representation of the nonlinear CR3BP dynamics and a residual based approach is used to identify the corresponding control input matrix. The model is then implemented in a receding-horizon target point controller and compared with uncontrolled propagation and a State …
Comparative Performance Of Physiological Vital-Sign Forecasting Under Random And Patient-Wise Splitting Using Deep Learning, Lavanya Vasavi Chittem Reddy
Comparative Performance Of Physiological Vital-Sign Forecasting Under Random And Patient-Wise Splitting Using Deep Learning, Lavanya Vasavi Chittem Reddy
Theses and Dissertations
Physiological vital-sign forecasting estimates future measurements based on recent temporal patterns and can support analysis of continuously recorded monitoring data. This study comparatively evaluated deep feedforward, recurrent, bidirectional recurrent, long short-term memory, and bidirectional long short-term memory architectures for one-step-ahead forecasting of peripheral oxygen saturation, heart rate, and pulse rate. Each model received consecutive observations of peripheral oxygen saturation, heart rate, pulse rate, respiratory rate, and age, while separate single-output models predicted the next value of the selected target.
Random and patient-wise data splitting were compared using identical input definitions, preprocessing procedures, model architectures, and training hyperparameters. The strongest architecture …
Developing Imitation Learning Policies By Exploring Diffusion Framework For Quadcopters, Likith Swamireddy
Developing Imitation Learning Policies By Exploring Diffusion Framework For Quadcopters, Likith Swamireddy
Theses and Dissertations
Imitation learning offers a promising approach in developing near-optimal onboard policies for nonlinear systems, by learning from computationally expensive trajectory planners during offline training. Existing State-of-the-art methods commonly learn deterministic mappings from observations to actions by training fast neural networks to mimic the expert demonstrations, which can limit their ability to capture the action distribution, when the policy is trained on multiple possible expert commands to reach the same target, and this may lead to unsafe scenarios in the obstacle environments. To address these challenges, this study explores Diffusion Models (DMs) as a feedback controller for quadcopters that learns the …
Study Of Fast Switching Metastable-State Photoacids And Controlled Drug Release From Polycaprolactone (Pcl) Vascular Scaffold, Rana Salman Abbood Abbood
Study Of Fast Switching Metastable-State Photoacids And Controlled Drug Release From Polycaprolactone (Pcl) Vascular Scaffold, Rana Salman Abbood Abbood
Theses and Dissertations
Metastable-state photoacid (mPAH) has become a common tool for controlling and driving chemical processes with light. mPAHs with fast reverse reactions are desirable for precise temporal control or generating quick pulses of proton concentration. In this work, different approaches towards fast reversing mPAHs are studied. Experimental and computational results showed that stabilizing the charge–transfer intermediate is an effective way to increase the rate. A novel mPAH with a reverse reaction ≈500 times faster than the most widely used mPAH in methanol has been developed. Another water-soluble mPAH exhibited a reverse reaction with a rate constant of 7.8 s−1, the fastest …
A Study On Some Distance Based Domination Parameters In Graphs And Their Applications, Shanmugavelan S Mr
A Study On Some Distance Based Domination Parameters In Graphs And Their Applications, Shanmugavelan S Mr
Theses and Dissertations
Distance-based domination has emerged as a significant development in graph theory, attributed to its applications in communication systems, interconnection networks, parallel architectures, and chemical graph models. This thesis focuses on two such graph invariants: hop domination number and 2-hop domination number of graphs. The hop domination number of some generalized graph structures like generalized thorn paths, generalized theta graphs, and snake graph families is studied along with a newly introduced family, namely generalized ciliates.
Moreover, a variant of hop domination number, namely, the 2-hop domination number, is studied for some grid families like ladder, hexagonal grid, and its variants. Furthermore, …
A Fundamental Study Of Fatty Acid Ionic Liquids And Their Effects On Biomolecules, Achismita Dutta
A Fundamental Study Of Fatty Acid Ionic Liquids And Their Effects On Biomolecules, Achismita Dutta
Theses and Dissertations
Fatty acid ionic liquids (FAILs) are a class of ionic liquids (ILs) with relatively low toxicity and potential applications in biological systems. This study examined the interactions of tetramethylguanidinium decanoate, tetramethylguanidinium octanoate, choline decanoate, and choline octanoate with lipid membranes, proteins, and nucleic acids. Membrane leakage experiments using model lipid vesicles showed that decanoate-based FAILs produced greater membrane permeabilization than octanoate-based analogues, consistent with their higher membrane permeability. These effects were stronger for the ILs than for decanoate alone and occurred below the critical micelle concentration (CMC), suggesting that micelle formation may not be essential for membrane disruption. The ability …
A Hybrid Rule-Based And Large Language Model Framework For Extracting Acronym–Definition Pairs From Scientific Literature, Petro Skrypnyk
A Hybrid Rule-Based And Large Language Model Framework For Extracting Acronym–Definition Pairs From Scientific Literature, Petro Skrypnyk
Theses and Dissertations
Authors of scientific papers rely heavily on acronyms and often use them without defining them, making the literature harder to read and index. This thesis develops and evaluates a hybrid rule-based and large language model (LLM) framework that extracts acronym–definition pairs from scientific PDF documents. It extends an earlier Rowan University system that combined a regular-expression parser with a single LLM on 200 papers. That system showed that neither the parser nor the LLM alone is sufficient for accurate extraction of the pairs. The framework is a fully automated pipeline from PDF input to scored results. It compares four LLM …
Struggling Readers Collaborate On Reading Interventions For Fifteen Minutes A Day, Jordan Dobzanski
Struggling Readers Collaborate On Reading Interventions For Fifteen Minutes A Day, Jordan Dobzanski
Theses and Dissertations
This thesis examines what happens when struggling readers collaborate on reading intervention practices for fifteen minutes a day. Relevant theories that guided this research included Bandura’s Social Learning Theory, Vygotsky’s Social Constructivist Theory, and Lankshear and Knobel’s New Literacies Theory. Throughout the six-week study, four third-grade students identified as below grade level participated in a collaborative reading intervention that focused on vocabulary development, fiction and informational text comprehension, student-led discussions, digital literacy activities, and reflective journaling. Students worked together in structured literature circles while engaging in literacy activities connected to their classroom curriculum. Data were analyzed through triangulation in order …
Polymer Nanocomposite Dielectrics For High-Temperature Superconducting Cables: Cryogenic Characterization And Testing Environment Development, Jared R. Ericksen
Polymer Nanocomposite Dielectrics For High-Temperature Superconducting Cables: Cryogenic Characterization And Testing Environment Development, Jared R. Ericksen
Theses and Dissertations
High-temperature superconducting (HTS) cables require dielectric insulation materials that can withstand cryogenic operating environments while maintaining electrical reliability, mechanical stability, and manufacturing compatibility. This thesis investigates polyamide-based polymer nanocomposites as candidate HTS cable insulation materials and develops cryogenic testing platforms for evaluating thin-film dielectrics at reduced temperatures. Two silicon-based filler systems are studied: sol-gel-derived silicon dioxide (SiO 2 ) nanoparticles and polyhedral oligomeric silsesquioxane (POSS). Dielectric breakdown behavior is evaluated under DC and AC high-potential testing, while mechanical behavior is assessed through tensile testing. The results show that PA/SiO 2 nanocomposites provide the strongest overall balance of mechanical reinforcement and …
A Framework For Automated Quantity Extraction From .Ifc Models And Normalized Bid Comparison, Asmaa Mohamed Farouk
A Framework For Automated Quantity Extraction From .Ifc Models And Normalized Bid Comparison, Asmaa Mohamed Farouk
Theses and Dissertations
Accurate bid comparison remains a major challenge in construction tendering due to
differences in Bill of Quantities formats, item naming conventions, and pricing methods across
contractor submissions. These variations require time-consuming manual work and often lead to
subjective decisions. This research presents a computational framework that uses Building
Information Modeling through the .ifc file format, combined with text analysis techniques for
automated bid normalization.
The developed system uses a dual-component approach. Phase 1 extracts quantities from .ifc
model files using 3D geometric calculations, automated element classification. Phase 2 uses text
mining with a domain-specific dictionary of construction terms to interpret …
Development Of Quantum Cryptographic Algorithm For Next Generation Secure Systems, Gururaja Ts Mr
Development Of Quantum Cryptographic Algorithm For Next Generation Secure Systems, Gururaja Ts Mr
Theses and Dissertations
The rapid advancement of digital communication and quantum technologies are developing at an accelerated pace makes cybersecurity and data protection a big challenge. The traditional cryptographic methods are increasingly under attack by phishing, brute force, cryptanalytic attack and threats of quantum computing. This research presents a quantum-secure communication based on Quantum Random Number Generator (QRNG), Quantum Key Distribution (QKD), Quantum Image Encryption (QIE) and secure quantum key access using a dongle-based hardware.
QRNG models were designed in the quantum simulator and hardware. The sequences produce high entropy and they passed the statistical randomness tests with p-values higher than 0.01 indicates …
Dual-Polymer Concrete With Recycled Pet And Hdpe Aggregates: Mechanical And Durability Performance Assessment, Omar Abd El Mageed Hammouda
Dual-Polymer Concrete With Recycled Pet And Hdpe Aggregates: Mechanical And Durability Performance Assessment, Omar Abd El Mageed Hammouda
Theses and Dissertations
This study investigates the fresh, mechanical, durability, thermal, performance as well as preliminary financial aspects of dual-polymer concrete incorporating recycled polyethylene terephthalate (PET) as a partial replacement for fine aggregate and recycled high-density polyethylene (HDPE) as a partial replacement for coarse aggregate, with silica fume as a supplementary cementitious material held constant at 10% by weight of cement. The study responds to the convergence of two pressing challenges in the Egyptian context: the scale of plastic waste mismanagement, which results in widespread informal open burning and environmental contamination, and the high operational energy demand of residential buildings in Egypt's hot …
Actionable Hydrologic Data To Information With National Water Model-Based Derived Dataset, Cutting-Edge Data Services, And Agentic Ai System, Sujan Chandra Mondol
Actionable Hydrologic Data To Information With National Water Model-Based Derived Dataset, Cutting-Edge Data Services, And Agentic Ai System, Sujan Chandra Mondol
Theses and Dissertations
Hydrologic data are the cornerstone of many complex hydrologic research and operational workflows that produce useful hydrologic information for water resources decision-making, flood risk communication, and water availability implications. The National Water Model (NWM) is a valuable source of hydrologic data, particularly for its extended coverage of unmonitored streams and the large-scale continuity of hydrologic processes. Precomputed secondary datasets derived from this simulated data, such as streamflow indices, can improve operational efficiency through thresholding. Disseminating the data through modern technologies, such as application programming interfaces, is required for ready integration into applications. However, if extraction requires an intermediate service, there …
Measuring Proteostasis Changes In Apolipoprotein E Mouse Models Using Quantitative And Kinetic Proteomic Methods, Ariel E.A. Denos
Measuring Proteostasis Changes In Apolipoprotein E Mouse Models Using Quantitative And Kinetic Proteomic Methods, Ariel E.A. Denos
Theses and Dissertations
Alzheimer's Disease (AD) is a neurological disorder associated with brain mass loss and cognitive decline. It affects millions of elderly people and is currently uncurable. Since 1906, when the disease was first described, researchers have uncovered many components of AD pathology. However, it is now evident that curing Alzheimer's Disease will require intervention before the pathological onset of amyloid beta plaque deposition, tau neurofibrillary tangles, and associated neuronal loss. Studying AD from the perspective of early intervention requires special attention to small changes that may disrupt the normal processing of cells. Cells undergo a natural cycle of creation and destruction …