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Switch From Canonical To Noncanonical Wnt Signaling Mediates High Glucose-Induced Adipogenesis, Emily C. Keats, James M. Dominguez, Maria B. Grant, Zia A. Khan
Switch From Canonical To Noncanonical Wnt Signaling Mediates High Glucose-Induced Adipogenesis, Emily C. Keats, James M. Dominguez, Maria B. Grant, Zia A. Khan
Paediatrics Publications
Human bone marrow mesenchymal progenitor cells (MPCs) are multipotent cells that play an essential role in endogenous repair and the maintenance of the stem cell niche. We have recently shown that high levels of glucose, conditions mimicking diabetes, cause impairment of MPCs, resulting in enhanced adipogenesis and suppression of osteogenesis. This implies that diabetes may lead to reduced endogenous repair mechanisms through altering the differentiation potential of MPCs and, consequently, disrupting the stem cell niche. Phenotypic alterations in the bone marrow of long-term diabetic patients closely resemble this observation. Here, we show that high levels of glucose selectively enhance autogenous …
Vascular Stem Cells In Diabetic Complications: Evidence For A Role In The Pathogenesis And The Therapeutic Promise, Emily C. Keats, Zia A. Khan
Vascular Stem Cells In Diabetic Complications: Evidence For A Role In The Pathogenesis And The Therapeutic Promise, Emily C. Keats, Zia A. Khan
Paediatrics Publications
Long standing diabetes leads to structural and functional alterations in both the micro- and the macro-vasculature. Vascular endothelial cells (ECs) are the primary target of the hyperglycemia-induced adverse effects. Vascular stem cells that give rise to endothelial progenitor cells (EPCs) and mesenchymal progenitor cells (MPCs) represent an attractive target for cell therapy for diabetic patients. A number of studies have reported EPC dysfunction as a novel participant in the culmination of the diabetic complications. The controversy behind the identity of EPCs and the similarity between these progenitor cells to hematopoietic cells has led to conflicting results. MPCs, on the other …