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Concise Review: Cell Therapy For Critical Limb Ischemia: An Integrated Review Of Preclinical And Clinical Studies, Mohammad Qadura, Daniella C. Terenzi, Subodh Verma, Mohammed Al-Omran, David A. Hess

Paediatrics Publications

Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is characterized by pain at rest and non-healing ulcers in the lower extremities. For patients with CLI, where the extent of atherosclerotic artery occlusion is too severe for surgical bypass or percutaneous interventions, limb amputation remains the only treatment option. Thus, cell-based therapy to restore perfusion and promote wound healing in patients with CLI is under intense investigation. Despite promising preclinical studies in animal models, transplantation of bone marrow (BM)-derived cell populations in patients with CLI has shown limited benefit preventing limb amputation. Early trials injected heterogenous mononuclear …