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Mechanisms Of Propranolol Action In Infantile Hemangioma, Jina J.Y. Kum, Zia A. Khan
Mechanisms Of Propranolol Action In Infantile Hemangioma, Jina J.Y. Kum, Zia A. Khan
Paediatrics Publications
Infantile hemangioma is a common tumor of infancy. Although most hemangiomas spontaneously regress, treatment is indicated based on complications, risk to organ development and function, and disfigurement. The serendipitous discovery of propranolol, a non-selective b-adrenergic receptor blocker, as an effective means to regress hemangiomas has made this a first-line therapy for hemangioma patients. Propranolol has shown remarkable response rates. There are, however, some adverse effects, which include changes in sleep, acrocyanosis, hypotension, and hypoglycemia. Over the last few years, researchers have focused on understanding the mechanisms by which propranolol causes hemangioma regression. This has entailed study of cultured vascular endothelial …
Pathophysiological Role Of Enhanced Bone Marrow Adipogenesis In Diabetic Complications, Meghan A. Piccinin, Zia A. Khan
Pathophysiological Role Of Enhanced Bone Marrow Adipogenesis In Diabetic Complications, Meghan A. Piccinin, Zia A. Khan
Paediatrics Publications
Diabetes leads to complications in select organ systems primarily by disrupting the vasculature of the target organs. These complications include both micro-(cardiomyopathy, retinopathy, nephropathy, and neuropathy) and macro-(atherosclerosis) angiopathies. Bone marrow angiopathy is also evident in both experimental models of the disease as well as in human diabetes. In addition to vascular disruption, bone loss and increased marrow adiposity have become hallmarks of the diabetic bone phenotype. Emerging evidence now implicates enhanced marrow adipogenesis and changes to cellular makeup of the marrow in a novel mechanistic link between various secondary complications of diabetes. In this review, we explore the mechanisms …