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Articles 1 - 30 of 30
Full-Text Articles in Entire DC Network
A Deep Learning Algorithm To Translate And Classify Cardiac Electrophysiology, Parya Aghasafari, Pei-Chi Yang, Divya C. Kernik, Kazuho Sakamoto, Yasunari Kanda, Junko Kurokawa, Igor Vorobyov, Colleen E. Clancy
A Deep Learning Algorithm To Translate And Classify Cardiac Electrophysiology, Parya Aghasafari, Pei-Chi Yang, Divya C. Kernik, Kazuho Sakamoto, Yasunari Kanda, Junko Kurokawa, Igor Vorobyov, Colleen E. Clancy
Open Access Publications
The development of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) has been a critical in vitro advance in the study of patient-specific physiology, pathophysiology, and pharmacology. We designed a new deep learning multitask network approach intended to address the low throughput, high variability, and immature phenotype of the iPSC-CM platform. The rationale for combining translation and classification tasks is because the most likely application of the deep learning technology we describe here is to translate iPSC-CMs following application of a perturbation. The deep learning network was trained using simulated action potential (AP) data and applied to classify cells into the drug-free …
Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human And Mouse Hosts, Bruce A Rosa, Caroline Snowden, John Martin, Kerstin Fischer, Jonah Kupritz, Ethiopia Beshah, Taniawati Supali, Lincoln Gankpala, Peter U Fischer, Joseph F Urban, Makedonka Mitreva
Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human And Mouse Hosts, Bruce A Rosa, Caroline Snowden, John Martin, Kerstin Fischer, Jonah Kupritz, Ethiopia Beshah, Taniawati Supali, Lincoln Gankpala, Peter U Fischer, Joseph F Urban, Makedonka Mitreva
Open Access Publications
The human whipworm
Calcium Carbonate Nanoparticles Stimulate Cancer Cell Reprogramming To Suppress Tumor Growth And Invasion In An Organ‑On‑A‑Chip System, Sandra F. Lam, Kevin W. Bishop, Rachel Mintz, Lei Fang, Samuel Achilefu
Calcium Carbonate Nanoparticles Stimulate Cancer Cell Reprogramming To Suppress Tumor Growth And Invasion In An Organ‑On‑A‑Chip System, Sandra F. Lam, Kevin W. Bishop, Rachel Mintz, Lei Fang, Samuel Achilefu
Open Access Publications
No abstract provided.
Moonshots For Aging, Sandeep Kumar, Timothy R Peterson
Moonshots For Aging, Sandeep Kumar, Timothy R Peterson
Open Access Publications
As the global population ages, there is increased interest in living longer and improving one's quality of life in later years. However, studying aging - the decline in body function - is expensive and time-consuming. And despite research success to make model organisms live longer, there still aren't really any feasible solutions for delaying aging in humans. With space travel, scientists and engineers couldn't know what it would take to get to the moon. They had to extrapolate from theory and shorter-range tests. Perhaps with aging, we need a similar moonshot philosophy. And though "shot" might imply medicine, perhaps we …
Perfect Timing: Circadian Rhythms, Sleep, And Immunity - An Nih Workshop Summary, Jeffrey A Haspel, Andrew E Gelman, Brian S Kim, Et Al
Perfect Timing: Circadian Rhythms, Sleep, And Immunity - An Nih Workshop Summary, Jeffrey A Haspel, Andrew E Gelman, Brian S Kim, Et Al
Open Access Publications
Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses - ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation -are mediated in a time of day-dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, "Sleep Insufficiency, Circadian Misalignment, and the Immune Response," to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, …
Implementation Of Wearable Sensing Technology For Movement: Pushing Forward Into The Routine Physical Rehabilitation Care Field, Catherine E Lang, Jessica Barth, Carey L Holleran, Jeff D Konrad, Marghuretta D Bland
Implementation Of Wearable Sensing Technology For Movement: Pushing Forward Into The Routine Physical Rehabilitation Care Field, Catherine E Lang, Jessica Barth, Carey L Holleran, Jeff D Konrad, Marghuretta D Bland
Open Access Publications
While the promise of wearable sensor technology to transform physical rehabilitation has been around for a number of years, the reality is that wearable sensor technology for the measurement of human movement has remained largely confined to rehabilitation research labs with limited ventures into clinical practice. The purposes of this paper are to: (1) discuss the major barriers in clinical practice and available wearable sensing technology; (2) propose benchmarks for wearable device systems that would make it feasible to implement them in clinical practice across the world and (3) evaluate a current wearable device system against the benchmarks as an …
Online And Clicker Quizzing On Jargon Terms Enhances Definition-Focused But Not Conceptually Focused Biology Exam Performance, Steven C. Pan, James Cooke, Jeri L. Little, Mark A. Mcdaniel, Erin R. Foster, Lisa Tabor Connor, Timothy C. Rickard
Online And Clicker Quizzing On Jargon Terms Enhances Definition-Focused But Not Conceptually Focused Biology Exam Performance, Steven C. Pan, James Cooke, Jeri L. Little, Mark A. Mcdaniel, Erin R. Foster, Lisa Tabor Connor, Timothy C. Rickard
Open Access Publications
Mastery of jargon terms is an important part of student learning in biology and other science, technology, engineering, and mathematics domains. In two experiments, we investigated whether prelecture quizzes enhance memory for jargon terms, and whether that enhanced familiarity can facilitate learning of related concepts that are encountered during subsequent lectures and readings. Undergraduate students enrolled in neuroanatomy and physiology courses completed 10-minute low-stakes quizzes with feedback on jargon terms either online (experiment 1) or using in-class clickers (experiment 2). Quizzes occurred before conventional course instruction in which the terms were used. On exams occurring up to 12 weeks later, …
Gut Microbiota: From The Forgotten Organ To A Potential Key Player In The Pathology Of Alzheimer's Disease, Dong-Oh Seo, David M Holtzman
Gut Microbiota: From The Forgotten Organ To A Potential Key Player In The Pathology Of Alzheimer's Disease, Dong-Oh Seo, David M Holtzman
Open Access Publications
More than 300 years ago, Antony van Leewenhoeck first described observing single-celled microorganisms, which he termed "animalcules," examining his saliva under a microscope. Although the idea of the coexistence of microorganisms in our body is not new, we have only recently been able to investigate their ecological relationship to our body, with the development of high-throughput molecular techniques. The diverse microorganism communities residing in our guts are established and maintained by complex interactions among microorganisms and their host. Notably, their alteration has been implicated in influencing various diseases including neurological diseases. Alzheimer's disease (AD) is the most common cause of …
A Mutation In Site-1 Protease Is Associated With A Complex Phenotype That Includes Episodic Hyperckemia And Focal Myoedema, George G. Schweitzer, Connie Gan, Robert C. Bucelli, Daniel Wegner, Robert E. Schmidt, Marwan Shinawi, Brian N. Finck, Rita T. Brookheart
A Mutation In Site-1 Protease Is Associated With A Complex Phenotype That Includes Episodic Hyperckemia And Focal Myoedema, George G. Schweitzer, Connie Gan, Robert C. Bucelli, Daniel Wegner, Robert E. Schmidt, Marwan Shinawi, Brian N. Finck, Rita T. Brookheart
Open Access Publications
No abstract provided.
Top 10 Research Priorities In Spatial Lifecourse Epidemiology, Peng Jia, Ross C. Brownson, Et Al.
Top 10 Research Priorities In Spatial Lifecourse Epidemiology, Peng Jia, Ross C. Brownson, Et Al.
Open Access Publications
No abstract provided.
High-Throughput Scaffold-Free Microtissues Through 3d Printing, Christen J. Boyer, David H. Ballard, Mansoureh Barzegar, J. Winny Yun, Jennifer E. Woerner, Ghali E. Ghali, Moheb Boktor, Yuping Wang, J. Steven Alexander
High-Throughput Scaffold-Free Microtissues Through 3d Printing, Christen J. Boyer, David H. Ballard, Mansoureh Barzegar, J. Winny Yun, Jennifer E. Woerner, Ghali E. Ghali, Moheb Boktor, Yuping Wang, J. Steven Alexander
Open Access Publications
No abstract provided.
A Systematic Meta-Analysis Of Oxygen-To-Glucose And Oxygen-To-Carbohydrate Ratios In The Resting Human Brain, Tyler Blazey, Abraham Z. Snyder, Manu S. Goyal, Andrei G. Vlassenko, Marcus E. Raichle
A Systematic Meta-Analysis Of Oxygen-To-Glucose And Oxygen-To-Carbohydrate Ratios In The Resting Human Brain, Tyler Blazey, Abraham Z. Snyder, Manu S. Goyal, Andrei G. Vlassenko, Marcus E. Raichle
Open Access Publications
No abstract provided.
Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms Of Eye Fatigue, Jonathan B. Lin, Blair W. Gerratt, Carl J. Bassi, Rajendra S. Apte
Short-Wavelength Light-Blocking Eyeglasses Attenuate Symptoms Of Eye Fatigue, Jonathan B. Lin, Blair W. Gerratt, Carl J. Bassi, Rajendra S. Apte
Open Access Publications
No abstract provided.
Nicotinamide Mononucleotide Supplementation Reverses Vascular Dysfunction And Oxidative Stress With Aging In Mice, Natalie E. De Picciotto, Lindsey B. Gano, Lawrence C. Johnson, Christopher R. Martens, Amy L. Sindler, Kathryn F. Mills, Shin-Ichiro Imai, Douglas R. Seals
Nicotinamide Mononucleotide Supplementation Reverses Vascular Dysfunction And Oxidative Stress With Aging In Mice, Natalie E. De Picciotto, Lindsey B. Gano, Lawrence C. Johnson, Christopher R. Martens, Amy L. Sindler, Kathryn F. Mills, Shin-Ichiro Imai, Douglas R. Seals
Open Access Publications
No abstract provided.
Angiotensin Converting Enzyme (Ace) Inhibitor Extends Caenorhabditis Elegans Life Span, Sandeep Kumar, Nicholas Dietrich, Kerry Kornfeld
Angiotensin Converting Enzyme (Ace) Inhibitor Extends Caenorhabditis Elegans Life Span, Sandeep Kumar, Nicholas Dietrich, Kerry Kornfeld
Open Access Publications
No abstract provided.
An Approach To Quantifying 3d Responses Of Cells To Extreme Strain, Yuhui Li, Guoyou Huang, Moxiao Li, Lin Wang, Elliot L. Elson, Tian Jian Lu, Guy M. Genin, Feng Xu
An Approach To Quantifying 3d Responses Of Cells To Extreme Strain, Yuhui Li, Guoyou Huang, Moxiao Li, Lin Wang, Elliot L. Elson, Tian Jian Lu, Guy M. Genin, Feng Xu
Open Access Publications
No abstract provided.
Effects Of Vitamin D Supplementation On C-Peptide And 25-Hydroxyvitamin D Concentrations At 3 And 6 Months, Paulette D. Chandler, Edward L. Giovannucci, Jamil B. Scott, Gary G. Bennett, Kimmie Ng, Andrew T. Chan, Bruce W. Hollis, Nader Rifai, Karen M. Emmons, Charles S. Fuchs, Bettina F. Drake
Effects Of Vitamin D Supplementation On C-Peptide And 25-Hydroxyvitamin D Concentrations At 3 And 6 Months, Paulette D. Chandler, Edward L. Giovannucci, Jamil B. Scott, Gary G. Bennett, Kimmie Ng, Andrew T. Chan, Bruce W. Hollis, Nader Rifai, Karen M. Emmons, Charles S. Fuchs, Bettina F. Drake
Open Access Publications
No abstract provided.
Mechanisms Of Hypoglycemia-Associated Autonomic Failure In Diabetes, Philip E. Cryer
Mechanisms Of Hypoglycemia-Associated Autonomic Failure In Diabetes, Philip E. Cryer
Open Access Publications
No abstract provided.
Tbc1d3, A Hominoid-Specific Gene, Delays Irs-1 Degradation And Promotes Insulin Signaling By Modulating P70 S6 Kinase Activity, Marisa J. Wainszelbaum, Jialu Liu, Chen Kong, Priya Srikanth, Dmitri Samovski, Xiong Su, Philip D. Stahl
Tbc1d3, A Hominoid-Specific Gene, Delays Irs-1 Degradation And Promotes Insulin Signaling By Modulating P70 S6 Kinase Activity, Marisa J. Wainszelbaum, Jialu Liu, Chen Kong, Priya Srikanth, Dmitri Samovski, Xiong Su, Philip D. Stahl
Open Access Publications
No abstract provided.
Three Ontologies To Define Phenotype Measurement Data, Mary Shimoyama, Rajni Nigam, Leslie Sanders Mcintosh, Rakesh Nagarajan, Treva Rice, D. C. Rao, Melinda R. Dwinell
Three Ontologies To Define Phenotype Measurement Data, Mary Shimoyama, Rajni Nigam, Leslie Sanders Mcintosh, Rakesh Nagarajan, Treva Rice, D. C. Rao, Melinda R. Dwinell
Open Access Publications
No abstract provided.
Ubiquitination And Degradation Of The Hominoid- Specific Oncoprotein Tbc1d3 Is Mediated By Cul7 E3 Ligase, Chen Kong, Dmitri Samovski, Priya Srikanth, Marisa J. Wainszelbaum, Audra J. Charron, Jialiu Liu, Jeffrey J. Lange, Pin-I Chen, Zhen-Qiang Pan, Xiong Su, Philip D. Stahl
Ubiquitination And Degradation Of The Hominoid- Specific Oncoprotein Tbc1d3 Is Mediated By Cul7 E3 Ligase, Chen Kong, Dmitri Samovski, Priya Srikanth, Marisa J. Wainszelbaum, Audra J. Charron, Jialiu Liu, Jeffrey J. Lange, Pin-I Chen, Zhen-Qiang Pan, Xiong Su, Philip D. Stahl
Open Access Publications
No abstract provided.
Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas
Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas
Open Access Publications
No abstract provided.
Identification Of Chemically Sulfated/Desulfated Glycosaminoglycans In Contaminated Heparins And Development Of A Simple Assay For The Detection Of Most Contaminants In Heparin, Jing Pan, Yi Qian, Xiaodong Zhou, Andrew Pazandak, Sarah B. Frazier, Peter Weiser, Hong Lu, Lijuan Zhang
Identification Of Chemically Sulfated/Desulfated Glycosaminoglycans In Contaminated Heparins And Development Of A Simple Assay For The Detection Of Most Contaminants In Heparin, Jing Pan, Yi Qian, Xiaodong Zhou, Andrew Pazandak, Sarah B. Frazier, Peter Weiser, Hong Lu, Lijuan Zhang
Open Access Publications
No abstract provided.
Fibroblast Growth Factor Receptors 1 And 2 In Keratinocytes Control The Epidermal Barrier And Cutaneous Homeostasis, Jingxuan Yang, Michael Meyer, Anna-Katharina Müller, Friederike Böhm, Richard Grose, Tina Dauwalder, Francois Verrey, Manfred Kopf, Juha Partanen, Wilhelm Bloch, David M. Ornitz, Sabine Werner
Fibroblast Growth Factor Receptors 1 And 2 In Keratinocytes Control The Epidermal Barrier And Cutaneous Homeostasis, Jingxuan Yang, Michael Meyer, Anna-Katharina Müller, Friederike Böhm, Richard Grose, Tina Dauwalder, Francois Verrey, Manfred Kopf, Juha Partanen, Wilhelm Bloch, David M. Ornitz, Sabine Werner
Open Access Publications
Fibroblast growth factors (FGFs) are master regulators of organogenesis and tissue homeostasis. In this study, we used different combinations of FGF receptor (FGFR)-deficient mice to unravel their functions in the skin. Loss of the IIIb splice variants of FGFR1 and FGFR2 in keratinocytes caused progressive loss of skin appendages, cutaneous inflammation, keratinocyte hyperproliferation, and acanthosis. We identified loss of FGF-induced expression of tight junction components with subsequent deficits in epidermal barrier function as the mechanism underlying the progressive inflammatory skin disease. The defective barrier causes activation of keratinocytes and epidermal gammadelta T cells, which produce interleukin-1 family member 8 and …
Defensins And The Convergent Evolution Of Platypus And Reptile Venom Genes, Camilla M. Whittington, Anthony T. Papenfuss, Paramjit Bansal, Allan M. Torres, Emily S.W. Wong, Janine E. Deakin, Tina Graves, Amber Alsop, Kyriena Schatzkamer, Colin Kremitzki, Chris P. Ponting, Peter Temple-Smith, Wesley C. Warren, Philip W. Kuchel, Katherine Belov
Defensins And The Convergent Evolution Of Platypus And Reptile Venom Genes, Camilla M. Whittington, Anthony T. Papenfuss, Paramjit Bansal, Allan M. Torres, Emily S.W. Wong, Janine E. Deakin, Tina Graves, Amber Alsop, Kyriena Schatzkamer, Colin Kremitzki, Chris P. Ponting, Peter Temple-Smith, Wesley C. Warren, Philip W. Kuchel, Katherine Belov
Open Access Publications
No abstract provided.
Nested Patch Pcr Enables Highly Multiplexed Mutation Discovery In Candidate Genes, Katherine Elena Varley, Robi David Mitra
Nested Patch Pcr Enables Highly Multiplexed Mutation Discovery In Candidate Genes, Katherine Elena Varley, Robi David Mitra
Open Access Publications
No abstract provided.
New Challenges In Studying Nutrition-Disease Interactions In The Developing World, Andrew M. Prentice, M. Eric Gershwin, Ulrich E. Schaible, Gerald T. Keusch, Cesar G. Victora, Jeffrey I. Gordon
New Challenges In Studying Nutrition-Disease Interactions In The Developing World, Andrew M. Prentice, M. Eric Gershwin, Ulrich E. Schaible, Gerald T. Keusch, Cesar G. Victora, Jeffrey I. Gordon
Open Access Publications
No abstract provided.
Large-Scale In Silico Mapping Of Complex Quantitative Traits In Inbred Mice, Pengyuan Liu, Haris Vikis, Yan Lu, Daolong Wang, Ming You
Large-Scale In Silico Mapping Of Complex Quantitative Traits In Inbred Mice, Pengyuan Liu, Haris Vikis, Yan Lu, Daolong Wang, Ming You
Open Access Publications
No abstract provided.
Genomic And Metabolic Studies Of The Impact Of Probiotics On A Model Gut Symbiont And Host, Justin L. Sonnenburg, Christina T. Chen, Jeffery I. Gordon
Genomic And Metabolic Studies Of The Impact Of Probiotics On A Model Gut Symbiont And Host, Justin L. Sonnenburg, Christina T. Chen, Jeffery I. Gordon
Open Access Publications
No abstract provided.
Transcriptional Regulation Of Metabotropic Glutamate Receptor 2/3 Expression By The Nf-Κb Pathway In Primary Dorsal Root Ganglia Neurons: A Possible Mechanism For The Analgesic Effect Of L-Acetylcarnitine, Santina Chiechio, Agata Copani, Laura De Petris, Maria Elena P. Morales, Ferdinando Nicoletti, Robert W. Gereau Iv
Transcriptional Regulation Of Metabotropic Glutamate Receptor 2/3 Expression By The Nf-Κb Pathway In Primary Dorsal Root Ganglia Neurons: A Possible Mechanism For The Analgesic Effect Of L-Acetylcarnitine, Santina Chiechio, Agata Copani, Laura De Petris, Maria Elena P. Morales, Ferdinando Nicoletti, Robert W. Gereau Iv
Open Access Publications
No abstract provided.